NO300689B1 - Imidazo£2,1-b|£3|benzazepinderivater og sammensetninger - Google Patents

Imidazo£2,1-b|£3|benzazepinderivater og sammensetninger Download PDF

Info

Publication number
NO300689B1
NO300689B1 NO934493A NO934493A NO300689B1 NO 300689 B1 NO300689 B1 NO 300689B1 NO 934493 A NO934493 A NO 934493A NO 934493 A NO934493 A NO 934493A NO 300689 B1 NO300689 B1 NO 300689B1
Authority
NO
Norway
Prior art keywords
alkyl
formula
substituted
hydroxycarbonyl
methyl
Prior art date
Application number
NO934493A
Other languages
English (en)
Norwegian (no)
Other versions
NO934493L (no
Inventor
Frans Eduard Janssens
Gaston Stanislas Marcell Diels
Joseph Elisabeth Leenaerts
Ludwig Paul Cooymans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO934493L publication Critical patent/NO934493L/no
Publication of NO300689B1 publication Critical patent/NO300689B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Paper (AREA)
  • Detergent Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Lubricants (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
NO934493A 1991-06-13 1993-12-09 Imidazo£2,1-b|£3|benzazepinderivater og sammensetninger NO300689B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71448791A 1991-06-13 1991-06-13
PCT/EP1992/001331 WO1992022553A1 (en) 1991-06-13 1992-06-09 IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[3,2-d]AZEPINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE

Publications (2)

Publication Number Publication Date
NO934493L NO934493L (no) 1994-01-04
NO300689B1 true NO300689B1 (no) 1997-07-07

Family

ID=24870247

Family Applications (2)

Application Number Title Priority Date Filing Date
NO934493D NO934493D0 (no) 1991-06-13 1993-12-09 Imidazo[2,1-b](pyrrolo, tieno eller furano)[3,2-d]-azepinderivater, sammensetninger og anvendelsesmetode
NO934493A NO300689B1 (no) 1991-06-13 1993-12-09 Imidazo£2,1-b|£3|benzazepinderivater og sammensetninger

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO934493D NO934493D0 (no) 1991-06-13 1993-12-09 Imidazo[2,1-b](pyrrolo, tieno eller furano)[3,2-d]-azepinderivater, sammensetninger og anvendelsesmetode

Country Status (26)

Country Link
US (1) US5461050A (fi)
EP (2) EP0588859B1 (fi)
JP (1) JP3182421B2 (fi)
KR (1) KR100247504B1 (fi)
CN (1) CN1033587C (fi)
AT (1) ATE247118T1 (fi)
AU (1) AU652841B2 (fi)
CA (1) CA2102889C (fi)
DE (1) DE69233161T2 (fi)
ES (1) ES2204892T3 (fi)
FI (1) FI104077B (fi)
HR (1) HRP920156A2 (fi)
HU (1) HU221013B1 (fi)
IE (1) IE921919A1 (fi)
IL (1) IL101851A (fi)
MA (1) MA22554A1 (fi)
MX (1) MX9202860A (fi)
NO (2) NO934493D0 (fi)
NZ (1) NZ242775A (fi)
PL (1) PL170376B1 (fi)
SI (1) SI9200104A (fi)
TN (1) TNSN92049A1 (fi)
TW (1) TW218382B (fi)
WO (1) WO1992022553A1 (fi)
ZA (1) ZA924327B (fi)
ZM (1) ZM2892A1 (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
GR1001385B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο 1,2-α (πυρρολο,?ειενο η φουρανο) 3,2-d αζεπίνης συν?έσεις και μέ?οδοι χρήσεως.
CA2150805C (en) * 1992-12-04 2006-08-15 Frans Eduard Janssens Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
RU2127737C1 (ru) * 1992-12-04 1999-03-20 Жансен Фармасетика Н.В. Производные триазоло-(пирроло-тиено- или фурано-)-азепина, обладающие антиаллергической активностью, способ их получения, промежуточное для их получения, фармацевтическая композиция и способ ее получения
US5674866A (en) * 1993-07-13 1997-10-07 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
AU1146099A (en) * 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
SK286158B6 (sk) * 1998-12-19 2008-04-07 Janssen Pharmaceutica N. V. Spirozlúčenina, spôsob a medziprodukt na jej prípravu, jej použitie, farmaceutická kompozícia s jejobsahom a spôsob jej prípravy
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
WO2002100862A2 (en) 2001-06-12 2002-12-19 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
AU2004259009A1 (en) * 2003-07-23 2005-02-03 Exelixis, Inc. Azepine derivatives as pharmaceutical agents
JP5078869B2 (ja) 2005-03-08 2012-11-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ニューロキニン（ｎｋ１）拮抗物質としてのジアザ−スピロ−［４．４］−ノナン誘導体
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
CN103570731B (zh) * 2012-07-30 2016-05-18 中国科学院广州生物医药与健康研究院 嘧啶并三环或嘧啶并四环类化合物及其药用组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
IL101851A (en) 1996-05-14
DE69233161D1 (de) 2003-09-18
CN1033587C (zh) 1996-12-18
ZM2892A1 (en) 1994-05-25
IE921919A1 (en) 1992-12-16
EP0588859A1 (en) 1994-03-30
FI935557A (fi) 1993-12-10
MA22554A1 (fr) 1992-12-31
JPH06507890A (ja) 1994-09-08
HU221013B1 (hu) 2002-07-29
HUT70428A (en) 1995-10-30
PL170376B1 (pl) 1996-12-31
NO934493L (no) 1994-01-04
WO1992022553A1 (en) 1992-12-23
CA2102889A1 (en) 1992-12-14
FI104077B1 (fi) 1999-11-15
NZ242775A (en) 1995-03-28
DE69233161T2 (de) 2004-05-27
ZA924327B (en) 1993-12-13
HU9303554D0 (en) 1994-04-28
US5461050A (en) 1995-10-24
MX9202860A (es) 1992-12-01
AU652841B2 (en) 1994-09-08
KR100247504B1 (ko) 2000-05-01
CA2102889C (en) 2002-11-26
CN1068116A (zh) 1993-01-20
HRP920156A2 (en) 1995-12-31
TNSN92049A1 (fr) 1993-06-08
IL101851A0 (en) 1992-12-30
NO934493D0 (no) 1993-12-09
ES2204892T3 (es) 2004-05-01
FI104077B (fi) 1999-11-15
EP0588859B1 (en) 2003-08-13
EP0518434A1 (en) 1992-12-16
TW218382B (fi) 1994-01-01
FI935557A0 (fi) 1993-12-10
AU1901192A (en) 1993-01-12
ATE247118T1 (de) 2003-08-15
JP3182421B2 (ja) 2001-07-03
SI9200104A (en) 1992-12-31

Similar Documents

Publication Publication Date Title
EP0588858B1 (en) IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE
NO300689B1 (no) Imidazo£2,1-b|£3|benzazepinderivater og sammensetninger
AU676702B2 (en) Antiallergic imidazo{1,2-a}(pyrrolo, thieno or furano){2,3-d}azepine derivatives
US5674866A (en) Antiallergic imidazoazepines
NO311619B1 (no) Triazol(pyrrol, tien eller furan)-azepinderivater med antiallergisk virkning

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees