NO300113B1 - Smerteregulerende sammensetning og fremgangsmåte for fremstilling - Google Patents
Smerteregulerende sammensetning og fremgangsmåte for fremstilling Download PDFInfo
- Publication number
- NO300113B1 NO300113B1 NO921834A NO921834A NO300113B1 NO 300113 B1 NO300113 B1 NO 300113B1 NO 921834 A NO921834 A NO 921834A NO 921834 A NO921834 A NO 921834A NO 300113 B1 NO300113 B1 NO 300113B1
- Authority
- NO
- Norway
- Prior art keywords
- butylaminobenzoate
- suspension
- polyethylene glycol
- polysorbate
- constitutes
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 63
- 208000002193 Pain Diseases 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 21
- WYNURVZXDYZDKR-UHFFFAOYSA-N butylamino benzoate Chemical compound CCCCNOC(=O)C1=CC=CC=C1 WYNURVZXDYZDKR-UHFFFAOYSA-N 0.000 claims description 54
- 239000000725 suspension Substances 0.000 claims description 44
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 42
- 239000002202 Polyethylene glycol Substances 0.000 claims description 41
- 229920001223 polyethylene glycol Polymers 0.000 claims description 41
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 33
- 229920000053 polysorbate 80 Polymers 0.000 claims description 33
- 229940068968 polysorbate 80 Drugs 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 20
- 238000000227 grinding Methods 0.000 claims description 19
- 238000002347 injection Methods 0.000 claims description 19
- 239000007924 injection Substances 0.000 claims description 19
- 239000000375 suspending agent Substances 0.000 claims description 14
- 239000000080 wetting agent Substances 0.000 claims description 14
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 231100000252 nontoxic Toxicity 0.000 claims description 10
- 230000003000 nontoxic effect Effects 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 238000003760 magnetic stirring Methods 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 210000005036 nerve Anatomy 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims 1
- IUWVALYLNVXWKX-UHFFFAOYSA-N butamben Chemical compound CCCCOC(=O)C1=CC=C(N)C=C1 IUWVALYLNVXWKX-UHFFFAOYSA-N 0.000 description 35
- 229960000400 butamben Drugs 0.000 description 34
- 239000008365 aqueous carrier Substances 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 4
- 229920000136 polysorbate Polymers 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 229950008882 polysorbate Drugs 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 2
- 229940064734 aminobenzoate Drugs 0.000 description 2
- 238000000498 ball milling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005188 flotation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229940050929 polyethylene glycol 3350 Drugs 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229920002642 Polysorbate 65 Polymers 0.000 description 1
- 229920002651 Polysorbate 85 Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- XSIFPSYPOVKYCO-UHFFFAOYSA-N butyl benzoate Chemical compound CCCCOC(=O)C1=CC=CC=C1 XSIFPSYPOVKYCO-UHFFFAOYSA-N 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000022371 chronic pain syndrome Diseases 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical class CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 238000010951 particle size reduction Methods 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 description 1
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 description 1
- 229940099511 polysorbate 65 Drugs 0.000 description 1
- 229940113171 polysorbate 85 Drugs 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- -1 sorbitol anhydrides Chemical class 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 239000007966 viscous suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69761891A | 1991-05-09 | 1991-05-09 | |
| US07/870,767 US5206267A (en) | 1991-05-09 | 1992-04-20 | Pain controlling composition and method of preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO921834D0 NO921834D0 (no) | 1992-05-08 |
| NO921834L NO921834L (no) | 1992-11-10 |
| NO300113B1 true NO300113B1 (no) | 1997-04-14 |
Family
ID=27106049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO921834A NO300113B1 (no) | 1991-05-09 | 1992-05-08 | Smerteregulerende sammensetning og fremgangsmåte for fremstilling |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5206267A (fr) |
| EP (1) | EP0512547B1 (fr) |
| JP (1) | JP2529055B2 (fr) |
| CA (1) | CA2068232C (fr) |
| DE (1) | DE69219197T2 (fr) |
| DK (1) | DK0512547T3 (fr) |
| ES (1) | ES2102423T3 (fr) |
| NO (1) | NO300113B1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
| WO2010101989A1 (fr) | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | Composition pharmaceutique pour l'administration à l'oeil de composés inhibant les récepteurs tyrosine kinase (rtki) |
| JP5996544B2 (ja) | 2010-10-15 | 2016-09-21 | クリアサイド・バイオメディカル・インコーポレーテッドＣｌｅａｒｓｉｄｅ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ | 眼球アクセス用装置 |
| KR20210133321A (ko) * | 2012-11-08 | 2021-11-05 | 클리어사이드 바이오메디컬, 인코포레이드 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
| EP4378444A3 (fr) | 2013-05-03 | 2024-07-03 | Clearside Biomedical, Inc. | Appareil et procédés d'injection oculaire |
| EP3452165A1 (fr) | 2016-05-02 | 2019-03-13 | Clearside Biomedical, Inc. | Systèmes et méthodes pour l'administration de médicaments par voie ophtalmique |
| IL305537A (en) | 2016-08-12 | 2023-10-01 | Clearside Biomedical Inc | Devices and methods for adjusting the insertion depth of a drug administration needle |
| WO2018204515A1 (fr) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Procédés d'administration ciblée de médicament au moyen d'une microaiguille |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB784659A (en) * | 1954-11-26 | 1957-10-16 | Upjohn Co | Therapeutic compositions and aqueous suspensions thereof |
| US3337400A (en) * | 1965-10-08 | 1967-08-22 | Joel P Smith | Aqueous post-surgical injection by infiltration with a local anesthetic, a substantially water-insoluble, local anti-inflammatory gluco corticoid, and an antibiotic |
| DE2714065A1 (de) * | 1977-03-30 | 1978-10-12 | Boehringer Mannheim Gmbh | Instillationszubereitung |
| US4599354A (en) * | 1985-03-11 | 1986-07-08 | Morton Shulman | Composition and method for producing prolonged pain relief |
| US4831023A (en) * | 1986-06-27 | 1989-05-16 | Thames Pharmacal Co., Inc. | Water washable vehicles for topical use |
| JPH0794385B2 (ja) * | 1987-11-28 | 1995-10-11 | サンスター株式会社 | 口腔鎮痛用組成物 |
| US5002974A (en) * | 1988-04-04 | 1991-03-26 | Warner-Lambert Co. | Anesthetic/skin moisturizing composition and method of preparing same |
| NL9000634A (nl) * | 1990-03-20 | 1991-10-16 | Catharina Ziekenhuis Stichting | Suspensie-injectiepreparaat op waterbasis, werkwijze voor de bereiding daarvan en toepassing van dit preparaat voor pijnbestrijding. |
-
1992
- 1992-04-20 US US07/870,767 patent/US5206267A/en not_active Expired - Lifetime
- 1992-05-07 ES ES92107732T patent/ES2102423T3/es not_active Expired - Lifetime
- 1992-05-07 DK DK92107732.7T patent/DK0512547T3/da active
- 1992-05-07 DE DE69219197T patent/DE69219197T2/de not_active Expired - Fee Related
- 1992-05-07 EP EP92107732A patent/EP0512547B1/fr not_active Expired - Lifetime
- 1992-05-08 CA CA002068232A patent/CA2068232C/fr not_active Expired - Fee Related
- 1992-05-08 NO NO921834A patent/NO300113B1/no not_active Application Discontinuation
- 1992-05-11 JP JP4117359A patent/JP2529055B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2102423T3 (es) | 1997-08-01 |
| DE69219197D1 (de) | 1997-05-28 |
| NO921834D0 (no) | 1992-05-08 |
| AU647999B2 (en) | 1994-03-31 |
| EP0512547A1 (fr) | 1992-11-11 |
| JP2529055B2 (ja) | 1996-08-28 |
| AU1614992A (en) | 1992-11-12 |
| DE69219197T2 (de) | 1997-08-07 |
| EP0512547B1 (fr) | 1997-04-23 |
| DK0512547T3 (da) | 1997-08-25 |
| JPH05155767A (ja) | 1993-06-22 |
| US5206267A (en) | 1993-04-27 |
| CA2068232A1 (fr) | 1992-11-10 |
| NO921834L (no) | 1992-11-10 |
| CA2068232C (fr) | 1997-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5576039A (en) | Colored jelly-type substance, method of preparation, and composition containing same | |
| DE69813757T2 (de) | Gekühltes wässriges Gelee und Verfahren zu dessen Herstellung | |
| NO300113B1 (no) | Smerteregulerende sammensetning og fremgangsmåte for fremstilling | |
| EP0495421A1 (fr) | Utilisation de carragheenane dans des compositions ophthalmologiques topiques | |
| PH26736A (en) | Beverages containing a beverage base and milk protein | |
| CN1196486C (zh) | 齐普拉西酮悬浮液 | |
| PL195410B1 (pl) | Zastosowanie kompozycji farmaceutycznej zawierającej alginian sodu do wytwarzania leku | |
| AU616049B2 (en) | Etoposide solutions | |
| NO316207B1 (no) | Anvendelse av kaliumbikarbonat for fremstilling av en vandig, hellbar flytende sammensetning samt farmasöytisk preparat omfattende denne | |
| AU4751396A (en) | Colored jelly-type substance, method of preparation, and composition containing same | |
| IE48601B1 (en) | Galactomannan polysaccharide gum formulation containing gellation inhibitor | |
| EP2459015A1 (fr) | Solutions de vitamine e microbiologiquement stables | |
| Van Buren | Effects of salts added after cooking on the texture of canned snap beans | |
| JP4110343B2 (ja) | ショ糖脂肪酸エステルを含有する分散性組成物 | |
| AU2018219383B2 (en) | Edible concentrate comprising microfibrillated cellulose | |
| JP2002045127A (ja) | 果実ジャム類および果実ソース類の製造方法 | |
| JP2002238520A (ja) | 浮遊固形物含有密封容器入り飲料およびその製造方法 | |
| GB2177589A (en) | Preserving fruit | |
| CN114344563B (zh) | 一种具有抗菌和促成骨性能的材料及其制备方法 | |
| JPH0481425B2 (fr) | ||
| CN115886011A (zh) | 一种杀菌剂组合物及其制备方法 | |
| JPH084457B2 (ja) | 緑茶の製造法 | |
| JPH02169503A (ja) | 藻類および細菌類の駆除剤スラリー組成物 | |
| JPH01146826A (ja) | 白金化合物の凍結乾燥製剤 | |
| JP2004049095A (ja) | 密閉容器入り乳飲料用安定剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |