NO300978B1 - Analogifremgangsmåte ved fremstilling av farmasöytisk aktivt peptid - Google Patents
Analogifremgangsmåte ved fremstilling av farmasöytisk aktivt peptidInfo
- Publication number
- NO300978B1 NO300978B1 NO894720A NO894720A NO300978B1 NO 300978 B1 NO300978 B1 NO 300978B1 NO 894720 A NO894720 A NO 894720A NO 894720 A NO894720 A NO 894720A NO 300978 B1 NO300978 B1 NO 300978B1
- Authority
- NO
- Norway
- Prior art keywords
- pro
- peptide
- lys
- arg
- thr
- Prior art date
Links
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- CMWYAOXYQATXSI-UHFFFAOYSA-N n,n-dimethylformamide;piperidine Chemical compound CN(C)C=O.C1CCNCC1 CMWYAOXYQATXSI-UHFFFAOYSA-N 0.000 description 1
- AYGYHGXUJBFUJU-UHFFFAOYSA-N n-[2-(prop-2-enoylamino)ethyl]prop-2-enamide Chemical compound C=CC(=O)NCCNC(=O)C=C AYGYHGXUJBFUJU-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000036441 nociceptive stimulation Effects 0.000 description 1
- 108091008700 nociceptors Proteins 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 150000003815 prostacyclins Chemical class 0.000 description 1
- 230000002997 prostaglandinlike Effects 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 230000020341 sensory perception of pain Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888807427A GB8807427D0 (en) | 1988-03-28 | 1988-03-28 | Peptides |
| GB888828833A GB8828833D0 (en) | 1988-03-28 | 1988-12-09 | Peptides |
| PCT/GB1989/000319 WO1989009226A1 (en) | 1988-03-28 | 1989-03-28 | Peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO894720D0 NO894720D0 (no) | 1989-11-27 |
| NO894720L NO894720L (no) | 1990-01-29 |
| NO300978B1 true NO300978B1 (no) | 1997-08-25 |
Family
ID=26293705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO894720A NO300978B1 (no) | 1988-03-28 | 1989-11-27 | Analogifremgangsmåte ved fremstilling av farmasöytisk aktivt peptid |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0335662B1 (sv) |
| JP (2) | JP2633369B2 (sv) |
| AT (1) | ATE125548T1 (sv) |
| CA (1) | CA1340186C (sv) |
| DE (1) | DE68923572T2 (sv) |
| FI (1) | FI95273C (sv) |
| GB (1) | GB2217331C (sv) |
| HK (1) | HK45895A (sv) |
| IE (1) | IE61222B1 (sv) |
| IL (1) | IL89770A (sv) |
| NO (1) | NO300978B1 (sv) |
| WO (1) | WO1989009226A1 (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
| IT1277841B1 (it) * | 1995-04-19 | 1997-11-12 | Molteni & C Dei Fratelli Alitt | Ammine dotate di attivita' analgesica, loro preparazione e uso |
| FR2738746B1 (fr) * | 1995-09-19 | 1997-11-14 | Oreal | Utilisation d'au moins un peptide dans une composition cosmetique ou pour la preparation d'un medicament |
| US7402559B2 (en) | 1999-03-24 | 2008-07-22 | Msh Pharma, Incorporated | Composition and method of treatment for urogenital conditions |
| ATE375801T1 (de) * | 1999-03-24 | 2007-11-15 | Zengen Inc | Antimikrobielle aminosäuresequenzen aus alpha- melanocyten-stimulierendem hormon |
| DE10106852A1 (de) * | 2001-02-14 | 2002-09-05 | T Luger | Entzündungshemmende Verbindungen |
| BR112016006348A2 (pt) * | 2013-09-23 | 2020-05-19 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | tripeptídeos anti-inflamatórios |
| AU2014345802B2 (en) | 2013-11-07 | 2018-01-25 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | Storage stable lyophilized tripeptide formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3778426A (en) * | 1970-12-16 | 1973-12-11 | Research Corp | Therapeutically useful polypeptides |
| IT8021120A0 (it) * | 1979-04-02 | 1980-04-01 | Inst Organicheskogo Sinteza Ak | Analogo ciclico del peptide naturale stimolante la fagocitosi: treonile-ciclo (n-lisile-prolile-arginile). |
| US4377515A (en) * | 1979-10-01 | 1983-03-22 | Merck & Co., Inc. | Long lasting agonists and antagonists of LH-RH |
| US4585757A (en) * | 1984-07-27 | 1986-04-29 | Texas Tech University Health Sciences Center | Hypotensive active peptides |
| AU602483B2 (en) * | 1985-01-18 | 1990-10-18 | Immunetech Pharmaceuticals | Immunoregulatory peptides |
-
1989
- 1989-03-28 WO PCT/GB1989/000319 patent/WO1989009226A1/en active IP Right Grant
- 1989-03-28 IL IL8977089A patent/IL89770A/en not_active IP Right Cessation
- 1989-03-28 DE DE68923572T patent/DE68923572T2/de not_active Expired - Fee Related
- 1989-03-28 AT AT89303054T patent/ATE125548T1/de not_active IP Right Cessation
- 1989-03-28 CA CA000594884A patent/CA1340186C/en not_active Expired - Fee Related
- 1989-03-28 GB GB8906972A patent/GB2217331C/en not_active Expired - Fee Related
- 1989-03-28 JP JP1503798A patent/JP2633369B2/ja not_active Expired - Lifetime
- 1989-03-28 EP EP89303054A patent/EP0335662B1/en not_active Expired - Lifetime
- 1989-03-29 IE IE99889A patent/IE61222B1/en not_active IP Right Cessation
- 1989-11-27 NO NO894720A patent/NO300978B1/no not_active IP Right Cessation
- 1989-11-27 FI FI895675A patent/FI95273C/sv not_active IP Right Cessation
-
1995
- 1995-03-30 HK HK45895A patent/HK45895A/xx not_active IP Right Cessation
-
1996
- 1996-07-23 JP JP8193524A patent/JP2781782B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE68923572T2 (de) | 1996-01-18 |
| JP2781782B2 (ja) | 1998-07-30 |
| JPH09165400A (ja) | 1997-06-24 |
| FI95273C (sv) | 1996-01-10 |
| GB8906972D0 (en) | 1989-05-10 |
| GB2217331B (en) | 1991-12-11 |
| IL89770A (en) | 1994-12-29 |
| CA1340186C (en) | 1998-12-15 |
| JP2633369B2 (ja) | 1997-07-23 |
| ATE125548T1 (de) | 1995-08-15 |
| HK45895A (en) | 1995-04-07 |
| JPH02504280A (ja) | 1990-12-06 |
| IE61222B1 (en) | 1994-10-19 |
| IE890998L (en) | 1989-09-28 |
| GB2217331A (en) | 1989-10-25 |
| EP0335662B1 (en) | 1995-07-26 |
| DE68923572D1 (de) | 1995-08-31 |
| NO894720L (no) | 1990-01-29 |
| FI895675A0 (sv) | 1989-11-27 |
| GB2217331C (en) | 1994-11-16 |
| AU629826B2 (en) | 1992-10-15 |
| FI95273B (sv) | 1995-09-29 |
| WO1989009226A1 (en) | 1989-10-05 |
| EP0335662A1 (en) | 1989-10-04 |
| AU3363789A (en) | 1989-10-16 |
| NO894720D0 (no) | 1989-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN SEPTEMBER 2003 |