NO20060815L - Aryldikarboksamider - Google Patents
AryldikarboksamiderInfo
- Publication number
- NO20060815L NO20060815L NO20060815A NO20060815A NO20060815L NO 20060815 L NO20060815 L NO 20060815L NO 20060815 A NO20060815 A NO 20060815A NO 20060815 A NO20060815 A NO 20060815A NO 20060815 L NO20060815 L NO 20060815L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- carboxy
- group
- aryldicarboxamides
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Den foreliggende oppfinnelsen angår aryldikarboksamider med formel (I) og anvendelse derav for behandlingen og/eller forebyggingen av overvekt og/eller metabolske lidelser formidlet gjennom insulinresistens eller hyperglykemi, omfattende diabetes type I og/eller II, utilstrekkelig glukosetoleranse, insulinresistens, hyperlipidemi, hypertriglyseridemi, hyperkolesterolemi, polycystisk eggstokksyndrom (PCOS). Spesielt angår den foreliggende oppfinnelsen anvendelsen av aryldikarboksamider med formel (I) for a modulere, nærmere bestemt inhibere, aktiviteten til PTP'er. A er en aminokarbonylenhet; Cy er en aryl-, heteroaryl-, arylheteroaryl-, heteroarylaryl-, arylaryl-, sykloalkyl- eller heterosyklisk gruppe; n er enten 0 eller 1; R1 og R er uavhengig av hverandre valgt fra gruppen bestående av hydrogen eller C1-C6-alkyl; R4 og R5 er hver uavhengig av hverandre valgt fra gruppen bestående av H, hydroksy, C1-C6-alkyl, karboksy, C1-C6-alkoksy, C1-C3-alkylkarboksy, C2-C3-alkenylkarboksy, C2-C3-alkynylkarboksy, amino eller R4 og R5 kan danne en umettet eller mettet heterosyklisk ring hvorved i det minste en av R4 eller R5 ikke er hydrogen eller C1-C6-alkyl.The present invention relates to aryldicarboxamides of formula (I) and their use for the treatment and / or prevention of obesity and / or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and / or II, insufficient glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridaemia, hypercholesterolemia, polycystic ovarian syndrome (PCOS). In particular, the present invention relates to the use of aryldicarboxamides of formula (I) for modulating, more specifically inhibiting, the activity of PTPs. A is an aminocarbonyl moiety; Cy is an aryl, heteroaryl, aryl heteroaryl, heteroarylaryl, arylaryl, cycloalkyl or heterocyclic group; n is either 0 or 1; R 1 and R are independently selected from the group consisting of hydrogen or C 1 -C 6 alkyl; R 4 and R 5 are each independently selected from the group consisting of H, hydroxy, C 1 -C 6 alkyl, carboxy, C 1 -C 6 alkoxy, C 1 -C 3 alkyl carboxy, C 2 -C 3 alkenyl carboxy, C 2 -C 3 alkynyl carboxy, amino or R4 and R5 may form an unsaturated or saturated heterocyclic ring whereby at least one of R4 or R5 is not hydrogen or C1-C6 alkyl.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03102236 | 2003-07-21 | ||
US51782403P | 2003-11-06 | 2003-11-06 | |
PCT/EP2004/051558 WO2005011685A1 (en) | 2003-07-21 | 2004-07-20 | Aryl dicarboxamides |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20060815L true NO20060815L (en) | 2006-02-20 |
Family
ID=34117529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20060815A NO20060815L (en) | 2003-07-21 | 2006-02-20 | Aryldikarboksamider |
Country Status (4)
Country | Link |
---|---|
CY (1) | CY1112175T1 (en) |
HR (1) | HRP20110716T1 (en) |
IL (1) | IL173196A0 (en) |
NO (1) | NO20060815L (en) |
-
2006
- 2006-01-17 IL IL173196A patent/IL173196A0/en unknown
- 2006-02-20 NO NO20060815A patent/NO20060815L/en not_active Application Discontinuation
-
2011
- 2011-10-05 HR HR20110716T patent/HRP20110716T1/en unknown
- 2011-12-29 CY CY20111101289T patent/CY1112175T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CY1112175T1 (en) | 2015-12-09 |
IL173196A0 (en) | 2006-06-11 |
HRP20110716T1 (en) | 2011-11-30 |
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Legal Events
Date | Code | Title | Description |
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CREP | Change of representative |
Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS |
|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |