NO20062694L - Inhibitor av mutant form av KIT - Google Patents

Inhibitor av mutant form av KIT

Info

Publication number
NO20062694L
NO20062694L NO20062694A NO20062694A NO20062694L NO 20062694 L NO20062694 L NO 20062694L NO 20062694 A NO20062694 A NO 20062694A NO 20062694 A NO20062694 A NO 20062694A NO 20062694 L NO20062694 L NO 20062694L
Authority
NO
Norway
Prior art keywords
kit
inhibitor
mutant form
mutant
administered
Prior art date
Application number
NO20062694A
Other languages
English (en)
Inventor
Elisabeth Buchdunger
Doriano Fabbro
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20062694L publication Critical patent/NO20062694L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/44—Multiple drug resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Den foreliggende oppfinnelse vedrører behandling av KIT avhengige sykdommer som er karakterisert ved en mutant form av KIT hvorved KIT mutanten er identifisert og en passende inhibitor av KIT mutanten valgt fra midostaurin, vatalanib og forbindelse A er administrert.
NO20062694A 2003-11-18 2006-06-12 Inhibitor av mutant form av KIT NO20062694L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52071403P 2003-11-18 2003-11-18
PCT/EP2004/013045 WO2005049032A1 (en) 2003-11-18 2004-11-17 Inhibitors of the mutant form of kit

Publications (1)

Publication Number Publication Date
NO20062694L true NO20062694L (no) 2006-06-12

Family

ID=34619508

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062694A NO20062694L (no) 2003-11-18 2006-06-12 Inhibitor av mutant form av KIT

Country Status (28)

Country Link
US (3) US8017621B2 (no)
EP (2) EP1917965A1 (no)
JP (3) JP4762150B2 (no)
KR (1) KR101153647B1 (no)
CN (3) CN1882344A (no)
AT (1) ATE428426T1 (no)
AU (1) AU2004290902B2 (no)
BR (1) BRPI0416680A (no)
CA (1) CA2546189C (no)
CY (1) CY1110354T1 (no)
DE (1) DE602004020654D1 (no)
DK (1) DK1686997T3 (no)
ES (1) ES2324917T3 (no)
HK (1) HK1093680A1 (no)
HR (1) HRP20090390T1 (no)
IL (2) IL175578A (no)
MA (1) MA28176A1 (no)
MX (1) MXPA06005598A (no)
NO (1) NO20062694L (no)
NZ (1) NZ547195A (no)
PL (1) PL1686997T3 (no)
PT (1) PT1686997E (no)
RU (2) RU2362562C2 (no)
SG (1) SG139747A1 (no)
SI (1) SI1686997T1 (no)
TN (1) TNSN06138A1 (no)
WO (1) WO2005049032A1 (no)
ZA (1) ZA200603905B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324604B (en) 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
JP4762150B2 (ja) 2003-11-18 2011-08-31 ノバルティス アーゲー Ｋｉｔの変異体の阻害剤
CN101010082A (zh) * 2004-08-31 2007-08-01 诺瓦提斯公司 米哚妥林用于治疗胃肠道基质瘤的用途
PL1879585T3 (pl) * 2005-05-02 2013-08-30 Novartis Ag Zastosowanie pochodnych pirymidyloaminobenzamidowych do leczenia mastocytozy układowej
CA2606068C (en) * 2005-05-02 2013-10-29 Novartis Ag Pyrimidylaminobenzamide derivatives for hypereosinophilic syndrome
CN101267837B (zh) * 2005-07-20 2010-12-15 彼得·瓦伦特 用于治疗系统性肥大细胞增生症的组合物
GT200600315A (es) * 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
RU2450814C2 (ru) * 2005-12-06 2012-05-20 Новартис Аг Производные пиримидиламинобензамида, предназначенные для лечения нейрофиброматоза
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
KR101579993B1 (ko) * 2008-01-23 2015-12-23 노파르티스 아게 이마티닙을 이용한 티로신 키나제 수용체 ｋｉｔ에 의해 매개되는 증식성 질환의 치료를 최적화하는 방법
EP3076966A2 (en) * 2013-12-02 2016-10-12 BerGenBio AS Use of kinase inhibitors
CN106188028A (zh) * 2015-05-05 2016-12-07 天津国际生物医药联合研究院 含恶二唑杂环类化合物及其制备方法和应用
WO2018014520A1 (zh) * 2016-07-18 2018-01-25 嘉兴雅康博医学检验所有限公司 用于检测c-kit基因突变的引物、探针及试剂盒
CN116808044A (zh) 2018-06-15 2023-09-29 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
TW202039862A (zh) * 2018-11-12 2020-11-01 美商藍印藥品公司 受體酪氨酸激酶(kit)基因突變
US20210308133A1 (en) * 2020-04-06 2021-10-07 The Board Of Regents Of The University Of Texas System Methods and compositions for inhibiting muscle wasting

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US5093330A (en) 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (no) 1992-04-03 1994-06-21 Ciba Geigy Ag
CA2148931A1 (en) 1993-10-01 1995-04-13 Jurg Zimmermann Pyrimidineamine derivatives and processes for the preparation thereof
US5543520A (en) 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
EP0723533A1 (en) * 1993-10-12 1996-07-31 The Du Pont Merck Pharmaceutical Company 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
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US6815791B1 (en) * 1997-02-10 2004-11-09 Fillfactory Buried, fully depletable, high fill factor photodiodes
CO4950519A1 (es) 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
GB2325934A (en) 1997-06-03 1998-12-09 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
WO1998055152A1 (en) 1997-06-06 1998-12-10 Baylor College Of Medicine The mast cell secretory machine as a target for anti-allergy drug development
US5874603A (en) 1997-07-15 1999-02-23 Gelest, Inc. Branched higher alkylsilanes
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
ES2326500T3 (es) 1997-11-13 2009-10-13 Mowycal Lending, Llc Pequeños peptidos y metodos para el tratamiento del asma y la inflamacion.
US20040157855A1 (en) * 2001-04-05 2004-08-12 Michael Heinrich Use of n-phenyl-2-pyrimidineamine derivativea against mast cell-based diseases like allergic disorders
US20050054617A1 (en) 2001-06-29 2005-03-10 Alain Moussy Use of potent, selective and non toxic c-kit inhibitors for treating mastocytosis
TWI315982B (en) 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
US20050095237A1 (en) 2001-12-11 2005-05-05 Emtage Peter C. Methods of therapy and diagnosis using targeting of cells that express P2Y10
US20050118600A1 (en) * 2002-03-13 2005-06-02 Yuko Aoki Method for selecting drug sensitivity-determining factors and method for predicting drug sensitivity using the selected factors
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0223341D0 (en) 2002-10-08 2002-11-13 Groningen Acad Ziekenhuis Organic compounds
TWI324604B (en) 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
ATE489109T1 (de) * 2003-09-19 2010-12-15 Novartis Pharma Gmbh Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin
JP4762150B2 (ja) 2003-11-18 2011-08-31 ノバルティス アーゲー Ｋｉｔの変異体の阻害剤
PL1879585T3 (pl) 2005-05-02 2013-08-30 Novartis Ag Zastosowanie pochodnych pirymidyloaminobenzamidowych do leczenia mastocytozy układowej
CN200998572Y (zh) * 2007-01-29 2008-01-02 深圳市龙岗区坪山宽富高尔夫器具厂 可携带配件的高尔夫球杆头套
JP5448036B2 (ja) * 2009-02-18 2014-03-19 トヨタ自動車株式会社 カルボン酸の製造方法

Also Published As

Publication number Publication date
JP4762150B2 (ja) 2011-08-31
MA28176A1 (fr) 2006-09-01
EP1686997B1 (en) 2009-04-15
US8124611B2 (en) 2012-02-28
HRP20090390T1 (hr) 2009-08-31
DK1686997T3 (da) 2009-07-27
US20120157441A1 (en) 2012-06-21
RU2405553C1 (ru) 2010-12-10
US20100179179A1 (en) 2010-07-15
DE602004020654D1 (de) 2009-05-28
IL175578A0 (en) 2008-04-13
RU2362562C2 (ru) 2009-07-27
PL1686997T3 (pl) 2009-09-30
WO2005049032A1 (en) 2005-06-02
JP2013241438A (ja) 2013-12-05
ATE428426T1 (de) 2009-05-15
IL175578A (en) 2013-10-31
TNSN06138A1 (fr) 2007-11-15
MXPA06005598A (es) 2006-08-11
SI1686997T1 (sl) 2009-08-31
RU2009110449A (ru) 2010-09-27
CN1882344A (zh) 2006-12-20
CN102274230B (zh) 2015-07-01
PT1686997E (pt) 2009-07-17
CY1110354T1 (el) 2015-04-29
ES2324917T3 (es) 2009-08-19
US20070213317A1 (en) 2007-09-13
EP1686997A1 (en) 2006-08-09
EP1917965A1 (en) 2008-05-07
US8017621B2 (en) 2011-09-13
CN101693031A (zh) 2010-04-14
CN102274230A (zh) 2011-12-14
AU2004290902A1 (en) 2005-06-02
SG139747A1 (en) 2008-02-29
NZ547195A (en) 2010-06-25
AU2004290902B2 (en) 2008-09-25
ZA200603905B (en) 2008-11-26
CA2546189C (en) 2013-04-23
BRPI0416680A (pt) 2007-02-13
IL229124A0 (en) 2013-12-31
RU2006121447A (ru) 2008-01-10
JP2007511567A (ja) 2007-05-10
CA2546189A1 (en) 2005-06-02
KR20060101761A (ko) 2006-09-26
HK1093680A1 (en) 2007-03-09
KR101153647B1 (ko) 2012-06-18
JP2011121973A (ja) 2011-06-23

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