NO303694B1 - Isolert rekombinant nukleinsyresekvens, nukleinsyrevektor, rekombinant mikroorganisme, celle, fremgangsmÕte for fremstilling av et neurotrofin-3 protein, samt anvendelse av en detekterbart merket nukleinsyresekvens - Google Patents
Isolert rekombinant nukleinsyresekvens, nukleinsyrevektor, rekombinant mikroorganisme, celle, fremgangsmÕte for fremstilling av et neurotrofin-3 protein, samt anvendelse av en detekterbart merket nukleinsyresekvens Download PDFInfo
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B75/00—Other engines
- F02B75/02—Engines characterised by their cycles, e.g. six-stroke
- F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
- F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/400,591 US5180820A (en) | 1989-08-30 | 1989-08-30 | Brain-derived neurotrophic factor |
| US49000490A | 1990-03-07 | 1990-03-07 | |
| US57018990A | 1990-08-20 | 1990-08-20 | |
| PCT/US1990/004916 WO1991003569A1 (en) | 1989-08-30 | 1990-08-29 | Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO911688D0 NO911688D0 (no) | 1991-04-29 |
| NO911688L NO911688L (no) | 1991-05-31 |
| NO303694B1 true NO303694B1 (no) | 1998-08-17 |
Family
ID=27410411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO911688A NO303694B1 (no) | 1989-08-30 | 1991-04-29 | Isolert rekombinant nukleinsyresekvens, nukleinsyrevektor, rekombinant mikroorganisme, celle, fremgangsmÕte for fremstilling av et neurotrofin-3 protein, samt anvendelse av en detekterbart merket nukleinsyresekvens |
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| Country | Link |
|---|---|
| EP (1) | EP0441947B1 (cs) |
| KR (1) | KR100196203B1 (cs) |
| CN (1) | CN1124342C (cs) |
| AT (1) | ATE153074T1 (cs) |
| AU (1) | AU643705B2 (cs) |
| CA (1) | CA2040437C (cs) |
| CZ (1) | CZ286015B6 (cs) |
| DE (1) | DE69030719T2 (cs) |
| ES (1) | ES2100891T3 (cs) |
| FI (1) | FI105343B (cs) |
| GR (1) | GR1000980B (cs) |
| HK (1) | HK1006579A1 (cs) |
| IE (1) | IE903129A1 (cs) |
| IL (1) | IL95511A (cs) |
| LV (1) | LV10792B (cs) |
| NO (1) | NO303694B1 (cs) |
| NZ (1) | NZ235086A (cs) |
| PT (1) | PT95153B (cs) |
| SG (1) | SG70560A1 (cs) |
| SK (1) | SK423090A3 (cs) |
| WO (1) | WO1991003569A1 (cs) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
| US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
| US5986070A (en) * | 1990-04-06 | 1999-11-16 | Amgen Inc. | Production of biologically active NGF proteins |
| US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
| US5606031A (en) * | 1990-04-06 | 1997-02-25 | Lile; Jack | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
| DK0499993T3 (da) * | 1991-02-18 | 1997-12-01 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af human nervevækstfaktor-2 |
| US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
| EP0593516B1 (en) * | 1991-07-10 | 2001-07-11 | Regeneron Pharmaceuticals, Inc. | Methods of treatment of motor neuron diseases using members of the bdnf/nt-3/ngf family of molecules |
| DE4237047A1 (en) * | 1991-11-04 | 1993-05-06 | I N R O Handels-Gmbh, 8750 Aschaffenburg, De | Drug contg. polypeptide homologous to nerve growth factor and slow virus sequence - for treating amyotrophic lateral sclerosis, spinal muscle atrophy or Parkinson's disease |
| ATE206056T1 (de) * | 1992-06-08 | 2001-10-15 | Takeda Chemical Industries Ltd | Therapeutisches agens für neutropenie |
| WO1993025684A1 (en) * | 1992-06-12 | 1993-12-23 | Regeneron Pharmaceuticals, Inc. | Therapeutic and diagnostic methods based on neurotrophin-4 expression |
| ES2149823T3 (es) * | 1992-09-03 | 2000-11-16 | Univ California | Factor y composiciones que afectan al tejido dorsal. |
| ES2279508T3 (es) * | 1992-11-13 | 2007-08-16 | Immunex Corporation | Ligando elk, una citoquina. |
| CA2117889A1 (en) * | 1993-02-11 | 1994-08-18 | Martin E. Schwab | A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration |
| JPH07246040A (ja) * | 1993-07-06 | 1995-09-26 | Takeda Chem Ind Ltd | ニューロトロフィン−３遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物 |
| WO1995026363A1 (en) * | 1994-03-29 | 1995-10-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Neurotrophin-6: a new member of the neurotrophin family |
| WO1995030434A1 (en) * | 1994-05-06 | 1995-11-16 | Regeneron Pharmaceuticals, Inc. | Methods based on the role of neurotrophin 3 in female reproduction |
| US6303769B1 (en) | 1994-07-08 | 2001-10-16 | Immunex Corporation | Lerk-5 dna |
| JP3738281B2 (ja) * | 1994-07-22 | 2006-01-25 | アベンティス ファーマ株式会社 | 新規な骨芽細胞増殖因子 |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
| EP0796275A2 (de) * | 1994-12-05 | 1997-09-24 | Roche Diagnostics GmbH | Gene und genprodukte zur diagnostik degenerativer nervenschädigungen |
| US5859311A (en) * | 1995-11-27 | 1999-01-12 | University Of Kentucky Research Foundation | Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use |
| WO1997038087A2 (en) | 1996-04-05 | 1997-10-16 | Chiron Corporation | Alphaviral vector with reduced inhibition of cellular macromolecular synthesis |
| BR9806912A (pt) * | 1997-01-17 | 2000-05-16 | Rhone Poulenc Rorer Sa | Processos para liberar um ou mais ácidos nucleicos em neurÈnios motores de mamìferos, para produzir proteìna em neurÈnios motores de mamìferos, para induzir nós periféricos ou colaterais de extremidades de axÈnios motores, para proteger contra degeneração axÈnica, para tratar um dano ao sistema nervoso, e, para tratar esclerose lateral amiotrófica. |
| CA2277955A1 (en) | 1997-01-23 | 1998-07-30 | Michiko Kishino | Remedies for diabetes |
| EP1050758A1 (en) * | 1999-05-03 | 2000-11-08 | Evotec BioSystems AG | Methods of diagnosing or treating neuropsychiatric diseases on basis of increased cerebrospinal fluid levels of neurotrophin 3 |
| WO2000067032A1 (en) * | 1999-05-03 | 2000-11-09 | Evotec Biosystems Ag | Methods of diagnosing or treating depression |
| CN1112215C (zh) * | 1999-12-28 | 2003-06-25 | 潘晓东 | 神经生长因子在治疗有机溶剂中毒性周围神经病中的用途 |
| WO2006108651A2 (en) * | 2005-04-12 | 2006-10-19 | Develogen Aktiengesellschaft | Use of activin products for preventing and treating diabetes and/or metabolic syndrome |
| WO2013068432A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Early diagnostic of neurodegenerative diseases |
| WO2013068431A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
| US20150184154A1 (en) | 2012-07-05 | 2015-07-02 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear | New treatment for neurodegenerative diseases |
| CN110862447A (zh) * | 2019-11-29 | 2020-03-06 | 武汉赛维尔生物科技有限公司 | 一种提高神经营养因子nt-3碱性蛋白产量的蛋白改造方法 |
| CN113940308A (zh) * | 2021-04-28 | 2022-01-18 | 重庆腾达牧业有限公司 | 大足黑山羊哺乳舍饲养管理方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4699875A (en) * | 1982-11-24 | 1987-10-13 | Baylor College Of Medicine | Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors |
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US6709837B1 (en) * | 1989-03-10 | 2004-03-23 | Takeda Chemical Industries, Inc. | Polypeptide and production thereof |
| US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
| US7020718B2 (en) | 2000-05-15 | 2006-03-28 | Hewlett-Packard Development Company, L.P. | System and method of aggregating discontiguous address ranges into addresses and masks using a plurality of repeating address blocks |
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1990
- 1990-08-28 IL IL9551190A patent/IL95511A/xx not_active IP Right Cessation
- 1990-08-28 GR GR900100647A patent/GR1000980B/el not_active IP Right Cessation
- 1990-08-29 CA CA002040437A patent/CA2040437C/en not_active Expired - Lifetime
- 1990-08-29 NZ NZ235086A patent/NZ235086A/en unknown
- 1990-08-29 AT AT90913954T patent/ATE153074T1/de not_active IP Right Cessation
- 1990-08-29 ES ES90913954T patent/ES2100891T3/es not_active Expired - Lifetime
- 1990-08-29 WO PCT/US1990/004916 patent/WO1991003569A1/en not_active Ceased
- 1990-08-29 DE DE69030719T patent/DE69030719T2/de not_active Expired - Lifetime
- 1990-08-29 IE IE312990A patent/IE903129A1/en not_active IP Right Cessation
- 1990-08-29 KR KR1019910700433A patent/KR100196203B1/ko not_active Expired - Lifetime
- 1990-08-29 EP EP90913954A patent/EP0441947B1/en not_active Expired - Lifetime
- 1990-08-29 AU AU64049/90A patent/AU643705B2/en not_active Expired
- 1990-08-29 SG SG1996007705A patent/SG70560A1/en unknown
- 1990-08-29 HK HK98105814A patent/HK1006579A1/en not_active IP Right Cessation
- 1990-08-30 CN CN90108379A patent/CN1124342C/zh not_active Expired - Lifetime
- 1990-08-30 SK SK4230-90A patent/SK423090A3/sk not_active IP Right Cessation
- 1990-08-30 CZ CS904230A patent/CZ286015B6/cs not_active IP Right Cessation
- 1990-08-30 PT PT95153A patent/PT95153B/pt not_active IP Right Cessation
-
1991
- 1991-04-29 NO NO911688A patent/NO303694B1/no not_active IP Right Cessation
- 1991-04-30 FI FI912105A patent/FI105343B/fi active
-
1993
- 1993-10-06 LV LVP-93-1135A patent/LV10792B/en unknown
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