NO300137B1 - 3-deoksy-oligosakkaridforbindelser, og farmasöytiske blandinger inneholdende dem - Google Patents
3-deoksy-oligosakkaridforbindelser, og farmasöytiske blandinger inneholdende dem Download PDFInfo
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- NO300137B1 NO300137B1 NO941461A NO941461A NO300137B1 NO 300137 B1 NO300137 B1 NO 300137B1 NO 941461 A NO941461 A NO 941461A NO 941461 A NO941461 A NO 941461A NO 300137 B1 NO300137 B1 NO 300137B1
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- 241000700159 Rattus Species 0.000 description 1
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- 102000002262 Thromboplastin Human genes 0.000 description 1
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- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- BHELZAPQIKSEDF-UHFFFAOYSA-N allyl bromide Chemical compound BrCC=C BHELZAPQIKSEDF-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-UHFFFAOYSA-N alpha-D-glucopyranose Natural products OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
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- 125000002102 aryl alkyloxo group Chemical group 0.000 description 1
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- AQIHMSVIAGNIDM-UHFFFAOYSA-N benzoyl bromide Chemical compound BrC(=O)C1=CC=CC=C1 AQIHMSVIAGNIDM-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229960002246 beta-d-glucopyranose Drugs 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- CZKMPDNXOGQMFW-UHFFFAOYSA-N chloro(triethyl)germane Chemical compound CC[Ge](Cl)(CC)CC CZKMPDNXOGQMFW-UHFFFAOYSA-N 0.000 description 1
- 229940117975 chromium trioxide Drugs 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N chromium trioxide Inorganic materials O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- GAMDZJFZMJECOS-UHFFFAOYSA-N chromium(6+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Cr+6] GAMDZJFZMJECOS-UHFFFAOYSA-N 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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- 239000007903 gelatin capsule Substances 0.000 description 1
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- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
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- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
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- 239000001257 hydrogen Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000014508 negative regulation of coagulation Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical group [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
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- 230000001172 regenerating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 150000004044 tetrasaccharides Chemical class 0.000 description 1
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- FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9304769A FR2704226B1 (fr) | 1993-04-22 | 1993-04-22 | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941461D0 NO941461D0 (no) | 1994-04-21 |
| NO941461L NO941461L (no) | 1994-10-24 |
| NO300137B1 true NO300137B1 (no) | 1997-04-14 |
Family
ID=9446334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941461A NO300137B1 (no) | 1993-04-22 | 1994-04-21 | 3-deoksy-oligosakkaridforbindelser, og farmasöytiske blandinger inneholdende dem |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5514659A (hu) |
| EP (1) | EP0621282B1 (hu) |
| JP (1) | JP3594990B2 (hu) |
| KR (1) | KR100324583B1 (hu) |
| CN (1) | CN1040539C (hu) |
| AT (1) | ATE155140T1 (hu) |
| AU (1) | AU665901B2 (hu) |
| CA (1) | CA2121997C (hu) |
| DE (1) | DE69404071T2 (hu) |
| ES (1) | ES2106463T3 (hu) |
| FI (1) | FI111725B (hu) |
| FR (1) | FR2704226B1 (hu) |
| HU (1) | HU226807B1 (hu) |
| NO (1) | NO300137B1 (hu) |
| NZ (1) | NZ260357A (hu) |
| RU (1) | RU2133752C1 (hu) |
| TW (1) | TW318183B (hu) |
| ZA (1) | ZA942767B (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL120722A (en) * | 1996-05-08 | 1999-07-14 | Akzo Nobel Nv | Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them |
| FR2751334B1 (fr) * | 1996-07-19 | 1998-10-16 | Sanofi Sa | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
| AUPO888497A0 (en) | 1997-09-01 | 1997-09-25 | Australian National University, The | Use of sulfated oligosaccharides as inhibitors of cardiovascular disease |
| AUPO976897A0 (en) | 1997-10-14 | 1997-11-06 | Australian National University, The | Use of sulfated oligosaccharides in lowering blood triglyceride levels |
| FR2874924B1 (fr) | 2004-09-09 | 2006-12-01 | Sanofi Aventis Sa | Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique |
| US8147126B2 (en) * | 2009-01-26 | 2012-04-03 | Spar Food Machinery Mfg. Co., Ltd. | Covering structure of a mixer |
| EP2464668B1 (en) * | 2009-07-31 | 2022-12-07 | Reliable Biopharmaceutical Corporation | Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof |
| FR2949115B1 (fr) | 2009-08-14 | 2012-11-02 | Sanofi Aventis | OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| FR2949114B1 (fr) | 2009-08-14 | 2011-08-26 | Sanofi Aventis | OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| US8420790B2 (en) | 2009-10-30 | 2013-04-16 | Reliable Biopharmaceutical Corporation | Efficient and scalable process for the manufacture of Fondaparinux sodium |
| JP2013537181A (ja) | 2010-09-10 | 2013-09-30 | サノフイ | 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類 |
| TWI434857B (zh) * | 2010-10-05 | 2014-04-21 | Scinopharm Taiwan Ltd | 應用於肝素五醣之雙醣之製備方法 |
| FR2970969B1 (fr) | 2011-01-27 | 2013-10-18 | Sanofi Aventis | Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique |
| WO2014205115A2 (en) * | 2013-06-19 | 2014-12-24 | The Regents Of The University Of California | Regioselective silyl exchange of per-silylated oligosaccharides |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2440376A1 (fr) * | 1978-11-06 | 1980-05-30 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
| US4826827A (en) * | 1979-10-05 | 1989-05-02 | Choay S.A. | Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs |
| US4818816A (en) * | 1981-04-28 | 1989-04-04 | Choay, S.A. | Process for the organic synthesis of oligosaccharides and derivatives thereof |
| US4788307A (en) * | 1986-04-30 | 1988-11-29 | Choay S.A. | Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity |
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| ES2060284T3 (es) * | 1990-04-23 | 1994-11-16 | Sanofi Elf | Un procedimiento para la preparacion de un derivado de carbohidrato que comprende una unidad de trisacarido. |
| IL102758A (en) * | 1991-08-23 | 1997-03-18 | Akzo Nv | Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them |
| DE4140117C1 (hu) * | 1991-12-05 | 1993-01-28 | Bayer Ag, 5090 Leverkusen, De |
-
1993
- 1993-04-22 FR FR9304769A patent/FR2704226B1/fr not_active Expired - Fee Related
-
1994
- 1994-04-19 AU AU60524/94A patent/AU665901B2/en not_active Expired
- 1994-04-20 FI FI941836A patent/FI111725B/fi not_active IP Right Cessation
- 1994-04-20 NZ NZ260357A patent/NZ260357A/en not_active IP Right Cessation
- 1994-04-20 JP JP8140794A patent/JP3594990B2/ja not_active Expired - Lifetime
- 1994-04-21 CN CN94104961A patent/CN1040539C/zh not_active Expired - Lifetime
- 1994-04-21 CA CA002121997A patent/CA2121997C/en not_active Expired - Lifetime
- 1994-04-21 US US08/230,921 patent/US5514659A/en not_active Expired - Lifetime
- 1994-04-21 NO NO941461A patent/NO300137B1/no not_active IP Right Cessation
- 1994-04-21 RU RU94013440/04A patent/RU2133752C1/ru active
- 1994-04-21 ZA ZA942767A patent/ZA942767B/xx unknown
- 1994-04-21 HU HU9401150A patent/HU226807B1/hu unknown
- 1994-04-22 DE DE69404071T patent/DE69404071T2/de not_active Expired - Lifetime
- 1994-04-22 EP EP94400879A patent/EP0621282B1/fr not_active Expired - Lifetime
- 1994-04-22 ES ES94400879T patent/ES2106463T3/es not_active Expired - Lifetime
- 1994-04-22 AT AT94400879T patent/ATE155140T1/de not_active IP Right Cessation
- 1994-04-22 KR KR1019940008484A patent/KR100324583B1/ko not_active IP Right Cessation
- 1994-05-24 TW TW083104690A patent/TW318183B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO941461L (no) | 1994-10-24 |
| RU2133752C1 (ru) | 1999-07-27 |
| FI111725B (fi) | 2003-09-15 |
| CA2121997A1 (en) | 1994-10-23 |
| HU226807B1 (en) | 2009-10-28 |
| FR2704226B1 (fr) | 1995-07-21 |
| EP0621282B1 (fr) | 1997-07-09 |
| TW318183B (hu) | 1997-10-21 |
| DE69404071T2 (de) | 1998-02-19 |
| AU6052494A (en) | 1994-10-27 |
| ES2106463T3 (es) | 1997-11-01 |
| NO941461D0 (no) | 1994-04-21 |
| JPH0789977A (ja) | 1995-04-04 |
| CN1040539C (zh) | 1998-11-04 |
| FR2704226A1 (fr) | 1994-10-28 |
| FI941836A0 (fi) | 1994-04-20 |
| KR100324583B1 (ko) | 2002-11-13 |
| CN1099038A (zh) | 1995-02-22 |
| EP0621282A1 (fr) | 1994-10-26 |
| ATE155140T1 (de) | 1997-07-15 |
| DE69404071D1 (de) | 1997-08-14 |
| CA2121997C (en) | 2005-09-27 |
| FI941836A (fi) | 1994-10-23 |
| JP3594990B2 (ja) | 2004-12-02 |
| NZ260357A (en) | 1995-12-21 |
| HUT67572A (en) | 1995-04-28 |
| AU665901B2 (en) | 1996-01-18 |
| HU9401150D0 (en) | 1994-07-28 |
| US5514659A (en) | 1996-05-07 |
| ZA942767B (en) | 1995-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |