NO20033862L - Fremgangsmåte for prevensjon eller terapi av inflammatoriske eller autoimmune lidelser ved administrering av integrin-alfa-beta3-antagonisteri kombinasjonmed andre profylaktiske eller terapeutiske midler - Google Patents

Fremgangsmåte for prevensjon eller terapi av inflammatoriske eller autoimmune lidelser ved administrering av integrin-alfa-beta3-antagonisteri kombinasjonmed andre profylaktiske eller terapeutiske midler

Info

Publication number
NO20033862L
NO20033862L NO20033862A NO20033862A NO20033862L NO 20033862 L NO20033862 L NO 20033862L NO 20033862 A NO20033862 A NO 20033862A NO 20033862 A NO20033862 A NO 20033862A NO 20033862 L NO20033862 L NO 20033862L
Authority
NO
Norway
Prior art keywords
beta3
integrin
prophylactic
inflammatory
therapy
Prior art date
Application number
NO20033862A
Other languages
English (en)
Norwegian (no)
Other versions
NO20033862D0 (no
Inventor
Christine Dingivan
Ronald Wilder
Original Assignee
Medimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Inc filed Critical Medimmune Inc
Publication of NO20033862D0 publication Critical patent/NO20033862D0/no
Publication of NO20033862L publication Critical patent/NO20033862L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20033862A 2001-03-02 2003-09-01 Fremgangsmåte for prevensjon eller terapi av inflammatoriske eller autoimmune lidelser ved administrering av integrin-alfa-beta3-antagonisteri kombinasjonmed andre profylaktiske eller terapeutiske midler NO20033862L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27309801P 2001-03-02 2001-03-02
US31632101P 2001-08-31 2001-08-31
US34691801P 2001-10-19 2001-10-19
US35842402P 2002-02-19 2002-02-19
PCT/US2002/006679 WO2002070007A1 (fr) 2001-03-02 2002-03-04 Prevention ou traitement de troubles inflammatoires ou auto-immuns par l'administration d'antagonistes de l'integrine $g(a)v$g(b)¿3?

Publications (2)

Publication Number Publication Date
NO20033862D0 NO20033862D0 (no) 2003-09-01
NO20033862L true NO20033862L (no) 2003-10-31

Family

ID=27501069

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033862A NO20033862L (no) 2001-03-02 2003-09-01 Fremgangsmåte for prevensjon eller terapi av inflammatoriske eller autoimmune lidelser ved administrering av integrin-alfa-beta3-antagonisteri kombinasjonmed andre profylaktiske eller terapeutiske midler

Country Status (12)

Country Link
US (2) US20020168360A1 (fr)
EP (1) EP1372720A4 (fr)
JP (1) JP2004536786A (fr)
CN (1) CN1507354A (fr)
AU (1) AU2002306651B2 (fr)
CA (1) CA2439852A1 (fr)
HU (1) HUP0303340A2 (fr)
IL (1) IL157706A0 (fr)
MX (1) MXPA03007878A (fr)
NO (1) NO20033862L (fr)
NZ (1) NZ528076A (fr)
WO (1) WO2002070007A1 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
EP1113497A3 (fr) * 1999-12-29 2006-01-25 Texas Instruments Incorporated Boîtier à semi-conducteur, avec l'impédance du conducteur sélectionnée au cour de l'assemblage
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US20060100167A1 (en) 2002-09-27 2006-05-11 Wood Christopher B Methods and compositions for the treatment of autoimmune disorders using clofarabine
US20060135463A1 (en) * 2002-09-27 2006-06-22 Wood Christopher B Methods and compositions for the treatment of lupus using clofarabine
US20040176272A1 (en) * 2003-01-30 2004-09-09 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
US20080025989A1 (en) * 2003-02-20 2008-01-31 Seattle Genetics, Inc. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
AU2004213053C1 (en) 2003-02-20 2009-07-16 Seagen Inc. Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
WO2004091510A2 (fr) * 2003-04-11 2004-10-28 Medimmune, Inc. Anticorps il-9 recombinants et leurs utilisations
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
JP4792392B2 (ja) 2003-09-11 2011-10-12 コーナーストーン セラピューティクス インコーポレイテッド Ｈｍｇｂ１に対するモノクローナル抗体
PL1667668T3 (pl) 2003-10-01 2008-10-31 Merck Patent Gmbh Antagoniści integryny alfavbeta3 oraz alfavbeta6 jako czynniki przeciwzwłóknieniowe
US20050180974A1 (en) * 2003-10-24 2005-08-18 Medtronic, Inc. Extracellular TNF inhibitors for treating CNS disorders
US7371381B2 (en) 2003-12-12 2008-05-13 Amgen Inc. Anti-galanin antibodies and uses thereof
MY162179A (en) 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
JP4879884B2 (ja) 2004-04-12 2012-02-22 メディミューン，エルエルシー 抗−ｉｌ−９抗体製剤及びその使用法
US7351739B2 (en) 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
JP5905183B2 (ja) 2004-05-12 2016-04-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． 感染を処置するためのゲルソリンの使用
EP1771565B1 (fr) 2004-07-20 2012-09-05 The Feinstein Institute for Medical Research Derives de proteine rage
WO2006034334A2 (fr) * 2004-09-21 2006-03-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Analogue peptidique capable d'ameliorer la stimulation d'une reponse ctl specifique des gliomes
WO2006044643A2 (fr) * 2004-10-15 2006-04-27 Seattle Genetics, Inc. Anticorps anti-cd70 et son utilisation pour le traitement et la prevention du cancer et des troubles immunitaires
US8337838B2 (en) * 2004-10-15 2012-12-25 Seattle Genetics, Inc. Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders
RU2007118691A (ru) * 2004-10-19 2008-11-27 Авентис Фармасьютикалз Инк. (Us) Применение 4-трифторметилфениламида (z)-2-циано-3-гидрокси-бут-2-еновой кислоты для лечения воспалительных заболеваний кишечника
US20060253100A1 (en) 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
EP2422811A2 (fr) 2004-10-27 2012-02-29 MedImmune, LLC Modulation d'une spécificité d'anticorps par adaptation sur mesure de son affinité a une antigène apparente
WO2006110819A2 (fr) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. Formes variantes de l'urate oxydase et leur utilisation
WO2006138429A2 (fr) 2005-06-16 2006-12-28 The Feinstein Institute For Medical Research Anticorps diriges contre hmgb1 et fragments de ceux-ci
GB0512225D0 (en) * 2005-06-16 2005-07-27 Univ Sheffield Immunoglobulin molecules
US20070110757A1 (en) 2005-06-23 2007-05-17 Ziping Wei Antibody formulations having optimized aggregation and fragmentation profiles
US7919264B2 (en) 2005-11-01 2011-04-05 Abbott Biotechnology Ltd. Methods and compositions for determining the efficacy of a treatment for ankylosing spondylitis using biomarkers
DK3279663T3 (da) * 2006-03-15 2021-10-18 Brigham & Womens Hospital Inc Anvendelse af gelsolin til diagnosticering og behandling af inflammationssygdomme
ES2455167T3 (es) * 2006-06-01 2014-04-14 The Regents Of The University Of California Método de terapia combinada y formulación
EP2043603A4 (fr) 2006-07-11 2010-10-27 Arubor Corp Prévention de la rhinosinusite et thérapie avec des inhibiteurs de cytokine proinflammatoires
DE102006033837A1 (de) * 2006-07-21 2008-01-31 Medac Gesellschaft für klinische Spezialpräparate m.b.H Konzentrierte Methotrexat-Lösungen
MX2009001110A (es) * 2006-08-03 2009-05-11 Vaccinex Inc Anticuerpos monoclonales anti-il-6 y usos de los mismos.
AU2007284690A1 (en) 2006-08-10 2008-02-21 Roy C. Levitt Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
CA3007075C (fr) 2006-09-07 2019-10-15 Arthur E. Frankel Methodes et compositions a base de conjugues toxine diphterique-interleukine 3
PL2250280T3 (pl) 2008-01-25 2015-06-30 Massachusetts Gen Hospital Terapeutyczne zastosowania gelsoliny w niewydolności nerek
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
WO2010042433A1 (fr) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combinaison d'anticorps cd137 et d'anticorps ctla-4 pour le traitement de maladies prolifératives
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
BRPI1010069A2 (pt) 2009-06-25 2016-03-15 Savient Pharmaceuticals Inc "método para prevenir reações à infusão durante terapia por uricase peguilada em pacientes; e método para diagnosticar se um paciente tratado com uricase peguilada desenvolverá reações à infusão ou desenvolverá liberação de uricase peguilada mediada por anticorpo sem a medição de títulos de anticorpos anti-peg e anti-uricase peguilada"
US20110150856A1 (en) * 2009-12-21 2011-06-23 Sarah Bacus Compositions and methods for treatment of vitiligo
EP2608799B1 (fr) 2010-08-24 2018-12-12 University of Pittsburgh - Of the Commonwealth System of Higher Education Vaccins contre le cancer du cerveau à base de peptides alpha-2 du récepteur de l'interleukine 13
DK2635607T3 (da) 2010-11-05 2019-11-18 Zymeworks Inc Stabilt heterodimert antistofdesign med mutationer i fc-domænet
HRP20211773T1 (hr) 2011-11-04 2022-03-04 Zymeworks Inc. Stabilna heterodimerni dizajn antitijela s mutacijama u fc domeni
ES2887580T3 (es) 2012-03-19 2021-12-23 Stemline Therapeutics Inc Métodos para el tratamiento y seguimiento del estado del cáncer
WO2013166594A1 (fr) 2012-05-10 2013-11-14 Zymeworks Inc. Constructions hétéromultimères de chaînes lourdes d'immunoglobulines comprenant des mutations dans le domaine fc
PL3536334T3 (pl) 2012-05-16 2021-12-06 Stemline Therapeutics Inc. Szczepionki przeciw rakowi ukierunkowane na komórki macierzyste raka
CN102827281B (zh) * 2012-08-03 2014-05-28 无锡傲锐东源生物科技有限公司 抗cd2蛋白单克隆抗体及其用途
JP6498210B2 (ja) * 2013-12-29 2019-04-10 チュアラボ オンコロジー, インコーポレーテッドCurelab Oncology, Inc. 炎症関連疾患の治療と予防のためのｐ６２／ｓｑｓｔｍ１に関する方法と組成物
US20160066601A1 (en) * 2014-09-06 2016-03-10 Ashley G. Herr Edible 3d printer filament
KR20190113858A (ko) 2017-01-30 2019-10-08 얀센 바이오테크 인코포레이티드 활성 건선성 관절염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
WO2020160325A1 (fr) * 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Réduction de l'immunogénicité de la pegloticase
EP3947442A2 (fr) 2019-03-28 2022-02-09 Danisco US Inc. Anticorps modifiés
US12037378B2 (en) * 2019-05-21 2024-07-16 Novartis Ag Variant CD58 domains and uses thereof
AU2020279987A1 (en) 2019-05-23 2021-11-18 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha
US20230203191A1 (en) 2020-03-30 2023-06-29 Danisco Us Inc Engineered antibodies

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4658019A (en) * 1979-04-26 1987-04-14 Ortho Pharmaceutical Corporation Complement-fixing monoclonal antibody to human T cells
US5851526A (en) * 1985-04-19 1998-12-22 Ludwig Institute For Cancer Research Methods of treating colon cancer utilizing tumor-specific antibodies
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
DE3631229A1 (de) * 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
US5306620A (en) * 1987-07-08 1994-04-26 The Scripps Research Institute Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation
CA2000048A1 (fr) * 1988-10-03 1990-04-03 Edward F. Plow Peptides et anticorps inhibant la liaison integrine-ligand
US5149780A (en) * 1988-10-03 1992-09-22 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
US5360716A (en) * 1988-10-24 1994-11-01 Otsuka Pharmaceutical Co., Ltd. Human tumor necrosis factor αspecific monoclonal antibody and method for detecting human tumor necrosis factor α
US5223395A (en) * 1988-12-01 1993-06-29 Centocor, Inc. Immunometric assays for tumor necrosis factor-alpha and methods for preventing the loss of biological activity of tumor necrosis factor-alpha in biological samples
US5147638A (en) * 1988-12-30 1992-09-15 Oklahoma Medical Research Foundation Inhibition of tumor growth by blockade of the protein C system
US5498694A (en) * 1989-05-25 1996-03-12 La Jolla Cancer Research Foundation Peptides of the cytoplasmic domain of integrin
US5959087A (en) * 1989-08-07 1999-09-28 Peptide Technology, Ltd. Tumour necrosis factor binding ligands
US5644034A (en) * 1989-08-07 1997-07-01 Peptide Technology Ltd. Tumour necrosis factor binding ligands
EP1132471A3 (fr) * 1989-09-12 2001-11-28 F. Hoffmann-La Roche Ag Protéines liant le TNF
US5262520A (en) * 1989-12-01 1993-11-16 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
US5196511A (en) * 1989-12-01 1993-03-23 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
US5136021A (en) * 1990-02-27 1992-08-04 Health Research, Inc. TNF-inhibitory protein and a method of production
DE4006269A1 (de) * 1990-02-28 1991-08-29 Max Planck Gesellschaft Antikoerper gegen den tumor-nekrosefaktor-rezeptor
US5830678A (en) * 1990-10-30 1998-11-03 Fred Hutchinson Cancer Research Center Method for identifying a target peptide that modulates the binding of epinectin ligand to integrin receptors
US5994510A (en) * 1990-12-21 1999-11-30 Celltech Therapeutics Limited Recombinant antibodies specific for TNFα
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
EP0571442A4 (fr) * 1991-01-14 1995-05-03 Univ New York Proteine tsg-14 induite par la cytokine, adn codant cette proteine et ses utilisations.
ATE153768T1 (de) * 1991-01-15 1997-06-15 Bayer Ag Ergänzung von oberflächenrezeptoren
MX9203138A (es) * 1991-03-12 1992-09-01 Biogen Inc Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos.
DK0503648T3 (da) * 1991-03-12 2000-10-30 Biogen Inc CD2-bindingsdomæne af lymfocytfunktion-associeret antigen 3
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US5656272A (en) * 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US5698195A (en) * 1991-03-18 1997-12-16 New York University Medical Center Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
US5310874A (en) * 1991-05-03 1994-05-10 The Scripps Research Institute Integrin α subunit cytoplasmic domain polypeptides and antibodies
US5334380A (en) * 1991-09-27 1994-08-02 Board Of Regents, The University Of Texas System Anti-endotoxin, interleukin-1 receptor antagonist and anti-tumor necrosis factor antibody with arginine-free formulations for the treatment of hypotension
US6162432A (en) * 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
JP3353209B2 (ja) * 1992-04-03 2002-12-03 ジェネンテク，インコーポレイテッド αｖβ３インテグリンに対する抗体
US5478725A (en) * 1992-06-12 1995-12-26 University Of Pennsylvania αv β3 integrin as a predictor of endometriosis
US6270766B1 (en) * 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
CA2146647C (fr) * 1992-10-08 2009-05-05 Marc Feldmann Traitement d'affections auto-immunes et inflammatoires
US5705481A (en) * 1992-11-06 1998-01-06 Merck Patent Gesellschaft Mit Beschrankter Haftung Cyclopeptides
US5817311A (en) * 1993-03-05 1998-10-06 Universite Catholique De Louvain Methods of inhibiting T-cell medicated immune responses with LO-CD2a-specific antibodies
US5730979A (en) * 1993-03-05 1998-03-24 Universite Catholique Delouvain LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation
US5951983A (en) * 1993-03-05 1999-09-14 Universite Catholique De Louvain Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
US5523209A (en) * 1994-03-14 1996-06-04 The Scripps Research Institute Methods for identifying inhibitors of integrin activation
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
DE4415310A1 (de) * 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptide
CA2192821A1 (fr) * 1994-06-24 1996-01-04 Wayne R. Gombotz Compositions a base de polypeptides et a liberation lente, et procedes de traitement des affections intestinales inflammatoires
DE69531187T2 (de) * 1994-12-20 2004-04-22 Merck Patent Gmbh Monoklonaler Antikörper gegen das Alpha-V-Integrin
US5780426A (en) * 1995-06-07 1998-07-14 Ixsys, Incorporated Fivemer cyclic peptide inhibitors of diseases involving αv β3
US5767071A (en) * 1995-06-07 1998-06-16 Ixsys Incorporated Sevenmer cyclic peptide inhibitors of diseases involving αv β3
US5817750A (en) * 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
US5817457A (en) * 1996-02-07 1998-10-06 Ma Bioservices, Inc. Methods and kits for detecting viral reverse transcriptase activity in a sample using an acidic pH or an elevated temperature
IL129344A0 (en) * 1996-11-27 2000-02-17 Du Pont Pharm Co Novel integrin receptor antagonists
US6596850B1 (en) * 1998-01-30 2003-07-22 Ixsys, Incorporated Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same
US20010011125A1 (en) * 1997-01-30 2001-08-02 William D. Huse Anti-alpha v beta 3 recombinant human antibodies, nucleic acids encoding same and methods of use
US6590079B2 (en) * 1997-01-30 2003-07-08 Ixsys, Incorporated Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same
DE69808609T2 (de) * 1997-04-11 2003-06-12 G.D. Searle & Co., Chicago Antagonistische anti-avb3 integrin antikörper
US5968741A (en) * 1997-04-11 1999-10-19 Cedars-Sinai Medical Center Methods of diagnosing a medically resistant clinical subtype of ulcerative colitis
US6171787B1 (en) * 1997-06-26 2001-01-09 Abbott Laboratories Member of the TNF family useful for treatment and diagnosis of disease
US6096707A (en) * 1997-07-11 2000-08-01 Biotie Therapies Ltd. Integrin binding peptide and use thereof
CA2309204A1 (fr) * 1997-11-26 1999-06-03 Dupont Pharmaceuticals Company 1,3,4-thiadiazoles et 1,3,4-oxadiazoles utilises comme antagonistes de .alpha.v.beta.3
US6048861A (en) * 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists
EP1105389A4 (fr) * 1998-08-13 2001-10-17 Merck & Co Inc Antagonistes de recepteurs d'integrine
US6160099A (en) * 1998-11-24 2000-12-12 Jonak; Zdenka Ludmila Anti-human αv β3 and αv β5 antibodies
RU2236251C2 (ru) * 1999-02-12 2004-09-20 Дзе Скриппс Рисерч Инститьют Способы лечения опухолей и метастазов с использованием комбинации антиангиогенной терапии и иммунотерапии
JP2001029067A (ja) * 1999-05-14 2001-02-06 Kanegafuchi Chem Ind Co Ltd 抗原特異的細胞傷害抑制性細胞の誘導方法
US6531580B1 (en) * 1999-06-24 2003-03-11 Ixsys, Inc. Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
EP1239877B1 (fr) * 1999-10-06 2008-01-09 Abbott GmbH & Co. KG Composition comprenant un inhibiteur du tnf-alpha et d'un antagoniste du recepteur alphavbeta3 d'integrine
ES2311483T3 (es) * 1999-12-14 2009-02-16 Genentech, Inc. Anatagonista del tnf-alfa y antagonista del lfa-1 para el tratamiento de la artritis reumatoide.

Also Published As

Publication number Publication date
US20090053234A1 (en) 2009-02-26
CA2439852A1 (fr) 2002-09-12
NO20033862D0 (no) 2003-09-01
HUP0303340A2 (hu) 2003-12-29
NZ528076A (en) 2005-09-30
EP1372720A1 (fr) 2004-01-02
AU2002306651B2 (en) 2007-12-13
AU2002306651B9 (en) 2002-09-19
EP1372720A4 (fr) 2006-07-26
IL157706A0 (en) 2004-03-28
US20020168360A1 (en) 2002-11-14
WO2002070007A1 (fr) 2002-09-12
JP2004536786A (ja) 2004-12-09
MXPA03007878A (es) 2004-07-08
CN1507354A (zh) 2004-06-23

Similar Documents

Publication Publication Date Title
NO20033862L (no) Fremgangsmåte for prevensjon eller terapi av inflammatoriske eller autoimmune lidelser ved administrering av integrin-alfa-beta3-antagonisteri kombinasjonmed andre profylaktiske eller terapeutiske midler
NO20053678D0 (no) Kombinasjonsterapi for behandling av immuninflammatoriske forstyrrelser
AU2002322478A1 (en) Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
NO20044054L (no) Administrering av midler for behandling av betennelse
IS7099A (is) Efnasambönd til að meðhöndla bólgutruflanir
EP1622589A4 (fr) Compositions, cibles, methodes et dispositifs pour le traitement de troubles oculaires et peri-oculaires
HK1109867A1 (en) Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders
DK1660057T3 (da) Kombinationsterapi til behandling af neovaskulære øjenlidelser
NO20041882L (no) Fremgangsmater for behandling av okulare neovaskulaere sykdommer.
NO20025286D0 (no) Aminosubstituerte dibenzotiofenderivater for behandling av forstyrrelser forÕrsaket av NP YP reseptoren
BRPI0418112A (pt) inibidores de p-38 quinase bicìclico heterocìclicos
NI200600319A (es) Antagonistas de ccr2 de sal cuaternaria
WO2005000298A3 (fr) Inhibiteurs de p-38
NO20034864L (no) Preparat for behandling av legemiddelindusert forstoppelse med 15-keto-prostaglandiner
IL162485A0 (en) Compounds for the treatment of inflammatory disorders
NO20034311D0 (no) CCR5-antagonister for behandling av AIDS
DK1764111T3 (da) Vaginalt indgivne anti-dysrytmi midler til behandling af uterin dysrytmi
AU2003213787A1 (en) Compositions and methods for the treatment of anorectal disorders
NO20043085L (no) Fremgangsmater og sammensetninger for behandling av forstyrrelser i sentralnervesystemet
NO20041386L (no) Kombinasjoner for bahandling av immunoinflammatoriske forstyrrelser
NO20034232D0 (no) Anvendelse av glukokortikoid-reseptor-spesifikke antagonister ved behandling av stresslidelser
NO20033417D0 (no) Anvendelse av CD23-antagonister for behandling av neoplastiske forstyrrelser
NO20034123L (no) Fremgangsmåte for behandling av brennstoff
DK1344526T3 (da) Midler til forebyggelse/behandling af inflammatoriske luftvejslidelser
NO20041024D0 (no) Anvendelse av BIBN4096 i kombinasjon med andre antimigrenelegemidler for behandling av migrene

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application