NO20053592L - Vann opploslige fenylpyridazinderivater og medikamenter inneholdende disse. - Google Patents
Vann opploslige fenylpyridazinderivater og medikamenter inneholdende disse.Info
- Publication number
- NO20053592L NO20053592L NO20053592A NO20053592A NO20053592L NO 20053592 L NO20053592 L NO 20053592L NO 20053592 A NO20053592 A NO 20053592A NO 20053592 A NO20053592 A NO 20053592A NO 20053592 L NO20053592 L NO 20053592L
- Authority
- NO
- Norway
- Prior art keywords
- water soluble
- drugs containing
- phenylpyridazine derivatives
- derivatives
- salt
- Prior art date
Links
- XWSSUYOEOWLFEI-UHFFFAOYSA-N 3-phenylpyridazine Chemical class C1=CC=CC=C1C1=CC=CN=N1 XWSSUYOEOWLFEI-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000015696 Interleukins Human genes 0.000 abstract 1
- 108010063738 Interleukins Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Et fenylpyridazin-derivat representert ved den generelle formel (1): (hvor, R1, R2, R3, X, Y, Z og n har samme betydning som definert i beskrivelsen); eller et salt derav og en medisin inneholdende derivatet eller saltet. Fenylpyridazin-derivatet har utmerket hemmende aktivitet mot interleukin-p-produksjon, og har høy vannoppløselighet og høy oral absorberbarhet
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003073403 | 2003-03-18 | ||
PCT/JP2004/003487 WO2004083188A1 (ja) | 2003-03-18 | 2004-03-16 | 水溶性フェニルピリダジン誘導体及びこれを含有する医薬 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20053592D0 NO20053592D0 (no) | 2005-07-25 |
NO20053592L true NO20053592L (no) | 2005-11-30 |
Family
ID=33027793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20053592A NO20053592L (no) | 2003-03-18 | 2005-07-25 | Vann opploslige fenylpyridazinderivater og medikamenter inneholdende disse. |
Country Status (13)
Country | Link |
---|---|
US (1) | US7211577B2 (no) |
EP (1) | EP1604984A1 (no) |
JP (1) | JPWO2004083188A1 (no) |
KR (1) | KR20050113627A (no) |
CN (1) | CN1759103A (no) |
AU (1) | AU2004221966A1 (no) |
BR (1) | BRPI0408359A (no) |
CA (1) | CA2518227A1 (no) |
MX (1) | MXPA05009972A (no) |
NO (1) | NO20053592L (no) |
RU (1) | RU2005132167A (no) |
TW (1) | TW200510335A (no) |
WO (1) | WO2004083188A1 (no) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
WO2007049732A1 (ja) * | 2005-10-28 | 2007-05-03 | Kowa Co., Ltd. | 関節リウマチの予防及び/又は治療法 |
BR112015018663A2 (pt) * | 2013-02-07 | 2017-07-18 | Merck Patent Gmbh | derivados de piridazinona-amidas |
JP6267729B2 (ja) * | 2013-02-07 | 2018-01-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 大環状ピリダジノン誘導体 |
FR3103701B1 (fr) * | 2019-11-28 | 2021-11-26 | Inst Nat Sante Rech Med | Composés de typen2-arylméthyl-4-haloalkyl-pyridazin-3-one et leur utilisation |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR206496A1 (es) | 1972-07-03 | 1976-07-30 | Riker Laboratories Inc | Procedimiento para la preparacion de 2-fenoxi-4-nitro-alquil o haloalquilsulfonanilidas |
JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
FI91062C (fi) | 1988-12-28 | 1994-05-10 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisten naftaleenijohdannaisten valmistamiseksi |
IL104369A0 (en) | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
DE69408598T2 (de) | 1993-06-08 | 1998-09-17 | Vertex Pharmaceuticals Inc Cam | Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren |
EP0871444A4 (en) | 1995-08-10 | 1999-01-13 | Merck & Co Inc | 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF |
ATE271547T1 (de) | 1997-03-14 | 2004-08-15 | Merck Frosst Canada Inc | Pyridazinone als inhibitoren von cyclooxygenase-2 |
DK1005460T3 (da) | 1997-08-22 | 2006-07-10 | Abbott Lab | Inhibitorer af biosyntesen af prostaglandin-endoperoxid H-synthase |
WO1999010331A1 (en) | 1997-08-22 | 1999-03-04 | Abbott Laboratories | Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors |
EP2017266A1 (en) * | 1997-11-19 | 2009-01-21 | Kowa Co., Ltd. | Pyridazine derivatives and medicines containing the same as effective ingredients |
TWI241295B (en) * | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
BR9914858A (pt) | 1998-10-27 | 2002-02-05 | Abbott Lab | Inibidores de biosìntese sintase h de endoperóxido de prostaglandina |
JP2000247959A (ja) * | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
US6861428B2 (en) * | 2001-09-26 | 2005-03-01 | Kowa Co., Ltd. | Water-soluble phenylpyridazine compounds and compositions containing the same |
PL368340A1 (en) * | 2001-09-26 | 2005-03-21 | Kowa Co, Ltd. | Water-soluble phenylpyridazine derivatives and drugs containing the same |
AU2004218161B9 (en) | 2003-03-07 | 2009-11-26 | Kowa Co., Ltd. | Benzofuran derivative |
-
2004
- 2004-03-16 MX MXPA05009972A patent/MXPA05009972A/es not_active Application Discontinuation
- 2004-03-16 JP JP2005503698A patent/JPWO2004083188A1/ja active Pending
- 2004-03-16 KR KR1020057016226A patent/KR20050113627A/ko not_active Application Discontinuation
- 2004-03-16 RU RU2005132167/04A patent/RU2005132167A/ru unknown
- 2004-03-16 AU AU2004221966A patent/AU2004221966A1/en not_active Abandoned
- 2004-03-16 WO PCT/JP2004/003487 patent/WO2004083188A1/ja active Application Filing
- 2004-03-16 CA CA002518227A patent/CA2518227A1/en not_active Abandoned
- 2004-03-16 CN CNA200480006774XA patent/CN1759103A/zh active Pending
- 2004-03-16 EP EP04721008A patent/EP1604984A1/en not_active Withdrawn
- 2004-03-16 US US10/544,881 patent/US7211577B2/en not_active Expired - Fee Related
- 2004-03-16 BR BRPI0408359-8A patent/BRPI0408359A/pt not_active IP Right Cessation
- 2004-03-18 TW TW093107278A patent/TW200510335A/zh unknown
-
2005
- 2005-07-25 NO NO20053592A patent/NO20053592L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA05009972A (es) | 2005-11-04 |
TW200510335A (en) | 2005-03-16 |
BRPI0408359A (pt) | 2006-03-21 |
US20060142292A1 (en) | 2006-06-29 |
WO2004083188A1 (ja) | 2004-09-30 |
US7211577B2 (en) | 2007-05-01 |
CN1759103A (zh) | 2006-04-12 |
JPWO2004083188A1 (ja) | 2006-06-22 |
NO20053592D0 (no) | 2005-07-25 |
EP1604984A1 (en) | 2005-12-14 |
AU2004221966A1 (en) | 2004-09-30 |
RU2005132167A (ru) | 2006-05-10 |
CA2518227A1 (en) | 2004-09-30 |
KR20050113627A (ko) | 2005-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |