NO315843B1 - Stabile vandige sammensetninger inneholdende <alfa>- interferonhybrid - Google Patents
Stabile vandige sammensetninger inneholdende <alfa>- interferonhybrid Download PDFInfo
- Publication number
- NO315843B1 NO315843B1 NO19942983A NO942983A NO315843B1 NO 315843 B1 NO315843 B1 NO 315843B1 NO 19942983 A NO19942983 A NO 19942983A NO 942983 A NO942983 A NO 942983A NO 315843 B1 NO315843 B1 NO 315843B1
- Authority
- NO
- Norway
- Prior art keywords
- interferon
- hybrid
- solution according
- stable solution
- concentration
- Prior art date
Links
- 229940079322 interferon Drugs 0.000 title claims description 5
- 239000000203 mixture Substances 0.000 title description 14
- 102000014150 Interferons Human genes 0.000 title description 3
- 108010050904 Interferons Proteins 0.000 title description 3
- 102000006992 Interferon-alpha Human genes 0.000 claims abstract description 25
- 108010047761 Interferon-alpha Proteins 0.000 claims abstract description 25
- 239000000872 buffer Substances 0.000 claims abstract description 12
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 239000003381 stabilizer Substances 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 27
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 12
- 239000004471 Glycine Substances 0.000 claims description 7
- 229920005862 polyol Polymers 0.000 claims description 7
- 150000003077 polyols Chemical class 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- 238000010255 intramuscular injection Methods 0.000 claims description 4
- 238000010253 intravenous injection Methods 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- 238000010254 subcutaneous injection Methods 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 13
- 238000009472 formulation Methods 0.000 description 12
- 238000003860 storage Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 238000001542 size-exclusion chromatography Methods 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000012430 stability testing Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- 239000000337 buffer salt Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229940047124 interferons Drugs 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000004007 reversed phase HPLC Methods 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 238000009010 Bradford assay Methods 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000033135 Classic hairy cell leukemia Diseases 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 102000040739 Secretory proteins Human genes 0.000 description 1
- 108091058545 Secretory proteins Proteins 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000010504 bond cleavage reaction Methods 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 239000008364 bulk solution Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 238000001641 gel filtration chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 201000009277 hairy cell leukemia Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012384 transportation and delivery Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939316849A GB9316849D0 (en) | 1993-08-13 | 1993-08-13 | Pharmaceutical compositions |
| GB9405879A GB9405879D0 (en) | 1994-03-24 | 1994-03-24 | Pharmaceutical compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO942983D0 NO942983D0 (no) | 1994-08-12 |
| NO942983L NO942983L (no) | 1995-02-14 |
| NO315843B1 true NO315843B1 (no) | 2003-11-03 |
Family
ID=26303371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19942983A NO315843B1 (no) | 1993-08-13 | 1994-08-12 | Stabile vandige sammensetninger inneholdende <alfa>- interferonhybrid |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5609868A (el) |
| EP (1) | EP0641567B1 (el) |
| JP (1) | JP3745395B2 (el) |
| KR (1) | KR100351495B1 (el) |
| AT (1) | ATE190498T1 (el) |
| AU (1) | AU679233B2 (el) |
| CA (1) | CA2129921C (el) |
| CY (1) | CY2230B1 (el) |
| DE (1) | DE69423402T2 (el) |
| DK (1) | DK0641567T3 (el) |
| ES (1) | ES2144034T3 (el) |
| FI (1) | FI111222B (el) |
| GR (1) | GR3033239T3 (el) |
| HU (1) | HU224613B1 (el) |
| IL (1) | IL110566A (el) |
| NO (1) | NO315843B1 (el) |
| NZ (1) | NZ264218A (el) |
| PT (1) | PT641567E (el) |
| TW (1) | TW249202B (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020102236A1 (en) * | 1994-12-08 | 2002-08-01 | Taylor Peter William | Liposomal interferon hybrid compositions |
| US20030190307A1 (en) | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| SK284989B6 (sk) * | 1996-12-24 | 2006-04-06 | Biogen, Inc. | Kvapalná kompozícia obsahujúca interferón a spôsob stabilizácie interferónu |
| KR19990075253A (ko) * | 1998-03-18 | 1999-10-15 | 성재갑 | 약학적으로 안정한 인터페론 제 |
| US6685933B1 (en) * | 1998-07-28 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Interferon α hybrids |
| ES2167189B1 (es) * | 1999-12-17 | 2003-04-01 | Lipotec Sa | Formulacion farmaceutica estable para la administracion intravenosa o intramuscular, de principios activos peptidicos |
| HU228583B1 (en) * | 2000-11-07 | 2013-04-29 | Novartis Vaccines & Diagnostic | Stabilized interferon compositions |
| US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| AR044302A1 (es) * | 2003-05-13 | 2005-09-07 | Ares Trading Sa | Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos |
| EP2476428B1 (en) * | 2005-06-29 | 2013-08-21 | Yeda Research and Development Co. Ltd. | Recombinant interferon alpha 2 (IFN alpha 2) mutants |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59196823A (ja) * | 1983-04-20 | 1984-11-08 | Sunstar Inc | 皮膚および粘膜の真菌症治療用外用剤 |
| US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| IL78231A (en) * | 1985-03-25 | 1990-07-26 | Schering Corp | Stable gamma-interferon formulation |
| DE3685996T2 (de) * | 1985-06-11 | 1993-01-14 | Ciba Geigy Ag | Hybrid-interferone. |
| US4847079A (en) * | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| IL88233A (en) * | 1987-11-03 | 1993-08-18 | Genentech Inc | Gamma interferon formulation |
| EP0331635A3 (en) * | 1988-02-29 | 1990-02-28 | The Board of Regents of the University of Texas System | Preparations for treating bladder cancer |
-
1994
- 1994-07-18 TW TW083106518A patent/TW249202B/zh active
- 1994-08-04 IL IL11056694A patent/IL110566A/xx not_active IP Right Cessation
- 1994-08-05 JP JP18465494A patent/JP3745395B2/ja not_active Expired - Fee Related
- 1994-08-05 AU AU68939/94A patent/AU679233B2/en not_active Ceased
- 1994-08-10 ES ES94305930T patent/ES2144034T3/es not_active Expired - Lifetime
- 1994-08-10 AT AT94305930T patent/ATE190498T1/de not_active IP Right Cessation
- 1994-08-10 US US08/288,671 patent/US5609868A/en not_active Expired - Lifetime
- 1994-08-10 EP EP94305930A patent/EP0641567B1/en not_active Expired - Lifetime
- 1994-08-10 PT PT94305930T patent/PT641567E/pt unknown
- 1994-08-10 DK DK94305930T patent/DK0641567T3/da active
- 1994-08-10 DE DE69423402T patent/DE69423402T2/de not_active Expired - Fee Related
- 1994-08-10 FI FI943705A patent/FI111222B/fi active
- 1994-08-11 CA CA002129921A patent/CA2129921C/en not_active Expired - Fee Related
- 1994-08-11 NZ NZ264218A patent/NZ264218A/en not_active IP Right Cessation
- 1994-08-12 HU HU9402356A patent/HU224613B1/hu not_active IP Right Cessation
- 1994-08-12 KR KR1019940019883A patent/KR100351495B1/ko not_active IP Right Cessation
- 1994-08-12 NO NO19942983A patent/NO315843B1/no not_active IP Right Cessation
-
2000
- 2000-04-14 GR GR20000400921T patent/GR3033239T3/el not_active IP Right Cessation
-
2001
- 2001-07-30 CY CY0100020A patent/CY2230B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2129921C (en) | 2006-12-05 |
| NO942983L (no) | 1995-02-14 |
| US5609868A (en) | 1997-03-11 |
| HU224613B1 (hu) | 2005-11-28 |
| CY2230B1 (en) | 2003-04-18 |
| NO942983D0 (no) | 1994-08-12 |
| DK0641567T3 (da) | 2000-08-14 |
| HUT68692A (en) | 1995-07-28 |
| IL110566A (en) | 1999-12-22 |
| FI943705A (fi) | 1995-02-14 |
| EP0641567B1 (en) | 2000-03-15 |
| KR100351495B1 (ko) | 2003-02-19 |
| GR3033239T3 (en) | 2000-09-29 |
| CA2129921A1 (en) | 1995-02-14 |
| ATE190498T1 (de) | 2000-04-15 |
| IL110566A0 (en) | 1995-01-24 |
| JPH07145070A (ja) | 1995-06-06 |
| EP0641567A1 (en) | 1995-03-08 |
| JP3745395B2 (ja) | 2006-02-15 |
| FI111222B (fi) | 2003-06-30 |
| PT641567E (pt) | 2000-08-31 |
| FI943705A0 (fi) | 1994-08-10 |
| KR950005325A (ko) | 1995-03-20 |
| AU679233B2 (en) | 1997-06-26 |
| DE69423402T2 (de) | 2000-08-03 |
| AU6893994A (en) | 1995-02-23 |
| TW249202B (el) | 1995-06-11 |
| DE69423402D1 (de) | 2000-04-20 |
| NZ264218A (en) | 1995-07-26 |
| ES2144034T3 (es) | 2000-06-01 |
| HU9402356D0 (en) | 1994-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4988562B2 (ja) | 安定化したインターフェロン液体製剤 | |
| TWI240627B (en) | Erythropoietin solution preparation | |
| EP0970703B1 (en) | Use of metal chelating agents to stabilize preparations containing interferon | |
| ES2286868T3 (es) | Composicion acuosa a base de hormana del crecimiento humana. | |
| JP5346065B2 (ja) | Ｈｓａを含まない安定なインターフェロン液体製剤 | |
| JP3927248B2 (ja) | Ｈｇｆ凍結乾燥製剤 | |
| NO315843B1 (no) | Stabile vandige sammensetninger inneholdende <alfa>- interferonhybrid | |
| AU2004298781B2 (en) | Stabilized interferon liquid formulations | |
| KR880002037B1 (ko) | 인터페론 조성물 및 이의 제조방법 | |
| JPS60260523A (ja) | インタ−フエロンの凍結乾燥医薬組成物 | |
| KR101191536B1 (ko) | 안정화된 인터페론 액상 제제 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |