NO313196B1 - Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette - Google Patents

Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette Download PDF

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Publication number
NO313196B1
NO313196B1 NO19971384A NO971384A NO313196B1 NO 313196 B1 NO313196 B1 NO 313196B1 NO 19971384 A NO19971384 A NO 19971384A NO 971384 A NO971384 A NO 971384A NO 313196 B1 NO313196 B1 NO 313196B1
Authority
NO
Norway
Prior art keywords
group
hydrochloride
methyl
pyrimidinyl
pyrazolyl
Prior art date
Application number
NO19971384A
Other languages
English (en)
Norwegian (no)
Other versions
NO971384L (no
NO971384D0 (no
Inventor
Akio Ejima
Masamichi Sugimori
Ikuo Mitsui
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of NO971384D0 publication Critical patent/NO971384D0/no
Publication of NO971384L publication Critical patent/NO971384L/no
Publication of NO313196B1 publication Critical patent/NO313196B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19971384A 1994-09-26 1997-03-24 Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette NO313196B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22942294 1994-09-26
JP13501095 1995-06-01
PCT/JP1995/001934 WO1996010024A1 (fr) 1994-09-26 1995-09-25 Derive pyrimidinylpyrazole

Publications (3)

Publication Number Publication Date
NO971384D0 NO971384D0 (no) 1997-03-24
NO971384L NO971384L (no) 1997-05-23
NO313196B1 true NO313196B1 (no) 2002-08-26

Family

ID=26468965

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19971384A NO313196B1 (no) 1994-09-26 1997-03-24 Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette

Country Status (13)

Country Link
US (1) US5852019A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0784055B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100388568B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1071754C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE232528T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2201110A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE69529619D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0784055T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2192584T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI971227A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO313196B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW312694B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1996010024A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
TW486478B (en) * 1997-01-27 2002-05-11 Daiichi Seiyaku Co Pyrazole derivatives exhibiting anti-tumor effects and a pharmaceutical composition comprising the same
US6573377B1 (en) * 1998-07-24 2003-06-03 Daiichi Pharmaceuticals Co., Ltd. Pyrazole derivatives and salts thereof
WO2000043385A1 (fr) * 1999-01-25 2000-07-27 Zenyaku Kogyo Kabushiki Kaisha Composes heterocycliques et agents antitumoraux les comprenant en tant que principe actif
ES2280530T3 (es) * 2001-04-27 2007-09-16 Zenyaku Kogyo Kabushiki Kaisha Compuesto heterociclico y agente antitumoral que contiene el mismo como principio activo.
WO2003011837A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. Tyrosine kinase inhibitors
US20050130989A1 (en) * 2003-01-28 2005-06-16 Aventis Pharma S. A. N-arylheteroaromatic products compositions containing them and use thereof
CA2512243A1 (fr) * 2003-01-28 2004-09-16 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
FR2850379B1 (fr) * 2003-01-28 2006-11-17 Aventis Pharma Sa Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
WO2005028467A1 (en) * 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
CN100532380C (zh) * 2004-03-31 2009-08-26 全药工业株式会社 杂环化合物和以其作为有效成分的抗恶性肿瘤药
SI1864665T1 (sl) * 2005-03-11 2012-09-28 Zenyaku Kogyo Kk Imunosupresivno sredstvo, ki obsega heterociklično spojino kot učinkovino
US20070244110A1 (en) * 2006-04-14 2007-10-18 Zenyaku Kogyo Kabushiki Kaisha Treatment of prostate cancer, melanoma or hepatic cancer
AU2007308154A1 (en) 2006-10-10 2008-04-17 Amgen Inc. N-aryl pyrazole compounds for use against diabetes
US10287269B2 (en) * 2015-03-26 2019-05-14 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as PDE2 inhibitors
CA3038280A1 (en) 2015-09-30 2017-04-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. - Generalverwaltung Heteroaryl derivatives as sepiapterin reductase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3778433A (en) * 1969-04-18 1973-12-11 Sumitomo Chemical Co Process for producing benzodiazepine derivatives
JPS4842072A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1971-09-29 1973-06-19
JPS61129129A (ja) * 1984-11-28 1986-06-17 Kureha Chem Ind Co Ltd 抗腫瘍剤
US5102893A (en) * 1986-07-07 1992-04-07 Warner-Lambert Company Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis

Also Published As

Publication number Publication date
KR970706275A (ko) 1997-11-03
KR100388568B1 (ko) 2003-10-04
CA2201110A1 (en) 1996-04-04
EP0784055B1 (en) 2003-02-12
HK1001396A1 (en) 1998-06-19
DE69529619T4 (de) 2005-01-27
NO971384L (no) 1997-05-23
CN1166833A (zh) 1997-12-03
EP0784055A1 (en) 1997-07-16
WO1996010024A1 (fr) 1996-04-04
NO971384D0 (no) 1997-03-24
DK0784055T3 (da) 2003-06-02
EP0784055A4 (en) 1998-01-07
CN1071754C (zh) 2001-09-26
FI971227L (fi) 1997-05-23
US5852019A (en) 1998-12-22
DE69529619T2 (de) 2003-12-18
ATE232528T1 (de) 2003-02-15
FI971227A7 (fi) 1997-05-23
ES2192584T3 (es) 2003-10-16
TW312694B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1997-08-11
FI971227A0 (fi) 1997-03-24
DE69529619D1 (en) 2003-03-20

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