NO300373B1 - Analogifremgangsmåte for fremstilling av nye terapeutisk aktive 2-sakkarinylmetylarylkarboksylater - Google Patents

Info

Publication number

NO300373B1

NO300373B1 NO914288A NO914288A NO300373B1 NO 300373 B1 NO300373 B1 NO 300373B1 NO 914288 A NO914288 A NO 914288A NO 914288 A NO914288 A NO 914288A NO 300373 B1 NO300373 B1 NO 300373B1

Authority

NO

Norway

Prior art keywords

isopropyl

mol

saccharinylmethyl

acid

methoxy

Prior art date

1990-11-01

Links

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• 238000004519 manufacturing process Methods 0.000 title claims description 31
• 150000007942 carboxylates Chemical class 0.000 title claims description 3
• -1 cyano, carboxy Chemical group 0.000 claims description 123
• 238000002360 preparation method Methods 0.000 claims description 77
• 150000001875 compounds Chemical class 0.000 claims description 66
• 238000000034 method Methods 0.000 claims description 66
• 125000000217 alkyl group Chemical group 0.000 claims description 59
• 239000002253 acid Substances 0.000 claims description 49
• 235000019204 saccharin Nutrition 0.000 claims description 37
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 36
• 150000003839 salts Chemical class 0.000 claims description 36
• 229940081974 saccharin Drugs 0.000 claims description 27
• 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 27
• 229910052783 alkali metal Inorganic materials 0.000 claims description 25
• 239000001257 hydrogen Substances 0.000 claims description 25
• 229910052739 hydrogen Inorganic materials 0.000 claims description 25
• 239000002585 base Substances 0.000 claims description 24
• 125000003545 alkoxy group Chemical group 0.000 claims description 23
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 22
• 229910052757 nitrogen Inorganic materials 0.000 claims description 21
• 229910052736 halogen Inorganic materials 0.000 claims description 16
• 150000002367 halogens Chemical class 0.000 claims description 16
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
• 150000007513 acids Chemical class 0.000 claims description 14
• 229920006395 saturated elastomer Polymers 0.000 claims description 13
• 150000002431 hydrogen Chemical class 0.000 claims description 11
• 150000001340 alkali metals Chemical class 0.000 claims description 10
• 239000007858 starting material Substances 0.000 claims description 9
• 125000005529 alkyleneoxy group Chemical group 0.000 claims description 8
• 125000001624 naphthyl group Chemical group 0.000 claims description 8
• 125000003282 alkyl amino group Chemical group 0.000 claims description 7
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
• 125000002947 alkylene group Chemical group 0.000 claims description 6
• 125000003342 alkenyl group Chemical group 0.000 claims description 5
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 5
• 125000000304 alkynyl group Chemical group 0.000 claims description 5
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
• 125000001424 substituent group Chemical group 0.000 claims description 5
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
• DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 4
• 150000001241 acetals Chemical class 0.000 claims description 4
• 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims description 4
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 4
• 125000000000 cycloalkoxy group Chemical group 0.000 claims description 4
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
• 125000005842 heteroatom Chemical group 0.000 claims description 4
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 4
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
• RTKLRMQWPJJDDV-UHFFFAOYSA-N CC(C)C1=C2C(=CC(=C1)O)S(=O)(=O)N(C2=O)CC3=C(C(=C(C=C3)Cl)C(=O)O)Cl Chemical compound CC(C)C1=C2C(=CC(=C1)O)S(=O)(=O)N(C2=O)CC3=C(C(=C(C=C3)Cl)C(=O)O)Cl RTKLRMQWPJJDDV-UHFFFAOYSA-N 0.000 claims description 3
• 125000005236 alkanoylamino group Chemical group 0.000 claims description 3
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 3
• 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims description 3
• 230000008569 process Effects 0.000 claims description 3
• BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 claims description 3
• 229910052716 thallium Inorganic materials 0.000 claims description 3
• 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 2
• UCYHGWXSCGARAR-UHFFFAOYSA-N 2,6-dichloro-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-4-propan-2-yl-6-[(1,1,3-trioxo-1,2-benzothiazol-2-yl)methyl]cyclohex-3-ene-1-carboxylic acid Chemical compound CC(C)C1=CC(C(C(C1)(CN2C(=O)C3=CC=CC=C3S2(=O)=O)Cl)C(=O)O)(OCC(=O)OC(C)(C)C)Cl UCYHGWXSCGARAR-UHFFFAOYSA-N 0.000 claims description 2
• LIZMRKGLSHQRMP-UHFFFAOYSA-N 2,6-dichloro-3-(2-morpholin-4-ylethoxy)benzoic acid Chemical compound OC(=O)C1=C(Cl)C=CC(OCCN2CCOCC2)=C1Cl LIZMRKGLSHQRMP-UHFFFAOYSA-N 0.000 claims description 2
• WDJQICUPDPUMGB-UHFFFAOYSA-N CC(C)C(CC(CN(C(C1=CC=CC=C11)=O)S1(=O)=O)(C1C(O)=O)Cl)=CC1(OCC(OCC1=CC=CC=C1)=O)Cl Chemical compound CC(C)C(CC(CN(C(C1=CC=CC=C11)=O)S1(=O)=O)(C1C(O)=O)Cl)=CC1(OCC(OCC1=CC=CC=C1)=O)Cl WDJQICUPDPUMGB-UHFFFAOYSA-N 0.000 claims description 2
• MDXKWOPUZACLHA-UHFFFAOYSA-N CCOC(C(C(CN(C(C1=CC=CC=C11)=O)S1(=O)=O)(C1)Cl)C(O)=O)(C=C1C(C)C)Cl Chemical compound CCOC(C(C(CN(C(C1=CC=CC=C11)=O)S1(=O)=O)(C1)Cl)C(O)=O)(C=C1C(C)C)Cl MDXKWOPUZACLHA-UHFFFAOYSA-N 0.000 claims description 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
• 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 2
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
• 150000007514 bases Chemical class 0.000 claims description 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 2
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
• 229910052760 oxygen Inorganic materials 0.000 claims description 2
• 239000001301 oxygen Chemical group 0.000 claims description 2
• DJTWDPHPNRZMAW-UHFFFAOYSA-N CC(C)C1=CC(C(C(C1)(CN2C(=O)C3=CC=CC=C3S2(=O)=O)Cl)C(=O)O)(OC)Cl Chemical compound CC(C)C1=CC(C(C(C1)(CN2C(=O)C3=CC=CC=C3S2(=O)=O)Cl)C(=O)O)(OC)Cl DJTWDPHPNRZMAW-UHFFFAOYSA-N 0.000 claims 2
• 125000000586 2-(4-morpholinyl)ethoxy group Chemical group [H]C([H])(O*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims 1
• LWYMNIBZHONCDP-UHFFFAOYSA-N CC(C)C1=C2C(=C(C(=C1)CN3C(=O)C4=CC=CC=C4S3(=O)=O)C(=O)O)C=CC(=C2OC)OC Chemical compound CC(C)C1=C2C(=C(C(=C1)CN3C(=O)C4=CC=CC=C4S3(=O)=O)C(=O)O)C=CC(=C2OC)OC LWYMNIBZHONCDP-UHFFFAOYSA-N 0.000 claims 1
• SVCHMCJCWYSJBF-UHFFFAOYSA-N CC(C)C1=CC(C(C(C1)(C)CN2C(=O)C3=CC=CC=C3S2(=O)=O)C(=O)O)(C)OC Chemical compound CC(C)C1=CC(C(C(C1)(C)CN2C(=O)C3=CC=CC=C3S2(=O)=O)C(=O)O)(C)OC SVCHMCJCWYSJBF-UHFFFAOYSA-N 0.000 claims 1
• BATPFYYLGOMDGO-UHFFFAOYSA-N CC(C)C1=CC(C(C(C1)(CN2C(=O)C3=CC=CC=C3S2(=O)=O)OC)C(=O)O)(OC)OC Chemical compound CC(C)C1=CC(C(C(C1)(CN2C(=O)C3=CC=CC=C3S2(=O)=O)OC)C(=O)O)(OC)OC BATPFYYLGOMDGO-UHFFFAOYSA-N 0.000 claims 1
• NXGQXCBAHDCARH-UHFFFAOYSA-N CC(C)C1=CC(C(C(C1S(=O)(=O)N2CCN(CC2)C)(CN3C(=O)C4=CC=CC=C4S3(=O)=O)Cl)C(=O)O)(OC)Cl Chemical compound CC(C)C1=CC(C(C(C1S(=O)(=O)N2CCN(CC2)C)(CN3C(=O)C4=CC=CC=C4S3(=O)=O)Cl)C(=O)O)(OC)Cl NXGQXCBAHDCARH-UHFFFAOYSA-N 0.000 claims 1
• 229910052717 sulfur Chemical group 0.000 claims 1
• 239000011593 sulfur Chemical group 0.000 claims 1
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 171
• 239000000243 solution Substances 0.000 description 135
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 118
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 118
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 104
• 238000006243 chemical reaction Methods 0.000 description 97
• 239000000203 mixture Substances 0.000 description 86
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 83
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 82
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 78
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 75
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 63
• 239000011541 reaction mixture Substances 0.000 description 49
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 46
• RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 46
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 45
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 42
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 41
• 235000019439 ethyl acetate Nutrition 0.000 description 40
• 239000007787 solid Substances 0.000 description 39
• 229960000583 acetic acid Drugs 0.000 description 35
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 33
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 33
• YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 33
• 239000000047 product Substances 0.000 description 32
• 239000002904 solvent Substances 0.000 description 30
• FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 30
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
• 239000000741 silica gel Substances 0.000 description 28
• 229910002027 silica gel Inorganic materials 0.000 description 28
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 25
• 238000010992 reflux Methods 0.000 description 24
• 239000003921 oil Substances 0.000 description 23
• 229940044609 sulfur dioxide Drugs 0.000 description 23
• VVPUIKNICYCXJZ-UHFFFAOYSA-N 4-iodobutyl benzoate Chemical compound ICCCCOC(=O)C1=CC=CC=C1 VVPUIKNICYCXJZ-UHFFFAOYSA-N 0.000 description 22
• 238000001914 filtration Methods 0.000 description 22
• 239000012362 glacial acetic acid Substances 0.000 description 22
• 238000003756 stirring Methods 0.000 description 22
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 20
• WGOPGODQLGJZGL-UHFFFAOYSA-N lithium;butane Chemical compound [Li+].CC[CH-]C WGOPGODQLGJZGL-UHFFFAOYSA-N 0.000 description 20
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 20
• 239000012267 brine Substances 0.000 description 19
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 19
• 238000010438 heat treatment Methods 0.000 description 18
• KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 17
• 239000000706 filtrate Substances 0.000 description 16
• JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 16
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 14
• KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 14
• 239000012044 organic layer Substances 0.000 description 14
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical class CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 13
• 238000000746 purification Methods 0.000 description 13
• ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 12
• KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 12
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
• 238000004587 chromatography analysis Methods 0.000 description 12
• 102000004190 Enzymes Human genes 0.000 description 11
• 108090000790 Enzymes Proteins 0.000 description 11
• 239000000460 chlorine Substances 0.000 description 11
• 229940088598 enzyme Drugs 0.000 description 11
• 239000000543 intermediate Substances 0.000 description 11
• 229910003002 lithium salt Inorganic materials 0.000 description 11
• 159000000002 lithium salts Chemical class 0.000 description 11
• ZTMWHBJKVKHBTO-UHFFFAOYSA-M sodium amino sulfate Chemical compound [Na+].NOS([O-])(=O)=O ZTMWHBJKVKHBTO-UHFFFAOYSA-M 0.000 description 11
• XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 10
• MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 10
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 10
• 229910021529 ammonia Inorganic materials 0.000 description 10
• IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 10
• ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 10
• 239000010410 layer Substances 0.000 description 10
• 239000012074 organic phase Substances 0.000 description 10
• 239000003960 organic solvent Substances 0.000 description 10
• 229910000027 potassium carbonate Inorganic materials 0.000 description 10
• WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 9
• NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 9
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 9
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
• 230000000694 effects Effects 0.000 description 9
• 239000000284 extract Substances 0.000 description 9
• 239000005457 ice water Substances 0.000 description 9
• 235000011181 potassium carbonates Nutrition 0.000 description 9
• 230000002829 reductive effect Effects 0.000 description 9
• VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 8
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 8
• DQPBABKTKYNPMH-UHFFFAOYSA-N amino hydrogen sulfate Chemical compound NOS(O)(=O)=O DQPBABKTKYNPMH-UHFFFAOYSA-N 0.000 description 8
• 235000011114 ammonium hydroxide Nutrition 0.000 description 8
• 229910052801 chlorine Inorganic materials 0.000 description 8
• 239000012043 crude product Substances 0.000 description 8
• 229910052744 lithium Inorganic materials 0.000 description 8
• 239000000908 ammonium hydroxide Substances 0.000 description 7
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
• 239000003054 catalyst Substances 0.000 description 7
• 230000003197 catalytic effect Effects 0.000 description 7
• 238000001816 cooling Methods 0.000 description 7
• 230000003647 oxidation Effects 0.000 description 7
• 238000007254 oxidation reaction Methods 0.000 description 7
• 239000000725 suspension Substances 0.000 description 7
• GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 6
• LWVDCUCGKCOXLT-UHFFFAOYSA-N 4-methyl-1,1-dioxo-1,2-benzothiazol-3-one Chemical compound CC1=CC=CC2=C1C(=O)NS2(=O)=O LWVDCUCGKCOXLT-UHFFFAOYSA-N 0.000 description 6
• WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 6
• 206010014561 Emphysema Diseases 0.000 description 6
• 101000856199 Homo sapiens Chymotrypsin-like protease CTRL-1 Proteins 0.000 description 6
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 6
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 6
• 229930040373 Paraformaldehyde Natural products 0.000 description 6
• 102000035195 Peptidases Human genes 0.000 description 6
• 108091005804 Peptidases Proteins 0.000 description 6
• 125000004432 carbon atom Chemical group C* 0.000 description 6
• 238000006264 debenzylation reaction Methods 0.000 description 6
• 238000003818 flash chromatography Methods 0.000 description 6
• 239000006260 foam Substances 0.000 description 6
• 230000002401 inhibitory effect Effects 0.000 description 6
• INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 6
• 229920002866 paraformaldehyde Polymers 0.000 description 6
• 239000011734 sodium Substances 0.000 description 6
• 239000011780 sodium chloride Substances 0.000 description 6
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