NO20092375L - Fremgangsmate for fremstilling av abacavir - Google Patents

Fremgangsmate for fremstilling av abacavir

Info

Publication number
NO20092375L
NO20092375L NO20092375A NO20092375A NO20092375L NO 20092375 L NO20092375 L NO 20092375L NO 20092375 A NO20092375 A NO 20092375A NO 20092375 A NO20092375 A NO 20092375A NO 20092375 L NO20092375 L NO 20092375L
Authority
NO
Norway
Prior art keywords
abacavir
preparation
compound
reacting
compound obtained
Prior art date
Application number
NO20092375A
Other languages
English (en)
Inventor
Ramon Berenguer Maimo
Julio Campon Pardo
Jorge Medrano Ruperez
Laia Elias Rius
Original Assignee
Esteve Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa
Publication of NO20092375L publication Critical patent/NO20092375L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det er beskrevet en fremgangsmåte for fremstilling av abacavir, eller dets salter eller dets solvater som omfatter trinnet med omsetning av en forbindelse (IV) hvor R, er en (C1-C4)-alkylrest med vannfri saltsyre/(C1-C6)-alkohol, og deretter med tri(C1-C4)-alkyl ortoformat, i fravær av vann. Framstillingsprosessen kan omfatte ytterligere trinn ved omsetning av den oppnådde forbindelsen med cyklopropylamin og etterfølgende hydrolyse for å gi abacavir.
NO20092375A 2006-12-21 2009-06-22 Fremgangsmate for fremstilling av abacavir NO20092375L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87134706P 2006-12-21 2006-12-21
EP06126797A EP1939196A1 (en) 2006-12-21 2006-12-21 Process for the preparation of abacavir
PCT/EP2007/064371 WO2008074874A1 (en) 2006-12-21 2007-12-20 Process for the preparation of abacavir

Publications (1)

Publication Number Publication Date
NO20092375L true NO20092375L (no) 2009-07-21

Family

ID=37912446

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092375A NO20092375L (no) 2006-12-21 2009-06-22 Fremgangsmate for fremstilling av abacavir

Country Status (18)

Country Link
US (1) US8097723B2 (no)
EP (2) EP1939196A1 (no)
JP (1) JP5166438B2 (no)
KR (1) KR20090094025A (no)
CN (1) CN101563346B (no)
AT (1) ATE473979T1 (no)
AU (1) AU2007336195A1 (no)
CA (1) CA2670432A1 (no)
DE (1) DE602007007824D1 (no)
ES (1) ES2348197T3 (no)
IL (1) IL198965A (no)
MX (1) MX2009006231A (no)
NO (1) NO20092375L (no)
PL (1) PL2125814T3 (no)
RU (1) RU2447073C2 (no)
SI (1) SI2125814T1 (no)
WO (1) WO2008074874A1 (no)
ZA (1) ZA200903648B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1905772A1 (en) * 2006-09-28 2008-04-02 Esteve Quimica, S.A. Process for the preparation of abacavir
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
CA2862006C (en) * 2012-01-03 2016-10-25 Cellceutix Corporation Carbocyclic nucleosides and their pharmaceutical use and compositions
CN104788451A (zh) * 2014-01-21 2015-07-22 浙江九洲药业股份有限公司 一种阿巴卡韦的制备方法
CN109239253B (zh) * 2018-09-21 2021-07-09 江苏威奇达药业有限公司 一种阿巴卡韦的杂质的高效液相检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB0320738D0 (en) * 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
EP1905772A1 (en) * 2006-09-28 2008-04-02 Esteve Quimica, S.A. Process for the preparation of abacavir
WO2008072074A1 (en) * 2006-12-11 2008-06-19 Aurobindo Pharma Limited An improved process for the preparation of purine derivative
US20100137592A1 (en) * 2007-06-21 2010-06-03 Asif Parvez Sayyed Process for preparing purine derivative

Also Published As

Publication number Publication date
JP2010513410A (ja) 2010-04-30
PL2125814T3 (pl) 2010-12-31
IL198965A0 (en) 2010-02-17
DE602007007824D1 (de) 2010-08-26
ATE473979T1 (de) 2010-07-15
IL198965A (en) 2012-08-30
CN101563346A (zh) 2009-10-21
KR20090094025A (ko) 2009-09-02
EP1939196A1 (en) 2008-07-02
JP5166438B2 (ja) 2013-03-21
US8097723B2 (en) 2012-01-17
RU2009128032A (ru) 2011-01-27
CN101563346B (zh) 2011-07-27
WO2008074874A1 (en) 2008-06-26
US20100041883A1 (en) 2010-02-18
CA2670432A1 (en) 2008-06-26
ES2348197T3 (es) 2010-12-01
EP2125814A1 (en) 2009-12-02
AU2007336195A1 (en) 2008-06-26
EP2125814B1 (en) 2010-07-14
RU2447073C2 (ru) 2012-04-10
SI2125814T1 (sl) 2010-12-31
MX2009006231A (es) 2009-06-22
ZA200903648B (en) 2010-08-25

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application