DE69233161D1 - Imidazo[1,2-a](Pyrrolo, Thieno oder Furano)[3,2-d]azepinderivate, Zubereitungen und ihre Verwendung - Google Patents

Imidazo[1,2-a](Pyrrolo, Thieno oder Furano)[3,2-d]azepinderivate, Zubereitungen und ihre Verwendung

Info

Publication number
DE69233161D1
DE69233161D1 DE69233161T DE69233161T DE69233161D1 DE 69233161 D1 DE69233161 D1 DE 69233161D1 DE 69233161 T DE69233161 T DE 69233161T DE 69233161 T DE69233161 T DE 69233161T DE 69233161 D1 DE69233161 D1 DE 69233161D1
Authority
DE
Germany
Prior art keywords
4alkyl
substituted
hydroxycarbonyl
represents hydrogen
4alkyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69233161T
Other languages
English (en)
Other versions
DE69233161T2 (de
Inventor
Eduard Janssens
Stanislas Diels
Elisabeth Leenaerts
Paul Cooymans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69233161D1 publication Critical patent/DE69233161D1/de
Application granted granted Critical
Publication of DE69233161T2 publication Critical patent/DE69233161T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fats And Perfumes (AREA)
  • Lubricants (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Detergent Compositions (AREA)
  • Paper (AREA)
DE69233161T 1991-06-13 1992-06-09 Imidazo[1,2-a](Pyrrolo, Thieno oder Furano)[3,2-d]azepinderivate, Zubereitungen und ihre Verwendung Expired - Fee Related DE69233161T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71448791A 1991-06-13 1991-06-13
US714487 1991-06-13
PCT/EP1992/001331 WO1992022553A1 (en) 1991-06-13 1992-06-09 IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[3,2-d]AZEPINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE

Publications (2)

Publication Number Publication Date
DE69233161D1 true DE69233161D1 (de) 2003-09-18
DE69233161T2 DE69233161T2 (de) 2004-05-27

Family

ID=24870247

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69233161T Expired - Fee Related DE69233161T2 (de) 1991-06-13 1992-06-09 Imidazo[1,2-a](Pyrrolo, Thieno oder Furano)[3,2-d]azepinderivate, Zubereitungen und ihre Verwendung

Country Status (26)

Country Link
US (1) US5461050A (de)
EP (2) EP0588859B1 (de)
JP (1) JP3182421B2 (de)
KR (1) KR100247504B1 (de)
CN (1) CN1033587C (de)
AT (1) ATE247118T1 (de)
AU (1) AU652841B2 (de)
CA (1) CA2102889C (de)
DE (1) DE69233161T2 (de)
ES (1) ES2204892T3 (de)
FI (1) FI104077B1 (de)
HR (1) HRP920156A2 (de)
HU (1) HU221013B1 (de)
IE (1) IE921919A1 (de)
IL (1) IL101851A (de)
MA (1) MA22554A1 (de)
MX (1) MX9202860A (de)
NO (2) NO300689B1 (de)
NZ (1) NZ242775A (de)
PL (1) PL170376B1 (de)
SI (1) SI9200104A (de)
TN (1) TNSN92049A1 (de)
TW (1) TW218382B (de)
WO (1) WO1992022553A1 (de)
ZA (1) ZA924327B (de)
ZM (1) ZM2892A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
GR1001385B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο 1,2-α (πυρρολο,?ειενο η φουρανο) 3,2-d αζεπίνης συν?έσεις και μέ?οδοι χρήσεως.
AU676702B2 (en) * 1992-12-04 1997-03-20 Janssen Pharmaceutica N.V. Antiallergic imidazo{1,2-a}(pyrrolo, thieno or furano){2,3-d}azepine derivatives
DE69328976T2 (de) * 1992-12-04 2001-02-15 Janssen Pharmaceutica Nv Antiallergisch triazolo (pyrrolo, thieno oder furano) azepinderivate
AU679102B2 (en) * 1993-07-13 1997-06-19 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
WO1999013871A2 (en) * 1997-09-18 1999-03-25 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents
US7148214B1 (en) * 1998-12-19 2006-12-12 Janssen Pharmaceutica, N.V. Antihistaminic spiro compounds
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
WO2002100862A2 (en) 2001-06-12 2002-12-19 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
BRPI0412262A (pt) * 2003-07-23 2006-09-19 X Ceptor Therapeutics Inc derivados de azepina como agentes farmacêuticos
NZ556628A (en) 2005-03-08 2009-09-25 Janssen Pharmaceutica Nv Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
CN103570731B (zh) * 2012-07-30 2016-05-18 中国科学院广州生物医药与健康研究院 嘧啶并三环或嘧啶并四环类化合物及其药用组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
TW218382B (de) 1994-01-01
HUT70428A (en) 1995-10-30
MA22554A1 (fr) 1992-12-31
FI104077B (fi) 1999-11-15
FI935557A0 (fi) 1993-12-10
CA2102889C (en) 2002-11-26
AU652841B2 (en) 1994-09-08
FI104077B1 (fi) 1999-11-15
FI935557A (fi) 1993-12-10
MX9202860A (es) 1992-12-01
HU9303554D0 (en) 1994-04-28
WO1992022553A1 (en) 1992-12-23
NO300689B1 (no) 1997-07-07
CA2102889A1 (en) 1992-12-14
NZ242775A (en) 1995-03-28
EP0588859B1 (de) 2003-08-13
IE921919A1 (en) 1992-12-16
NO934493L (no) 1994-01-04
KR100247504B1 (ko) 2000-05-01
US5461050A (en) 1995-10-24
HRP920156A2 (en) 1995-12-31
JP3182421B2 (ja) 2001-07-03
EP0588859A1 (de) 1994-03-30
SI9200104A (en) 1992-12-31
IL101851A0 (en) 1992-12-30
ZA924327B (en) 1993-12-13
ATE247118T1 (de) 2003-08-15
IL101851A (en) 1996-05-14
CN1068116A (zh) 1993-01-20
DE69233161T2 (de) 2004-05-27
ES2204892T3 (es) 2004-05-01
PL170376B1 (pl) 1996-12-31
NO934493D0 (no) 1993-12-09
ZM2892A1 (en) 1994-05-25
JPH06507890A (ja) 1994-09-08
HU221013B1 (hu) 2002-07-29
TNSN92049A1 (fr) 1993-06-08
AU1901192A (en) 1993-01-12
EP0518434A1 (de) 1992-12-16
CN1033587C (zh) 1996-12-18

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ATE250061T1 (de) Imidazo(2,1-b)benzazepinderivate, zusammensetzungen und anwendungsmethoden
DE69233161D1 (de) Imidazo[1,2-a](Pyrrolo, Thieno oder Furano)[3,2-d]azepinderivate, Zubereitungen und ihre Verwendung
NZ232283A (en) Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes
CA2150805A1 (en) Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
NO174670C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 1H-pyrido(4,3-b)indol-1-on-derivater

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee