NO20060815L - Aryldikarboksamider - Google Patents

Aryldikarboksamider

Info

Publication number
NO20060815L
NO20060815L NO20060815A NO20060815A NO20060815L NO 20060815 L NO20060815 L NO 20060815L NO 20060815 A NO20060815 A NO 20060815A NO 20060815 A NO20060815 A NO 20060815A NO 20060815 L NO20060815 L NO 20060815L
Authority
NO
Norway
Prior art keywords
alkyl
carboxy
group
aryldicarboxamides
hydrogen
Prior art date
Application number
NO20060815A
Other languages
English (en)
Inventor
Agnes Bombrun
Dominique Swinnen
Thomas J Russel
Jean-Francois Pons
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2004/051558 external-priority patent/WO2005011685A1/en
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20060815L publication Critical patent/NO20060815L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Den foreliggende oppfinnelsen angår aryldikarboksamider med formel (I) og anvendelse derav for behandlingen og/eller forebyggingen av overvekt og/eller metabolske lidelser formidlet gjennom insulinresistens eller hyperglykemi, omfattende diabetes type I og/eller II, utilstrekkelig glukosetoleranse, insulinresistens, hyperlipidemi, hypertriglyseridemi, hyperkolesterolemi, polycystisk eggstokksyndrom (PCOS). Spesielt angår den foreliggende oppfinnelsen anvendelsen av aryldikarboksamider med formel (I) for a modulere, nærmere bestemt inhibere, aktiviteten til PTP'er. A er en aminokarbonylenhet; Cy er en aryl-, heteroaryl-, arylheteroaryl-, heteroarylaryl-, arylaryl-, sykloalkyl- eller heterosyklisk gruppe; n er enten 0 eller 1; R1 og R er uavhengig av hverandre valgt fra gruppen bestående av hydrogen eller C1-C6-alkyl; R4 og R5 er hver uavhengig av hverandre valgt fra gruppen bestående av H, hydroksy, C1-C6-alkyl, karboksy, C1-C6-alkoksy, C1-C3-alkylkarboksy, C2-C3-alkenylkarboksy, C2-C3-alkynylkarboksy, amino eller R4 og R5 kan danne en umettet eller mettet heterosyklisk ring hvorved i det minste en av R4 eller R5 ikke er hydrogen eller C1-C6-alkyl.
NO20060815A 2003-07-21 2006-02-20 Aryldikarboksamider NO20060815L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03102236 2003-07-21
US51782403P 2003-11-06 2003-11-06
PCT/EP2004/051558 WO2005011685A1 (en) 2003-07-21 2004-07-20 Aryl dicarboxamides

Publications (1)

Publication Number Publication Date
NO20060815L true NO20060815L (no) 2006-02-20

Family

ID=34117529

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060815A NO20060815L (no) 2003-07-21 2006-02-20 Aryldikarboksamider

Country Status (4)

Country Link
CY (1) CY1112175T1 (no)
HR (1) HRP20110716T1 (no)
IL (1) IL173196A0 (no)
NO (1) NO20060815L (no)

Also Published As

Publication number Publication date
IL173196A0 (en) 2006-06-11
HRP20110716T1 (hr) 2011-11-30
CY1112175T1 (el) 2015-12-09

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