NO306497B1 - Anvendelse av piperidinderivater til fremstilling av medikamenter til behandling av psykiske og nevrologiske lidelser - Google Patents
Anvendelse av piperidinderivater til fremstilling av medikamenter til behandling av psykiske og nevrologiske lidelserInfo
- Publication number
- NO306497B1 NO306497B1 NO934494A NO934494A NO306497B1 NO 306497 B1 NO306497 B1 NO 306497B1 NO 934494 A NO934494 A NO 934494A NO 934494 A NO934494 A NO 934494A NO 306497 B1 NO306497 B1 NO 306497B1
- Authority
- NO
- Norway
- Prior art keywords
- sup
- sub
- hydrogen
- treatment
- alkylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK113191A DK113191D0 (da) | 1991-06-13 | 1991-06-13 | Spirocycliske forbindelser |
DK112991A DK112991D0 (da) | 1991-06-13 | 1991-06-13 | Carbocycliske eller heterocycliske forbindelser |
DK15792A DK15792D0 (da) | 1992-02-10 | 1992-02-10 | Spirocyclic compounds |
PCT/DK1992/000183 WO1992022554A1 (fr) | 1991-06-13 | 1992-06-12 | Derives de piperidine produisant un effet anxiolytique |
Publications (2)
Publication Number | Publication Date |
---|---|
NO934494L NO934494L (no) | 1994-02-11 |
NO306497B1 true NO306497B1 (no) | 1999-11-15 |
Family
ID=27220471
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO934494A NO306497B1 (no) | 1991-06-13 | 1993-12-09 | Anvendelse av piperidinderivater til fremstilling av medikamenter til behandling av psykiske og nevrologiske lidelser |
NO934494D NO934494D0 (no) | 1991-06-13 | 1993-12-09 | Piperidinderivater med anxiolytisk effekt |
NO994487A NO994487D0 (no) | 1991-06-13 | 1999-09-16 | Piperidinderivater med anxiolytisk effekt |
NO19994488A NO310275B1 (no) | 1991-06-13 | 1999-09-16 | Piperidinderivater med anxiolytisk effekt |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO934494D NO934494D0 (no) | 1991-06-13 | 1993-12-09 | Piperidinderivater med anxiolytisk effekt |
NO994487A NO994487D0 (no) | 1991-06-13 | 1999-09-16 | Piperidinderivater med anxiolytisk effekt |
NO19994488A NO310275B1 (no) | 1991-06-13 | 1999-09-16 | Piperidinderivater med anxiolytisk effekt |
Country Status (22)
Country | Link |
---|---|
US (4) | US5665725A (fr) |
EP (4) | EP0853085A1 (fr) |
JP (3) | JP2834577B2 (fr) |
KR (1) | KR100212231B1 (fr) |
AT (2) | ATE170523T1 (fr) |
AU (1) | AU664557B2 (fr) |
CA (1) | CA2111204C (fr) |
CZ (1) | CZ289479B6 (fr) |
DE (2) | DE69233038T2 (fr) |
DK (1) | DK0593511T3 (fr) |
ES (1) | ES2123557T3 (fr) |
FI (2) | FI108137B (fr) |
HK (1) | HK1009272A1 (fr) |
HU (1) | HU210869A9 (fr) |
IE (3) | IE921882A1 (fr) |
IL (1) | IL102155A0 (fr) |
NO (4) | NO306497B1 (fr) |
NZ (1) | NZ243065A (fr) |
RU (1) | RU2142952C1 (fr) |
SG (1) | SG48237A1 (fr) |
SK (3) | SK281748B6 (fr) |
WO (1) | WO1992022554A1 (fr) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
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TW263504B (fr) * | 1991-10-03 | 1995-11-21 | Pfizer | |
GB9305641D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
JPH08511522A (ja) * | 1993-06-07 | 1996-12-03 | メルク エンド カンパニー インコーポレーテッド | ニューロキニンアンタゴニストとしてのスピロ置換アザ環 |
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
US5654316A (en) * | 1995-06-06 | 1997-08-05 | Schering Corporation | Piperidine derivatives as neurokinin antagonists |
IL123583A (en) * | 1995-10-13 | 2003-07-31 | Neurosearch As | 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them |
KR20000010972A (ko) * | 1996-05-13 | 2000-02-25 | 사라 엔 람베쓰 | 살충제용 이환식 아민 |
WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
CZ184199A3 (cs) | 1996-11-26 | 1999-08-11 | Zeneca Limited | Deriváty 8-azabicyklo[3,2,1]oktanu, 8-azabicyklo[3,2,1]okt-6-enu, 9-azabicyklo[3,3,1]nonanu, 9-aza-3-oxabicyklo[3,3,1]nonanu a 9-aza-3-thiabicyklo[3,3,1]nonanu, způsob jejich přípravy a insekticidní, akaricidní nebo nematocidní prostředky, které je obsahují |
GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
GB9704948D0 (en) * | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
JP2002500668A (ja) * | 1997-05-29 | 2002-01-08 | イーライ・リリー・アンド・カンパニー | 5−HT▲下1A▼および5−HT▲下1Dα▼アンタゴニスト |
US6376505B1 (en) | 1997-05-29 | 2002-04-23 | Eli Lilly And Company | 5-HT1A and 5-HT1Dαdalpha antagonists |
DE19725664A1 (de) | 1997-06-18 | 1998-12-24 | Merck Patent Gmbh | 3-Benzylpiperidine |
CA2291067C (fr) | 1997-07-08 | 2002-07-30 | H. Lundbeck A/S | Procede de preparation de citalopram |
UA64769C2 (uk) * | 1997-11-07 | 2004-03-15 | Х. Луннбек А/С | Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування |
WO1998019512A2 (fr) | 1997-11-11 | 1998-05-14 | H. Lundbeck A/S | Procede de preparation de citaloprame |
US6013652A (en) * | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
US6166209A (en) * | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
PL342989A1 (en) * | 1998-04-07 | 2001-07-16 | Lundbeck & Co As H | Treatment of panic attacks |
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JP2002524515A (ja) * | 1998-09-15 | 2002-08-06 | ハー・ルンドベック・アクチエゼルスカベット | うつ病の治療方法 |
US6506378B1 (en) | 1998-12-16 | 2003-01-14 | Arch Development Corporation | Vesicular monoamine transporter gene therapy in Parkinson's disease |
TWI243173B (en) * | 1999-11-17 | 2005-11-11 | Akzo Nobel Nv | Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives |
US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
JP4745491B2 (ja) * | 2000-10-11 | 2011-08-10 | 株式会社明治 | インドール長鎖アルコール及びこれを含有する医薬 |
US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
AR035521A1 (es) * | 2000-12-22 | 2004-06-02 | Lundbeck & Co As H | Derivados de 3-indolina y composicion farmaceutica que los comprende |
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WO2002102387A1 (fr) * | 2001-06-18 | 2002-12-27 | H. Lundbeck A/S | Traitement de la douleur neuropathique |
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US6727264B1 (en) | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
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EP1781288A2 (fr) | 2004-08-19 | 2007-05-09 | Vertex Pharmaceuticals Incorporated | Modulateurs des recepteurs muscariniques |
MX2007002341A (es) | 2004-08-27 | 2007-09-25 | Esteve Labor Dr | Inhibidores del receptor sigma. |
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BRPI0514692A (pt) | 2004-08-27 | 2008-06-17 | Esteve Labor Dr | inibidores do receptor sigma |
CA2577089A1 (fr) | 2004-08-27 | 2006-03-02 | Laboratorios Del Dr. Esteve, S.A. | Inhibiteurs de recepteurs sigma |
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1992
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- 1992-06-12 EP EP98101728A patent/EP0853085A1/fr not_active Withdrawn
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- 1992-06-12 EP EP92610044A patent/EP0518805A1/fr active Pending
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