ES2167667T3 - Composiciones de contraste para resonancia magnetica nuclear. - Google Patents

Composiciones de contraste para resonancia magnetica nuclear.

Info

Publication number
ES2167667T3
ES2167667T3 ES97120436T ES97120436T ES2167667T3 ES 2167667 T3 ES2167667 T3 ES 2167667T3 ES 97120436 T ES97120436 T ES 97120436T ES 97120436 T ES97120436 T ES 97120436T ES 2167667 T3 ES2167667 T3 ES 2167667T3
Authority
ES
Spain
Prior art keywords
magnetic resonance
nuclear magnetic
contrast compositions
compositions
resonance contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97120436T
Other languages
English (en)
Inventor
Allan Dean Sherry
Garry E Kiefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
University of Texas System
Original Assignee
Dow Chemical Co
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/662,075 external-priority patent/US4639365A/en
Application filed by Dow Chemical Co, University of Texas System filed Critical Dow Chemical Co
Application granted granted Critical
Publication of ES2167667T3 publication Critical patent/ES2167667T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

UNA COMPOSICION DE CONTRASTE PARA RESONANCIA MAGNETICA NUCLEAR, QUE ESTA FORMADA POR UN COMPLEJO DE LANTANIDO PARAMAGNETICOCOMPUESTO TETRAAZAMACROCICLICO REPRESENTADO POR LA FORMULA: DONDE, X ES 2, 3 O UNA COMBINACION DE P 2(S) Y Q 3(S), SIENDO P+Q= 4; R ES (CH 2 ) Z P(=O)OR 1 OR 2 ; R 1 ES H O CH 3 ; R 2 ES C N H 1+2N ; Z ESTA C OMPRENDIDO ENTRE 1 Y 3; R ES 2 O 3; M ES UN LANTANIDO PARAMAGNETICO; Y N ESTA COMPRENDIDO ENTRE 4 Y 6. LAS COMPOSICIONES DE CONTRASTE PARA RESONANCIA MAGNETICA NUCLEAR SON ESPECIALMENTE ADECUADAS PARA OBTENER LA IMAGEN DEL HIGADO DE UN SUJETO.
ES97120436T 1984-10-18 1993-06-28 Composiciones de contraste para resonancia magnetica nuclear. Expired - Lifetime ES2167667T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/662,075 US4639365A (en) 1984-10-18 1984-10-18 Gadolinium chelates as NMR contrast agents
US07/923,715 US5362476A (en) 1984-10-18 1992-07-31 Alkyl phosphonate polyazamacrocyclic cheates for MRI

Publications (1)

Publication Number Publication Date
ES2167667T3 true ES2167667T3 (es) 2002-05-16

Family

ID=34922820

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97120436T Expired - Lifetime ES2167667T3 (es) 1984-10-18 1993-06-28 Composiciones de contraste para resonancia magnetica nuclear.

Country Status (19)

Country Link
US (2) US5362476A (es)
EP (2) EP0855401B1 (es)
JP (1) JP3411919B2 (es)
CN (1) CN1040750C (es)
AT (2) ATE169827T1 (es)
AU (1) AU4654893A (es)
CA (1) CA2140557A1 (es)
DE (2) DE69320481T2 (es)
DK (1) DK0855401T3 (es)
ES (1) ES2167667T3 (es)
FI (1) FI950397A0 (es)
HU (1) HUT70447A (es)
IL (1) IL106164A0 (es)
MX (1) MX9304624A (es)
NO (1) NO306466B1 (es)
PH (1) PH30934A (es)
PT (1) PT855401E (es)
WO (1) WO1994003464A1 (es)
ZA (1) ZA935541B (es)

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US7186688B1 (en) 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
EP0955044B1 (en) * 1995-06-26 2005-11-16 Chelator LLC Method of inhibiting bacterial or fungal growth using a complexing agent
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US5952732A (en) * 1997-11-10 1999-09-14 Scarpitti; Ernest A Vehicle security system
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
DE60024891T2 (de) * 1999-09-13 2006-08-24 Bristol-Myers Squibb Pharma Co. Makrocyclische Chelatbildner für Metallopharmazeutika
EP1362861B1 (en) * 1999-09-13 2005-12-14 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US6565828B2 (en) 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
CA2422306A1 (en) * 2000-08-07 2002-02-14 Vanderbilt University Compositions and methods for detecting and quantifying cox-2 activity and 2-arachidonylglycerol metabolites
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
EP1429783A4 (en) * 2001-09-04 2006-08-09 Univ Texas Tech MULTIMODAL IMAGING CHELATES FOR MULTIPLE USES
WO2003035114A1 (en) * 2001-10-22 2003-05-01 Dow Global Technologies Inc. Radiopharmaceutical agent for the treatment of early stage cancer
US7432371B2 (en) * 2002-02-07 2008-10-07 Covalent Partners, Llc Nanofilm and membrane compositions
US20040034223A1 (en) * 2002-02-07 2004-02-19 Covalent Partners, Llc. Amphiphilic molecular modules and constructs based thereon
US20040106741A1 (en) * 2002-09-17 2004-06-03 Kriesel Joshua W. Nanofilm compositions with polymeric components
WO2006020779A2 (en) * 2004-08-10 2006-02-23 Dow Global Technologies Inc. Targeting chelants and chelates
EP2097438B1 (en) 2006-12-11 2015-08-26 Bracco Imaging S.p.A Fibrin binding peptide conjugates for diagnostic and therapeutic applications
EP2476703A1 (en) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
US7595699B1 (en) * 2008-03-04 2009-09-29 Freescale Semiconductor, Inc. Look loop circuit and method having improved lock time
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
BR112013000236B1 (pt) * 2010-07-06 2018-11-13 Catexel Limited método de produzir um composto, e, sal protonado
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
IL260957B2 (en) 2016-02-09 2023-11-01 Bracco Suisse Sa Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof

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US3930867A (en) * 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
US3996276A (en) * 1975-08-22 1976-12-07 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic phosphorous triamides
US4038312A (en) * 1975-08-22 1977-07-26 E. I. Du Pont De Nemours And Company Tricyclic phosphorous triamides
US3987128A (en) * 1975-08-22 1976-10-19 E. I. Du Pont De Nemours And Company Tetracyclic tetraamino phosphoranes and method of preparation
US4085106A (en) * 1976-01-07 1978-04-18 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic trisaminomethanes
GB1529150A (en) * 1977-05-17 1978-10-18 Tabushi I Alkyl substituted cyclic alkyltetramines
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Also Published As

Publication number Publication date
DE69320481T2 (de) 1999-03-18
IL106164A0 (en) 1993-10-20
US5362476A (en) 1994-11-08
MX9304624A (es) 1994-08-31
US5630997A (en) 1997-05-20
CN1040750C (zh) 1998-11-18
DE69320481D1 (de) 1998-09-24
CA2140557A1 (en) 1994-02-17
JP3411919B2 (ja) 2003-06-03
EP0855401B1 (en) 2001-11-21
DE69331203T2 (de) 2002-05-08
NO306466B1 (no) 1999-11-08
DK0855401T3 (da) 2002-05-21
EP0652885A1 (en) 1995-05-17
WO1994003464A1 (en) 1994-02-17
JPH08500346A (ja) 1996-01-16
CN1084514A (zh) 1994-03-30
NO950346D0 (no) 1995-01-30
ATE169827T1 (de) 1998-09-15
EP0652885B1 (en) 1998-08-19
HUT70447A (en) 1995-10-30
FI950397A (fi) 1995-01-30
ZA935541B (en) 1994-02-24
AU4654893A (en) 1994-03-03
ATE209211T1 (de) 2001-12-15
DE69331203D1 (de) 2002-01-03
HU9500283D0 (en) 1995-03-28
EP0855401A1 (en) 1998-07-29
NO950346L (no) 1995-01-30
PT855401E (pt) 2002-04-29
PH30934A (en) 1997-12-23
FI950397A0 (fi) 1995-01-30

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