NO316027B1 - Fremgangsmåter for screening av substanser med en modulerende virkning på en interleukin-5-reseptoravhengig cellul¶r signaloverföringsvei,samt pattedyrceller - Google Patents

Fremgangsmåter for screening av substanser med en modulerende virkning på en interleukin-5-reseptoravhengig cellul¶r signaloverföringsvei,samt pattedyrceller Download PDF

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Publication number
NO316027B1
NO316027B1 NO19954781A NO954781A NO316027B1 NO 316027 B1 NO316027 B1 NO 316027B1 NO 19954781 A NO19954781 A NO 19954781A NO 954781 A NO954781 A NO 954781A NO 316027 B1 NO316027 B1 NO 316027B1
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Norway
Prior art keywords
receptor
cells
interleukin
subunit
recombinant dna
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Application number
NO19954781A
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English (en)
Norwegian (no)
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NO954781L (no
NO954781D0 (no
Inventor
Armin Peter Czernilofsky
Ulrike Weyer
Ian G Young
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Boehringer Ingelheim Int
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Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO954781D0 publication Critical patent/NO954781D0/no
Publication of NO954781L publication Critical patent/NO954781L/no
Publication of NO316027B1 publication Critical patent/NO316027B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19954781A 1993-05-27 1995-11-24 Fremgangsmåter for screening av substanser med en modulerende virkning på en interleukin-5-reseptoravhengig cellul¶r signaloverföringsvei,samt pattedyrceller NO316027B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4317577A DE4317577A1 (de) 1993-05-27 1993-05-27 Verfahren zum Screenen von Substanzen mit modulierender Wirkung auf einen Interleukin-5-Rezeptor-abhängigen zellulären Signalübertragungsweg
PCT/EP1994/001735 WO1994028170A1 (de) 1993-05-27 1994-05-27 Verfahren zum screenen von substanzen mit modulierender wirkung auf einen interleukin-5-rezeptor-abhängigen zellulären signalübertragungsweg

Publications (3)

Publication Number Publication Date
NO954781D0 NO954781D0 (no) 1995-11-24
NO954781L NO954781L (no) 1996-01-23
NO316027B1 true NO316027B1 (no) 2003-12-01

Family

ID=6488996

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19954781A NO316027B1 (no) 1993-05-27 1995-11-24 Fremgangsmåter for screening av substanser med en modulerende virkning på en interleukin-5-reseptoravhengig cellul¶r signaloverföringsvei,samt pattedyrceller

Country Status (17)

Country Link
US (1) US5922549A (ru)
EP (1) EP0701628B1 (ru)
JP (1) JPH08510643A (ru)
KR (1) KR100318188B1 (ru)
CN (1) CN1125467A (ru)
AT (1) ATE162555T1 (ru)
AU (1) AU691816B2 (ru)
CA (1) CA2163549A1 (ru)
DE (2) DE4317577A1 (ru)
DK (1) DK0701628T3 (ru)
ES (1) ES2113109T3 (ru)
FI (1) FI111016B (ru)
HU (1) HU220345B (ru)
NO (1) NO316027B1 (ru)
NZ (1) NZ291131A (ru)
RU (1) RU2139936C1 (ru)
WO (1) WO1994028170A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405350D0 (en) * 1994-03-18 1994-05-04 Sandoz Ltd Organic compounds
US5668110A (en) * 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5677280A (en) * 1995-06-07 1997-10-14 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5683983A (en) * 1995-06-07 1997-11-04 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US7109299B1 (en) 1999-12-16 2006-09-19 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
WO2002028168A1 (en) * 2000-10-03 2002-04-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education High efficiency regulatable gene expression system
US20040170614A1 (en) * 2002-10-30 2004-09-02 Gail Bishop Somatic cell gene targeting vectors and methods of use thereof
US20040209246A1 (en) * 2003-04-15 2004-10-21 Agouron Pharmaceuticals, Inc. Dual reporter/dye reduction methodology for evaluating antiviral and cytotoxicity of hepatitis C virus inhibitors
US20050112551A1 (en) * 2003-11-24 2005-05-26 Agouron Pharmaceuticals, Inc. Dual assay for evaluating activity and cytotoxicity of compounds in the same population of cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5453491A (en) * 1990-09-11 1995-09-26 Kiyoshi Takatsu Murine interleukin-5 receptor
WO1992013063A1 (en) * 1991-01-18 1992-08-06 Oncogene Science, Inc. Methods of transcriptionally modulating expression of growth factor genes and growth factor receptor genes
AU655850B2 (en) * 1991-10-01 1995-01-12 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The A method of identifying ligands and antagonists of ligands

Also Published As

Publication number Publication date
NO954781L (no) 1996-01-23
CN1125467A (zh) 1996-06-26
EP0701628A1 (de) 1996-03-20
KR100318188B1 (ko) 2002-06-20
CA2163549A1 (en) 1994-12-08
NO954781D0 (no) 1995-11-24
AU691816B2 (en) 1998-05-28
KR960702532A (ko) 1996-04-27
WO1994028170A1 (de) 1994-12-08
HU220345B (hu) 2001-12-28
US5922549A (en) 1999-07-13
FI955700A (fi) 1995-11-27
FI111016B (fi) 2003-05-15
NZ291131A (en) 1996-10-28
DE59405120D1 (de) 1998-02-26
ES2113109T3 (es) 1998-04-16
HUT73742A (en) 1996-09-30
EP0701628B1 (de) 1998-01-21
HU9503363D0 (en) 1996-01-29
DE4317577A1 (de) 1994-12-01
RU2139936C1 (ru) 1999-10-20
JPH08510643A (ja) 1996-11-12
FI955700A0 (fi) 1995-11-27
ATE162555T1 (de) 1998-02-15
AU6997794A (en) 1994-12-20
DK0701628T3 (da) 1998-09-21

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