NO303694B1 - Isolert rekombinant nukleinsyresekvens, nukleinsyrevektor, rekombinant mikroorganisme, celle, fremgangsmÕte for fremstilling av et neurotrofin-3 protein, samt anvendelse av en detekterbart merket nukleinsyresekvens - Google Patents
Isolert rekombinant nukleinsyresekvens, nukleinsyrevektor, rekombinant mikroorganisme, celle, fremgangsmÕte for fremstilling av et neurotrofin-3 protein, samt anvendelse av en detekterbart merket nukleinsyresekvens Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B75/00—Other engines
- F02B75/02—Engines characterised by their cycles, e.g. six-stroke
- F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
- F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/400,591 US5180820A (en) | 1989-08-30 | 1989-08-30 | Brain-derived neurotrophic factor |
| US49000490A | 1990-03-07 | 1990-03-07 | |
| US57018990A | 1990-08-20 | 1990-08-20 | |
| PCT/US1990/004916 WO1991003569A1 (en) | 1989-08-30 | 1990-08-29 | Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO911688D0 NO911688D0 (no) | 1991-04-29 |
| NO911688L NO911688L (no) | 1991-05-31 |
| NO303694B1 true NO303694B1 (no) | 1998-08-17 |
Family
ID=27410411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO911688A NO303694B1 (no) | 1989-08-30 | 1991-04-29 | Isolert rekombinant nukleinsyresekvens, nukleinsyrevektor, rekombinant mikroorganisme, celle, fremgangsmÕte for fremstilling av et neurotrofin-3 protein, samt anvendelse av en detekterbart merket nukleinsyresekvens |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0441947B1 (cs) |
| KR (1) | KR100196203B1 (cs) |
| CN (1) | CN1124342C (cs) |
| AT (1) | ATE153074T1 (cs) |
| AU (1) | AU643705B2 (cs) |
| CA (1) | CA2040437C (cs) |
| CZ (1) | CZ286015B6 (cs) |
| DE (1) | DE69030719T2 (cs) |
| ES (1) | ES2100891T3 (cs) |
| FI (1) | FI105343B (cs) |
| GR (1) | GR1000980B (cs) |
| HK (1) | HK1006579A1 (cs) |
| IE (1) | IE903129A1 (cs) |
| IL (1) | IL95511A (cs) |
| LV (1) | LV10792B (cs) |
| NO (1) | NO303694B1 (cs) |
| NZ (1) | NZ235086A (cs) |
| PT (1) | PT95153B (cs) |
| SG (1) | SG70560A1 (cs) |
| SK (1) | SK423090A3 (cs) |
| WO (1) | WO1991003569A1 (cs) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
| US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
| US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
| US5986070A (en) * | 1990-04-06 | 1999-11-16 | Amgen Inc. | Production of biologically active NGF proteins |
| US5606031A (en) * | 1990-04-06 | 1997-02-25 | Lile; Jack | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
| ES2104743T3 (es) * | 1991-02-18 | 1997-10-16 | Takeda Chemical Industries Ltd | Metodo para producir factor 2 de crecimiento nervioso humano. |
| US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
| ZA923639B (en) * | 1991-07-10 | 1993-02-24 | Regeneron Pharma | Methods of treatment of motor neuron diseases using members of the bdnf/nt-3/ngf family of molecules |
| DE4237047A1 (en) * | 1991-11-04 | 1993-05-06 | I N R O Handels-Gmbh, 8750 Aschaffenburg, De | Drug contg. polypeptide homologous to nerve growth factor and slow virus sequence - for treating amyotrophic lateral sclerosis, spinal muscle atrophy or Parkinson's disease |
| EP0573904B1 (en) * | 1992-06-08 | 2001-09-26 | Takeda Chemical Industries, Ltd. | Therapeutic agent for neutropenia |
| WO1993025684A1 (en) * | 1992-06-12 | 1993-12-23 | Regeneron Pharmaceuticals, Inc. | Therapeutic and diagnostic methods based on neurotrophin-4 expression |
| DE69329031T2 (de) * | 1992-09-03 | 2001-03-22 | The Regents Of The University Of California, Oakland | Das dorsalgewebe beeinflussender faktor |
| DK0669929T3 (da) * | 1992-11-13 | 2007-01-29 | Immunex Corp | Elk-ligand, et cytokin |
| WO1994017831A1 (en) * | 1993-02-11 | 1994-08-18 | Erziehungsdirektion Of The Canton Zurich | A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration |
| JPH07246040A (ja) * | 1993-07-06 | 1995-09-26 | Takeda Chem Ind Ltd | ニューロトロフィン−３遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物 |
| EP0753013A1 (en) * | 1994-03-29 | 1997-01-15 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. | Neurotrophin-6: a new member of the neurotrophin family |
| WO1995030434A1 (en) * | 1994-05-06 | 1995-11-16 | Regeneron Pharmaceuticals, Inc. | Methods based on the role of neurotrophin 3 in female reproduction |
| US6303769B1 (en) | 1994-07-08 | 2001-10-16 | Immunex Corporation | Lerk-5 dna |
| JP3738281B2 (ja) * | 1994-07-22 | 2006-01-25 | アベンティス ファーマ株式会社 | 新規な骨芽細胞増殖因子 |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
| EP0796275A2 (de) * | 1994-12-05 | 1997-09-24 | Roche Diagnostics GmbH | Gene und genprodukte zur diagnostik degenerativer nervenschädigungen |
| US5859311A (en) * | 1995-11-27 | 1999-01-12 | University Of Kentucky Research Foundation | Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use |
| EP0907746B1 (en) | 1996-04-05 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| IL130852A0 (en) * | 1997-01-17 | 2001-01-28 | Rhone Poulenc Rorer Sa | Adenoviral-vector-mediated gene transfer into medullary motor neurons |
| AU718500B2 (en) | 1997-01-23 | 2000-04-13 | Sumitomo Pharmaceuticals Company, Limited | Remedies for diabetes |
| WO2000067032A1 (en) * | 1999-05-03 | 2000-11-09 | Evotec Biosystems Ag | Methods of diagnosing or treating depression |
| EP1050758A1 (en) * | 1999-05-03 | 2000-11-08 | Evotec BioSystems AG | Methods of diagnosing or treating neuropsychiatric diseases on basis of increased cerebrospinal fluid levels of neurotrophin 3 |
| CN1112215C (zh) * | 1999-12-28 | 2003-06-25 | 潘晓东 | 神经生长因子在治疗有机溶剂中毒性周围神经病中的用途 |
| WO2006108651A2 (en) * | 2005-04-12 | 2006-10-19 | Develogen Aktiengesellschaft | Use of activin products for preventing and treating diabetes and/or metabolic syndrome |
| WO2013068431A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
| EP2776838A1 (en) | 2011-11-08 | 2014-09-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Early diagnostic of neurodegenerative diseases |
| WO2014006114A1 (en) | 2012-07-05 | 2014-01-09 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
| CN110862447A (zh) * | 2019-11-29 | 2020-03-06 | 武汉赛维尔生物科技有限公司 | 一种提高神经营养因子nt-3碱性蛋白产量的蛋白改造方法 |
| CN113940308A (zh) * | 2021-04-28 | 2022-01-18 | 重庆腾达牧业有限公司 | 大足黑山羊哺乳舍饲养管理方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4699875A (en) * | 1982-11-24 | 1987-10-13 | Baylor College Of Medicine | Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors |
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US6709837B1 (en) * | 1989-03-10 | 2004-03-23 | Takeda Chemical Industries, Inc. | Polypeptide and production thereof |
| US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
| US7020718B2 (en) | 2000-05-15 | 2006-03-28 | Hewlett-Packard Development Company, L.P. | System and method of aggregating discontiguous address ranges into addresses and masks using a plurality of repeating address blocks |
-
1990
- 1990-08-28 IL IL9551190A patent/IL95511A/xx not_active IP Right Cessation
- 1990-08-28 GR GR900100647A patent/GR1000980B/el not_active IP Right Cessation
- 1990-08-29 AT AT90913954T patent/ATE153074T1/de not_active IP Right Cessation
- 1990-08-29 HK HK98105814A patent/HK1006579A1/en not_active IP Right Cessation
- 1990-08-29 KR KR1019910700433A patent/KR100196203B1/ko not_active Expired - Lifetime
- 1990-08-29 IE IE312990A patent/IE903129A1/en not_active IP Right Cessation
- 1990-08-29 WO PCT/US1990/004916 patent/WO1991003569A1/en active IP Right Grant
- 1990-08-29 DE DE69030719T patent/DE69030719T2/de not_active Expired - Lifetime
- 1990-08-29 SG SG1996007705A patent/SG70560A1/en unknown
- 1990-08-29 AU AU64049/90A patent/AU643705B2/en not_active Expired
- 1990-08-29 ES ES90913954T patent/ES2100891T3/es not_active Expired - Lifetime
- 1990-08-29 NZ NZ235086A patent/NZ235086A/en unknown
- 1990-08-29 EP EP90913954A patent/EP0441947B1/en not_active Expired - Lifetime
- 1990-08-29 CA CA002040437A patent/CA2040437C/en not_active Expired - Lifetime
- 1990-08-30 SK SK4230-90A patent/SK423090A3/sk not_active IP Right Cessation
- 1990-08-30 CN CN90108379A patent/CN1124342C/zh not_active Expired - Lifetime
- 1990-08-30 PT PT95153A patent/PT95153B/pt not_active IP Right Cessation
- 1990-08-30 CZ CS904230A patent/CZ286015B6/cs not_active IP Right Cessation
-
1991
- 1991-04-29 NO NO911688A patent/NO303694B1/no not_active IP Right Cessation
- 1991-04-30 FI FI912105A patent/FI105343B/fi active
-
1993
- 1993-10-06 LV LVP-93-1135A patent/LV10792B/en unknown
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