NO20060141L - Substituerte 3-alkyl- og 3-alkenylazetidinderivater - Google Patents

Substituerte 3-alkyl- og 3-alkenylazetidinderivater

Info

Publication number
NO20060141L
NO20060141L NO20060141A NO20060141A NO20060141L NO 20060141 L NO20060141 L NO 20060141L NO 20060141 A NO20060141 A NO 20060141A NO 20060141 A NO20060141 A NO 20060141A NO 20060141 L NO20060141 L NO 20060141L
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NO
Norway
Prior art keywords
treatment
disorders
useful
compounds
schizophrenia
Prior art date
Application number
NO20060141A
Other languages
English (en)
Inventor
Robert K Baker
Jianming Bao
Shouwu Miao
Kathleen M Rupprecht
Original Assignee
Merck & Co Inc
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Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20060141L publication Critical patent/NO20060141L/no

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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P25/06—Antimigraine agents
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Nye forbindelser med strukturformel (I) er. antagonister og/eller omvendte agonister av cannabinoid-1 (CBl)-reseptoren og er anvendelige ved behandling, forebygging og demping av sykdommer som er mediert av CB1-reseptoren.Forbindelsene ifølge foreliggende oppfinnelse er. anvendelige som sentraltvirkende legemidler ved behandling av psykose, hukommelsessvikt,. kognitive forstyrrelser, migrene, nevropati, nevroinflammatoriske lidelser, inkludert multippel sklerose og Guillain-Barre-syndrom og det inflammatoriske sekvele ved viral encefalitt, cerebrale vaskulære hendelser og hodeskade, angstlidelser, stress, epilepsi, Parkinsons' sykdom, bevegelsesforstyrrelser og schizofreni. Forbindelsene er også anvendelige for behandling av stoffmisbruklidelser, behandling av fedme eller spiseforstyrrelser, så vel som ved behandling av astma, konstipasjon, kronisk intestinal pseudoobstruksion oe levercirrhose.
NO20060141A 2003-06-11 2006-01-10 Substituerte 3-alkyl- og 3-alkenylazetidinderivater NO20060141L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47785003P 2003-06-11 2003-06-11
PCT/US2004/018348 WO2005000809A1 (en) 2003-06-11 2004-06-09 Substituted 3-alkyl and 3-alkenyl azetidine derivatives

Publications (1)

Publication Number Publication Date
NO20060141L true NO20060141L (no) 2006-03-13

Family

ID=33551769

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060141A NO20060141L (no) 2003-06-11 2006-01-10 Substituerte 3-alkyl- og 3-alkenylazetidinderivater

Country Status (20)

Country Link
US (2) US7485732B2 (no)
EP (1) EP1636181A1 (no)
JP (3) JP3939744B2 (no)
KR (1) KR20060019587A (no)
CN (1) CN1802351A (no)
AU (1) AU2004252109B2 (no)
BR (1) BRPI0411131A (no)
CA (1) CA2527933C (no)
CO (1) CO5650244A2 (no)
EC (1) ECSP056207A (no)
IL (1) IL172417A0 (no)
IS (1) IS8146A (no)
MA (1) MA27847A1 (no)
MX (1) MXPA05013583A (no)
NO (1) NO20060141L (no)
NZ (1) NZ543451A (no)
RU (1) RU2006100298A (no)
UA (1) UA83230C2 (no)
WO (1) WO2005000809A1 (no)
ZA (1) ZA200509019B (no)

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GB0117387D0 (en) 2001-07-17 2001-09-05 Novartis Ag Organic compounds
FR2829028B1 (fr) 2001-08-29 2004-12-17 Aventis Pharma Sa Association d'un antagoniste du recepteur cb1 et d'un produit qui active la neurotransmission dopaminergique dans le cerveau, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de
FR2829027A1 (fr) 2001-08-29 2003-03-07 Aventis Pharma Sa Association avec un antagoniste du recepteur cb1, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de parkinson
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NZ543016A (en) 2003-05-01 2009-03-31 Vernalis Res Ltd Azetidinecarboxamide derivatives and their use in the treatment of CB1 receptor mediated disorders
BRPI0411131A (pt) * 2003-06-11 2006-07-18 Merck & Co Inc composto, método de tratar uma doença mediada pelo receptor de canabinóide 1, método de previnir a obesidade de uma pessoa com risco de obesidade, composição, e, uso de um composto
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RU2006100298A (ru) 2006-05-10
AU2004252109A1 (en) 2005-01-06
AU2004252109B2 (en) 2010-04-08
KR20060019587A (ko) 2006-03-03
CA2527933C (en) 2009-08-11
JP3939744B2 (ja) 2007-07-04
IL172417A0 (en) 2006-04-10
CA2527933A1 (en) 2005-01-06
ZA200509019B (en) 2006-11-29
NZ543451A (en) 2008-08-29
US7906503B2 (en) 2011-03-15
CN1802351A (zh) 2006-07-12
MXPA05013583A (es) 2006-03-09
CO5650244A2 (es) 2006-06-30
JP2007186518A (ja) 2007-07-26
US20060293299A1 (en) 2006-12-28
UA83230C2 (ru) 2008-06-25
EP1636181A1 (en) 2006-03-22
US7485732B2 (en) 2009-02-03
JP2007500246A (ja) 2007-01-11
JP2011144196A (ja) 2011-07-28
ECSP056207A (es) 2006-04-19
US20090069284A1 (en) 2009-03-12
BRPI0411131A (pt) 2006-07-18
MA27847A1 (fr) 2006-04-03

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