NO320491B1 - Fremgangsmate for hormonutskifting og hormondispenser - Google Patents
Fremgangsmate for hormonutskifting og hormondispenser Download PDFInfo
- Publication number
- NO320491B1 NO320491B1 NO19981412A NO981412A NO320491B1 NO 320491 B1 NO320491 B1 NO 320491B1 NO 19981412 A NO19981412 A NO 19981412A NO 981412 A NO981412 A NO 981412A NO 320491 B1 NO320491 B1 NO 320491B1
- Authority
- NO
- Norway
- Prior art keywords
- progestogen
- estrogen
- dispenser
- pharmaceutical composition
- volume
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/0005—Containers or packages provided with a piston or with a movable bottom or partition having approximately the same section as the container
- B65D83/0011—Containers or packages provided with a piston or with a movable bottom or partition having approximately the same section as the container moved by a screw-shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/22—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with two or more compartments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/325—Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/0005—Containers or packages provided with a piston or with a movable bottom or partition having approximately the same section as the container
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Feed For Specific Animals (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Catching Or Destruction (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53540295A | 1995-09-28 | 1995-09-28 | |
| PCT/EP1996/004261 WO1997011680A2 (en) | 1995-09-28 | 1996-09-30 | Hormone replacement therapy method and hormone dispenser |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO981412D0 NO981412D0 (no) | 1998-03-27 |
| NO981412L NO981412L (no) | 1998-05-12 |
| NO320491B1 true NO320491B1 (no) | 2005-12-12 |
Family
ID=24134029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19981412A NO320491B1 (no) | 1995-09-28 | 1998-03-27 | Fremgangsmate for hormonutskifting og hormondispenser |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5897539A (ko) |
| EP (1) | EP0854705B1 (ko) |
| JP (1) | JPH11512703A (ko) |
| KR (1) | KR20000004898A (ko) |
| CN (1) | CN1158206C (ko) |
| AT (1) | ATE255406T1 (ko) |
| AU (1) | AU714084B2 (ko) |
| BR (1) | BR9610915A (ko) |
| CA (1) | CA2232621A1 (ko) |
| CZ (1) | CZ95598A3 (ko) |
| DE (1) | DE69630968T2 (ko) |
| DK (1) | DK0854705T3 (ko) |
| ES (1) | ES2211983T3 (ko) |
| HK (1) | HK1016887A1 (ko) |
| HU (1) | HUP9802608A3 (ko) |
| IL (1) | IL123691A (ko) |
| MX (1) | MX9802370A (ko) |
| NO (1) | NO320491B1 (ko) |
| PL (1) | PL185848B1 (ko) |
| PT (1) | PT854705E (ko) |
| TR (1) | TR199800560T1 (ko) |
| TW (1) | TW329389B (ko) |
| WO (1) | WO1997011680A2 (ko) |
| ZA (1) | ZA968227B (ko) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| US6551611B2 (en) * | 1995-09-28 | 2003-04-22 | Schering Aktiengesellschaft | Hormone replacement therapy method |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US6448233B1 (en) | 1997-07-08 | 2002-09-10 | Cosmoferm B.V. | Topical application of a combination of benzoyl peroxide and a second active ingredient |
| AU2005201151B2 (en) * | 1999-03-30 | 2008-01-10 | Jencap Research Ltd | Low dose estrogen interrupted hormone replacement therapy |
| CA2267743C (en) * | 1999-03-30 | 2011-07-26 | Robert F. Casper | Low dose estrogen interrupted hormone replacement therapy |
| EP2305267A3 (en) * | 1999-08-31 | 2011-08-17 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| IL148339A0 (en) * | 1999-08-31 | 2002-09-12 | Schering Ag | Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive |
| US20040191276A1 (en) * | 1999-11-30 | 2004-09-30 | Cutispharma, Inc. | Compositions and kits for compounding pharmaceuticals |
| SK288129B6 (sk) * | 2000-01-18 | 2013-10-02 | Bayer Schering Pharma Aktiengesellschaft | Drospirenone for hormonal substitution treatment |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| MXPA02007165A (es) * | 2000-01-28 | 2003-09-22 | Endorech Inc | Moduladores del receptor selectivo de estrogenos en combinacion con estrogenos. |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US20040176336A1 (en) * | 2000-03-21 | 2004-09-09 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US20050113351A1 (en) * | 2000-03-21 | 2005-05-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| US20070225379A1 (en) * | 2001-08-03 | 2007-09-27 | Carrara Dario Norberto R | Transdermal delivery of systemically active central nervous system drugs |
| DE60143360D1 (de) * | 2000-08-03 | 2010-12-09 | Antares Pharma Ipl Ag | Zusammensetzung zur transdermalen und/oder transmukosalen Verabreichung von Wirkstoffen, die ausreichende therapeutische Spiegel garantiert |
| US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US7198801B2 (en) * | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| DE10045380A1 (de) * | 2000-09-14 | 2002-04-04 | Schering Ag | Verfahren zur Kontrazeption und dessen Darreichungsform |
| AU2002306629A1 (en) * | 2001-03-02 | 2002-09-19 | Euro-Celtique, S.A. | Method and apparatus for compounding individualized dosage forms |
| AU2002240949A1 (en) * | 2001-03-21 | 2002-10-03 | Schering Aktiengesellschaft | Pharmaceutical combined preparations containing aromatase inhibitors and substances having an estrogen effect in addition to the use thereof for producing a medicament for estrogen-replacement-therapy |
| US7455656B2 (en) * | 2001-07-26 | 2008-11-25 | Langeler Gerard E | Pill delivery system |
| WO2003082299A1 (en) * | 2002-04-03 | 2003-10-09 | Jencap Research Ltd. | Improved hormone replacement therapy |
| MXPA04010682A (es) * | 2002-04-26 | 2004-12-13 | Schering Ag | Tratamiento contra la hipertension en mujeres quienes reciben tratamiento restitutivo hormonal. |
| US20040062794A1 (en) * | 2002-09-30 | 2004-04-01 | Lee Shulman | 17Beta- estradiol/levonorgestrel transdermal patch for hormone replacement therapy |
| US7786101B2 (en) * | 2002-11-05 | 2010-08-31 | Bayer Schering Pharma Ag | Cardiovascular protection using anti-aldosteronic progestins |
| US6669390B1 (en) * | 2002-11-22 | 2003-12-30 | John J. Porter | Breath freshener with mouthwash atomizer |
| US7354598B2 (en) * | 2002-12-20 | 2008-04-08 | Kimberly-Clark Worldwide, Inc. | Packaging two different substrates |
| US7858607B2 (en) * | 2003-03-14 | 2010-12-28 | Mamchur Stephen A | System for use by compounding pharmacists to produce hormone replacement medicine customized for each consumer |
| US7785584B2 (en) * | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
| MXPA06003316A (es) * | 2003-10-10 | 2006-06-08 | Antares Pharma Ipl Ag | Formulacion farmaceutica transdermica para minimizar los residuos en la piel. |
| US7293738B2 (en) * | 2003-11-26 | 2007-11-13 | Kimberly-Clark Worldwide, Inc. | Freestanding dispenser for dispensing two different substrates |
| US20050222106A1 (en) * | 2004-04-01 | 2005-10-06 | Stefan Bracht | Drospirenone-containing preparations for transdermal use |
| US7425340B2 (en) * | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
| US20060040904A1 (en) * | 2004-08-17 | 2006-02-23 | Ahmed Salah U | Vaginal cream compositions, kits thereof and methods of using thereof |
| US8067399B2 (en) * | 2005-05-27 | 2011-11-29 | Antares Pharma Ipl Ag | Method and apparatus for transdermal or transmucosal application of testosterone |
| US7537139B2 (en) * | 2005-05-27 | 2009-05-26 | Henkel Corporation | Dual chamber piston pressure pack dispenser system |
| WO2007011764A2 (en) * | 2005-07-15 | 2007-01-25 | Bayer Schering Pharma Aktiengesellschaft | Drospirenone containing transdermal drug delivery devices and methods of delivery thereof |
| EP2289486A1 (en) * | 2005-12-27 | 2011-03-02 | Teva Women's Health, Inc. | Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof |
| CN101426475A (zh) | 2006-04-21 | 2009-05-06 | 安塔雷斯制药Ipl股份公司 | 使用用于经皮或经粘膜应用的制剂治疗热潮红的方法 |
| US7476291B2 (en) * | 2006-09-28 | 2009-01-13 | Lam Research Corporation | High chamber temperature process and chamber design for photo-resist stripping and post-metal etch passivation |
| WO2008067991A2 (en) * | 2006-12-08 | 2008-06-12 | Antares Pharma Ipl Ag | Skin-friendly drug complexes for transdermal administration |
| US8658628B2 (en) * | 2009-06-18 | 2014-02-25 | Karan Y. Baucom | Hormone delivery system and method |
| US9795617B2 (en) | 2009-06-18 | 2017-10-24 | Baucom Institute for Longevity and Life Enhancement, Inc. | Hormone delivery system and method |
| WO2012151295A2 (en) | 2011-05-02 | 2012-11-08 | Mouse Trap Design, Llc | Mixing and dispensing device |
| CA2745320A1 (en) * | 2011-07-06 | 2013-01-06 | Duoject Medical Systems Inc. | Reconstitution device |
| EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150122837A1 (en) | 2013-11-07 | 2015-05-07 | Mouse Trap Design, Llc | Mixing and dispensing device |
| CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| EP3156349B1 (en) * | 2015-10-16 | 2018-07-04 | Fontem Holdings 1 B.V. | Mixing bottle |
| US10184818B2 (en) | 2015-11-12 | 2019-01-22 | Nodari Rizun | Device and method for dispensing paste-like or sticky nutritional substance |
| US9903747B2 (en) * | 2015-11-12 | 2018-02-27 | Nodari Rizun | Device and method for dispersing paste-like or sticky nutritional substance in a fluid |
| BR112018070199A2 (pt) | 2016-04-01 | 2019-01-29 | Therapeuticsmd Inc | composição farmacêutica de hormônio esteroide |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| CN108310608B (zh) * | 2018-02-02 | 2020-07-31 | 韩明辉 | 一种医疗康复护理用涂药器 |
| US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| EP3833631A4 (en) * | 2018-08-10 | 2022-04-20 | Azura Ophthalmics Ltd | DISPENSER FOR ACCURATE EXTRACTION OF A SEMI-SOLID PRODUCT |
| US11382400B2 (en) | 2018-08-10 | 2022-07-12 | Go Products Co. | Material applicator |
| CN111038860A (zh) * | 2018-10-12 | 2020-04-21 | 元盛生医电子股份有限公司 | 容器结构 |
| WO2021007591A1 (en) * | 2019-07-09 | 2021-01-14 | The Procter & Gamble Company | Multi-composition product dispenser |
| CN115279458A (zh) | 2020-01-10 | 2022-11-01 | 阿祖拉眼科有限公司 | 组合物和敏感性说明 |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1586771A (en) * | 1976-10-22 | 1981-03-25 | Plessey Co Ltd | Taximeter |
| DE2927584A1 (de) * | 1979-07-07 | 1981-01-22 | Henkel Kgaa | Vorrichtung zum dosieren von zweikomponenten-produkten |
| FR2525183A2 (fr) * | 1982-04-19 | 1983-10-21 | Fabre Sa Pierre | Dispositif de distribution en proportion reglable de deux substances pateuses |
| US4871092A (en) * | 1982-07-10 | 1989-10-03 | Ing. Erich Pfeiffer Gmbh & Co. Kg | Atomizing or metering pump |
| US4687663B1 (en) * | 1983-03-01 | 1997-10-07 | Chesebrough Ponds Usa Co | Dental preparation article and method for storage and delivery thereof |
| US4705783A (en) * | 1985-06-25 | 1987-11-10 | Sri International | 9α, 11β-substituted and 11β-substituted estranes |
| DE3614515A1 (de) * | 1986-04-29 | 1987-11-05 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer medien |
| IE61236B1 (en) * | 1986-07-15 | 1994-10-19 | American Home Prod | Combination dosage form for pre-menopausal women |
| US4906169A (en) * | 1986-12-29 | 1990-03-06 | Rutgers, The State University Of New Jersey | Transdermal estrogen/progestin dosage unit, system and process |
| US5422119A (en) * | 1987-09-24 | 1995-06-06 | Jencap Research Ltd. | Transdermal hormone replacement therapy |
| US5108995A (en) * | 1987-09-24 | 1992-04-28 | Jencap Research Ltd. | Hormone preparation and method |
| US4838457A (en) * | 1988-05-09 | 1989-06-13 | Swahl James C | Lotion blending and dispensing unit |
| US5020694A (en) * | 1989-03-16 | 1991-06-04 | Chesebrough-Pond's, Inc. | Multi-cavity dispensing container |
| US5059426A (en) * | 1989-03-22 | 1991-10-22 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| FR2652567B1 (fr) * | 1989-10-04 | 1992-01-10 | Oreal | Dispositif de distribution comportant au moins un flacon a embout cassable. |
| US5116865A (en) * | 1990-09-05 | 1992-05-26 | Peters Richard H | 15,16-seco-19-nor progestins |
| US5286258A (en) * | 1991-03-08 | 1994-02-15 | Habley Medical Technology Corporation | Multipharmaceutical delivery system |
| US5240146A (en) * | 1990-12-14 | 1993-08-31 | Smedley William H | Variable proportion dispenser |
| US5518734A (en) * | 1991-09-25 | 1996-05-21 | Beta Pharmaceuticals Co. | Transdermal delivery system for estradiol and process for manufacturing said device |
| US5339990A (en) * | 1992-11-10 | 1994-08-23 | Wilder Robert E | Adjustable pump dispenser |
| DE4344405C2 (de) * | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
| US5552394A (en) * | 1994-07-22 | 1996-09-03 | The Medical College Of Hampton Roads | Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy |
-
1996
- 1996-09-27 US US08/721,965 patent/US5897539A/en not_active Expired - Fee Related
- 1996-09-27 US US08/721,968 patent/US5922349A/en not_active Expired - Fee Related
- 1996-09-30 KR KR1019980702325A patent/KR20000004898A/ko not_active Application Discontinuation
- 1996-09-30 DE DE69630968T patent/DE69630968T2/de not_active Expired - Fee Related
- 1996-09-30 WO PCT/EP1996/004261 patent/WO1997011680A2/en not_active Application Discontinuation
- 1996-09-30 AU AU72827/96A patent/AU714084B2/en not_active Ceased
- 1996-09-30 TR TR1998/00560T patent/TR199800560T1/xx unknown
- 1996-09-30 CZ CZ98955A patent/CZ95598A3/cs unknown
- 1996-09-30 IL IL12369196A patent/IL123691A/en not_active IP Right Cessation
- 1996-09-30 PT PT96934493T patent/PT854705E/pt unknown
- 1996-09-30 EP EP96934493A patent/EP0854705B1/en not_active Expired - Lifetime
- 1996-09-30 CN CNB961973226A patent/CN1158206C/zh not_active Expired - Fee Related
- 1996-09-30 AT AT96934493T patent/ATE255406T1/de not_active IP Right Cessation
- 1996-09-30 DK DK96934493T patent/DK0854705T3/da active
- 1996-09-30 HU HU9802608A patent/HUP9802608A3/hu unknown
- 1996-09-30 JP JP9513154A patent/JPH11512703A/ja not_active Ceased
- 1996-09-30 ZA ZA968227A patent/ZA968227B/xx unknown
- 1996-09-30 PL PL96325978A patent/PL185848B1/pl not_active IP Right Cessation
- 1996-09-30 ES ES96934493T patent/ES2211983T3/es not_active Expired - Lifetime
- 1996-09-30 CA CA002232621A patent/CA2232621A1/en not_active Abandoned
- 1996-09-30 BR BR9610915A patent/BR9610915A/pt not_active IP Right Cessation
- 1996-10-23 TW TW085113007A patent/TW329389B/zh active
-
1998
- 1998-03-26 MX MX9802370A patent/MX9802370A/es not_active IP Right Cessation
- 1998-03-27 NO NO19981412A patent/NO320491B1/no unknown
-
1999
- 1999-05-04 HK HK99102005A patent/HK1016887A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5922349A (en) | 1999-07-13 |
| NO981412D0 (no) | 1998-03-27 |
| CA2232621A1 (en) | 1997-04-03 |
| EP0854705A2 (en) | 1998-07-29 |
| ES2211983T3 (es) | 2004-07-16 |
| HUP9802608A3 (en) | 1999-07-28 |
| ZA968227B (en) | 1997-07-21 |
| TW329389B (en) | 1998-04-11 |
| HUP9802608A2 (hu) | 1999-02-01 |
| AU7282796A (en) | 1997-04-17 |
| TR199800560T1 (xx) | 1998-06-22 |
| IL123691A0 (en) | 1998-10-30 |
| IL123691A (en) | 2001-10-31 |
| PT854705E (pt) | 2004-04-30 |
| JPH11512703A (ja) | 1999-11-02 |
| ATE255406T1 (de) | 2003-12-15 |
| WO1997011680A3 (en) | 1997-04-24 |
| PL185848B1 (pl) | 2003-08-29 |
| MX9802370A (es) | 1998-08-30 |
| BR9610915A (pt) | 1999-03-30 |
| EP0854705B1 (en) | 2003-12-03 |
| CN1158206C (zh) | 2004-07-21 |
| KR20000004898A (ko) | 2000-01-25 |
| CN1198093A (zh) | 1998-11-04 |
| PL325978A1 (en) | 1998-08-17 |
| NO981412L (no) | 1998-05-12 |
| DE69630968D1 (en) | 2004-01-15 |
| DK0854705T3 (da) | 2004-04-13 |
| AU714084B2 (en) | 1999-12-16 |
| US5897539A (en) | 1999-04-27 |
| CZ95598A3 (cs) | 1999-06-16 |
| HK1016887A1 (en) | 1999-11-12 |
| DE69630968T2 (de) | 2004-10-21 |
| WO1997011680A2 (en) | 1997-04-03 |
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