NO20040500L - 1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister - Google Patents
1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonisterInfo
- Publication number
- NO20040500L NO20040500L NO20040500A NO20040500A NO20040500L NO 20040500 L NO20040500 L NO 20040500L NO 20040500 A NO20040500 A NO 20040500A NO 20040500 A NO20040500 A NO 20040500A NO 20040500 L NO20040500 L NO 20040500L
- Authority
- NO
- Norway
- Prior art keywords
- receptor antagonists
- gonadotropin
- releasing hormone
- trions
- triazine
- Prior art date
Links
- 229940127445 Gonadotropin Releasing Hormone Receptor Antagonists Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
- 102000008238 LHRH Receptors Human genes 0.000 abstract 1
- 108010021290 LHRH Receptors Proteins 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000003163 gonadal steroid hormone Substances 0.000 abstract 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
-
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C07D251/34—Cyanuric or isocyanuric esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31001801P | 2001-08-02 | 2001-08-02 | |
| PCT/US2002/024451 WO2003011839A1 (en) | 2001-08-02 | 2002-08-02 | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20040500L true NO20040500L (no) | 2004-03-08 |
Family
ID=23200637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20040500A NO20040500L (no) | 2001-08-02 | 2004-01-29 | 1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6677340B2 (no) |
| EP (1) | EP1412338B1 (no) |
| JP (1) | JP4328617B2 (no) |
| KR (1) | KR20040030892A (no) |
| AT (1) | ATE316078T1 (no) |
| AU (1) | AU2002324586B2 (no) |
| CA (1) | CA2455833A1 (no) |
| DE (1) | DE60208803T2 (no) |
| ES (1) | ES2256522T3 (no) |
| MX (1) | MXPA04000984A (no) |
| NO (1) | NO20040500L (no) |
| WO (1) | WO2003011839A1 (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002324586B2 (en) * | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
| US7071200B2 (en) | 2003-07-07 | 2006-07-04 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| EA010370B1 (ru) | 2003-07-07 | 2008-08-29 | Ньюрокрайн Байосайенсиз, Инк. | Производные пиримидин-2,4-диона в качестве антагонистов рецептора гонадотропин-высвобождающего гормона |
| US7015226B2 (en) | 2003-07-07 | 2006-03-21 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| DE102004033902A1 (de) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
| GB0622472D0 (en) * | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
| CL2008000986A1 (es) | 2007-04-06 | 2008-10-17 | Neurocrine Biosciences Inc | COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV |
| NZ580457A (en) | 2007-04-06 | 2012-03-30 | Neurocrine Biosciences Inc | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| EP2095818A1 (en) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
| TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
| WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
| HUE061751T2 (hu) | 2018-02-26 | 2023-08-28 | AlzeCure Pharma AB | Triazinszármazékok neurotrofinokhoz kapcsolódó betegségek kezelésére |
| GB201810668D0 (en) | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
| GB201810669D0 (en) * | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866567A (en) | 1995-06-01 | 1999-02-02 | Takeda Chemical Industries, Ltd. | Diazepinones, their production and use |
| CZ146196A3 (en) * | 1995-06-02 | 1997-05-14 | American Cyanamid Co | 1-(3-heterocyclylphenyl)-s-triazin-2,4,6-oxo or thiotriones and herbicidal agent based thereon |
| CA2229205A1 (en) | 1995-10-19 | 1997-04-24 | Shuichi Furuya | Thienopyridine derivatives, their productions and use |
| WO1997014682A1 (en) | 1995-10-19 | 1997-04-24 | Takeda Chemical Industries, Ltd. | Quinoline derivatives as gnrh antagonists |
| WO1997021435A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US5849764A (en) | 1995-12-14 | 1998-12-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1997021703A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US5780437A (en) | 1995-12-14 | 1998-07-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EA000992B1 (ru) | 1995-12-14 | 2000-08-28 | Мерк Энд Ко., Инк. | Антагонисты гормона, высвобождающего гонадотропин |
| JP3092946B2 (ja) | 1995-12-14 | 2000-09-25 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモン拮抗剤 |
| AU3071397A (en) | 1996-05-20 | 1997-12-09 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| AU706818B2 (en) | 1996-05-20 | 1999-06-24 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP0920319A4 (en) | 1996-05-20 | 2002-05-02 | Merck & Co Inc | GONADOLIBERIN ANTAGONISTS |
| US6150352A (en) * | 1996-05-20 | 2000-11-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP0986385A4 (en) | 1997-06-05 | 2001-05-16 | Merck & Co Inc | GONADOLIBERINE ANTAGONISTS |
| CA2291647A1 (en) | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| AU7806998A (en) | 1997-06-05 | 1998-12-21 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1998055470A1 (en) | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6313301B1 (en) | 1997-08-13 | 2001-11-06 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives, their intermediates and production thereof |
| US6194419B1 (en) | 1997-12-26 | 2001-02-27 | Takeda Chemical Industries, Ltd. | Nitrogen-containing heterocyclic compounds, their production and use |
| TWI225863B (en) | 1999-03-24 | 2005-01-01 | Takeda Chemical Industries Ltd | Thienopyrimidine compounds, their production and use |
| MXPA02003614A (es) | 1999-10-15 | 2002-10-23 | Neurocrine Biosciences Inc | Antagonistas del receptor de la hormona liberadora de ganadotropina y metodos relacionados con los mismos.. |
| AU2002324586B2 (en) * | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
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2002
- 2002-08-01 AU AU2002324586A patent/AU2002324586B2/en not_active Expired - Fee Related
- 2002-08-02 ES ES02759239T patent/ES2256522T3/es not_active Expired - Lifetime
- 2002-08-02 KR KR10-2004-7001492A patent/KR20040030892A/ko not_active Application Discontinuation
- 2002-08-02 EP EP02759239A patent/EP1412338B1/en not_active Expired - Lifetime
- 2002-08-02 WO PCT/US2002/024451 patent/WO2003011839A1/en active IP Right Grant
- 2002-08-02 US US10/211,955 patent/US6677340B2/en not_active Expired - Lifetime
- 2002-08-02 AT AT02759239T patent/ATE316078T1/de not_active IP Right Cessation
- 2002-08-02 JP JP2003517031A patent/JP4328617B2/ja not_active Expired - Fee Related
- 2002-08-02 MX MXPA04000984A patent/MXPA04000984A/es not_active Application Discontinuation
- 2002-08-02 DE DE60208803T patent/DE60208803T2/de not_active Expired - Lifetime
- 2002-08-02 CA CA002455833A patent/CA2455833A1/en not_active Abandoned
-
2003
- 2003-11-10 US US10/705,723 patent/US20040162290A1/en not_active Abandoned
-
2004
- 2004-01-29 NO NO20040500A patent/NO20040500L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002324586B2 (en) | 2008-04-24 |
| DE60208803D1 (de) | 2006-04-06 |
| EP1412338A1 (en) | 2004-04-28 |
| CA2455833A1 (en) | 2003-02-13 |
| US20040162290A1 (en) | 2004-08-19 |
| MXPA04000984A (es) | 2005-02-17 |
| US20030130282A1 (en) | 2003-07-10 |
| ATE316078T1 (de) | 2006-02-15 |
| ES2256522T3 (es) | 2006-07-16 |
| WO2003011839A1 (en) | 2003-02-13 |
| DE60208803T2 (de) | 2006-08-31 |
| EP1412338B1 (en) | 2006-01-18 |
| US6677340B2 (en) | 2004-01-13 |
| JP2005501055A (ja) | 2005-01-13 |
| KR20040030892A (ko) | 2004-04-09 |
| JP4328617B2 (ja) | 2009-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |