CR8128A - Metodos para producir fragmentos de epotilonas c1-c15 y derivados de los mismos. - Google Patents

Metodos para producir fragmentos de epotilonas c1-c15 y derivados de los mismos.

Info

Publication number
CR8128A
CR8128A CR8128A CR8128A CR8128A CR 8128 A CR8128 A CR 8128A CR 8128 A CR8128 A CR 8128A CR 8128 A CR8128 A CR 8128A CR 8128 A CR8128 A CR 8128A
Authority
CR
Costa Rica
Prior art keywords
derivatives
epotilones
methods
same
produce fragments
Prior art date
Application number
CR8128A
Other languages
English (en)
Inventor
Klar Ulrich
Buchmann Bernd
Schwede Wolfang
Skuballa Werner
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CR8128A publication Critical patent/CR8128A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/17—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describe un procedimiento para la preparacion de fragmentos de epotilonas C1-C15 y sus derivados, en el que se une un fragmento de C1-C6 con un fragmento de C7-C12, para formar un fragmento de C1-C12y este se hace reaccionar luego con un fragmento de C12-C15 en el producto previo de epotilona C1-C15 por preparar
CR8128A 2003-07-03 2005-12-09 Metodos para producir fragmentos de epotilonas c1-c15 y derivados de los mismos. CR8128A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10331004A DE10331004A1 (de) 2003-07-03 2003-07-03 Verfahren für die Herstellung von C1-C15-Fragmenten von Epothilonen und deren Derivaten

Publications (1)

Publication Number Publication Date
CR8128A true CR8128A (es) 2006-05-29

Family

ID=33559999

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8128A CR8128A (es) 2003-07-03 2005-12-09 Metodos para producir fragmentos de epotilonas c1-c15 y derivados de los mismos.

Country Status (17)

Country Link
US (1) US20070142675A1 (es)
EP (1) EP1641734A1 (es)
JP (1) JP2009513498A (es)
KR (1) KR20060030102A (es)
CN (2) CN101293819A (es)
AU (1) AU2004254200A1 (es)
BR (1) BRPI0412179A (es)
CA (1) CA2531078A1 (es)
CR (1) CR8128A (es)
DE (1) DE10331004A1 (es)
EA (1) EA200600149A1 (es)
EC (1) ECSP066344A (es)
IL (1) IL172936A0 (es)
MX (1) MXPA06000172A (es)
NO (1) NO20060554L (es)
RS (1) RS20050973A (es)
WO (1) WO2005003071A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2003211A4 (en) 2006-03-28 2010-12-01 Sumitomo Chemical Co PROCESS FOR PRODUCING OPTICALLY ACTIVE (S) -7-HYDROXY-6-METHYLHEPTANE-2-ONE AND PRECURSOR THEREOF
CN101519404B (zh) * 2008-02-29 2016-01-20 唐莉 15环噻酮衍生物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969145A (en) * 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
EP1386922B1 (en) * 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereof, analogues and uses thereof
US6204388B1 (en) * 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP1847540A1 (de) * 1997-08-09 2007-10-24 Bayer Schering Pharma Aktiengesellschaft Neue Epothilonderivate, Herstellungsverfahren dafür und ihre pharmazeutische Verwendung
AU772750C (en) * 1999-04-30 2005-02-24 Schering Aktiengesellschaft 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
US6518421B1 (en) * 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
US6933385B2 (en) * 2001-08-03 2005-08-23 Schering Ag Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
US20030176368A1 (en) * 2001-09-06 2003-09-18 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
DE10164592A1 (de) * 2001-12-21 2003-07-03 Schering Ag C1-C6-Epothilon-Fragmente und Verfahren für die Herstellung von C1-C6-Fragmenten von Epothilonen und deren Derivaten
EP1340498A1 (en) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Use of epothilones in the treatment of brain diseases associated with proliferative processes

Also Published As

Publication number Publication date
RS20050973A (en) 2007-09-21
CN1816514A (zh) 2006-08-09
WO2005003071A1 (de) 2005-01-13
EP1641734A1 (de) 2006-04-05
CA2531078A1 (en) 2005-01-13
CN100480225C (zh) 2009-04-22
JP2009513498A (ja) 2009-04-02
EA200600149A1 (ru) 2006-08-25
CN101293819A (zh) 2008-10-29
NO20060554L (no) 2006-04-03
MXPA06000172A (es) 2006-04-27
US20070142675A1 (en) 2007-06-21
BRPI0412179A (pt) 2006-08-22
ECSP066344A (es) 2006-08-30
IL172936A0 (en) 2006-06-11
AU2004254200A1 (en) 2005-01-13
DE10331004A1 (de) 2005-02-24
KR20060030102A (ko) 2006-04-07

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