GB784659A - Therapeutic compositions and aqueous suspensions thereof - Google Patents

Therapeutic compositions and aqueous suspensions thereof

Info

Publication number
GB784659A
GB784659A GB28818/55A GB2881855A GB784659A GB 784659 A GB784659 A GB 784659A GB 28818/55 A GB28818/55 A GB 28818/55A GB 2881855 A GB2881855 A GB 2881855A GB 784659 A GB784659 A GB 784659A
Authority
GB
United Kingdom
Prior art keywords
penicillin
esters
insoluble
ethylenediamine
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28818/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB784659A publication Critical patent/GB784659A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

A solid, insoluble organic medicinal agent of specific gravity less than about two is dispersed in an aqueous polyalkylene glycol vehicle to give a fluid stable aqueous suspension. The solid medicinal agent may be mixed with a solid polyalkylene glycol of molecular weight greater than about 4000 and then dispersed in an aqueous vehicle to give the stable suspension. Specified medicinal agents include antibiotics such as erythromycin, chloramphenicol, tetracycline, oxytetracycline, chlortetracycline and their insoluble salts and esters; insoluble penicillin compounds such as N,N1-dibenzylethylene diamine di-penicillin, N,N1-di(a -methylbenzyl)-ethylenediamine di-penicillin, N,N1-difurfuryl-ethylenediamine di-penicillin, N,N1-bis-(3,5,5-trimethylhexyl) ethylenediamine di-penicillin, aluminium penicillin sulphonamides, procaine penicillins G, O and K, and 2-chlorprocaine penicillin; steroids such as progesterone, testosterone propionate, estradiol mono-benzoate, cortisone, hydrocortisone, and insoluble cortisone and hydrocortisone esters; halosteroids such as 9-a -chloro- and 9-a -fluorocortisones and 9-a -chloro- and 9-a -fluorohydrocortisones and esters thereof; sulphamerazine, sulphadiazine, sulphamethazine and other sulphonamides; barbiturates such as barbital, phenobarbital, 2 - monobromoisovaleryl - carbamide, bromodiethylacetylurea, salicylamide and acetophenetidin. Additional ingredients comprise non-ionic surface-active agents such as polyoxyalkylene ethers of partial higher fatty acid esters of polyhydroxy alcohols, arylalkyl-polyether alcohols, polyethylene glycol fatty acid esters, and dialkylsulphosuccinates; lubricants such as glycerol, sorbitol and propylene glycol; preservatives such as sodium ethylmercurithiosalicylate, chlorbutanol, myristyl g -picolinium chloride, benzyl alcohol, sodium benzoate and methyl paraben; buffers, stabilizers, colouring, sweetening and flavouring agents. Other additives specified include carboxymethyl-hydroxymethyl cellulose, hydroxy-ethyl cellulose, dextran, methyl cellulose, polyvinyl pyrrolidone, gelatine, alginates, tragacanth, pectin, acacia, soluble starches, lecithin and cephalin. The suspensions may be used for parenteral, ophthalmic, oral and topical administration. Numerous examples are given.
GB28818/55A 1954-11-26 1955-10-10 Therapeutic compositions and aqueous suspensions thereof Expired GB784659A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US784659XA 1954-11-26 1954-11-26

Publications (1)

Publication Number Publication Date
GB784659A true GB784659A (en) 1957-10-16

Family

ID=22144199

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28818/55A Expired GB784659A (en) 1954-11-26 1955-10-10 Therapeutic compositions and aqueous suspensions thereof

Country Status (2)

Country Link
DE (1) DE1083985B (en)
GB (1) GB784659A (en)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2975099A (en) * 1958-06-25 1961-03-14 Upjohn Co Polyethylene glycol suppository bases
US2976213A (en) * 1959-11-18 1961-03-21 Robins Co Inc A H Injectable skeletal muscle relaxant
US3073742A (en) * 1957-04-09 1963-01-15 Byk Gulden Lomberg Chem Fab Stable, bacteriostatic composition
US3075878A (en) * 1959-08-31 1963-01-29 Pabst Brewing Co Fungicidal composition of polyoxyalkylene glycol surface active agent and polyamidohygrostreptin or polyaminohygrostreptin, and method of use
US3075879A (en) * 1960-03-21 1963-01-29 Strully Leonard Vincent Composition of matter and process for the control of drug resistant microorganisms
US3089818A (en) * 1960-06-02 1963-05-14 Baxter Laboratories Inc Water dispersible antibiotics
US3157572A (en) * 1961-01-06 1964-11-17 American Cyanamid Co Parenteral diuretic compositions of 5-acylimino-4-substituted-delta2-1, 3, 4-thiadiazolidine-2-sulfonamides
US3201257A (en) * 1963-01-17 1965-08-17 Union Carbide Corp Egg albumin compositions
US3227657A (en) * 1962-09-20 1966-01-04 Minerals & Chem Philipp Corp Glycol coated attapulgite clay and compositions including the same
US3328252A (en) * 1963-11-12 1967-06-27 Auburn Res Foundation Pasteurella and salmonella vaccines
US3624208A (en) * 1967-01-20 1971-11-30 Wyandotte Chemicals Corp Floating bath oil composition
FR2096879A1 (en) * 1970-07-09 1972-03-03 Rougier Andre Antibiotic/corticosteroid solns - for rectal administration
US3671545A (en) * 1969-05-05 1972-06-20 Synergistics Inc Polyvinylpyrrolidone-iodine compounds
FR2184719A1 (en) * 1972-05-12 1973-12-28 Armour Pharma
FR2385395A1 (en) * 1977-03-30 1978-10-27 Boehringer Mannheim Gmbh COMPOSITION FOR INSTILLATIONS
EP0045655A2 (en) * 1980-08-04 1982-02-10 Merck & Co. Inc. Solubilization of ivermectin in water
EP0197308A2 (en) * 1985-03-11 1986-10-15 Morton Shulman Composition and method for producing prolonged pain relief
EP0512547A1 (en) * 1991-05-09 1992-11-11 Morton Shulman Pain controlling composition and method of preparation
US5346903A (en) * 1990-03-20 1994-09-13 Stichting Catharina Ziekenhuis Aqueous suspension preparation for injection, method for producing the same and use thereof for producing pain relief
WO2005020880A2 (en) 2003-09-03 2005-03-10 Miscon Trading S.A. Methods for the treatment of endometriosis
US20130202658A1 (en) * 2010-06-08 2013-08-08 Rb Pharmaceuticals Limited Compositions Comprising Buprenorphine
US9782402B2 (en) 2010-06-08 2017-10-10 Indivior Uk Limited Injectable composition comprising buprenorphine
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
US11000520B2 (en) 2014-11-07 2021-05-11 Indivior Uk Limited Buprenorphine dosing regimens

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2619447A (en) * 1949-03-11 1952-11-25 American Cyanamid Co Injectable penicillin preparations

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3073742A (en) * 1957-04-09 1963-01-15 Byk Gulden Lomberg Chem Fab Stable, bacteriostatic composition
US2975099A (en) * 1958-06-25 1961-03-14 Upjohn Co Polyethylene glycol suppository bases
US3075878A (en) * 1959-08-31 1963-01-29 Pabst Brewing Co Fungicidal composition of polyoxyalkylene glycol surface active agent and polyamidohygrostreptin or polyaminohygrostreptin, and method of use
US2976213A (en) * 1959-11-18 1961-03-21 Robins Co Inc A H Injectable skeletal muscle relaxant
US3075879A (en) * 1960-03-21 1963-01-29 Strully Leonard Vincent Composition of matter and process for the control of drug resistant microorganisms
US3089818A (en) * 1960-06-02 1963-05-14 Baxter Laboratories Inc Water dispersible antibiotics
US3157572A (en) * 1961-01-06 1964-11-17 American Cyanamid Co Parenteral diuretic compositions of 5-acylimino-4-substituted-delta2-1, 3, 4-thiadiazolidine-2-sulfonamides
US3227657A (en) * 1962-09-20 1966-01-04 Minerals & Chem Philipp Corp Glycol coated attapulgite clay and compositions including the same
US3201257A (en) * 1963-01-17 1965-08-17 Union Carbide Corp Egg albumin compositions
US3328252A (en) * 1963-11-12 1967-06-27 Auburn Res Foundation Pasteurella and salmonella vaccines
US3624208A (en) * 1967-01-20 1971-11-30 Wyandotte Chemicals Corp Floating bath oil composition
US3671545A (en) * 1969-05-05 1972-06-20 Synergistics Inc Polyvinylpyrrolidone-iodine compounds
FR2096879A1 (en) * 1970-07-09 1972-03-03 Rougier Andre Antibiotic/corticosteroid solns - for rectal administration
FR2184719A1 (en) * 1972-05-12 1973-12-28 Armour Pharma
FR2385395A1 (en) * 1977-03-30 1978-10-27 Boehringer Mannheim Gmbh COMPOSITION FOR INSTILLATIONS
EP0045655A2 (en) * 1980-08-04 1982-02-10 Merck & Co. Inc. Solubilization of ivermectin in water
EP0045655A3 (en) * 1980-08-04 1982-10-06 Merck & Co. Inc. Solubilization of ivermectin in water
EP0197308A2 (en) * 1985-03-11 1986-10-15 Morton Shulman Composition and method for producing prolonged pain relief
EP0197308A3 (en) * 1985-03-11 1987-08-26 Morton Shulman Composition and method for producing prolonged pain relief
JPH064534B2 (en) 1985-03-11 1994-01-19 モートン シュルマン Combination drug for long-term pain relief
US5346903A (en) * 1990-03-20 1994-09-13 Stichting Catharina Ziekenhuis Aqueous suspension preparation for injection, method for producing the same and use thereof for producing pain relief
US5206267A (en) * 1991-05-09 1993-04-27 Morton Shulman Pain controlling composition and method of preparation
EP0512547A1 (en) * 1991-05-09 1992-11-11 Morton Shulman Pain controlling composition and method of preparation
US9468647B2 (en) 2003-09-03 2016-10-18 Miscon Trading S.A. Methods for the treatment of endometriosis
WO2005020880A2 (en) 2003-09-03 2005-03-10 Miscon Trading S.A. Methods for the treatment of endometriosis
EP1660009A2 (en) * 2003-09-03 2006-05-31 Miscon Trading S.A. Methods for the treatment of endometriosis
EP1660009A4 (en) * 2003-09-03 2010-02-17 Miscon Trading S A Methods for the treatment of endometriosis
JP2013035866A (en) * 2003-09-03 2013-02-21 Miscon Trading Sa Method for treating endometriosis
EP2617411A1 (en) * 2003-09-03 2013-07-24 Miscon Trading S.A. Methods for the Treatment of Endometriosis
US9532995B2 (en) 2003-09-03 2017-01-03 Miscon Trading S.A. Methods for the treatment of endometriosis
US9782402B2 (en) 2010-06-08 2017-10-10 Indivior Uk Limited Injectable composition comprising buprenorphine
US9295645B2 (en) * 2010-06-08 2016-03-29 Indivior Uk Limited Compositions comprising buprenorphine
US20130202658A1 (en) * 2010-06-08 2013-08-08 Rb Pharmaceuticals Limited Compositions Comprising Buprenorphine
US9827241B2 (en) 2010-06-08 2017-11-28 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10172849B2 (en) 2010-06-08 2019-01-08 Indivior Uk Limited Compositions comprising buprenorphine
US10198218B2 (en) 2010-06-08 2019-02-05 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10558394B2 (en) 2010-06-08 2020-02-11 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10592168B1 (en) 2010-06-08 2020-03-17 Indivior Uk Limited Injectable flowable composition comprising buprenorphine
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions
US10517864B2 (en) 2014-03-10 2019-12-31 Indivior Uk Limited Sustained-release buprenorphine solutions
US11000520B2 (en) 2014-11-07 2021-05-11 Indivior Uk Limited Buprenorphine dosing regimens
US11839611B2 (en) 2014-11-07 2023-12-12 Indivior Uk Limited Buprenorphine dosing regimens
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder

Also Published As

Publication number Publication date
DE1083985B (en) 1960-06-23

Similar Documents

Publication Publication Date Title
GB784659A (en) Therapeutic compositions and aqueous suspensions thereof
US20010036966A1 (en) Aqueous suspension with good redispersibility
AU2001291637B2 (en) Topical composition containing at least one vitamin D or one vitamin D analogue and at least one corticosteroid
US5340572A (en) Alkaline ophthalmic suspensions
GB983130A (en) Improvements in preparations for the removal of wax from the ear
US10016442B2 (en) Estrogen compositions for vaginal administration
GB1047518A (en) 17ª‡-monoesters of 11,17,21-trihydroxy steroid compounds
JPS60174715A (en) Local medicine releasing system
GB1316556A (en) Topical ointment base
GB1191965A (en) Betamethasone 17-Benzoate
ES8306591A1 (en) Topically administrable pharmaceutical compositions containing anti-inflammatory steroids
US6379692B1 (en) Pharmaceutical composition comprising a suspension for the active ingredient
GB1476717A (en) Tretinoin in a gel vehicle for acne treatment
FR2081436B1 (en)
IE41287B1 (en) Topical steroid formulation
AU615473B2 (en) Stabilisation of therapeutically active proteins in a pharmaceutical composition
GB1455552A (en) Pharmaceutical composition for topical administration
Cohen et al. Huge mesenteric mucinous cystadenoma in normal pregnancy
US2742396A (en) Ointment base
US5061486A (en) Dithranol composition containing no oily ingredients
SE7507413L (en) GALENIC PREPARATION.
US3070502A (en) Parenteral aqueous tetracycline composition containing n, n-dimethylacetamide solvent
GB1133800A (en) Pharmaceutical compositions
GB1297890A (en)
IE37718B1 (en) Pharmaceutical compositions