NO20060554L - Fremgangsmate for fremstilling av C1-C15-fragmenter av epotiloner og derivater derav - Google Patents

Fremgangsmate for fremstilling av C1-C15-fragmenter av epotiloner og derivater derav

Info

Publication number
NO20060554L
NO20060554L NO20060554A NO20060554A NO20060554L NO 20060554 L NO20060554 L NO 20060554L NO 20060554 A NO20060554 A NO 20060554A NO 20060554 A NO20060554 A NO 20060554A NO 20060554 L NO20060554 L NO 20060554L
Authority
NO
Norway
Prior art keywords
fragments
epothilones
derivatives
fragment
preparing
Prior art date
Application number
NO20060554A
Other languages
English (en)
Norwegian (no)
Inventor
Ulrich Klar
Werner Skuballa
Wolfgang Schwede
Bernd Buchmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20060554L publication Critical patent/NO20060554L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/17Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20060554A 2003-07-03 2006-02-02 Fremgangsmate for fremstilling av C1-C15-fragmenter av epotiloner og derivater derav NO20060554L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10331004A DE10331004A1 (de) 2003-07-03 2003-07-03 Verfahren für die Herstellung von C1-C15-Fragmenten von Epothilonen und deren Derivaten
PCT/EP2004/006685 WO2005003071A1 (de) 2003-07-03 2004-06-19 Verfahren für die herstellung von c1-c15-fragmenten von epothilonen und deren derivaten

Publications (1)

Publication Number Publication Date
NO20060554L true NO20060554L (no) 2006-04-03

Family

ID=33559999

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060554A NO20060554L (no) 2003-07-03 2006-02-02 Fremgangsmate for fremstilling av C1-C15-fragmenter av epotiloner og derivater derav

Country Status (17)

Country Link
US (1) US20070142675A1 (de)
EP (1) EP1641734A1 (de)
JP (1) JP2009513498A (de)
KR (1) KR20060030102A (de)
CN (2) CN100480225C (de)
AU (1) AU2004254200A1 (de)
BR (1) BRPI0412179A (de)
CA (1) CA2531078A1 (de)
CR (1) CR8128A (de)
DE (1) DE10331004A1 (de)
EA (1) EA200600149A1 (de)
EC (1) ECSP066344A (de)
IL (1) IL172936A0 (de)
MX (1) MXPA06000172A (de)
NO (1) NO20060554L (de)
RS (1) RS20050973A (de)
WO (1) WO2005003071A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2003211A4 (de) 2006-03-28 2010-12-01 Sumitomo Chemical Co Verfahren zur herstellung von optisch aktivem (s)-7-hydroxy-6-methylheptan-2-on und einer vorstufe davon
CN101519404B (zh) * 2008-02-29 2016-01-20 唐莉 15环噻酮衍生物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969145A (en) * 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
US6204388B1 (en) * 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2273083C (en) * 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
ES2290993T3 (es) * 1997-08-09 2008-02-16 Bayer Schering Pharma Aktiengesellschaft Nuevos derivados de epotilona, proceso para su produccion y su utilizacion farmaceutica.
US7125893B1 (en) * 1999-04-30 2006-10-24 Schering Ag 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
US6518421B1 (en) * 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
US6933385B2 (en) * 2001-08-03 2005-08-23 Schering Ag Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
US20030176368A1 (en) * 2001-09-06 2003-09-18 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
DE10164592A1 (de) * 2001-12-21 2003-07-03 Schering Ag C1-C6-Epothilon-Fragmente und Verfahren für die Herstellung von C1-C6-Fragmenten von Epothilonen und deren Derivaten
EP1340498A1 (de) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Verwendung von Epothilonen zur Behandlung von mit proliferativen Prozessen assoziierten Gehirnerkrankungen

Also Published As

Publication number Publication date
CN1816514A (zh) 2006-08-09
EA200600149A1 (ru) 2006-08-25
ECSP066344A (es) 2006-08-30
US20070142675A1 (en) 2007-06-21
MXPA06000172A (es) 2006-04-27
AU2004254200A1 (en) 2005-01-13
CN101293819A (zh) 2008-10-29
DE10331004A1 (de) 2005-02-24
RS20050973A (sr) 2007-09-21
JP2009513498A (ja) 2009-04-02
KR20060030102A (ko) 2006-04-07
WO2005003071A1 (de) 2005-01-13
IL172936A0 (en) 2006-06-11
BRPI0412179A (pt) 2006-08-22
EP1641734A1 (de) 2006-04-05
CA2531078A1 (en) 2005-01-13
CN100480225C (zh) 2009-04-22
CR8128A (es) 2006-05-29

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application