NO20073170L - Kaspaseinhibitorer og anvendelse derav - Google Patents

Kaspaseinhibitorer og anvendelse derav

Info

Publication number
NO20073170L
NO20073170L NO20073170A NO20073170A NO20073170L NO 20073170 L NO20073170 L NO 20073170L NO 20073170 A NO20073170 A NO 20073170A NO 20073170 A NO20073170 A NO 20073170A NO 20073170 L NO20073170 L NO 20073170L
Authority
NO
Norway
Prior art keywords
caspase inhibitors
present
methods
provides
compositions
Prior art date
Application number
NO20073170A
Other languages
English (en)
Norwegian (no)
Inventor
Michael Mortimore
Ronald Knegtel
Jean-Damien Charrier
John R Studley
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20073170L publication Critical patent/NO20073170L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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NO20073170A 2004-11-24 2007-06-22 Kaspaseinhibitorer og anvendelse derav NO20073170L (no)

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PCT/US2005/042139 WO2006057961A1 (en) 2004-11-24 2005-11-21 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors

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Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
AU2003248758A1 (en) 2002-06-28 2004-01-19 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
TW200500343A (en) 2002-12-20 2005-01-01 Vertex Pharma Caspase inhibitors and uses thereof
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
EP1750689A1 (en) * 2004-05-15 2007-02-14 Vertex Pharmaceuticals Incorporated Treating seizures using ice inhibitors
SI1928454T1 (sl) 2005-05-10 2015-01-30 Intermune, Inc. Piridonski derivati za moduliranje s stresom aktiviranega protein kinaznega sistema
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
CA2859604C (en) 2011-12-21 2019-12-17 Ono Pharmaceutical Co., Ltd. Compounds
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논
US11447497B2 (en) 2018-06-29 2022-09-20 Histogen, Inc. (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
WO2023215559A1 (en) * 2022-05-05 2023-11-09 Aria Pharmaceuticals, Inc. Compounds, compositions, and methods

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207145D0 (en) 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
CN1504462A (zh) 1994-03-31 2004-06-16 ������˹ҩƷ��˾ 作为白细胞介素抑制剂的嘧啶基衍生物
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5847135A (en) 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
DE69634122D1 (de) 1995-04-27 2005-02-03 Mitsubishi Pharma Corp Heterocyclische amidverbindungen und deren medizinische verwendung
EP0932598A1 (en) 1996-10-11 1999-08-04 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6197750B1 (en) 1998-07-02 2001-03-06 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
ATE363465T1 (de) 1999-04-09 2007-06-15 Cytovia Inc Caspase inhibitoren und ihre verwendung
AR026748A1 (es) * 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
US6878743B2 (en) * 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
EP1499898A2 (en) 2002-04-19 2005-01-26 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
AU2003248758A1 (en) 2002-06-28 2004-01-19 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
TW200500343A (en) 2002-12-20 2005-01-01 Vertex Pharma Caspase inhibitors and uses thereof
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
CN101268084A (zh) 2005-07-28 2008-09-17 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物

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EP1833794B1 (en) 2012-02-01
ZA200704913B (en) 2008-09-25
CA2588713A1 (en) 2006-06-01
WO2006057961A1 (en) 2006-06-01
US8362043B2 (en) 2013-01-29
MX2007006258A (es) 2007-07-20
EP1833794A1 (en) 2007-09-19
JP2008521809A (ja) 2008-06-26
CN101098855B (zh) 2012-06-06
AU2005309776B2 (en) 2011-12-22
CN101098855A (zh) 2008-01-02
KR20070086610A (ko) 2007-08-27
AU2005309776A1 (en) 2006-06-01
JP2009108067A (ja) 2009-05-21
RU2007123615A (ru) 2008-12-27
IL183373A0 (en) 2007-09-20
NZ555565A (en) 2008-11-28
ATE543803T1 (de) 2012-02-15
RU2412936C2 (ru) 2011-02-27
US20060160862A1 (en) 2006-07-20
ES2380632T3 (es) 2012-05-17

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