NO20060405L - Forbedrede halohydrindehalogenaser og relaterte polynukleotider - Google Patents

Forbedrede halohydrindehalogenaser og relaterte polynukleotider

Info

Publication number
NO20060405L
NO20060405L NO20060405A NO20060405A NO20060405L NO 20060405 L NO20060405 L NO 20060405L NO 20060405 A NO20060405 A NO 20060405A NO 20060405 A NO20060405 A NO 20060405A NO 20060405 L NO20060405 L NO 20060405L
Authority
NO
Norway
Prior art keywords
halohydrin
halogenases
enhanced
related polynucleotides
polypeptides
Prior art date
Application number
NO20060405A
Other languages
English (en)
Norwegian (no)
Inventor
Christopher S Davis
Gjalr W Huisman
Lisa Marie Newman
Richard John Fox
Vesna Gavrilovic
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of NO20060405L publication Critical patent/NO20060405L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20060405A 2003-08-11 2006-01-25 Forbedrede halohydrindehalogenaser og relaterte polynukleotider NO20060405L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49438203P 2003-08-11 2003-08-11
US54603304P 2004-02-18 2004-02-18
PCT/US2004/026654 WO2005017141A1 (en) 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides

Publications (1)

Publication Number Publication Date
NO20060405L true NO20060405L (no) 2006-03-10

Family

ID=34197997

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060405A NO20060405L (no) 2003-08-11 2006-01-25 Forbedrede halohydrindehalogenaser og relaterte polynukleotider

Country Status (12)

Country Link
US (3) US7824898B2 (pt)
EP (1) EP1654356A1 (pt)
JP (1) JP2007502123A (pt)
KR (1) KR20060064617A (pt)
AU (1) AU2004265693A1 (pt)
BR (1) BRPI0413501A (pt)
CA (1) CA2535255A1 (pt)
IL (1) IL173261A0 (pt)
MX (1) MXPA06001725A (pt)
NO (1) NO20060405L (pt)
SG (1) SG148180A1 (pt)
WO (1) WO2005017141A1 (pt)

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US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1660669A4 (en) 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1654356A1 (en) 2003-08-11 2006-05-10 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
EP1966385B1 (en) * 2005-12-21 2012-05-02 Basf Se A process for the production of an optically enriched tertiary alcohol
WO2007099107A1 (en) 2006-03-03 2007-09-07 Basf Se Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
KR101180239B1 (ko) 2007-03-07 2012-09-05 미츠비시 레이온 가부시키가이샤 개량형 할로하이드린 에폭시데이즈
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
CN102066561B (zh) 2008-06-13 2013-09-25 科德克希思公司 合成多核苷酸变体的方法
WO2010027710A2 (en) * 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025238A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010080635A2 (en) * 2008-12-18 2010-07-15 Codexis, Inc. Recombinant halohydrin dehalogenase polypeptides
US8293507B2 (en) 2009-02-26 2012-10-23 Codexis, Inc. Transaminase biocatalysts
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
EP2446025B1 (en) 2009-06-22 2018-08-08 Codexis, Inc. Ketoreductase-mediated stereoselective route to alpha chloroalcohols
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
EP3301208B1 (en) 2009-09-18 2020-11-04 Codexis, Inc. Reduced codon mutagenesis
CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
WO2012024104A2 (en) 2010-08-16 2012-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
US9267159B2 (en) 2010-12-08 2016-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
HUE046089T2 (hu) 2011-11-18 2020-01-28 Codexis Inc Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához
WO2013170050A1 (en) 2012-05-11 2013-11-14 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN104372038A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法
EP3068793B1 (en) 2013-11-13 2021-02-17 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP3224354B1 (en) 2014-11-25 2021-01-13 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
DK3256577T3 (da) 2015-02-10 2020-09-14 Codexis Inc Ketoreduktase polypeptider til syntesen af chirale forbindelser
CN104745557B (zh) * 2015-03-05 2017-09-22 浙江工业大学 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用
EP3093337A3 (en) 2015-05-13 2017-03-15 Samsung Electronics Co., Ltd. Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same
EP3178922B1 (en) 2015-12-07 2019-05-22 Samsung Electronics Co., Ltd. Bacterial cytochrome p450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
CN109295044A (zh) * 2018-10-26 2019-02-01 浙江大学 一种卤醇脱卤酶突变体及其应用
CA3118923A1 (en) * 2018-11-07 2020-05-14 The Royal Institution For The Advancement Of Learning/Mcgill University Testosterone-inducing peptide compounds and associated combinations
WO2024150146A1 (en) 2023-01-12 2024-07-18 Novartis Ag Engineered ketoreductase polypeptides
CN119530210B (zh) * 2024-11-12 2025-10-03 南京师范大学 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用

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EP0879890A1 (en) 1997-05-21 1998-11-25 Rijksuniversiteit te Groningen Enantioselective epoxide hydrolases and genes encoding these
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JP2003504070A (ja) 1999-07-09 2003-02-04 フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツング ケトカルボン酸及びそのエステルの還元のための方法
AU1551701A (en) 1999-12-03 2001-06-12 Kaneka Corporation Novel carbonyl reductase, gene thereof and method of using the same
EP1158054A1 (en) 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatic conversion of epoxides
CA2493941A1 (en) * 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1660669A4 (en) 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
EP1654356A1 (en) 2003-08-11 2006-05-10 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides

Also Published As

Publication number Publication date
CA2535255A1 (en) 2005-02-24
BRPI0413501A (pt) 2006-10-10
US7824898B2 (en) 2010-11-02
EP1654356A1 (en) 2006-05-10
US20100167345A1 (en) 2010-07-01
US20120208259A1 (en) 2012-08-16
AU2004265693A1 (en) 2005-02-24
IL173261A0 (en) 2006-06-11
JP2007502123A (ja) 2007-02-08
US20050153417A1 (en) 2005-07-14
US8101395B2 (en) 2012-01-24
SG148180A1 (en) 2008-12-31
WO2005017141A1 (en) 2005-02-24
MXPA06001725A (es) 2006-04-27
KR20060064617A (ko) 2006-06-13
US8535910B2 (en) 2013-09-17

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