NO20062335L - Nye diazaspiroalkaner og deres anvendelse i behandlingen av CCR8 medierte sykdommer - Google Patents
Nye diazaspiroalkaner og deres anvendelse i behandlingen av CCR8 medierte sykdommerInfo
- Publication number
- NO20062335L NO20062335L NO20062335A NO20062335A NO20062335L NO 20062335 L NO20062335 L NO 20062335L NO 20062335 A NO20062335 A NO 20062335A NO 20062335 A NO20062335 A NO 20062335A NO 20062335 L NO20062335 L NO 20062335L
- Authority
- NO
- Norway
- Prior art keywords
- diazaspiroalkanes
- treatment
- new
- mediated diseases
- ccr8 mediated
- Prior art date
Links
- 102100036305 C-C chemokine receptor type 8 Human genes 0.000 title 1
- 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302811A SE0302811D0 (sv) | 2003-10-23 | 2003-10-23 | Novel compounds |
| PCT/SE2004/001522 WO2005040167A1 (en) | 2003-10-23 | 2004-10-21 | Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062335L true NO20062335L (no) | 2006-07-19 |
Family
ID=29546627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062335A NO20062335L (no) | 2003-10-23 | 2006-05-23 | Nye diazaspiroalkaner og deres anvendelse i behandlingen av CCR8 medierte sykdommer |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070249648A1 (OSRAM) |
| EP (1) | EP1678178A1 (OSRAM) |
| JP (1) | JP2007509141A (OSRAM) |
| KR (1) | KR20060088557A (OSRAM) |
| CN (1) | CN1898239A (OSRAM) |
| AR (1) | AR046600A1 (OSRAM) |
| AU (1) | AU2004284028B2 (OSRAM) |
| BR (1) | BRPI0415613A (OSRAM) |
| CA (1) | CA2542226A1 (OSRAM) |
| IL (1) | IL174698A0 (OSRAM) |
| MX (1) | MXPA06004300A (OSRAM) |
| NO (1) | NO20062335L (OSRAM) |
| SE (1) | SE0302811D0 (OSRAM) |
| TW (1) | TW200528451A (OSRAM) |
| UY (1) | UY28572A1 (OSRAM) |
| WO (1) | WO2005040167A1 (OSRAM) |
| ZA (1) | ZA200603174B (OSRAM) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| SE0303090D0 (sv) | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
| SE0303541D0 (sv) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
| JP4845873B2 (ja) * | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| EP1869046A1 (en) * | 2005-04-04 | 2007-12-26 | AstraZeneca AB | Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases |
| US20090118318A1 (en) * | 2005-04-04 | 2009-05-07 | Stephen Connolly | Novel Diazaspiroalkanes and Their Use for Treatment of CCR8 Mediated Diseases |
| EP1869045A1 (en) * | 2005-04-04 | 2007-12-26 | AstraZeneca AB | Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases |
| GB0514018D0 (en) * | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| TW200800999A (en) * | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| EP1960382A1 (en) | 2005-11-03 | 2008-08-27 | ChemBridge Research Laboratories, Inc. | Heterocyclic compounds as tyrosine kinase modulators |
| US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
| AU2007256597A1 (en) * | 2006-06-09 | 2007-12-13 | Icos Corporation | Substituted phenyl acetic acids as DP-2 antagonists |
| JP2009543860A (ja) * | 2006-07-19 | 2009-12-10 | アストラゼネカ・アクチエボラーグ | 新規三環系スピロピペリジン化合物、それらの合成およびケモカイン受容体活性モジュレーターとしてのそれらの使用 |
| CN101541795A (zh) | 2006-09-15 | 2009-09-23 | 先灵公司 | 用于治疗疼痛、糖尿病和脂类代谢紊乱的螺-稠合氮杂环丁烷衍生物 |
| WO2008033468A2 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
| MX2009002920A (es) * | 2006-09-15 | 2009-04-01 | Schering Corp | Tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos. |
| WO2008099165A1 (en) * | 2007-02-15 | 2008-08-21 | Astrazeneca Ab | Piperidine derivatives and their use for treatment of ccr8 mediated diseases |
| US8278313B2 (en) | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
| US8436005B2 (en) | 2008-04-03 | 2013-05-07 | Abbott Laboratories | Macrocyclic pyrimidine derivatives |
| WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
| WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| US8268853B2 (en) | 2009-06-25 | 2012-09-18 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| KR101455917B1 (ko) * | 2010-03-19 | 2014-11-03 | 화이자 인코포레이티드 | 2,3-디히드로-1h-인덴-1-일-2,7-디아자스피로[3.5]노난 유도체 및 그렐린 수용체의 길항제 또는 역 작용제로서의 그 용도 |
| EP2773351B1 (en) | 2011-10-31 | 2017-08-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| GB201122113D0 (en) * | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| CN107569483B (zh) * | 2012-06-08 | 2021-09-17 | 高等教育联邦系统-匹兹堡大学 | 选自苄星青霉素化合物等的化合物在制备用于治疗炎症疾病的药物中的用途 |
| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
| ES2753163T3 (es) | 2012-09-25 | 2020-04-07 | Hoffmann La Roche | Derivados de hexahidropirrolo[3,4-c]pirrol y compuestos relacionados como inhibidores de la autotaxina (ATX) y como inhibidores de la producción de ácido lisofosfatídico (LPA) para tratar, por ejemplo, enfermedades renales |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| WO2015048567A1 (en) * | 2013-09-26 | 2015-04-02 | Sanford-Burnham Medical Research Institute | Spirocyclic ebi2 modulators |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| CA2923523A1 (en) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
| EP3119774A1 (en) * | 2014-03-17 | 2017-01-25 | reMynd NV | Oxadiazole compounds |
| SG11201607839UA (en) | 2014-03-26 | 2016-10-28 | Hoffmann La Roche | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| JP6554481B2 (ja) | 2014-03-26 | 2019-07-31 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | オートタキシン(atx)及びリゾホスファチジン酸(lpa)産生の阻害剤としての縮合[1,4]ジアゼピン化合物 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| MX382355B (es) | 2015-04-10 | 2025-03-13 | Araxes Pharma Llc | Compuestos de quinazolina sustituidos y métodos de uso de los mismos. |
| MX375424B (es) | 2015-07-31 | 2025-03-06 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| WO2017050792A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| JP6877413B2 (ja) | 2015-09-24 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二重atx/ca阻害剤としての新規な二環式化合物 |
| CA2983782A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| EP3353181B1 (en) | 2015-09-24 | 2021-08-11 | F. Hoffmann-La Roche AG | Bicyclic compounds as dual atx/ca inhibitors |
| US10975071B2 (en) | 2015-09-28 | 2021-04-13 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058792A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| WO2017058807A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| MX2018005967A (es) | 2015-11-16 | 2018-08-29 | Araxes Pharma Llc | Compuestos de quinazolina 2-sustituida que comprenden un grupo heterociclico sustituido y metodos de uso de los mismos. |
| MX2019008626A (es) | 2017-01-20 | 2019-09-19 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). |
| SG11201906427QA (en) | 2017-01-23 | 2019-08-27 | Pfizer | Heterocyclic spiro compounds as magl inhibitors |
| US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
| US11059819B2 (en) | 2017-01-26 | 2021-07-13 | Janssen Biotech, Inc. | Fused hetero-hetero bicyclic compounds and methods of use thereof |
| EP3573970A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| EP3573964A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Benzothiophene and benzothiazole compounds and methods of use thereof |
| WO2018140512A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| KR20190129924A (ko) | 2017-03-16 | 2019-11-20 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물 |
| MX2019013954A (es) | 2017-05-25 | 2020-08-31 | Araxes Pharma Llc | Inhibidores covalentes de kras. |
| JP2020521740A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | 変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体 |
| CN110156674A (zh) * | 2018-02-13 | 2019-08-23 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物 |
| KR20210045998A (ko) | 2018-08-01 | 2021-04-27 | 아락세스 파마 엘엘씨 | 헤테로사이클릭 스피로 화합물 및 암 치료를 위한 그의 사용 방법 |
| TW202024083A (zh) | 2018-09-03 | 2020-07-01 | 德商拜耳廠股份有限公司 | 3,9-二氮雜螺[5.5]十一烷化合物 |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| CN113207291A (zh) * | 2018-10-24 | 2021-08-03 | 亚瑞克西斯制药公司 | 2-(2-丙烯酰基-2,6-二氮杂螺[3.4]辛-6-基)-6-(1h-吲唑-4-基)苄腈衍生物及相关化合物作为用于抑制肿瘤转移的g12c突变kras蛋白的抑制剂 |
| CN115989223B (zh) * | 2020-07-03 | 2024-09-20 | 南京艾美斐生物医药科技有限公司 | 使用CCR8抑制剂靶向Tregs的方法和组合物 |
| BR112023015210A2 (pt) | 2021-01-29 | 2023-11-07 | Cedilla Therapeutics Inc | Inibidores de cdk2 e métodos de uso dos mesmos |
| CN117561058A (zh) | 2021-06-26 | 2024-02-13 | 塞迪拉治疗股份有限公司 | Cdk2抑制剂及其使用方法 |
| KR20240102969A (ko) * | 2021-10-13 | 2024-07-03 | 밴쿠아 바이오, 인크. | 글루코세레브로시다제 활성의 소분자 조절제 및 이의 용도 |
| AR131211A1 (es) | 2022-11-30 | 2025-02-26 | Idorsia Pharmaceuticals Ltd | Derivados de aril- y heteroaril-sulfonamida como moduladores de ccr8 |
Family Cites Families (7)
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|---|---|---|---|---|
| US4010201A (en) * | 1974-04-12 | 1977-03-01 | The Upjohn Company | Organic compounds |
| US4263317A (en) * | 1979-09-06 | 1981-04-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s |
| WO1999040070A1 (en) * | 1998-02-04 | 1999-08-12 | Banyu Pharmaceutical Co., Ltd. | N-acyl cyclic amine derivatives |
| AU2002363236A1 (en) * | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
| SE0202133D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| AU2003261415C1 (en) * | 2002-08-09 | 2010-01-14 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| US20070021498A1 (en) * | 2004-10-14 | 2007-01-25 | Nafizal Hossain | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity |
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2003
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2004
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- 2004-10-21 AU AU2004284028A patent/AU2004284028B2/en not_active Ceased
- 2004-10-21 BR BRPI0415613-7A patent/BRPI0415613A/pt not_active IP Right Cessation
- 2004-10-21 US US10/575,525 patent/US20070249648A1/en not_active Abandoned
- 2004-10-21 JP JP2006536485A patent/JP2007509141A/ja active Pending
- 2004-10-21 MX MXPA06004300A patent/MXPA06004300A/es unknown
- 2004-10-21 EP EP04793824A patent/EP1678178A1/en not_active Withdrawn
- 2004-10-21 KR KR1020067007682A patent/KR20060088557A/ko not_active Withdrawn
- 2004-10-21 WO PCT/SE2004/001522 patent/WO2005040167A1/en not_active Ceased
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| AU2004284028B2 (en) | 2008-03-06 |
| JP2007509141A (ja) | 2007-04-12 |
| SE0302811D0 (sv) | 2003-10-23 |
| CN1898239A (zh) | 2007-01-17 |
| AU2004284028A1 (en) | 2005-05-06 |
| AR046600A1 (es) | 2005-12-14 |
| US20070249648A1 (en) | 2007-10-25 |
| CA2542226A1 (en) | 2005-05-06 |
| EP1678178A1 (en) | 2006-07-12 |
| UY28572A1 (es) | 2005-05-31 |
| TW200528451A (en) | 2005-09-01 |
| BRPI0415613A (pt) | 2006-12-05 |
| KR20060088557A (ko) | 2006-08-04 |
| MXPA06004300A (es) | 2006-06-05 |
| ZA200603174B (en) | 2007-03-28 |
| IL174698A0 (en) | 2006-08-20 |
| WO2005040167A1 (en) | 2005-05-06 |
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