NO301544B1 - Analogifremgangsmåte for fremstilling av en insulinanalog - Google Patents
Analogifremgangsmåte for fremstilling av en insulinanalog Download PDFInfo
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- NO301544B1 NO301544B1 NO914085A NO914085A NO301544B1 NO 301544 B1 NO301544 B1 NO 301544B1 NO 914085 A NO914085 A NO 914085A NO 914085 A NO914085 A NO 914085A NO 301544 B1 NO301544 B1 NO 301544B1
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- Prior art keywords
- insulin
- chain
- amino acid
- amino acids
- trp
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- 210000002288 golgi apparatus Anatomy 0.000 description 1
- 229960000789 guanidine hydrochloride Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
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- HNTDJKLSENGQMG-UHFFFAOYSA-N methylsulfanylbenzene;trifluoromethanesulfonic acid Chemical compound CSC1=CC=CC=C1.OS(=O)(=O)C(F)(F)F HNTDJKLSENGQMG-UHFFFAOYSA-N 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
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- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
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- 235000010265 sodium sulphite Nutrition 0.000 description 1
- HAEPBEMBOAIUPN-UHFFFAOYSA-L sodium tetrathionate Chemical compound O.O.[Na+].[Na+].[O-]S(=O)(=O)SSS([O-])(=O)=O HAEPBEMBOAIUPN-UHFFFAOYSA-L 0.000 description 1
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- AZAKMLHUDVIDFN-UHFFFAOYSA-N tert-butyl nitrate Chemical compound CC(C)(C)O[N+]([O-])=O AZAKMLHUDVIDFN-UHFFFAOYSA-N 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
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- 238000013519 translation Methods 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34092989A | 1989-04-20 | 1989-04-20 | |
| PCT/US1990/002070 WO1990012814A1 (fr) | 1989-04-20 | 1990-04-17 | Analogues d'insuline hepatospecifiques |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO914085D0 NO914085D0 (no) | 1991-10-17 |
| NO914085L NO914085L (no) | 1991-11-28 |
| NO301544B1 true NO301544B1 (no) | 1997-11-10 |
Family
ID=23335524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO914085A NO301544B1 (no) | 1989-04-20 | 1991-10-17 | Analogifremgangsmåte for fremstilling av en insulinanalog |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0469084B1 (fr) |
| JP (1) | JPH04504858A (fr) |
| AT (1) | ATE120762T1 (fr) |
| AU (1) | AU631868B2 (fr) |
| CA (1) | CA2014896A1 (fr) |
| DE (1) | DE69018461T2 (fr) |
| FI (1) | FI914898A0 (fr) |
| GR (1) | GR1000908B (fr) |
| HU (1) | HU210142B (fr) |
| IE (1) | IE67353B1 (fr) |
| IL (1) | IL94163A (fr) |
| NO (1) | NO301544B1 (fr) |
| PT (1) | PT93832B (fr) |
| WO (1) | WO1990012814A1 (fr) |
| ZA (1) | ZA902965B (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK158390D0 (da) * | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
| DK33591D0 (fr) * | 1991-02-27 | 1991-02-27 | Novo Nordisk As | |
| US5268453A (en) * | 1991-08-08 | 1993-12-07 | Scios Inc. | Tissue-selective insulin analogs |
| GB9316895D0 (en) * | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
| US5915378A (en) * | 1993-01-29 | 1999-06-29 | Aradigm Corporation | Creating an aerosolized formulation of insulin |
| US6131567A (en) * | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
| US5970973A (en) * | 1993-01-29 | 1999-10-26 | Aradigm Corporation | Method of delivering insulin lispro |
| US5873358A (en) * | 1993-01-29 | 1999-02-23 | Aradigm Corporation | Method of maintaining a diabetic patient's blood glucose level in a desired range |
| US6024090A (en) | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
| US5743250A (en) | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
| US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
| TW360548B (en) * | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
| US6342225B1 (en) | 1993-08-13 | 2002-01-29 | Deutshces Wollforschungsinstitut | Pharmaceutical active conjugates |
| US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| AUPP609198A0 (en) * | 1998-09-22 | 1998-10-15 | Curtin University Of Technology | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| EP1174437A4 (fr) | 1999-04-26 | 2006-03-15 | Ajinomoto Kk | Inhibiteur hormonal stimulant les melanocytes |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| WO2006019015A1 (fr) * | 2004-08-18 | 2006-02-23 | Kaneka Corporation | Peptide capable de se lier à une protéine de liaison à l'insuline et adsorbant contenant celui-ci |
| WO2007020256A1 (fr) | 2005-08-16 | 2007-02-22 | Novo Nordisk A/S | Procede permettant de realiser des polypeptides d'insuline matures |
| HUE029512T2 (en) | 2006-09-22 | 2017-03-28 | Novo Nordisk As | Protease Resistant Insulin Analogs |
| JP5503968B2 (ja) | 2006-09-27 | 2014-05-28 | ノボ・ノルデイスク・エー／エス | 成熟インスリンポリペプチドの作製方法 |
| US20110065633A1 (en) | 2008-01-30 | 2011-03-17 | Indiana University Research And Technology Corporation | Ester-based peptide prodrugs |
| WO2009112583A2 (fr) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Analogues de l’insuline stabilisés une protéase |
| WO2009115469A1 (fr) | 2008-03-18 | 2009-09-24 | Novo Nordisk A/S | Analogues de l'insuline acylés stabilisés vis-à-vis des protéases |
| CN102245633A (zh) * | 2008-12-09 | 2011-11-16 | 诺沃—诺迪斯克有限公司 | 新的胰岛素类似物 |
| CA2744558A1 (fr) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Promedicaments insuliniques a base d'amide |
| JP5789515B2 (ja) | 2008-12-19 | 2015-10-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン類似体 |
| AU2011268327B2 (en) | 2010-06-16 | 2016-02-25 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| EP2585102B1 (fr) | 2010-06-24 | 2015-05-06 | Indiana University Research and Technology Corporation | Promédicaments insuliniques à base d'amide |
| WO2013096386A1 (fr) | 2011-12-20 | 2013-06-27 | Indiana University Research And Technology Corporation | Analogues d'insuline à base de ctp pour le traitement du diabète |
| JP6387008B2 (ja) | 2012-09-26 | 2018-09-05 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリンアナローグダイマー |
| US9670162B2 (en) | 2013-03-14 | 2017-06-06 | The Board Of Trustees Of The Leland Stanford Junio | Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof |
| RU2678134C2 (ru) | 2013-03-14 | 2019-01-23 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Конъюгаты инсулин-инкретин |
| WO2015052088A1 (fr) | 2013-10-07 | 2015-04-16 | Novo Nordisk A/S | Nouveau dérivé d'un analogue de l'insuline |
| EP3206710B1 (fr) | 2014-09-24 | 2020-05-06 | Indiana University Research & Technology Corporation | Conjugués d'insuline-incrétines |
| ES2947409T3 (es) | 2014-09-24 | 2023-08-08 | Univ Indiana Res & Tech Corp | Profármacos de insulina a base de amida lipídica |
| HRP20221324T1 (hr) | 2016-12-16 | 2022-12-23 | Novo Nordisk A/S | Farmaceutski pripravci koji sadrže inzulin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
-
1990
- 1990-04-17 JP JP2506816A patent/JPH04504858A/ja active Pending
- 1990-04-17 WO PCT/US1990/002070 patent/WO1990012814A1/fr active IP Right Grant
- 1990-04-17 DE DE69018461T patent/DE69018461T2/de not_active Expired - Fee Related
- 1990-04-17 EP EP90908000A patent/EP0469084B1/fr not_active Expired - Lifetime
- 1990-04-17 AT AT90908000T patent/ATE120762T1/de not_active IP Right Cessation
- 1990-04-17 AU AU55415/90A patent/AU631868B2/en not_active Ceased
- 1990-04-17 HU HU903398A patent/HU210142B/hu not_active IP Right Cessation
- 1990-04-18 GR GR900100290A patent/GR1000908B/el unknown
- 1990-04-19 ZA ZA902965A patent/ZA902965B/xx unknown
- 1990-04-19 IE IE140490A patent/IE67353B1/en not_active IP Right Cessation
- 1990-04-19 CA CA002014896A patent/CA2014896A1/fr not_active Abandoned
- 1990-04-20 PT PT93832A patent/PT93832B/pt not_active IP Right Cessation
- 1990-04-22 IL IL9416390A patent/IL94163A/en not_active IP Right Cessation
-
1991
- 1991-10-17 NO NO914085A patent/NO301544B1/no unknown
- 1991-10-17 FI FI914898A patent/FI914898A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04504858A (ja) | 1992-08-27 |
| EP0469084B1 (fr) | 1995-04-05 |
| IE67353B1 (en) | 1996-03-20 |
| EP0469084A1 (fr) | 1992-02-05 |
| NO914085L (no) | 1991-11-28 |
| GR1000908B (el) | 1993-03-16 |
| HU210142B (en) | 1995-02-28 |
| DE69018461T2 (de) | 1995-08-03 |
| IL94163A (en) | 1995-08-31 |
| DE69018461D1 (de) | 1995-05-11 |
| PT93832A (pt) | 1990-11-20 |
| HUT59941A (en) | 1992-07-28 |
| IE901404L (en) | 1990-10-20 |
| ZA902965B (en) | 1991-02-27 |
| FI914898A0 (fi) | 1991-10-17 |
| HU903398D0 (en) | 1991-12-30 |
| IL94163A0 (en) | 1991-01-31 |
| WO1990012814A1 (fr) | 1990-11-01 |
| PT93832B (pt) | 1996-09-30 |
| NO914085D0 (no) | 1991-10-17 |
| CA2014896A1 (fr) | 1990-10-20 |
| AU5541590A (en) | 1990-11-16 |
| AU631868B2 (en) | 1992-12-10 |
| GR900100290A (en) | 1991-09-27 |
| ATE120762T1 (de) | 1995-04-15 |
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