NO20055708L - Syntetisk gen som koder for humant karsinembryonalt antigen og anvendelser derav - Google Patents

Syntetisk gen som koder for humant karsinembryonalt antigen og anvendelser derav

Info

Publication number
NO20055708L
NO20055708L NO20055708A NO20055708A NO20055708L NO 20055708 L NO20055708 L NO 20055708L NO 20055708 A NO20055708 A NO 20055708A NO 20055708 A NO20055708 A NO 20055708A NO 20055708 L NO20055708 L NO 20055708L
Authority
NO
Norway
Prior art keywords
cea
gene encoding
embryonic antigen
encoding human
synthetic gene
Prior art date
Application number
NO20055708A
Other languages
English (en)
Other versions
NO20055708D0 (no
Inventor
Nicola La Monica
Armin Lahm
Carmela Mennuni
Rocco Savino
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of NO20055708D0 publication Critical patent/NO20055708D0/no
Publication of NO20055708L publication Critical patent/NO20055708L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Syntetiske polynukleotider som koder for himiant karsinoembryonalt antigen (CEA) bhr tilveiebrakt, der de syntetiske polynukleotidene er kodonoptimaliserte for uttrykking i et himiant cellulært miljø. Genet som koder for CEA er vanligvis assosiert med utviklingen av humane karsinomer. Foreliggende oppfirmelse tilveiebringer preparater og fremgangsmåter for å utløse eller forbedre immunitet ovenfor proteinproduktet som er uttrykt fra det CEA-tumorassosierte antigenet, der forstyrret CEA uttrykking er assosiert med et karsinom eller dets utvikling. Derme oppfirmelsen tilveiebringer spesifikt adenovirusvektor- og plasmidkonstruksjoner som bærer kodonoptimalisert human CEA og tilkjermegir deres anvendelse i vaksiner og farmasøytiske preparater for å forebygge eller behandle kreft.
NO20055708A 2003-05-05 2005-12-02 Syntetisk gen som koder for humant karsinembryonalt antigen og anvendelser derav NO20055708L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46797103P 2003-05-05 2003-05-05
US54361204P 2004-02-11 2004-02-11
PCT/EP2004/004802 WO2004099247A2 (en) 2003-05-05 2004-05-03 Synthetic gene encoding human carcinoembryonic antigen and uses thereof

Publications (2)

Publication Number Publication Date
NO20055708D0 NO20055708D0 (no) 2005-12-02
NO20055708L true NO20055708L (no) 2006-02-06

Family

ID=33436748

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055708A NO20055708L (no) 2003-05-05 2005-12-02 Syntetisk gen som koder for humant karsinembryonalt antigen og anvendelser derav

Country Status (12)

Country Link
US (1) US20070104685A1 (no)
EP (1) EP1622937A2 (no)
JP (1) JP2007523610A (no)
KR (1) KR20060003903A (no)
CN (1) CN1784424A (no)
AU (1) AU2004235943A1 (no)
CA (1) CA2523720A1 (no)
IS (1) IS8053A (no)
NO (1) NO20055708L (no)
NZ (1) NZ543922A (no)
RU (1) RU2005137697A (no)
WO (1) WO2004099247A2 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1658370A1 (en) * 2003-08-22 2006-05-24 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Synthetic gene encoding rhesus monkey carcinoembryonic antigen and uses thereof
EP1716173B8 (en) * 2004-02-11 2012-06-27 Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. Carcinoembryonic antigen fusion protein and uses thereof
JP4881623B2 (ja) 2006-01-27 2012-02-22 シスメックス株式会社 Ｃｅａ核酸増幅用プライマー、プライマーセット、及びがんの診断支援方法
WO2007090596A1 (en) * 2006-02-06 2007-08-16 Medizinische Universität Wien Vaccine and antigen mimotopes against cancerous diseases associated with the carcinoembryonic antigen cea
EP3061462B1 (en) 2007-07-02 2019-02-27 Etubics Corporation Methods and compositions for producing an adenovirus vector for use with multiple vaccinations
US7994276B2 (en) * 2007-07-27 2011-08-09 Immatics Biotechnologies Gmbh Composition of tumour-associated peptides and related anti-cancer vaccine
WO2009117656A2 (en) * 2008-03-21 2009-09-24 Vectorlogics,Inc. Capsid-incorporated antigen for novel adenovirus vaccine
KR101815322B1 (ko) * 2010-01-12 2018-01-05 서울대학교산학협력단 항암 펩타이드 서열
US9605276B2 (en) * 2012-08-24 2017-03-28 Etubics Corporation Replication defective adenovirus vector in vaccination
JP6647315B2 (ja) 2015-01-09 2020-02-14 イーチュービクス コーポレイション 組み合わせ免疫療法のための方法および組成物
CN107530383A (zh) 2015-01-09 2018-01-02 埃图比克斯公司 用于埃博拉病毒疫苗接种的方法和组合物
US11149087B2 (en) 2015-04-20 2021-10-19 Etubics Corporation Methods and compositions for combination immunotherapy
US20210388383A1 (en) * 2018-10-12 2021-12-16 Children's Hospital Medical Center Modular expression systems for gene expression and methods of using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795737A (en) * 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
DE10055545A1 (de) * 2000-11-09 2002-07-25 Deutsches Krebsforsch Für Expression in Eukaryonten optimierte HPV 16-L1 und HPV 16-L2 kodierende DNA Sequenzen

Also Published As

Publication number Publication date
NZ543922A (en) 2008-05-30
NO20055708D0 (no) 2005-12-02
RU2005137697A (ru) 2006-05-10
WO2004099247A3 (en) 2005-02-24
CA2523720A1 (en) 2004-11-18
US20070104685A1 (en) 2007-05-10
EP1622937A2 (en) 2006-02-08
IS8053A (is) 2005-09-29
AU2004235943A1 (en) 2004-11-18
KR20060003903A (ko) 2006-01-11
WO2004099247A2 (en) 2004-11-18
JP2007523610A (ja) 2007-08-23
CN1784424A (zh) 2006-06-07

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