NO20071221L - Systemer og fremgangsmater for protein produksjon. - Google Patents

Systemer og fremgangsmater for protein produksjon.

Info

Publication number
NO20071221L
NO20071221L NO20071221A NO20071221A NO20071221L NO 20071221 L NO20071221 L NO 20071221L NO 20071221 A NO20071221 A NO 20071221A NO 20071221 A NO20071221 A NO 20071221A NO 20071221 L NO20071221 L NO 20071221L
Authority
NO
Norway
Prior art keywords
cells
protein
interest
systems
polypeptide
Prior art date
Application number
NO20071221A
Other languages
English (en)
Inventor
Yijie Gao
Nicole M Piche
Mei Geng
Stephen H Herrmann
Xiaotian Zhong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20071221L publication Critical patent/NO20071221L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen angår systemer og metoder for å produsere proteiner av interesse. Oppfinnelsen anvender genetisk-modifiserte dyre- eller planteceller som har modifisert proteinfolding eller prosesseringskapasiteter. I ett aspekt angår oppfinnelsen genetisk-konstmerte celler omfattende én eller flere rekombinante ekspresjonskassetter som koder for (1) et protein av interesse og (2) et polypeptid som er funksjonelt i den ufoldede protein respons (UPR)-vei i cellene. Co-ekspresjon av polypeptidet øker betydelig utbyttet av proteinet av interesse i de genetisk-modifiserte cellene. I ett eksempel er de genetisk-modifiserte cellene dyreceller og det co-uttrykte polypeptidet er en komponent eller modulator i en XBPI - eller ATF6-mediert UPR-vei.
NO20071221A 2004-09-02 2007-03-06 Systemer og fremgangsmater for protein produksjon. NO20071221L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60643904P 2004-09-02 2004-09-02
PCT/US2005/031081 WO2006028889A2 (en) 2004-09-02 2005-09-01 Systems and methods for protein production

Publications (1)

Publication Number Publication Date
NO20071221L true NO20071221L (no) 2007-03-30

Family

ID=36036848

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071221A NO20071221L (no) 2004-09-02 2007-03-06 Systemer og fremgangsmater for protein produksjon.

Country Status (16)

Country Link
US (3) US7514237B2 (no)
EP (2) EP1784490B1 (no)
JP (2) JP2008511335A (no)
KR (1) KR20070053732A (no)
CN (1) CN101048509A (no)
AU (1) AU2005282746A1 (no)
BR (1) BRPI0514870A (no)
CA (1) CA2577073C (no)
CR (1) CR8927A (no)
EC (1) ECSP077295A (no)
ES (2) ES2649862T3 (no)
IL (1) IL181278A0 (no)
MX (1) MX2007002379A (no)
NO (1) NO20071221L (no)
RU (1) RU2007106442A (no)
WO (1) WO2006028889A2 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5548932B2 (ja) * 2006-09-25 2014-07-16 国立大学法人大阪大学 Ａｔｆ４および／またはｇａｄｄ３４を利用した蛋白質高生産方法
CA2726289A1 (en) 2008-05-28 2009-12-23 Bayer Healthcare Llc Methods and compositions for production of recombinant protein in hbx-expressing mammalian cells
JP2011523560A (ja) 2008-06-02 2011-08-18 ダナ−ファーバー キャンサー インスティテュート インク． Ｘｂｐ１ペプチド、ｃｄ１３８ペプチドおよびｃｓ１ペプチド
US9315565B2 (en) 2009-02-10 2016-04-19 Ucb Pharma, S.A. Method for producing protein
GB0902180D0 (en) 2009-02-10 2009-03-25 Ucb Pharma Sa Method for producing protein
WO2010151827A1 (en) * 2009-06-25 2010-12-29 Bayer Healthcare Llc X-box binding proteins (xbp-1) variants and methods of using the same
TW201823460A (zh) * 2012-05-29 2018-07-01 美商再生元醫藥公司 生產細胞株增強子
CL2015003242A1 (es) 2015-11-04 2016-10-14 Univ Chile Virus aav/upr-plus, proteína de fusión upr-plus, método de tratamiento genético y su uso en el tratamiento enfermedades neurodegenerativas, tales como las enfermedades de parkinson y huntington, entre otras.
BR112020000406A2 (pt) * 2017-07-10 2022-09-13 Inst De Biologia Molecular Do Parana Ibmp Plataforma genética para superexpressão heteróloga associada à seleção de células altamente produtoras de proteínas
CN107858378B (zh) * 2017-11-20 2020-11-10 中国科学院生物物理研究所 衰老细胞模型及其制备方法
CN110093361B (zh) * 2019-04-17 2023-05-09 拜澳泰克(沈阳)生物医学集团有限公司 一种增强基因表达的增强子多肽及其应用
AU2021350195A1 (en) 2020-09-28 2023-05-04 Vestaron Corporation Mu-diguetoxin-dc1a variant polypeptides for pest control
JP2024501662A (ja) * 2020-12-22 2024-01-15 エフ． ホフマン－ラ ロシュ アーゲー Ｘｂｐ１を標的とするオリゴヌクレオチド
WO2022235929A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
WO2023122805A1 (en) 2021-12-20 2023-06-29 Vestaron Corporation Sorbitol driven selection pressure method
WO2024026406A2 (en) 2022-07-29 2024-02-01 Vestaron Corporation Next Generation ACTX Peptides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063630A (en) 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
AU745960C (en) 1997-11-18 2003-09-18 Pioneer Hi-Bred International, Inc. A novel method for the integration of foreign DNA into eukaryoticgenomes
WO2000001835A2 (en) 1998-07-01 2000-01-13 Austrian Nordic Biotherapeutics Ag Targeted integration into chromosomes using retroviral vectors
JP2001054391A (ja) * 1998-11-13 2001-02-27 Hsp Kenkyusho:Kk 小胞体ストレス転写因子
EP1266018B1 (en) 2000-03-24 2008-05-07 Genencor International, Inc. Production of secreted proteins by recombinant eukaryotic cells
AU2003234198A1 (en) * 2002-04-22 2003-11-03 University Of Michigan Novel genes, compositions, and methods for modulating the unfolded protein response
JP4446057B2 (ja) * 2002-08-28 2010-04-07 独立行政法人理化学研究所 生体刺激存在下でのｍＲＮＡのフレームシフトを利用した蛋白質の発現方法
WO2004111194A2 (en) * 2003-06-11 2004-12-23 Biogen Idec Ma Inc. Method to increase protein production in culture

Also Published As

Publication number Publication date
US20090221035A1 (en) 2009-09-03
EP2316955B1 (en) 2017-10-04
CA2577073C (en) 2016-10-11
ES2649862T3 (es) 2018-01-16
JP5508460B2 (ja) 2014-05-28
JP2008511335A (ja) 2008-04-17
CR8927A (es) 2007-08-28
EP1784490B1 (en) 2017-11-01
KR20070053732A (ko) 2007-05-25
ECSP077295A (es) 2007-04-26
US20120322104A1 (en) 2012-12-20
AU2005282746A1 (en) 2006-03-16
BRPI0514870A (pt) 2008-06-24
JP2012161318A (ja) 2012-08-30
IL181278A0 (en) 2007-07-04
CN101048509A (zh) 2007-10-03
WO2006028889A3 (en) 2006-10-05
EP2316955A1 (en) 2011-05-04
RU2007106442A (ru) 2008-10-10
ES2653843T3 (es) 2018-02-09
WO2006028889A2 (en) 2006-03-16
US20060053502A1 (en) 2006-03-09
US8173394B2 (en) 2012-05-08
US7514237B2 (en) 2009-04-07
CA2577073A1 (en) 2006-03-16
MX2007002379A (es) 2007-04-23
EP1784490A2 (en) 2007-05-16

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