NO306466B1 - Blandinger som omfatter tetraazamakrocyklisk forbindelse-metallkomplekser for å forbedre et röntgenbilde, eventuelt en scintigrafiavbildning av et individ, samt tetraazamakrocyklisk forbindelse-metallkomplekser og anvendelse av dem - Google Patents

Blandinger som omfatter tetraazamakrocyklisk forbindelse-metallkomplekser for å forbedre et röntgenbilde, eventuelt en scintigrafiavbildning av et individ, samt tetraazamakrocyklisk forbindelse-metallkomplekser og anvendelse av dem

Info

Publication number
NO306466B1
NO306466B1 NO950346A NO950346A NO306466B1 NO 306466 B1 NO306466 B1 NO 306466B1 NO 950346 A NO950346 A NO 950346A NO 950346 A NO950346 A NO 950346A NO 306466 B1 NO306466 B1 NO 306466B1
Authority
NO
Norway
Prior art keywords
tetraazamacrocyclic
compound
metal complexes
image
enhance
Prior art date
Application number
NO950346A
Other languages
English (en)
Norwegian (no)
Other versions
NO950346L (no
NO950346D0 (no
Inventor
Allan Dean Sherry
Garry E Kiefer
Original Assignee
Univ Texas
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/662,075 external-priority patent/US4639365A/en
Application filed by Univ Texas, Dow Chemical Co filed Critical Univ Texas
Publication of NO950346L publication Critical patent/NO950346L/no
Publication of NO950346D0 publication Critical patent/NO950346D0/no
Publication of NO306466B1 publication Critical patent/NO306466B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
NO950346A 1984-10-18 1995-01-30 Blandinger som omfatter tetraazamakrocyklisk forbindelse-metallkomplekser for å forbedre et röntgenbilde, eventuelt en scintigrafiavbildning av et individ, samt tetraazamakrocyklisk forbindelse-metallkomplekser og anvendelse av dem NO306466B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/662,075 US4639365A (en) 1984-10-18 1984-10-18 Gadolinium chelates as NMR contrast agents
US07/923,715 US5362476A (en) 1984-10-18 1992-07-31 Alkyl phosphonate polyazamacrocyclic cheates for MRI
PCT/US1993/006158 WO1994003464A1 (fr) 1984-10-18 1993-06-28 Composes polyazamacrocycliques pour la complexation d'ions metalliques

Publications (3)

Publication Number Publication Date
NO950346L NO950346L (no) 1995-01-30
NO950346D0 NO950346D0 (no) 1995-01-30
NO306466B1 true NO306466B1 (no) 1999-11-08

Family

ID=34922820

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950346A NO306466B1 (no) 1984-10-18 1995-01-30 Blandinger som omfatter tetraazamakrocyklisk forbindelse-metallkomplekser for å forbedre et röntgenbilde, eventuelt en scintigrafiavbildning av et individ, samt tetraazamakrocyklisk forbindelse-metallkomplekser og anvendelse av dem

Country Status (19)

Country Link
US (2) US5362476A (fr)
EP (2) EP0855401B1 (fr)
JP (1) JP3411919B2 (fr)
CN (1) CN1040750C (fr)
AT (2) ATE169827T1 (fr)
AU (1) AU4654893A (fr)
CA (1) CA2140557A1 (fr)
DE (2) DE69331203T2 (fr)
DK (1) DK0855401T3 (fr)
ES (1) ES2167667T3 (fr)
FI (1) FI950397A (fr)
HU (1) HUT70447A (fr)
IL (1) IL106164A0 (fr)
MX (1) MX9304624A (fr)
NO (1) NO306466B1 (fr)
PH (1) PH30934A (fr)
PT (1) PT855401E (fr)
WO (1) WO1994003464A1 (fr)
ZA (1) ZA935541B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714604A (en) * 1993-05-06 1998-02-03 The Dow Chemical Company Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives
US7186688B1 (en) 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
EP0841951A2 (fr) * 1995-06-26 1998-05-20 Concat Ltd. Composes avec affinite et selectivite de chelation vis-a-vis d'elements de la premiere serie de transition et leur utilisation en therapie et en diagnostic medicaux
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US5952732A (en) * 1997-11-10 1999-09-14 Scarpitti; Ernest A Vehicle security system
EP1362861B1 (fr) * 1999-09-13 2005-12-14 Bristol-Myers Squibb Pharma Company Chelatants macrocycliques destinés à des produits métallopharmaceutiques
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
AU7353400A (en) * 1999-09-13 2001-04-17 Du Pont Pharmaceuticals Company Macrocyclic chelants for metallopharmaceuticals
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
WO2002012445A1 (fr) * 2000-08-07 2002-02-14 Vanderbilt University Detection de l'activite cox-2 et des metabolites d'anandamide
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
AU2002323528C1 (en) * 2001-09-04 2009-11-12 Texas Tech University Multi-use multimodal imaging chelates
EP1438076B1 (fr) * 2001-10-22 2006-06-14 Dow Global Technologies Inc. Agent radiopharmaceutique pour le traitement du cancer a un stade precoce
US20040034223A1 (en) * 2002-02-07 2004-02-19 Covalent Partners, Llc. Amphiphilic molecular modules and constructs based thereon
US7432371B2 (en) * 2002-02-07 2008-10-07 Covalent Partners, Llc Nanofilm and membrane compositions
US20040106741A1 (en) * 2002-09-17 2004-06-03 Kriesel Joshua W. Nanofilm compositions with polymeric components
EP1778699A4 (fr) * 2004-08-10 2009-02-25 Dow Global Technologies Inc Chelateurs et composes chelates de ciblage
JP5364589B2 (ja) 2006-12-11 2013-12-11 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 診断および治療適用用フィブリン結合ペプチドコンジュゲート
EP2476703A1 (fr) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Anticorps humains à réaction croisée avec des antigènes bactériens et propres de plaques athérosclérotiques
US7595699B1 (en) * 2008-03-04 2009-09-29 Freescale Semiconductor, Inc. Look loop circuit and method having improved lock time
EP2147684A1 (fr) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Agents de diagnostics sélectifs contre les métalloprotéases
BR112013000236B1 (pt) * 2010-07-06 2018-11-13 Catexel Limited método de produzir um composto, e, sal protonado
WO2012095516A1 (fr) 2011-01-14 2012-07-19 Bracco Imaging Spa Anticorps humain à réaction croisée avec un antigène bactérien et un auto-antigène de plaques athéroscléreuses
JP6991148B2 (ja) 2016-02-09 2022-01-12 ブラッコ・スイス・ソシエテ・アノニム セレクチン標的化のための組み換えキメラタンパク質

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932451A (en) * 1973-11-27 1976-01-13 E. I. Du Pont De Nemours & Company 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids
US3930867A (en) * 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
US3987128A (en) * 1975-08-22 1976-10-19 E. I. Du Pont De Nemours And Company Tetracyclic tetraamino phosphoranes and method of preparation
US4038312A (en) * 1975-08-22 1977-07-26 E. I. Du Pont De Nemours And Company Tricyclic phosphorous triamides
US3996276A (en) * 1975-08-22 1976-12-07 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic phosphorous triamides
US4085106A (en) * 1976-01-07 1978-04-18 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic trisaminomethanes
GB1529150A (en) * 1977-05-17 1978-10-18 Tabushi I Alkyl substituted cyclic alkyltetramines
US4337154A (en) * 1979-04-04 1982-06-29 Nippon Shokubai Kagaku Kogyo Co., Ltd. Crosslinked composite semipermeable membrane
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4421671A (en) * 1982-06-18 1983-12-20 General Electric Company Rare-earth-doped yttria-gadolinia ceramic scintillators
SU1081169A1 (ru) * 1982-12-13 1984-03-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова @ , @ , @ -Трис(диоксифосфорилметил)-1,4,7-триазациклононан в качестве комплексона дл селективного св зывани катионов магни ,цинка,меди,никел
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
CA1317937C (fr) * 1984-10-18 1993-05-18 A. Dean Sherry Chelates de gadolinium et de derives carboxymethyles de polyazamacrocycles servant d'agents contrastants en rmn
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
WO1990007261A2 (fr) * 1988-12-22 1990-07-12 The Dow Chemical Company Procede de preparation de polyazamacrocycles mono-n-alkyles
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
GB8914543D0 (en) * 1989-06-23 1989-08-09 Parker David Chemical compounds
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
FI950397A0 (fi) 1995-01-30
MX9304624A (es) 1994-08-31
NO950346L (no) 1995-01-30
JP3411919B2 (ja) 2003-06-03
CN1040750C (zh) 1998-11-18
CA2140557A1 (fr) 1994-02-17
IL106164A0 (en) 1993-10-20
EP0652885A1 (fr) 1995-05-17
DK0855401T3 (da) 2002-05-21
ES2167667T3 (es) 2002-05-16
PH30934A (en) 1997-12-23
US5630997A (en) 1997-05-20
DE69320481T2 (de) 1999-03-18
FI950397A (fi) 1995-01-30
AU4654893A (en) 1994-03-03
HUT70447A (en) 1995-10-30
HU9500283D0 (en) 1995-03-28
EP0855401B1 (fr) 2001-11-21
ATE209211T1 (de) 2001-12-15
JPH08500346A (ja) 1996-01-16
US5362476A (en) 1994-11-08
EP0855401A1 (fr) 1998-07-29
ATE169827T1 (de) 1998-09-15
DE69331203T2 (de) 2002-05-08
PT855401E (pt) 2002-04-29
DE69320481D1 (de) 1998-09-24
NO950346D0 (no) 1995-01-30
ZA935541B (en) 1994-02-24
WO1994003464A1 (fr) 1994-02-17
EP0652885B1 (fr) 1998-08-19
DE69331203D1 (de) 2002-01-03
CN1084514A (zh) 1994-03-30

Similar Documents

Publication Publication Date Title
NO306466B1 (no) Blandinger som omfatter tetraazamakrocyklisk forbindelse-metallkomplekser for å forbedre et röntgenbilde, eventuelt en scintigrafiavbildning av et individ, samt tetraazamakrocyklisk forbindelse-metallkomplekser og anvendelse av dem
NO173767C (no) Magnetisk resonansbildeforsterkende blanding
IL79506A0 (en) Polycyclic aromatic compounds,their preparation and pharmaceutical and cosmetic compositions containing them
ATE2017T1 (de) Mischungen von optischen aufhellern und deren verwendung.
MY109593A (en) Iodinated benzoyl acetals and ketals for x-ray imaging
DK638088D0 (da) Substituerede dicarboxylsyre-bis(3,5-dicarbamoyl-2,4,6-trijodanilider), fremgangsmaade til fremstilling deraf samt roentgenkontrastmidler indeholdende disse
YU48318B (sh) Postupak za dobijanje novih trijodobenzen jedinjenja i kontrasnog agensa koji ih sadrži
ES457405A1 (es) Procedimiento de preparacion de compuestos opacificantes.
ES8105367A1 (es) Perfeccionamientos en o relacionados con compuestos organi- cos
DE3361497D1 (en) 1,3-diaza-9-thia-anthracene-2,4-diones and photopolymerizable mixture containing these compounds
RU93050205A (ru) Иодированные смачивающие вещества, рентгеноконтрастное средство на их основе, способ получения рентгеновского изображения
GR3005041T3 (fr)

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees