NO20071860L - Forbindelser, sammensetninger og fremgangsmater for a hemme alpha-synukleintoksisitet - Google Patents
Forbindelser, sammensetninger og fremgangsmater for a hemme alpha-synukleintoksisitetInfo
- Publication number
- NO20071860L NO20071860L NO20071860A NO20071860A NO20071860L NO 20071860 L NO20071860 L NO 20071860L NO 20071860 A NO20071860 A NO 20071860A NO 20071860 A NO20071860 A NO 20071860A NO 20071860 L NO20071860 L NO 20071860L
- Authority
- NO
- Norway
- Prior art keywords
- compositions
- compounds
- methods
- synuclein
- synuclein toxicity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001988 toxicity Effects 0.000 title abstract 2
- 231100000419 toxicity Toxicity 0.000 title abstract 2
- 102000003802 alpha-Synuclein Human genes 0.000 title 1
- 108090000185 alpha-Synuclein Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- -1 aryl styryl ketones Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61079604P | 2004-09-17 | 2004-09-17 | |
| PCT/US2005/033050 WO2006034003A2 (en) | 2004-09-17 | 2005-09-16 | Compounds, compositions and methods of inhibiting a-synuclein toxicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20071860L true NO20071860L (no) | 2007-06-05 |
Family
ID=36090510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20071860A NO20071860L (no) | 2004-09-17 | 2007-04-13 | Forbindelser, sammensetninger og fremgangsmater for a hemme alpha-synukleintoksisitet |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8440705B2 (de) |
| EP (2) | EP1802303B1 (de) |
| JP (1) | JP5001843B2 (de) |
| CN (2) | CN101060839A (de) |
| AT (1) | ATE531367T1 (de) |
| AU (1) | AU2005287137B2 (de) |
| BR (1) | BRPI0515549A (de) |
| CA (1) | CA2580767A1 (de) |
| ES (1) | ES2376108T3 (de) |
| NO (1) | NO20071860L (de) |
| NZ (4) | NZ554545A (de) |
| WO (1) | WO2006034003A2 (de) |
| ZA (1) | ZA200703110B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ570103A (en) * | 2006-01-26 | 2011-11-25 | Foldrx Pharmaceuticals Inc | Compounds and methods for modulating protein trafficking |
| US20100278733A1 (en) * | 2006-05-24 | 2010-11-04 | Morio Nakayama | Composition for diagnosis of amyloid-related disease |
| WO2008025152A1 (en) * | 2006-08-28 | 2008-03-06 | Mcmaster University | Antibacterial agents |
| NZ600449A (en) * | 2009-12-16 | 2014-10-31 | Neuropore Therapies Inc | Compound suitable for the treatment of synucleopathies |
| ES2550939T3 (es) | 2010-07-16 | 2015-11-13 | Nivalis Therapeutics, Inc. | Nuevos compuestos de dihidropiridin-2-(1H)-ona como inhibidores de la S-nitrosoglutatión reductasa y antagonistas del receptor de la neurocinina-3 |
| US20130158035A1 (en) * | 2010-08-24 | 2013-06-20 | Brigham Young University | Antimetastatic compounds |
| JP5719028B2 (ja) | 2010-10-06 | 2015-05-13 | グラクソスミスクライン エルエルシー | Pi3キナーゼ阻害剤としてのベンズイミダゾール誘導体 |
| CN103347520A (zh) * | 2010-10-13 | 2013-10-09 | 波士顿大学管理委员会 | 用作癌症化学治疗的晚期sv40因子(lsf)的抑制剂 |
| US9802948B2 (en) | 2010-10-13 | 2017-10-31 | Trustees Of Boston Univeristy | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics |
| US9815845B2 (en) | 2010-10-13 | 2017-11-14 | Trustees Of Boston University | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| CN103906751A (zh) * | 2011-10-02 | 2014-07-02 | 波士顿大学董事会 | 作为晚期SV40因子(LSF)抑制剂用于治疗癌症的[1,3]二氧杂环戊烯并[4,5-g]喹啉-6(5H)-硫酮和[1,3]二氧杂环戊烯并[4,5-g][1,2,4]三唑并[1,5-a]喹啉衍生物 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
| CA2906197A1 (en) | 2013-03-15 | 2014-09-18 | Whitehead Institute For Biomedical Research | Cellular discovery platform for neurodegenerative diseases |
| CA2954978A1 (en) * | 2014-07-29 | 2016-02-04 | Institut Pasteur De Lille | 2-oxo-3,4-dihydropyridine-5-carboxylates and their use |
| EP3842514A1 (de) | 2014-09-12 | 2021-06-30 | Whitehead Institute for Biomedical Research | Zellen zur expression von apolipoprotein e und verwendungen davon |
| GB201509663D0 (en) * | 2015-06-03 | 2015-07-15 | Johnson Matthey Plc | Benzo(h)quinoline ligands and complexes thereof |
| KR102662996B1 (ko) | 2016-04-08 | 2024-05-07 | 베이롤 칼리지 오브 메드신 | 스테로이드 수용체 공활성제의 소분자 조절제 및 이의 사용 방법 |
| US11110080B2 (en) | 2017-03-27 | 2021-09-07 | The Regents Of The University Of Colorado, A Body Corporate | Small molecule inhibitors of bacterial efflux pumps and methods of using same |
| WO2019074898A1 (en) * | 2017-10-09 | 2019-04-18 | Alsatech, Inc. | DISAGGREGATION OF ALPHA-SYNUCLEIN WITH SMALL MOLECULES |
| US11420977B2 (en) | 2018-08-02 | 2022-08-23 | Trustees Of Boston University | Late SV40 (LSF) inhibitors |
| JP7604387B2 (ja) * | 2019-03-28 | 2024-12-23 | ファースト・バイオセラピューティクス・インコーポレイテッド | ベンゾチアゾール化合物の薬学的塩、多形体及びその製造方法 |
| WO2021150835A1 (en) | 2020-01-24 | 2021-07-29 | Trustees Of Boston University | Heterocyclic lsf inhibitors and their uses |
| CN112062770A (zh) * | 2020-08-21 | 2020-12-11 | 台州学院 | 一种稠环二氢吡啶酮的制备方法 |
| US11458132B2 (en) | 2020-09-01 | 2022-10-04 | Trustees Of Boston University | Quinolin-2(1H)-one inhibitors of Late SV40 Factor |
| WO2024133857A1 (en) * | 2022-12-22 | 2024-06-27 | Universite Cote D'azur | Amidinourea derivatives and their use in the treatment of cancer |
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-
2005
- 2005-09-16 EP EP05813951A patent/EP1802303B1/de not_active Expired - Lifetime
- 2005-09-16 NZ NZ554545A patent/NZ554545A/en not_active IP Right Cessation
- 2005-09-16 JP JP2007532478A patent/JP5001843B2/ja not_active Expired - Fee Related
- 2005-09-16 CN CNA2005800393033A patent/CN101060839A/zh active Pending
- 2005-09-16 CN CN2011101571162A patent/CN102379872A/zh active Pending
- 2005-09-16 NZ NZ584773A patent/NZ584773A/en not_active IP Right Cessation
- 2005-09-16 CA CA002580767A patent/CA2580767A1/en not_active Abandoned
- 2005-09-16 EP EP11186929A patent/EP2433634A3/de not_active Withdrawn
- 2005-09-16 NZ NZ588432A patent/NZ588432A/en not_active IP Right Cessation
- 2005-09-16 WO PCT/US2005/033050 patent/WO2006034003A2/en not_active Ceased
- 2005-09-16 AT AT05813951T patent/ATE531367T1/de active
- 2005-09-16 BR BRPI0515549-5A patent/BRPI0515549A/pt not_active IP Right Cessation
- 2005-09-16 AU AU2005287137A patent/AU2005287137B2/en not_active Ceased
- 2005-09-16 NZ NZ588431A patent/NZ588431A/en not_active IP Right Cessation
- 2005-09-16 US US11/575,481 patent/US8440705B2/en not_active Expired - Fee Related
- 2005-09-16 ES ES05813951T patent/ES2376108T3/es not_active Expired - Lifetime
-
2007
- 2007-04-13 NO NO20071860A patent/NO20071860L/no not_active Application Discontinuation
- 2007-04-16 ZA ZA200703110A patent/ZA200703110B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE531367T1 (de) | 2011-11-15 |
| BRPI0515549A (pt) | 2008-07-29 |
| EP1802303A4 (de) | 2009-12-16 |
| EP1802303B1 (de) | 2011-11-02 |
| AU2005287137B2 (en) | 2012-03-22 |
| US8440705B2 (en) | 2013-05-14 |
| NZ588432A (en) | 2012-03-30 |
| US20080261953A1 (en) | 2008-10-23 |
| NZ554545A (en) | 2010-10-29 |
| ZA200703110B (en) | 2008-08-27 |
| CN101060839A (zh) | 2007-10-24 |
| ES2376108T3 (es) | 2012-03-09 |
| JP5001843B2 (ja) | 2012-08-15 |
| AU2005287137A1 (en) | 2006-03-30 |
| CN102379872A (zh) | 2012-03-21 |
| JP2008513471A (ja) | 2008-05-01 |
| WO2006034003A2 (en) | 2006-03-30 |
| HK1105893A1 (en) | 2008-02-29 |
| NZ584773A (en) | 2012-07-27 |
| EP1802303A2 (de) | 2007-07-04 |
| EP2433634A2 (de) | 2012-03-28 |
| EP2433634A3 (de) | 2012-07-18 |
| NZ588431A (en) | 2012-02-24 |
| WO2006034003A3 (en) | 2006-07-13 |
| CA2580767A1 (en) | 2006-03-30 |
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