NO306021B1 - 3-(indol-3-yl)propensyrederivater som NMDA-antagonister - Google Patents

3-(indol-3-yl)propensyrederivater som NMDA-antagonister

Info

Publication number
NO306021B1
NO306021B1 NO954769A NO954769A NO306021B1 NO 306021 B1 NO306021 B1 NO 306021B1 NO 954769 A NO954769 A NO 954769A NO 954769 A NO954769 A NO 954769A NO 306021 B1 NO306021 B1 NO 306021B1
Authority
NO
Norway
Prior art keywords
acid derivatives
propenoic acid
indol
hydrogen
represented
Prior art date
Application number
NO954769A
Other languages
English (en)
Norwegian (no)
Other versions
NO954769L (no
NO954769D0 (no
Inventor
Francesco Gerald Salituro
Bruce Michael Baron
Boyd Lynn Harrison
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO954769D0 publication Critical patent/NO954769D0/no
Publication of NO954769L publication Critical patent/NO954769L/no
Publication of NO306021B1 publication Critical patent/NO306021B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO954769A 1993-05-27 1995-11-24 3-(indol-3-yl)propensyrederivater som NMDA-antagonister NO306021B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6836793A 1993-05-27 1993-05-27
US13932393A 1993-10-19 1993-10-19
US19081494A 1994-02-02 1994-02-02
PCT/US1994/005023 WO1994027964A1 (en) 1993-05-27 1994-05-02 3-(indol-3-yl) propenoic acid derivatives and as nmda antagonists

Publications (3)

Publication Number Publication Date
NO954769D0 NO954769D0 (no) 1995-11-24
NO954769L NO954769L (no) 1996-01-25
NO306021B1 true NO306021B1 (no) 1999-09-06

Family

ID=27371322

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954769A NO306021B1 (no) 1993-05-27 1995-11-24 3-(indol-3-yl)propensyrederivater som NMDA-antagonister

Country Status (17)

Country Link
EP (1) EP0701551B1 (en:Method)
JP (1) JP3334805B2 (en:Method)
KR (1) KR100314482B1 (en:Method)
CN (1) CN1051302C (en:Method)
AT (1) ATE151750T1 (en:Method)
AU (1) AU681402B2 (en:Method)
CA (1) CA2161768C (en:Method)
DE (1) DE69402703T2 (en:Method)
DK (1) DK0701551T3 (en:Method)
ES (1) ES2103590T3 (en:Method)
FI (1) FI955604L (en:Method)
GR (1) GR3023973T3 (en:Method)
HU (1) HU216633B (en:Method)
IL (1) IL109744A (en:Method)
NO (1) NO306021B1 (en:Method)
TW (1) TW262467B (en:Method)
WO (1) WO1994027964A1 (en:Method)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5563157B1 (en) 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
KR20000048715A (ko) * 1996-09-30 2000-07-25 게리 디. 스트리트, 스티븐 엘. 네스비트 Ｎｍｄａ (ｎ-메틸-ｄ-아스파르테이트) 길항제
CN101770315B (zh) 2009-01-05 2012-05-23 鸿富锦精密工业（深圳）有限公司 具有滑动控制的触摸电子装置及其滑动控制方法
CN113419009B (zh) * 2021-06-29 2023-02-07 国家烟草质量监督检验中心 一种氟噻虫砜代谢物的液相色谱串联质谱测定方法
CN113419008B (zh) * 2021-06-29 2023-02-07 国家烟草质量监督检验中心 一种氟噻虫砜代谢物的合相色谱串联质谱测定方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
WO2019021625A1 (ja) * 2017-07-25 2019-01-31 株式会社日立ハイテクノロジーズ 自動分析装置

Also Published As

Publication number Publication date
EP0701551B1 (en) 1997-04-16
GR3023973T3 (en) 1997-10-31
HU216633B (hu) 1999-07-28
JPH09508615A (ja) 1997-09-02
CN1124484A (zh) 1996-06-12
JP3334805B2 (ja) 2002-10-15
CN1051302C (zh) 2000-04-12
WO1994027964A1 (en) 1994-12-08
KR960702438A (ko) 1996-04-27
IL109744A (en) 1999-06-20
FI955604A7 (fi) 1995-11-21
CA2161768C (en) 1998-08-18
HUT74620A (en) 1997-01-28
HU9503367D0 (en) 1996-01-29
ATE151750T1 (de) 1997-05-15
KR100314482B1 (ko) 2002-02-28
CA2161768A1 (en) 1994-12-08
DE69402703T2 (de) 1997-11-27
EP0701551A1 (en) 1996-03-20
NO954769L (no) 1996-01-25
NO954769D0 (no) 1995-11-24
TW262467B (en:Method) 1995-11-11
FI955604A0 (fi) 1995-11-21
AU6784394A (en) 1994-12-20
IL109744A0 (en) 1994-08-26
ES2103590T3 (es) 1997-09-16
DK0701551T3 (da) 1997-10-20
FI955604L (fi) 1995-11-21
AU681402B2 (en) 1997-08-28
DE69402703D1 (de) 1997-05-22

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Legal Events

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN NOVEMBER 2003