NO20064686L - Fremgangsmate for produksjon av kirale, sekundaere alkoholer - Google Patents

Fremgangsmate for produksjon av kirale, sekundaere alkoholer

Info

Publication number
NO20064686L
NO20064686L NO20064686A NO20064686A NO20064686L NO 20064686 L NO20064686 L NO 20064686L NO 20064686 A NO20064686 A NO 20064686A NO 20064686 A NO20064686 A NO 20064686A NO 20064686 L NO20064686 L NO 20064686L
Authority
NO
Norway
Prior art keywords
alkyl
formula
alcohol
secondary alcohols
haloalkyl
Prior art date
Application number
NO20064686A
Other languages
English (en)
Inventor
Thomas Dax
Michael Stanek
Peter Pochlauer
Original Assignee
Dsm Fine Chem Austria Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Fine Chem Austria Gmbh filed Critical Dsm Fine Chem Austria Gmbh
Publication of NO20064686L publication Critical patent/NO20064686L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Det er beskrevet en fremgangsmåte for fremstilling av kirale, sekundære alkoholer med formel (I), hvori A representerer en aromatisk, heterocyklisk eller alicyklisk ring eller et ringsystem med 4 til 20 C-atomer, n representerer 0, 1, 2, 3, 4 eller 5, R representerer halogen, OH og 0-beskyttende gruppe, N02, N,N-R2,R3-amin, R2 og R3 representerer C1 -C6 alkyl, fenyl eller benzyl, N,N-R2,R3 -amino-C1-C6 alkyl, C1 -C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoksy, C1-C4 alkoksykarbonyl eller CN og R1 representerer N,N-R2,R3-amin, N,N-R2,R3-amino-C1-C6 alkyl, C1-C12 alkyl, C1-C6-haloalkyl, C1-C4 alkoksykarbonyl, C1-C6 alkoksy-C1-C6 alkyl eller et C2-C5 alkylenradikal som danner et ringsystem sammen med A-radikalet. Ifølge den oppfinneriske fremgangsmåten, a) reduseres et keton med formel (II) eventuelt til den tilsvarende racemiske alkoholen av formel (III) ved hjelp av en alifatisk C1-C6-alkohol i nærvær av en overgangsmetallkatalysator og en base, og b) alkoholen med formel (III) reageres til en blanding av (R)-ester med formel (IV), hvori R4 representerer H eller C1-C5 alkyl og (S)-alkohol med formel (I) i nærvær av en forestringskatalysator og en acyldonor, hvorved (S)-alkoholen isoleres fra reaksjonsblandingen ved hjelp av krystallisering eller destillering ifølge aggregattilstanden derav.
NO20064686A 2004-03-18 2006-10-17 Fremgangsmate for produksjon av kirale, sekundaere alkoholer NO20064686L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0047104A AT500556A1 (de) 2004-03-18 2004-03-18 Verfahren zur herstellung von chiralen, sekundären alkoholen
PCT/EP2005/001977 WO2005095628A1 (de) 2004-03-18 2005-02-25 Verfahren zur herstellung von chiralen, sekundären alkoholen

Publications (1)

Publication Number Publication Date
NO20064686L true NO20064686L (no) 2006-12-18

Family

ID=34960671

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20064686A NO20064686L (no) 2004-03-18 2006-10-17 Fremgangsmate for produksjon av kirale, sekundaere alkoholer

Country Status (7)

Country Link
US (1) US20070196904A1 (no)
EP (1) EP1725674A1 (no)
JP (1) JP2007529207A (no)
CN (1) CN1934267A (no)
AT (1) AT500556A1 (no)
NO (1) NO20064686L (no)
WO (1) WO2005095628A1 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102851349A (zh) * 2012-09-27 2013-01-02 南京工业大学 同时获得两种单一手性仲醇的方法
CN105132394B (zh) * 2015-09-24 2018-03-16 中国科学院南海海洋研究所 一种脂肪酶lipase6及其编码基因和应用
CN109735582B (zh) * 2018-12-24 2022-06-21 浙江工业大学 一种脂肪酶催化在线合成环己醇类β-氨基醇衍生物的方法
CN110240538B (zh) * 2019-06-27 2022-04-22 万华化学集团股份有限公司 一种制备高碳支链仲醇的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
JP3638643B2 (ja) * 1994-10-14 2005-04-13 高砂香料工業株式会社 光学活性１−オクテン−３−オールの製造法
AU2002365968A1 (en) * 2001-11-19 2003-06-10 Merck And Co., Inc. Process for the synthesis of (r)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol and esters thereof by dynamic kinetic resolution

Also Published As

Publication number Publication date
WO2005095628A1 (de) 2005-10-13
AT500556A1 (de) 2006-01-15
US20070196904A1 (en) 2007-08-23
JP2007529207A (ja) 2007-10-25
EP1725674A1 (de) 2006-11-29
CN1934267A (zh) 2007-03-21

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