NO20076071L - Trombininhiberende 2-okso-1,2,5,6-tetrahydropyridinderivater - Google Patents

Trombininhiberende 2-okso-1,2,5,6-tetrahydropyridinderivater

Info

Publication number
NO20076071L
NO20076071L NO20076071A NO20076071A NO20076071L NO 20076071 L NO20076071 L NO 20076071L NO 20076071 A NO20076071 A NO 20076071A NO 20076071 A NO20076071 A NO 20076071A NO 20076071 L NO20076071 L NO 20076071L
Authority
NO
Norway
Prior art keywords
oxo
thrombin
thrombin inhibitory
tetrahydropyridine derivatives
disorders
Prior art date
Application number
NO20076071A
Other languages
English (en)
Inventor
Magnus Polla
Ingmar Nilsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20076071L publication Critical patent/NO20076071L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Det tilveiebringes en forbindelse med formel (I):. hvor,a,,a,,,, R,til R, A og G har betydninger som angitt i beskrivelsen, idet disse forbindelsene er anvendelige som, eller er anvendelige som promedikamenter av, konkurrerende hemmere av trypsinlignende proteaser, så som trombin, og således spesielt ved behandling av lidelser hvor hemning av trombin er fordelaktig (for eksempel lidelser så som tromboembolismer, hvor hemning av trombin er nødvendig eller ønsket, og/eller lidelser hvor antikoagulerende terapi er indikert).
NO20076071A 2005-06-17 2007-11-27 Trombininhiberende 2-okso-1,2,5,6-tetrahydropyridinderivater NO20076071L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0501413 2005-06-17
PCT/SE2006/000709 WO2006135323A1 (en) 2005-06-17 2006-06-14 Thrombin inhibiting 2-oxo-1, 2, 5, 6-tetrahydropyridine derivatives

Publications (1)

Publication Number Publication Date
NO20076071L true NO20076071L (no) 2008-01-08

Family

ID=37532584

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076071A NO20076071L (no) 2005-06-17 2007-11-27 Trombininhiberende 2-okso-1,2,5,6-tetrahydropyridinderivater

Country Status (18)

Country Link
US (1) US20080207695A1 (no)
EP (1) EP1893601A1 (no)
JP (1) JP2008546684A (no)
KR (1) KR20080021145A (no)
CN (1) CN101243069A (no)
AR (1) AR054512A1 (no)
AU (1) AU2006258300A1 (no)
BR (1) BRPI0612045A2 (no)
CA (1) CA2610428A1 (no)
EC (1) ECSP088111A (no)
IL (1) IL187580A0 (no)
MX (1) MX2007016090A (no)
NO (1) NO20076071L (no)
RU (1) RU2007146731A (no)
TW (1) TW200738675A (no)
UY (1) UY29600A1 (no)
WO (1) WO2006135323A1 (no)
ZA (1) ZA200710564B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354444B2 (en) 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
CN113698386B (zh) * 2020-05-22 2022-12-27 上海美悦生物科技发展有限公司 一种4(1h)-吡啶酮类化合物、其药物组合物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU698911B2 (en) * 1995-04-04 1998-11-12 Merck & Co., Inc. Thrombin inhibitors
JPH11508558A (ja) * 1995-06-27 1999-07-27 メルク エンド カンパニー インコーポレーテッド ピリジノン トロンビン阻害剤
CZ340898A3 (cs) * 1996-04-23 1999-02-17 Merck And Co., Inc. Sloučenina, způsob její výroby a farmaceutický prostředek
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors
US5792779A (en) * 1997-02-19 1998-08-11 Merck & Co., Inc. Pyridinone thrombin inhibitors
US5866573A (en) * 1997-04-21 1999-02-02 Merck & Co., Inc. Pyrazinone thrombin inhibitors
UA75093C2 (en) * 2000-10-06 2006-03-15 Dimensional Pharm Inc Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors
WO2002057225A2 (en) * 2000-12-18 2002-07-25 Merck & Co., Inc. Thrombin inhibitors
US6946283B2 (en) * 2001-01-05 2005-09-20 William Marsh Rice University Ginkgo biloba levopimaradiene synthase
US7026324B2 (en) * 2001-02-09 2006-04-11 Merck & Co., Inc. Thrombin inhibitors
SI21097A (sl) * 2001-12-04 2003-06-30 Univerza V Ljubljani Inhibitorji trombina
AR047521A1 (es) * 2004-02-06 2006-01-25 Astrazeneca Ab Compuestos piridin-2-ona utiles como inhibidores de trombina

Also Published As

Publication number Publication date
IL187580A0 (en) 2008-03-20
JP2008546684A (ja) 2008-12-25
UY29600A1 (es) 2007-01-31
AR054512A1 (es) 2007-06-27
CA2610428A1 (en) 2006-12-21
AU2006258300A1 (en) 2006-12-21
WO2006135323A1 (en) 2006-12-21
CN101243069A (zh) 2008-08-13
ZA200710564B (en) 2008-11-26
BRPI0612045A2 (pt) 2018-07-24
US20080207695A1 (en) 2008-08-28
MX2007016090A (es) 2008-03-10
TW200738675A (en) 2007-10-16
RU2007146731A (ru) 2009-07-27
ECSP088111A (es) 2008-02-20
EP1893601A1 (en) 2008-03-05
KR20080021145A (ko) 2008-03-06

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