NO301227B1 - Arylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse - Google Patents

Arylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse Download PDF

Info

Publication number
NO301227B1
NO301227B1 NO934760A NO934760A NO301227B1 NO 301227 B1 NO301227 B1 NO 301227B1 NO 934760 A NO934760 A NO 934760A NO 934760 A NO934760 A NO 934760A NO 301227 B1 NO301227 B1 NO 301227B1
Authority
NO
Norway
Prior art keywords
tropane
oxadiazol
pyridyl
dichlorophenyl
normethyl
Prior art date
Application number
NO934760A
Other languages
English (en)
Norwegian (no)
Other versions
NO934760L (no
NO934760D0 (no
Inventor
Peter Moldt
Joergen Scheel-Krueger
Leif Helth Jensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK921541A external-priority patent/DK154192D0/da
Priority claimed from DK71893A external-priority patent/DK71893D0/da
Priority claimed from US08/093,184 external-priority patent/US5554626A/en
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO934760D0 publication Critical patent/NO934760D0/no
Publication of NO934760L publication Critical patent/NO934760L/no
Publication of NO301227B1 publication Critical patent/NO301227B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO934760A 1992-12-23 1993-12-22 Arylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse NO301227B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK921541A DK154192D0 (da) 1992-12-23 1992-12-23 Heterocycliske forbindelser
DK71893A DK71893D0 (da) 1993-06-18 1993-06-18 Heterocykliske forbindelser
US08/093,184 US5554626A (en) 1992-12-23 1993-07-16 Substituted heterocyclic compounds as dopamine-reuptake inhibitors

Publications (3)

Publication Number Publication Date
NO934760D0 NO934760D0 (no) 1993-12-22
NO934760L NO934760L (no) 1994-06-24
NO301227B1 true NO301227B1 (no) 1997-09-29

Family

ID=27220884

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934760A NO301227B1 (no) 1992-12-23 1993-12-22 Arylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse

Country Status (9)

Country Link
EP (1) EP0604352B1 (fi)
JP (1) JPH06293760A (fi)
AT (1) ATE225787T1 (fi)
AU (1) AU672644B2 (fi)
CA (1) CA2112083C (fi)
DE (1) DE69332366T2 (fi)
FI (1) FI935799A (fi)
NO (1) NO301227B1 (fi)
NZ (1) NZ250514A (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
ATE224392T1 (de) * 1995-11-02 2002-10-15 Neurosearch As Kondensierte tropanderivate als neurotransmitter- reuptake-inhibitoren
CA2244773C (en) 1996-02-22 2006-01-03 Neurosearch A/S Tropane-derivatives, their preparation and use
AU5790598A (en) * 1996-12-02 1998-06-29 Georgetown University Tropane derivatives and method for their synthesis
GB9915617D0 (en) * 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
WO2003045388A1 (en) 2001-11-30 2003-06-05 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
EP2269608A3 (en) 2003-10-16 2011-02-16 NeuroSearch AS Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
EP1779851A1 (en) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes
US20100035914A1 (en) * 2006-09-11 2010-02-11 Barbara Bertani Azabicyclic compounds as inhibitors of monoamines reuptake
WO2010125033A1 (en) * 2009-04-29 2010-11-04 Glaxo Group Limited Azabicyclo[4.1.0]heptane derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
FR2276823A1 (fr) * 1974-07-04 1976-01-30 Roussel Uclaf Nouveaux derives de la dibenzo(b.e)thiepine et leurs sels, procede de preparation et application a titre de medicaments desdits produits
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
EP0398578B1 (en) * 1989-05-17 1997-03-12 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
ATE182794T1 (de) * 1991-11-15 1999-08-15 Res Triangle Inst Kokainrezeptor bindende liganden
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5268480A (en) * 1992-09-22 1993-12-07 Mayo Foundation For Medical Education And Research Cocaine analogs
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds

Also Published As

Publication number Publication date
FI935799A (fi) 1994-06-24
CA2112083A1 (en) 1994-06-24
JPH06293760A (ja) 1994-10-21
DE69332366T2 (de) 2003-06-18
NO934760L (no) 1994-06-24
EP0604352A2 (en) 1994-06-29
CA2112083C (en) 2002-02-19
EP0604352A3 (en) 1995-02-08
NZ250514A (en) 1996-03-26
FI935799A0 (fi) 1993-12-22
AU5236393A (en) 1994-07-07
NO934760D0 (no) 1993-12-22
DE69332366D1 (de) 2002-11-14
ATE225787T1 (de) 2002-10-15
EP0604352B1 (en) 2002-10-09
AU672644B2 (en) 1996-10-10

Similar Documents

Publication Publication Date Title
KR100344328B1 (ko) 아릴치환된헤테로사이클릭화합물,이의제조방법및이를함유하는약제학적조성물
RU2167876C2 (ru) 2,3-трансдизамещенное тропановое производное, способ его получения, фармацевтическая композиция
EP0756596B1 (en) Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors
SK283425B6 (sk) Deriváty 8-azabicyklo[3,2,1]okt-2-énu, spôsob ich prípravy a použitia
CZ113898A3 (cs) Kondenzované tropanové deriváty, způsob jejich výroby, farmaceutické prostředky, které je obsahují a jejich použití k léčení
CA2112084C (en) Antidepressant and antiparkinsonian compounds
US5554626A (en) Substituted heterocyclic compounds as dopamine-reuptake inhibitors
NO301227B1 (no) Arylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse
NO301164B1 (no) Alkylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse
MXPA96004966A (en) Tropan-2-aldoxine derivatives as inhibitors of neurotransmal restoration
MXPA98003554A (en) Frozen tropan derivatives, its preparation and

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JUNE 2003