NO319867B1 - Humaniserte antistoffer mot leukocytt-adhesjonsmolekyl VLA-4, bindingsfragment derav, farmasoytisk preparat omfattende det humaniserte antistoffet eller et bindingsfragment derav, samt anvendelser av det humaniserte antistoff. - Google Patents

Humaniserte antistoffer mot leukocytt-adhesjonsmolekyl VLA-4, bindingsfragment derav, farmasoytisk preparat omfattende det humaniserte antistoffet eller et bindingsfragment derav, samt anvendelser av det humaniserte antistoff. Download PDF

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Publication number
NO319867B1
NO319867B1 NO19963097A NO963097A NO319867B1 NO 319867 B1 NO319867 B1 NO 319867B1 NO 19963097 A NO19963097 A NO 19963097A NO 963097 A NO963097 A NO 963097A NO 319867 B1 NO319867 B1 NO 319867B1
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NO
Norway
Prior art keywords
humanized
mouse
human
immunoglobulin
variable region
Prior art date
Application number
NO19963097A
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English (en)
Norwegian (no)
Other versions
NO963097L (no
NO963097D0 (no
Inventor
Jose William Saldanha
Mary M Bendig
Olivier J Leger
Tarran S Jones
Ted Yednock
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of NO963097D0 publication Critical patent/NO963097D0/no
Publication of NO963097L publication Critical patent/NO963097L/no
Publication of NO319867B1 publication Critical patent/NO319867B1/no

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19963097A 1994-01-25 1996-07-24 Humaniserte antistoffer mot leukocytt-adhesjonsmolekyl VLA-4, bindingsfragment derav, farmasoytisk preparat omfattende det humaniserte antistoffet eller et bindingsfragment derav, samt anvendelser av det humaniserte antistoff. NO319867B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18626994A 1994-01-25 1994-01-25
PCT/US1995/001219 WO1995019790A1 (en) 1994-01-25 1995-01-25 Humanized antibodies against leukocyte adhesion molecule vla-4

Publications (3)

Publication Number Publication Date
NO963097D0 NO963097D0 (no) 1996-07-24
NO963097L NO963097L (no) 1996-09-24
NO319867B1 true NO319867B1 (no) 2005-09-26

Family

ID=22684288

Family Applications (3)

Application Number Title Priority Date Filing Date
NO19963097A NO319867B1 (no) 1994-01-25 1996-07-24 Humaniserte antistoffer mot leukocytt-adhesjonsmolekyl VLA-4, bindingsfragment derav, farmasoytisk preparat omfattende det humaniserte antistoffet eller et bindingsfragment derav, samt anvendelser av det humaniserte antistoff.
NO2006008C NO2006008I2 (no) 1994-01-25 2006-08-07 Natalizumab, anti alfa-4 integrin humanized monoclonal antibody
NO2017040C NO2017040I2 (no) 1994-01-25 2017-08-01 Natalizumab, anti alfa-4 integrin humanisert monoklonalt antistoff - forlenget SPC

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO2006008C NO2006008I2 (no) 1994-01-25 2006-08-07 Natalizumab, anti alfa-4 integrin humanized monoclonal antibody
NO2017040C NO2017040I2 (no) 1994-01-25 2017-08-01 Natalizumab, anti alfa-4 integrin humanisert monoklonalt antistoff - forlenget SPC

Country Status (21)

Country Link
EP (2) EP1759709B1 (cs)
JP (5) JP4115517B2 (cs)
KR (1) KR100367948B1 (cs)
CN (1) CN1211123C (cs)
AT (1) ATE333895T1 (cs)
AU (1) AU703152B2 (cs)
CA (1) CA2182013C (cs)
DE (2) DE122006000043I1 (cs)
DK (2) DK1759709T3 (cs)
ES (2) ES2270425T3 (cs)
FI (1) FI117509B (cs)
FR (1) FR06C0024I2 (cs)
HU (1) HU220799B1 (cs)
LU (1) LU91271I2 (cs)
MX (1) MX9602971A (cs)
NL (1) NL300238I2 (cs)
NO (3) NO319867B1 (cs)
NZ (1) NZ279730A (cs)
PL (1) PL181827B1 (cs)
PT (1) PT804237E (cs)
WO (1) WO1995019790A1 (cs)

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CA2153692C (en) 1993-01-12 2011-11-08 Roy R. Lobb Recombinant anti-vla4 antibody molecules
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DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7618630B2 (en) 1998-09-14 2009-11-17 Board Of Regents, The University Of Texas System Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
SI1113810T1 (sl) * 1998-09-14 2009-04-30 Univ Texas Postopki za zdravljenje multiplega mieloma in kostne resorpcije, inducirane z mielomom, z uporabo antagonistov integrin/receptorske vezave
AU783054B2 (en) 1999-04-22 2005-09-22 Biogen Ma Inc. Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit
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DK1488806T3 (en) 1999-06-01 2016-02-08 Biogen Ma Inc Blocking monoclonal antibody to VLA-1 and its use in the treatment of vascular disorders
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CA2394431C (en) * 1999-12-16 2015-06-30 Jane Relton Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
AU2002258778C1 (en) 2001-04-13 2008-12-04 Biogen Ma Inc. Antibodies to VLA-1
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
NZ535320A (en) 2002-02-25 2008-05-30 Elan Pharm Inc Administration of agents that bind to an alpha-4 integrin for the treatment of inflammation
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CN100432105C (zh) * 2002-12-17 2008-11-12 默克专利有限公司 与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合
CU23403A1 (es) * 2003-04-23 2009-08-04 Centro Inmunologia Molecular Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores
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CA2629147A1 (en) * 2005-11-17 2007-05-31 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with .alpha.4.beta.7 integrin
EP2034830B1 (en) 2006-05-25 2014-09-03 Biogen Idec MA Inc. Anti-vla-1 antibody for treating stroke
EP2124996A4 (en) 2007-02-20 2010-03-24 Merrimack Pharmaceuticals Inc METHOD FOR TREATING MULTIPLE SCLEROSIS BY ADMINISTERING AN ALPHA FETOPROTEIN COMBINED WITH AN INTEGRINANT AGONIST
CN103977404A (zh) * 2007-06-14 2014-08-13 比奥根艾迪克Ma公司 抗体制剂
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Also Published As

Publication number Publication date
CN1140413A (zh) 1997-01-15
EP0804237A4 (en) 2003-04-16
NO2006008I1 (no) 2006-08-07
DK1759709T3 (da) 2013-06-10
FI962958L (fi) 1996-09-24
NO963097L (no) 1996-09-24
ES2424292T3 (es) 2013-09-30
DE69535133D1 (de) 2006-09-07
AU1696095A (en) 1995-08-08
PT804237E (pt) 2006-10-31
NZ279730A (en) 1998-04-27
MX9602971A (es) 1998-01-31
ATE333895T1 (de) 2006-08-15
DK0804237T3 (da) 2006-10-16
FR06C0024I1 (cs) 2006-10-13
HU220799B1 (hu) 2002-05-28
NL300238I2 (nl) 2007-05-01
PL181827B1 (pl) 2001-09-28
JPH09508272A (ja) 1997-08-26
EP0804237B1 (en) 2006-07-26
PL315634A1 (en) 1996-11-25
JP2009235078A (ja) 2009-10-15
JP2013165718A (ja) 2013-08-29
ES2270425T3 (es) 2007-04-01
AU703152B2 (en) 1999-03-18
DE69535133T2 (de) 2008-08-21
JP2006045237A (ja) 2006-02-16
EP0804237B8 (en) 2006-11-08
CA2182013C (en) 2007-07-17
EP1759709A1 (en) 2007-03-07
HU9602019D0 (en) 1996-09-30
KR970700513A (ko) 1997-02-12
EP1759709B1 (en) 2013-02-27
NO2017040I2 (no) 2018-08-28
JP2013173738A (ja) 2013-09-05
DE122006000043I1 (de) 2007-02-15
FI962958A0 (fi) 1996-07-24
NL300238I1 (cs) 2006-10-02
NO2006008I2 (no) 2009-06-15
FR06C0024I2 (fr) 2009-01-02
NO2017040I1 (no) 2017-08-01
NO963097D0 (no) 1996-07-24
LU91271I2 (fr) 2006-10-02
JP5487382B2 (ja) 2014-05-07
WO1995019790A1 (en) 1995-07-27
CA2182013A1 (en) 1995-07-27
FI117509B (fi) 2006-11-15
EP0804237A1 (en) 1997-11-05
KR100367948B1 (ko) 2003-07-12
JP4115517B2 (ja) 2008-07-09
HUT75129A (en) 1997-04-28
CN1211123C (zh) 2005-07-20

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