NO20082386L - Ligander som har bindingsspesifisitet for EGFR og/eller VEGF og fremgangsmater for anvendelse derav - Google Patents
Ligander som har bindingsspesifisitet for EGFR og/eller VEGF og fremgangsmater for anvendelse deravInfo
- Publication number
- NO20082386L NO20082386L NO20082386A NO20082386A NO20082386L NO 20082386 L NO20082386 L NO 20082386L NO 20082386 A NO20082386 A NO 20082386A NO 20082386 A NO20082386 A NO 20082386A NO 20082386 L NO20082386 L NO 20082386L
- Authority
- NO
- Norway
- Prior art keywords
- ligands
- egfr
- vegf
- methods
- binding specificity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SAMMENDRAG Det er beskrevet ligander som har bindingsspesifisitet for vaskulær endotel-vekstfaktor (VEGF), for epidermal vekstfaktor reseptor (EGFR) eller for VEGF og EGFR. Fremgangsmåter for anvendelse av disse ligandene er også beskrevet. Spesielt er anvendelse av disse ligandene for kreftterapi beskrevet.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74299205P | 2005-12-06 | 2005-12-06 | |
US75835506P | 2006-01-11 | 2006-01-11 | |
PCT/GB2006/004559 WO2007066106A1 (en) | 2005-12-06 | 2006-12-05 | Ligands that have binding specificity for egfr and/or vegf and methods of use therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20082386L true NO20082386L (no) | 2008-08-27 |
Family
ID=37820653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082386A NO20082386L (no) | 2005-12-06 | 2008-05-26 | Ligander som har bindingsspesifisitet for EGFR og/eller VEGF og fremgangsmater for anvendelse derav |
Country Status (13)
Country | Link |
---|---|
US (2) | US20100056439A1 (no) |
EP (1) | EP1966242A1 (no) |
JP (1) | JP2009518024A (no) |
KR (1) | KR20080077261A (no) |
AU (1) | AU2006323412A1 (no) |
BR (1) | BRPI0619463A2 (no) |
CA (1) | CA2632417A1 (no) |
CR (1) | CR10024A (no) |
EA (1) | EA013878B1 (no) |
MA (1) | MA30021B1 (no) |
NO (1) | NO20082386L (no) |
TW (1) | TW200804425A (no) |
WO (1) | WO2007066106A1 (no) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7696320B2 (en) * | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
GB0621513D0 (en) | 2006-10-30 | 2006-12-06 | Domantis Ltd | Novel polypeptides and uses thereof |
GB0724331D0 (en) * | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
CA2697032C (en) | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
GB2468232B (en) * | 2007-11-30 | 2012-10-24 | Glaxo Group Ltd | Antigen-bindng constructs |
KR20100098697A (ko) * | 2007-12-13 | 2010-09-08 | 글락소 그룹 리미티드 | 폐 전달을 위한 조성물 |
EA021967B1 (ru) | 2008-01-03 | 2015-10-30 | Дзе Скриппс Рисерч Инститьют | Доставка антител посредством модульного домена распознавания |
US8454960B2 (en) * | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
CN102046207B (zh) | 2008-03-31 | 2013-08-28 | 葛兰素集团有限公司 | 药物融合物和缀合物 |
WO2009127691A1 (en) | 2008-04-17 | 2009-10-22 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
WO2010033249A2 (en) * | 2008-09-22 | 2010-03-25 | Massachusetts Institute Of Technology | Compositions of and methods using ligand dimers |
WO2010046337A2 (en) * | 2008-10-21 | 2010-04-29 | Domantis Limited | Ligands that have binding specificity for dc-sign |
EP2356147A1 (en) * | 2008-11-26 | 2011-08-17 | Glaxo Group Limited | Polypeptides, antibody variable domains&antagonists |
CA2749339A1 (en) | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
WO2010094720A2 (en) * | 2009-02-19 | 2010-08-26 | Glaxo Group Limited | Improved anti-tnfr1 polypeptides, antibody variable domains & antagonists |
RU2011138951A (ru) | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
CA2763491A1 (en) * | 2009-05-28 | 2010-12-02 | Paul Andrew Hamblin | Antigen-binding proteins |
BR112012001681A2 (pt) * | 2009-07-16 | 2019-09-24 | Graxo Group Ltd | domínios variáveis de ligação de anti-albumina sérica aperfeiçoados |
CA2788993A1 (en) | 2010-02-05 | 2011-08-11 | Ablynx N.V. | Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same |
US9029328B2 (en) | 2010-03-24 | 2015-05-12 | The Brigham And Women's Hospital, Inc. | Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
BR112013003899A2 (pt) * | 2010-08-20 | 2016-06-07 | Glaxosmithkline Ip Dev Ltd | domínio variável único da imunoglobina anti-albumina sérica (sa), ligando multiespecífico, proteína de fusão, composição, ácido nucleico, vetor, célula hospedeira isolada, e, método de tratar ou previnir uma doença ou distúrbio em um paciente |
US20130236467A1 (en) * | 2010-11-24 | 2013-09-12 | Jeremy Griggs | Multispecific antigen binding proteins targeting hgf |
CA2837169C (en) | 2011-05-24 | 2021-11-09 | Zyngenia, Inc. | Multispecific complexes comprising angiopoietin-2-binding peptide and their uses |
EP2777707A1 (en) | 2013-03-11 | 2014-09-17 | Wake Forest University Health Sciences | Method of Treating Brain Tumors |
BR112015023752B1 (pt) | 2013-03-15 | 2023-11-14 | Zyngenia, Inc. | Domínio de reconhecimento modular (mrd), complexo compreendendo mrd e cetuximabe, usos do complexo para inibir a angiogênese e tratar câncer e composição farmacêutica compreendendo o dito complexo |
PL3049439T3 (pl) * | 2013-09-26 | 2020-07-13 | Ablynx N.V. | Bispecyficzne nanociała |
CA2974192C (en) | 2015-01-21 | 2024-02-20 | Inhibrx Biopharma LLC | Non-immunogenic single domain antibodies |
JP6640232B2 (ja) * | 2015-02-06 | 2020-02-05 | ユニバーシティ オブ メリーランド,ボルチモア | クロストリジウム・ディフィシル感染症の治療のための、クロストリジウム・ディフィシルのトキシンa及びトキシンbに対する四重特異性の八量体型結合剤及び抗体 |
HUE051896T2 (hu) | 2015-07-16 | 2021-03-29 | Inhibrx Inc | Multivalens és multispecifikus DR5-kötõ fúziós fehérjék |
KR101685532B1 (ko) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
US11773172B2 (en) | 2018-03-19 | 2023-10-03 | WuXi Biologics Ireland Limited | Anti-EGFR antibody polypeptide |
EA202192654A1 (ru) * | 2019-03-29 | 2021-12-30 | Грин Кросс Корпорейшн | Слитый белок, содержащий анти-мезотелин антитело, анти-cd3 антитело или анти-egfr антитело, биспецифическое или триспецифическое антитело, содержащие его, и их применения |
US12043652B2 (en) | 2020-08-28 | 2024-07-23 | Trustees Of Boston University | Engineered extracellular receptor constructs and uses thereof |
CN115724968B (zh) * | 2021-08-27 | 2023-08-08 | 三优生物医药(上海)有限公司 | Vegf结合分子及其用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0699237B1 (en) * | 1994-03-17 | 2003-02-19 | MERCK PATENT GmbH | Anti-egfr single-chain fvs and anti-egfr antibodies |
ATE318143T1 (de) * | 1996-10-25 | 2006-03-15 | Gilead Sciences Inc | Gefaesszellen wachstumsfaktor (vegf) nukleinsaureligand-komplexe |
DE122007000021I1 (de) * | 1997-04-07 | 2007-05-24 | Genentech Inc | Anti-vefg Antibodies |
JP2004529610A (ja) * | 2000-10-13 | 2004-09-30 | ユーエイビー リサーチ ファンデーション | ヒト抗上皮増殖因子受容体一本鎖抗体 |
RU2295537C2 (ru) * | 2000-10-20 | 2007-03-20 | Тугаи Сейяку Кабусики Кайся | Модифицированное агонистическое антитело |
US7667004B2 (en) * | 2001-04-17 | 2010-02-23 | Abmaxis, Inc. | Humanized antibodies against vascular endothelial growth factor |
US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
CN1678634A (zh) * | 2002-06-28 | 2005-10-05 | 多曼蒂斯有限公司 | 免疫球蛋白单个变体抗原结合区及其特异性构建体 |
EP1558645B1 (en) * | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
EP1578801A2 (en) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
ES2315664T3 (es) * | 2003-06-30 | 2009-04-01 | Domantis Limited | Anticuerpos de dominio unico (dab) pegilados. |
US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
ATE485307T1 (de) * | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
US20090252681A1 (en) * | 2005-10-11 | 2009-10-08 | Ablynx N.V. | Nanobodies and Polypeptides Against EGFR and IGF-IR |
-
2006
- 2006-12-05 EA EA200801172A patent/EA013878B1/ru not_active IP Right Cessation
- 2006-12-05 WO PCT/GB2006/004559 patent/WO2007066106A1/en active Application Filing
- 2006-12-05 US US12/086,020 patent/US20100056439A1/en not_active Abandoned
- 2006-12-05 AU AU2006323412A patent/AU2006323412A1/en not_active Abandoned
- 2006-12-05 JP JP2008543892A patent/JP2009518024A/ja active Pending
- 2006-12-05 TW TW095145121A patent/TW200804425A/zh unknown
- 2006-12-05 BR BRPI0619463-0A patent/BRPI0619463A2/pt not_active IP Right Cessation
- 2006-12-05 CA CA002632417A patent/CA2632417A1/en not_active Abandoned
- 2006-12-05 EP EP06820440A patent/EP1966242A1/en not_active Withdrawn
- 2006-12-05 KR KR1020087016537A patent/KR20080077261A/ko not_active Application Discontinuation
-
2008
- 2008-05-26 NO NO20082386A patent/NO20082386L/no unknown
- 2008-05-27 CR CR10024A patent/CR10024A/es not_active Application Discontinuation
- 2008-06-02 MA MA30990A patent/MA30021B1/fr unknown
-
2012
- 2012-10-26 US US13/644,414 patent/US20130041136A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA013878B1 (ru) | 2010-08-30 |
US20100056439A1 (en) | 2010-03-04 |
US20130041136A1 (en) | 2013-02-14 |
BRPI0619463A2 (pt) | 2013-01-08 |
AU2006323412A1 (en) | 2007-06-14 |
CA2632417A1 (en) | 2007-06-14 |
WO2007066106A1 (en) | 2007-06-14 |
CR10024A (es) | 2008-09-22 |
MA30021B1 (fr) | 2008-12-01 |
EA200801172A1 (ru) | 2008-12-30 |
EP1966242A1 (en) | 2008-09-10 |
TW200804425A (en) | 2008-01-16 |
JP2009518024A (ja) | 2009-05-07 |
KR20080077261A (ko) | 2008-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20082386L (no) | Ligander som har bindingsspesifisitet for EGFR og/eller VEGF og fremgangsmater for anvendelse derav | |
NO20082960L (no) | Ligander med bindingsspesifisitet for VEGF og/eller EGFR og fremgangsmater for anvendelse derav | |
LTPA2017011I1 (lt) | Antikūnas prieš PDGFR-alfa, skirtas naudoti auglių gydymui | |
NO20083397L (no) | Anti-EphB4-antistoffer og fremgangsmater for anvendelse av disse | |
SG170793A1 (en) | Anti-mn antibodies and methods of using same | |
WO2007149482A3 (en) | Xanthohumol based protein kinase modulation cancer treatment | |
NO20083127L (no) | Fremgangsmater og preparater for malretting av polyubiquitin | |
WO2008140493A3 (en) | Anti-egfr family antibodies, bispecific anti-egfr family antibodies and methods of use thereof | |
NO20090047L (no) | Anti-DLL4-antistoffer og fremgangsmater for anvendelse av disse | |
NO20083891L (no) | Anti-5T4 antistoffer og anvendelser derav | |
NO20083147L (no) | Anti-OX40L-antistoffer og fremgangsmater for anvendelse av disse | |
EA200702278A1 (ru) | Антитела, специфичные в отношении tgf-бета 1 | |
NO20064194L (no) | Fremgangsmate for a modulere IL-23-aktivitet, beslektede reagenser | |
MY160445A (en) | Dual Variable Domain Immunoglobulins And Uses Thereof | |
NO20092052L (no) | Antistoffer og immunkonjugater, og anvendelser derav | |
WO2009009173A3 (en) | Klotho-beta for use in treating cancer, liver disorders, gallstones, wasting syndrome and obesity-related diseases | |
NO20085422L (no) | Bindingsproteiner for hepatocyttvekstfaktor (HGF) | |
NO20085421L (no) | Bindingsproteiner for hepatocyttvekstfaktor (HGF) | |
DK1951759T3 (da) | Anti-EGFR-antistoffer | |
EA200801430A1 (ru) | Производные триазола | |
DK1782070T3 (da) | Tumorassocieret antigenprofiler i cancerdiagnostik og immunterapi | |
NO20083593L (no) | Anti-EphrinB2-antistoffer og fremgangsmater for anvendelse av disse | |
ATE452149T1 (de) | Modifizierte polyolefinwachse | |
WO2008151819A3 (en) | Treatment of tumors using specific anti-l1 antibody | |
NO20090333L (no) | Fremgangsmater og preparater rettet mot hepsin |