NO306561B1 - Dyrkingsmedium for krevende organismer - Google Patents
Dyrkingsmedium for krevende organismer Download PDFInfo
- Publication number
- NO306561B1 NO306561B1 NO914764A NO914764A NO306561B1 NO 306561 B1 NO306561 B1 NO 306561B1 NO 914764 A NO914764 A NO 914764A NO 914764 A NO914764 A NO 914764A NO 306561 B1 NO306561 B1 NO 306561B1
- Authority
- NO
- Norway
- Prior art keywords
- culture medium
- nad
- fos
- hemin
- blood
- Prior art date
Links
- 239000001963 growth medium Substances 0.000 title claims abstract description 57
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 34
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 34
- 231100000419 toxicity Toxicity 0.000 claims abstract description 6
- 230000001988 toxicity Effects 0.000 claims abstract description 6
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 18
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 claims description 14
- 229940025294 hemin Drugs 0.000 claims description 13
- 239000002609 medium Substances 0.000 claims description 12
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 10
- 102000001554 Hemoglobins Human genes 0.000 claims description 10
- 108010054147 Hemoglobins Proteins 0.000 claims description 10
- 108010010803 Gelatin Proteins 0.000 claims description 9
- 229920000159 gelatin Polymers 0.000 claims description 9
- 239000008273 gelatin Substances 0.000 claims description 9
- 235000019322 gelatine Nutrition 0.000 claims description 9
- 235000011852 gelatine desserts Nutrition 0.000 claims description 9
- 229940098773 bovine serum albumin Drugs 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 102000009027 Albumins Human genes 0.000 claims description 7
- 108010088751 Albumins Proteins 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 229920002851 polycationic polymer Polymers 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 150000003628 tricarboxylic acids Chemical class 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- 108010044091 Globulins Proteins 0.000 claims description 3
- 102000006395 Globulins Human genes 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004472 Lysine Substances 0.000 claims description 3
- 102000007327 Protamines Human genes 0.000 claims description 3
- 108010007568 Protamines Proteins 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 125000002091 cationic group Chemical group 0.000 claims description 3
- 238000003776 cleavage reaction Methods 0.000 claims description 3
- 150000002357 guanidines Chemical class 0.000 claims description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 3
- 229950008679 protamine sulfate Drugs 0.000 claims description 3
- 230000007017 scission Effects 0.000 claims description 3
- BMUDPLZKKRQECS-UHFFFAOYSA-K 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid iron(3+) hydroxide Chemical compound [OH-].[Fe+3].[N-]1C2=C(C)C(CCC(O)=O)=C1C=C([N-]1)C(CCC(O)=O)=C(C)C1=CC(C(C)=C1C=C)=NC1=CC(C(C)=C1C=C)=NC1=C2 BMUDPLZKKRQECS-UHFFFAOYSA-K 0.000 claims description 2
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 claims description 2
- 108010062374 Myoglobin Proteins 0.000 claims description 2
- 229920006317 cationic polymer Polymers 0.000 claims description 2
- 229960001231 choline Drugs 0.000 claims description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 2
- 150000003278 haem Chemical class 0.000 claims description 2
- 229940109738 hematin Drugs 0.000 claims description 2
- 229950003776 protoporphyrin Drugs 0.000 claims description 2
- 102000036675 Myoglobin Human genes 0.000 claims 1
- 239000013589 supplement Substances 0.000 abstract description 32
- 239000003102 growth factor Substances 0.000 abstract description 18
- 238000001514 detection method Methods 0.000 abstract description 9
- 238000009640 blood culture Methods 0.000 description 31
- 229950006238 nadide Drugs 0.000 description 21
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 20
- 231100000331 toxic Toxicity 0.000 description 15
- 230000002588 toxic effect Effects 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 108010014172 Factor V Proteins 0.000 description 12
- 238000002955 isolation Methods 0.000 description 12
- 108010014173 Factor X Proteins 0.000 description 11
- 210000001124 body fluid Anatomy 0.000 description 10
- 239000010839 body fluid Substances 0.000 description 10
- LYPFDBRUNKHDGX-SOGSVHMOSA-N N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 Chemical compound N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 LYPFDBRUNKHDGX-SOGSVHMOSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 229960002197 temoporfin Drugs 0.000 description 9
- 241000606790 Haemophilus Species 0.000 description 8
- 239000012530 fluid Substances 0.000 description 7
- 241000588653 Neisseria Species 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 241000606768 Haemophilus influenzae Species 0.000 description 5
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 230000003472 neutralizing effect Effects 0.000 description 4
- 241000207201 Gardnerella vaginalis Species 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
- 241000588650 Neisseria meningitidis Species 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 229940047650 haemophilus influenzae Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 230000001175 peptic effect Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MXXTVDSLIANCNG-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate;dimethyl sulfate;1-ethenylpyrrolidin-2-one Chemical compound COS(=O)(=O)OC.C=CN1CCCC1=O.CN(C)CCOC(=O)C(C)=C MXXTVDSLIANCNG-UHFFFAOYSA-N 0.000 description 2
- 208000031729 Bacteremia Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 206010017523 Fungaemia Diseases 0.000 description 2
- 241000207202 Gardnerella Species 0.000 description 2
- 241000606766 Haemophilus parainfluenzae Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 241000202944 Mycoplasma sp. Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000192035 Peptostreptococcus anaerobius Species 0.000 description 2
- 108010071390 Serum Albumin Proteins 0.000 description 2
- 102000007562 Serum Albumin Human genes 0.000 description 2
- 241001478880 Streptobacillus moniliformis Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 210000003567 ascitic fluid Anatomy 0.000 description 2
- 235000010633 broth Nutrition 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 150000001991 dicarboxylic acids Chemical class 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- BTIJJDXEELBZFS-UHFFFAOYSA-K hemin Chemical group [Cl-].[Fe+3].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 BTIJJDXEELBZFS-UHFFFAOYSA-K 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000009629 microbiological culture Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000003170 nutritional factors Nutrition 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 229940074571 peptostreptococcus anaerobius Drugs 0.000 description 2
- 229920001463 polyanetholesulfonic acid sodium salt Polymers 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- YXVCLPJQTZXJLH-UHFFFAOYSA-N thiamine(1+) diphosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N YXVCLPJQTZXJLH-UHFFFAOYSA-N 0.000 description 2
- 108010050327 trypticase-soy broth Proteins 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 239000004381 Choline salt Substances 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 102100030856 Myoglobin Human genes 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 208000037815 bloodstream infection Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019417 choline salt Nutrition 0.000 description 1
- -1 co-enzyme A Chemical compound 0.000 description 1
- 229950001485 cocarboxylase Drugs 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- 235000014304 histidine Nutrition 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940101270 nicotinamide adenine dinucleotide (nad) Drugs 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000001974 tryptic soy broth Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/045—Culture media therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Farming Of Fish And Shellfish (AREA)
- Mushroom Cultivation (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62287490A | 1990-12-06 | 1990-12-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO914764D0 NO914764D0 (no) | 1991-12-04 |
| NO914764L NO914764L (no) | 1992-06-09 |
| NO306561B1 true NO306561B1 (no) | 1999-11-22 |
Family
ID=24495852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO914764A NO306561B1 (no) | 1990-12-06 | 1991-12-04 | Dyrkingsmedium for krevende organismer |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0489392B1 (de) |
| JP (1) | JP2786962B2 (de) |
| AT (1) | ATE148173T1 (de) |
| AU (1) | AU653964B2 (de) |
| CA (1) | CA2055973C (de) |
| DE (1) | DE69124349T2 (de) |
| DK (1) | DK0489392T3 (de) |
| ES (1) | ES2100199T3 (de) |
| FI (1) | FI100990B (de) |
| MY (1) | MY106928A (de) |
| NO (1) | NO306561B1 (de) |
| NZ (1) | NZ240659A (de) |
| TW (1) | TW241301B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494808A (en) * | 1994-09-15 | 1996-02-27 | Merck & Co., Inc. | Defined medium OMPC fermentation process |
| JP3687859B2 (ja) * | 1994-10-31 | 2005-08-24 | ▲いん▼▲てつ▼ 小林 | 微生物輸送用培地 |
| US6555333B1 (en) * | 2002-05-14 | 2003-04-29 | Pml Microbiologicals, Inc. | Broad spectrum fastidious organism culture medium |
| US7491517B2 (en) * | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| FR2918671B1 (fr) | 2007-07-10 | 2010-10-15 | Sanofi Pasteur | Milieu de culture d'haemophilus influenzae type b. |
| US8932851B2 (en) | 2009-07-01 | 2015-01-13 | bioMērieux, Inc. | Method and culture medium for enhanced detection of Mycobacterium |
| US8389268B2 (en) | 2009-07-01 | 2013-03-05 | BIOMéRIEUX, INC. | Method and culture medium for enhanced detection of mycobacterium |
| HUE030643T2 (en) | 2009-07-01 | 2017-06-28 | Bio Merieux Inc | Method and culture medium for improved detection of microbial bacteria |
| US20170022542A1 (en) | 2015-07-20 | 2017-01-26 | PZM Diagnostics, LLC | Methods for culture and identification of mycrobacterium avium subspecies in crohn's disease |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2047739A (en) * | 1979-04-27 | 1980-12-03 | Roche Products Ltd | Nutrient medium |
-
1991
- 1991-11-19 AU AU87969/91A patent/AU653964B2/en not_active Ceased
- 1991-11-19 NZ NZ240659A patent/NZ240659A/en unknown
- 1991-11-21 CA CA002055973A patent/CA2055973C/en not_active Expired - Fee Related
- 1991-11-22 MY MYPI91002159A patent/MY106928A/en unknown
- 1991-11-26 TW TW080109294A patent/TW241301B/zh active
- 1991-12-03 EP EP91120711A patent/EP0489392B1/de not_active Expired - Lifetime
- 1991-12-03 AT AT91120711T patent/ATE148173T1/de not_active IP Right Cessation
- 1991-12-03 ES ES91120711T patent/ES2100199T3/es not_active Expired - Lifetime
- 1991-12-03 DK DK91120711.6T patent/DK0489392T3/da active
- 1991-12-03 DE DE69124349T patent/DE69124349T2/de not_active Expired - Fee Related
- 1991-12-04 FI FI915713A patent/FI100990B/fi not_active IP Right Cessation
- 1991-12-04 NO NO914764A patent/NO306561B1/no not_active IP Right Cessation
- 1991-12-06 JP JP3323225A patent/JP2786962B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MY106928A (en) | 1995-08-30 |
| FI915713A0 (fi) | 1991-12-04 |
| EP0489392B1 (de) | 1997-01-22 |
| FI100990B (fi) | 1998-03-31 |
| ATE148173T1 (de) | 1997-02-15 |
| DE69124349D1 (de) | 1997-03-06 |
| EP0489392A3 (en) | 1992-12-09 |
| AU8796991A (en) | 1992-06-11 |
| TW241301B (de) | 1995-02-21 |
| JPH0541975A (ja) | 1993-02-23 |
| CA2055973C (en) | 1997-06-10 |
| DE69124349T2 (de) | 1997-07-17 |
| JP2786962B2 (ja) | 1998-08-13 |
| FI915713A (fi) | 1992-06-07 |
| AU653964B2 (en) | 1994-10-20 |
| NZ240659A (en) | 1995-07-26 |
| DK0489392T3 (da) | 1997-07-28 |
| NO914764L (no) | 1992-06-09 |
| ES2100199T3 (es) | 1997-06-16 |
| EP0489392A2 (de) | 1992-06-10 |
| CA2055973A1 (en) | 1992-06-07 |
| NO914764D0 (no) | 1991-12-04 |
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