BR9914858A - Inibidores de biosìntese sintase h de endoperóxido de prostaglandina - Google Patents
Inibidores de biosìntese sintase h de endoperóxido de prostaglandinaInfo
- Publication number
- BR9914858A BR9914858A BR9914858-7A BR9914858A BR9914858A BR 9914858 A BR9914858 A BR 9914858A BR 9914858 A BR9914858 A BR 9914858A BR 9914858 A BR9914858 A BR 9914858A
- Authority
- BR
- Brazil
- Prior art keywords
- cox
- inhibitors
- cyclooxygenase
- kidneys
- biosynthesis inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 4
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 4
- 108010037464 Cyclooxygenase 1 Proteins 0.000 abstract 2
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 abstract 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 2
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 2
- 108010029485 Protein Isoforms Proteins 0.000 abstract 2
- 210000003734 kidney Anatomy 0.000 abstract 2
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17960598A | 1998-10-27 | 1998-10-27 | |
US26187299A | 1999-03-03 | 1999-03-03 | |
US29849099A | 1999-04-23 | 1999-04-23 | |
PCT/US1999/025234 WO2000024719A1 (en) | 1998-10-27 | 1999-10-27 | Prostaglandin endoperoxide h synthase biosynthesis inhibitors |
US09/427,768 US6307047B1 (en) | 1997-08-22 | 1999-10-27 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914858A true BR9914858A (pt) | 2002-02-05 |
Family
ID=27497355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914858-7A BR9914858A (pt) | 1998-10-27 | 1999-10-27 | Inibidores de biosìntese sintase h de endoperóxido de prostaglandina |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1124804B1 (pt) |
JP (1) | JP2003512292A (pt) |
KR (1) | KR100666838B1 (pt) |
CN (1) | CN1279026C (pt) |
AT (1) | ATE302759T1 (pt) |
BG (1) | BG65261B1 (pt) |
BR (1) | BR9914858A (pt) |
CA (1) | CA2347982A1 (pt) |
CZ (1) | CZ300570B6 (pt) |
DE (1) | DE69926903T2 (pt) |
DK (1) | DK1124804T3 (pt) |
ES (1) | ES2249919T3 (pt) |
HK (1) | HK1041876B (pt) |
HU (1) | HUP0105248A3 (pt) |
NO (1) | NO318623B1 (pt) |
PL (1) | PL198503B1 (pt) |
SK (1) | SK286806B6 (pt) |
TR (1) | TR200101765T2 (pt) |
WO (1) | WO2000024719A1 (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2324126T3 (es) | 1997-11-19 | 2009-07-30 | Kowa Co., Ltd. | Derivados de piridazina y medicamentos que los contienen como ingrediente activo. |
TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
JP2000247959A (ja) | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
US6716829B2 (en) | 2000-07-27 | 2004-04-06 | Pharmacia Corporation | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders |
AR031129A1 (es) | 2000-09-15 | 2003-09-10 | Pharmacia Corp | Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa |
TWI290130B (en) | 2000-09-15 | 2007-11-21 | Pharmacia Corp | 2-Amino-2alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors |
US7012098B2 (en) | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
DE10129320A1 (de) | 2001-06-19 | 2003-04-10 | Norbert Mueller | Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen |
GEP20063937B (en) | 2002-02-14 | 2006-10-10 | Pharmacia Corp | Substituted pyridinones as modulators of p38 map kinase |
ES2341240T3 (es) | 2002-12-13 | 2010-06-17 | Warner-Lambert Company Llc | Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior. |
US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
KR20050113627A (ko) | 2003-03-18 | 2005-12-02 | 코와 가부시키가이샤 | 수용성 페닐피리다진 유도체 및 이를 함유하는 의약 |
JP4354984B2 (ja) | 2003-05-07 | 2009-10-28 | オステオロジックス エイ/エス | 水溶性ストロンチウム塩を用いる軟骨/骨症状の治療 |
ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
EP1916240A1 (en) * | 2006-10-25 | 2008-04-30 | Syngeta Participations AG | Pyridazine derivatives |
CN101600458A (zh) | 2006-12-22 | 2009-12-09 | 瑞蔻达蒂爱尔兰有限公司 | 采用α2δ配体和NSAID的下泌尿道疾病的联合治疗 |
DE102007008840A1 (de) | 2007-02-23 | 2008-08-28 | Bayer Healthcare Ag | Neue polymorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-methyl-1-butoxy)-5-[4-methylsulfonyl)phenyl]-3(2H)-pyridazinon (FHMP) |
DE102007008839A1 (de) * | 2007-02-23 | 2008-08-28 | Bayer Healthcare Ag | Verfahren zur Herstellung von 4-(3-Hydroxy-3-methyl-butoxy)-5-[4-(methylsulfonyl)phenyl]-2-arylpyridazin-3(2H)-onen |
DE102007008843A1 (de) | 2007-02-23 | 2008-08-28 | Bayer Healthcare Ag | Verfahren zur Herstellung von 4,5-Dihalogen-2-aryl-2H-pyridazin-3-onen |
DE102007020689A1 (de) * | 2007-05-03 | 2008-11-06 | Bayer Healthcare Ag | Neue polymorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-methyl-1-butoxy-5-[4-methylsulfonyl)phenyl]3/2H)-pyridazinon (FHMP) |
DE102007020690A1 (de) | 2007-05-03 | 2008-11-06 | Bayer Healthcare Ag | Neue amorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-mehtyl-1-butoxy)-6[4-methylsulfonyl)phenyl]-3(2H)-pyridazinon (FHMP) |
DE102007025717A1 (de) * | 2007-06-01 | 2008-12-11 | Merck Patent Gmbh | Arylether-pyridazinonderivate |
GB0716414D0 (en) * | 2007-08-22 | 2007-10-03 | Syngenta Participations Ag | Novel insecticides |
CA2691782A1 (en) | 2007-09-11 | 2009-03-19 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole n-oxides |
GB0903493D0 (en) | 2009-02-27 | 2009-04-08 | Vantia Ltd | New compounds |
JP2012131708A (ja) * | 2009-04-28 | 2012-07-12 | Nissan Chem Ind Ltd | 4位置換ピリダジノン化合物及びp2x7受容体阻害剤 |
FR2969606B1 (fr) * | 2010-12-22 | 2013-01-11 | Pf Medicament | Derives de diarylpyridazinones, leur preparation et leur application en therapeutique humaine |
JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
CN107334767B (zh) * | 2017-06-08 | 2019-03-05 | 中国医学科学院医药生物技术研究所 | 一种哒嗪酮类化合物在肿瘤治疗中的应用 |
WO2021124344A1 (en) * | 2019-12-18 | 2021-06-24 | Abida | Pyridazine derivatives and their use as cyclooxygenase-2 inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4238490A (en) * | 1979-02-12 | 1980-12-09 | Diamond Shamrock Corporation | Antihypertensive pyridazin(2H)-3-ones |
BR8108745A (pt) * | 1980-08-07 | 1982-07-06 | Diamond Shamrock Corp | Difenilpiridazinonas herbicidas e reguladores do crescimento da planta |
US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
CA2224563A1 (en) * | 1995-06-12 | 1996-12-27 | G.D. Searle & Co. | Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations |
ES2224366T3 (es) * | 1997-03-14 | 2005-03-01 | MERCK FROSST CANADA & CO. | Piridazinonas como inhibidores de ciclooxigenasa-2. |
CZ300847B6 (cs) * | 1997-08-22 | 2009-08-26 | Abbott Laboratories | Arylpyridazinony jako inhibitory biosyntézy prostaglandin endoperoxid H synthasy, jejich použití a farmaceutická kompozice s jejich obsahem |
EP1007515A1 (en) * | 1997-08-22 | 2000-06-14 | Abbott Laboratories | Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors |
WO1999010332A1 (en) * | 1997-08-22 | 1999-03-04 | Abbott Laboratories | Prostaglandin endoperoxide h synthase biosynthesis inhibitors |
-
1999
- 1999-10-27 ES ES99953259T patent/ES2249919T3/es not_active Expired - Lifetime
- 1999-10-27 WO PCT/US1999/025234 patent/WO2000024719A1/en active Application Filing
- 1999-10-27 PL PL349256A patent/PL198503B1/pl not_active IP Right Cessation
- 1999-10-27 AT AT99953259T patent/ATE302759T1/de not_active IP Right Cessation
- 1999-10-27 BR BR9914858-7A patent/BR9914858A/pt not_active IP Right Cessation
- 1999-10-27 JP JP2000578289A patent/JP2003512292A/ja not_active Ceased
- 1999-10-27 DE DE69926903T patent/DE69926903T2/de not_active Expired - Lifetime
- 1999-10-27 EP EP99953259A patent/EP1124804B1/en not_active Expired - Lifetime
- 1999-10-27 CN CNB998147265A patent/CN1279026C/zh not_active Expired - Fee Related
- 1999-10-27 HU HU0105248A patent/HUP0105248A3/hu unknown
- 1999-10-27 DK DK99953259T patent/DK1124804T3/da active
- 1999-10-27 TR TR2001/01765T patent/TR200101765T2/xx unknown
- 1999-10-27 KR KR1020017005342A patent/KR100666838B1/ko not_active IP Right Cessation
- 1999-10-27 CA CA002347982A patent/CA2347982A1/en not_active Abandoned
- 1999-10-27 CZ CZ20011481A patent/CZ300570B6/cs not_active IP Right Cessation
- 1999-10-27 SK SK554-2001A patent/SK286806B6/sk not_active IP Right Cessation
-
2001
- 2001-04-26 NO NO20012061A patent/NO318623B1/no not_active IP Right Cessation
- 2001-05-19 BG BG105523A patent/BG65261B1/bg unknown
-
2002
- 2002-02-19 HK HK02101207.5A patent/HK1041876B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20010081101A (ko) | 2001-08-27 |
EP1124804B1 (en) | 2005-08-24 |
DE69926903T2 (de) | 2006-07-13 |
ES2249919T3 (es) | 2006-04-01 |
SK5542001A3 (en) | 2001-12-03 |
DK1124804T3 (da) | 2005-12-12 |
DE69926903D1 (en) | 2005-09-29 |
WO2000024719A1 (en) | 2000-05-04 |
NO20012061L (no) | 2001-06-27 |
CN1342149A (zh) | 2002-03-27 |
TR200101765T2 (tr) | 2002-02-21 |
JP2003512292A (ja) | 2003-04-02 |
HUP0105248A2 (hu) | 2002-07-29 |
CA2347982A1 (en) | 2000-05-04 |
BG65261B1 (bg) | 2007-10-31 |
SK286806B6 (sk) | 2009-05-07 |
PL198503B1 (pl) | 2008-06-30 |
BG105523A (en) | 2001-12-29 |
NO318623B1 (no) | 2005-04-18 |
HUP0105248A3 (en) | 2002-09-30 |
NO20012061D0 (no) | 2001-04-26 |
KR100666838B1 (ko) | 2007-01-11 |
PL349256A1 (en) | 2002-07-01 |
ATE302759T1 (de) | 2005-09-15 |
CZ20011481A3 (cs) | 2001-09-12 |
HK1041876A1 (en) | 2002-07-26 |
HK1041876B (zh) | 2006-06-23 |
CN1279026C (zh) | 2006-10-11 |
EP1124804A1 (en) | 2001-08-22 |
CZ300570B6 (cs) | 2009-06-17 |
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Legal Events
Date | Code | Title | Description |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O E 11 DA LPI. |
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B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA:INT.CI.C07D 237/14, C07D 237/18, C07D 401/04, C07D 401/06, C07D 405/04, C07D 409/04, A61K 31/50, A61K 31/501, A61P 19/02, A61P 29/00 Ipc: C07D 237/14 (2011.01), A61K 31/50 (2011.01), C07D |
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B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 12A, 13A E 14A ANUIDADES. |
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B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2256 DE 01/04/2014 POR TER SIDO INDEVIDA. |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ATE A 21A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |