NO317795B1 - Anvendelse av vesentlig udenaturert myseproteinkonsentrat for fremstilling av en farmasoytisk blanding for behandling av HIV-seropositive individer. - Google Patents
Anvendelse av vesentlig udenaturert myseproteinkonsentrat for fremstilling av en farmasoytisk blanding for behandling av HIV-seropositive individer. Download PDFInfo
- Publication number
- NO317795B1 NO317795B1 NO19943804A NO943804A NO317795B1 NO 317795 B1 NO317795 B1 NO 317795B1 NO 19943804 A NO19943804 A NO 19943804A NO 943804 A NO943804 A NO 943804A NO 317795 B1 NO317795 B1 NO 317795B1
- Authority
- NO
- Norway
- Prior art keywords
- whey protein
- protein concentrate
- increase
- well
- undenatured
- Prior art date
Links
- 108010046377 Whey Proteins Proteins 0.000 title claims abstract description 68
- 235000021119 whey protein Nutrition 0.000 title claims abstract description 66
- 102000007544 Whey Proteins Human genes 0.000 title claims abstract description 61
- 239000012141 concentrate Substances 0.000 title claims abstract description 46
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 82
- 229960003180 glutathione Drugs 0.000 claims abstract description 41
- 108010024636 Glutathione Proteins 0.000 claims abstract description 34
- 230000037396 body weight Effects 0.000 claims abstract description 16
- 210000004369 blood Anatomy 0.000 claims abstract description 10
- 239000008280 blood Substances 0.000 claims abstract description 10
- 210000005087 mononuclear cell Anatomy 0.000 claims abstract description 9
- 235000018102 proteins Nutrition 0.000 claims description 22
- 102000004169 proteins and genes Human genes 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 18
- 108010071390 Serum Albumin Proteins 0.000 claims description 15
- 102000007562 Serum Albumin Human genes 0.000 claims description 15
- 108060003951 Immunoglobulin Proteins 0.000 claims description 11
- 102000018358 immunoglobulin Human genes 0.000 claims description 11
- PABVKUJVLNMOJP-WHFBIAKZSA-N Glu-Cys Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CS)C(O)=O PABVKUJVLNMOJP-WHFBIAKZSA-N 0.000 claims description 10
- 230000036642 wellbeing Effects 0.000 claims description 10
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- 239000008267 milk Substances 0.000 claims description 9
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- 238000004519 manufacturing process Methods 0.000 claims description 7
- 230000028993 immune response Effects 0.000 claims description 6
- 210000000601 blood cell Anatomy 0.000 claims description 5
- 235000004252 protein component Nutrition 0.000 claims description 4
- 210000003022 colostrum Anatomy 0.000 claims description 3
- 235000021277 colostrum Nutrition 0.000 claims description 3
- 102000004407 Lactalbumin Human genes 0.000 claims description 2
- 108090000942 Lactalbumin Proteins 0.000 claims description 2
- 102000008192 Lactoglobulins Human genes 0.000 claims description 2
- 108010060630 Lactoglobulins Proteins 0.000 claims description 2
- 230000001413 cellular effect Effects 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims description 2
- 235000021241 α-lactalbumin Nutrition 0.000 claims description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 4
- 229940098773 bovine serum albumin Drugs 0.000 claims 4
- 102000010445 Lactoferrin Human genes 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 101000798100 Bos taurus Lactotransferrin Proteins 0.000 claims 1
- 108010063045 Lactoferrin Proteins 0.000 claims 1
- 229940072440 bovine lactoferrin Drugs 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 1
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
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- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 2
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- 230000009469 supplementation Effects 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RITKHVBHSGLULN-CRCLSJGQSA-N γ-glutamylcysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](CS)C(O)=O RITKHVBHSGLULN-CRCLSJGQSA-N 0.000 description 2
- WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 description 1
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- 108010036164 Glutathione synthase Proteins 0.000 description 1
- 102100034294 Glutathione synthetase Human genes 0.000 description 1
- MFBYPDKTAJXHNI-VKHMYHEASA-N Gly-Cys Chemical compound [NH3+]CC(=O)N[C@@H](CS)C([O-])=O MFBYPDKTAJXHNI-VKHMYHEASA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 210000004970 cd4 cell Anatomy 0.000 description 1
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- 235000021245 dietary protein Nutrition 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Marine Sciences & Fisheries (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/866,756 US5456924A (en) | 1988-12-23 | 1992-04-10 | Method of treatment of HIV-seropositive individuals with dietary whey proteins |
| PCT/CA1993/000107 WO1993020831A1 (en) | 1992-04-10 | 1993-03-22 | Method of treatment of hiv-seropositive individuals with dietary whey proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO943804D0 NO943804D0 (no) | 1994-10-07 |
| NO943804L NO943804L (no) | 1994-10-07 |
| NO317795B1 true NO317795B1 (no) | 2004-12-13 |
Family
ID=25348339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19943804A NO317795B1 (no) | 1992-04-10 | 1994-10-07 | Anvendelse av vesentlig udenaturert myseproteinkonsentrat for fremstilling av en farmasoytisk blanding for behandling av HIV-seropositive individer. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5456924A (de) |
| EP (1) | EP0634934B1 (de) |
| JP (1) | JP2738592B2 (de) |
| KR (1) | KR100297959B1 (de) |
| CN (1) | CN1070371C (de) |
| AT (1) | ATE187335T1 (de) |
| AU (1) | AU687731B2 (de) |
| CA (1) | CA2090186C (de) |
| CZ (1) | CZ283386B6 (de) |
| DE (1) | DE69327236T2 (de) |
| DK (1) | DK0634934T3 (de) |
| ES (1) | ES2143503T3 (de) |
| IL (1) | IL105339A (de) |
| MX (1) | MX9302057A (de) |
| NO (1) | NO317795B1 (de) |
| NZ (1) | NZ251271A (de) |
| TW (1) | TW384223B (de) |
| WO (1) | WO1993020831A1 (de) |
| ZA (1) | ZA932526B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5531989A (en) | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Immunoglobulin and fiber-containing composition for human gastrointestinal health |
| US6241983B1 (en) | 1994-10-28 | 2001-06-05 | Metagenics, Inc. | Bacteria-and fiber-containing composition for human gastrointestinal health |
| US5985275A (en) * | 1995-04-12 | 1999-11-16 | New York Blood Center | β-Lactoglobulin modified with aromatic anhydride compound for preventing HIV infection |
| CA2165937A1 (en) * | 1995-05-09 | 1996-11-10 | Immunotec Research Corporation Ltd. | Process for producing an undenatured whey protein concentrate |
| EP0915661A4 (de) * | 1996-03-06 | 2004-09-08 | Belloch Corp I | Verfahren zur behandlung flüssiger stoffe |
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| WO1999064022A1 (en) * | 1998-06-10 | 1999-12-16 | Crum Albert B | Prophylactic and therapeutic nutritional supplement for creation/maintenance of health-protective intestinal microflora and enhancement of the immune system |
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| FR2840318B1 (fr) * | 2002-05-29 | 2004-12-03 | Quoc Kiet Pham | Nouveaux sulfolipides antiretroviraux extraits de spirulines, leur procede d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs de la transcriptase inverse des virus vih |
| FR2889067B1 (fr) * | 2005-07-29 | 2011-11-11 | Cie Laitiere Europeenne | "utilisation d'une fraction proteique laitiere pour preparer une composition amincissante et/ou ameliorant la composition corporelle" |
| DE102006052504A1 (de) | 2006-11-06 | 2008-05-08 | Temper, Rupert | Verfahren zum Herstellen eines Mittels gegen eine Infektionskrankheit |
| US20080119386A1 (en) * | 2006-11-22 | 2008-05-22 | Carl Germano | Nutritional formula for athletes' recovery |
| WO2008095276A1 (en) * | 2007-02-06 | 2008-08-14 | Cymcorp International, Inc. | Novel non-toxic composition and method of using such for treating a degenerative or an immune system-related disease |
| US20100069288A1 (en) * | 2008-09-12 | 2010-03-18 | Wulf Droge | Use of cysteine-rich whey derived protein in patients receiving chemotherapy or radiotherapy to improve patient survival |
| JP2013079216A (ja) | 2011-10-04 | 2013-05-02 | Snow Brand Milk Products Co Ltd | 感覚改善剤 |
| JP6234777B2 (ja) * | 2013-10-31 | 2017-11-22 | 株式会社日立製作所 | 光多値送信器および光トランスポンダ |
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| WO2018057514A1 (en) | 2016-09-23 | 2018-03-29 | Immunotec Inc. | Compositions for restoring gene expression in neuropsychiatric or neurodegenerative disorders |
| CA2970699A1 (en) | 2017-06-14 | 2018-12-14 | Elizabeth E. Ignowski | Compositions for increasing resilience to traumatic brain injury |
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| CA858533A (en) * | 1970-12-15 | Lahav Eitan | Polypeptidic antibiotic substances derived from casein by fermentation | |
| FR2565985B1 (fr) * | 1984-06-19 | 1987-09-25 | Rhone Poulenc Sante | Nouvelles substances biologiquement actives obtenues a partir de la caseine bovine, leur procede de preparation et les compositions qui les contiennent |
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-
1992
- 1992-04-10 US US07/866,756 patent/US5456924A/en not_active Expired - Lifetime
-
1993
- 1993-02-23 CA CA002090186A patent/CA2090186C/en not_active Expired - Lifetime
- 1993-03-22 WO PCT/CA1993/000107 patent/WO1993020831A1/en active IP Right Grant
- 1993-03-22 AT AT93907682T patent/ATE187335T1/de active
- 1993-03-22 CZ CZ942461A patent/CZ283386B6/cs not_active IP Right Cessation
- 1993-03-22 KR KR1019940703473A patent/KR100297959B1/ko not_active IP Right Cessation
- 1993-03-22 NZ NZ251271A patent/NZ251271A/en unknown
- 1993-03-22 EP EP93907682A patent/EP0634934B1/de not_active Expired - Lifetime
- 1993-03-22 JP JP5517869A patent/JP2738592B2/ja not_active Expired - Lifetime
- 1993-03-22 AU AU38812/93A patent/AU687731B2/en not_active Expired
- 1993-03-22 DK DK93907682T patent/DK0634934T3/da active
- 1993-03-22 ES ES93907682T patent/ES2143503T3/es not_active Expired - Lifetime
- 1993-03-22 DE DE69327236T patent/DE69327236T2/de not_active Expired - Lifetime
- 1993-04-07 MX MX9302057A patent/MX9302057A/es unknown
- 1993-04-08 ZA ZA932526A patent/ZA932526B/xx unknown
- 1993-04-08 IL IL10533993A patent/IL105339A/en not_active IP Right Cessation
- 1993-04-09 TW TW082102661A patent/TW384223B/zh not_active IP Right Cessation
- 1993-04-09 CN CN93104081A patent/CN1070371C/zh not_active Expired - Lifetime
-
1994
- 1994-10-07 NO NO19943804A patent/NO317795B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2090186C (en) | 1999-03-16 |
| CZ246194A3 (en) | 1995-04-12 |
| CN1083704A (zh) | 1994-03-16 |
| NZ251271A (en) | 1998-05-27 |
| TW384223B (en) | 2000-03-11 |
| MX9302057A (es) | 1994-07-29 |
| NO943804D0 (no) | 1994-10-07 |
| ATE187335T1 (de) | 1999-12-15 |
| EP0634934B1 (de) | 1999-12-08 |
| DK0634934T3 (da) | 2000-06-13 |
| IL105339A0 (en) | 1993-08-18 |
| AU3881293A (en) | 1993-11-18 |
| CN1070371C (zh) | 2001-09-05 |
| CA2090186A1 (en) | 1993-10-11 |
| JPH07504677A (ja) | 1995-05-25 |
| WO1993020831A1 (en) | 1993-10-28 |
| US5456924A (en) | 1995-10-10 |
| CZ283386B6 (cs) | 1998-04-15 |
| EP0634934A1 (de) | 1995-01-25 |
| KR100297959B1 (ko) | 2001-10-24 |
| KR950700752A (ko) | 1995-02-20 |
| DE69327236D1 (de) | 2000-01-13 |
| AU687731B2 (en) | 1998-03-05 |
| ES2143503T3 (es) | 2000-05-16 |
| IL105339A (en) | 1998-07-15 |
| NO943804L (no) | 1994-10-07 |
| DE69327236T2 (de) | 2000-03-30 |
| ZA932526B (en) | 1994-03-09 |
| JP2738592B2 (ja) | 1998-04-08 |
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Legal Events
| Date | Code | Title | Description |
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| MK1K | Patent expired |