NO20025281L - Peptid-deformylase-inhibitorer - Google Patents

Peptid-deformylase-inhibitorer

Info

Publication number
NO20025281L
NO20025281L NO20025281A NO20025281A NO20025281L NO 20025281 L NO20025281 L NO 20025281L NO 20025281 A NO20025281 A NO 20025281A NO 20025281 A NO20025281 A NO 20025281A NO 20025281 L NO20025281 L NO 20025281L
Authority
NO
Norway
Prior art keywords
peptide deformylase
deformylase inhibitors
inhibitors
peptide
new methods
Prior art date
Application number
NO20025281A
Other languages
English (en)
Other versions
NO20025281D0 (no
Inventor
Kelly M Aubart
Iv Siegfried B Christensen
Jacques Briand
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20025281D0 publication Critical patent/NO20025281D0/no
Publication of NO20025281L publication Critical patent/NO20025281L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/14—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

PDF inhibitorer og nye fremgangsmåter for deres anvendelse er tilveiebrakt.
NO20025281A 2000-05-05 2002-11-04 Peptid-deformylase-inhibitorer NO20025281L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20194300P 2000-05-05 2000-05-05
US23808400P 2000-10-04 2000-10-04
PCT/US2001/014593 WO2001085170A1 (en) 2000-05-05 2001-05-04 Peptide deformylase inhibitors

Publications (2)

Publication Number Publication Date
NO20025281D0 NO20025281D0 (no) 2002-11-04
NO20025281L true NO20025281L (no) 2003-01-03

Family

ID=26897227

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025281A NO20025281L (no) 2000-05-05 2002-11-04 Peptid-deformylase-inhibitorer

Country Status (20)

Country Link
US (2) US6806369B2 (no)
EP (1) EP1283711B1 (no)
JP (1) JP2003532677A (no)
KR (1) KR20020093127A (no)
CN (1) CN1427721A (no)
AR (1) AR029916A1 (no)
AT (1) ATE389403T1 (no)
AU (1) AU2001261218A1 (no)
BR (1) BR0110206A (no)
CA (1) CA2408236A1 (no)
CZ (1) CZ20023618A3 (no)
DE (1) DE60133273T2 (no)
ES (1) ES2300330T3 (no)
HU (1) HUP0302505A2 (no)
IL (1) IL152638A0 (no)
MX (1) MXPA02010843A (no)
NO (1) NO20025281L (no)
NZ (1) NZ521560A (no)
PL (1) PL359865A1 (no)
WO (1) WO2001085170A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60232650D1 (de) * 2001-04-05 2009-07-30 Smithkline Beecham Corp Peptiddeformylaseinhibitoren
JP4266815B2 (ja) * 2001-06-05 2009-05-20 スミスクライン・ビーチャム・コーポレイション ペプチドデホルミラーゼ阻害剤
AU2003296960A1 (en) * 2002-12-11 2004-06-30 Smithkline Beecham Corporation Peptide deformylase inhibitors
EP1683521A1 (en) * 2005-01-21 2006-07-26 Centre National De La Recherche Scientifique (Cnrs) Peptide deformylase inhibitors, their use, and pharmaceutical compositions containing the same
DE102005019181A1 (de) 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
JP2008538776A (ja) * 2005-04-25 2008-11-06 ノバルティス アクチエンゲゼルシャフト ペプチド脱ホルミル酵素（ｐｄｆ）阻害剤として有用なイミダゾ［１，２−ａ］ピリジン誘導体
CA2610304A1 (en) * 2005-06-07 2006-12-14 Novartis Ag Peptide deformylase (pdf) inhibitors 4
WO2007040289A1 (en) * 2005-10-05 2007-04-12 Promeditech Inc. Deformylase inhibitor, process for the preparation thereof, and composition comprising the same
KR100753796B1 (ko) * 2006-07-28 2007-08-31 주식회사 프로메디텍 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282986A (en) * 1960-10-06 1966-11-01 Merck & Co Inc N-acylated hydroxamic acids and derivatives thereof
JP2559699B2 (ja) 1985-03-16 1996-12-04 ザ ウエルカム フアウンデ−シヨン リミテツド 新規なアリ−ル誘導体
GB8531838D0 (en) 1985-12-30 1986-02-05 Wellcome Found Aryl derivatives
PL154186B1 (en) 1987-07-15 1991-07-31 Wellcome Found Method for manufacturing arylic derivatives of the hydroxamic acid
CN1178906C (zh) 1997-07-31 2004-12-08 艾博特公司 基质金属蛋白酶的逆异羟肟酸盐抑制剂
US6235786B1 (en) 1997-08-06 2001-05-22 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6294573B1 (en) 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
KR100600518B1 (ko) * 1998-02-07 2006-07-13 브리티쉬 바이오테크 파마슈티칼스 리미티드 항균제
AR028075A1 (es) * 2000-05-05 2003-04-23 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
US20040034024A1 (en) 2001-05-04 2004-02-19 Aubart Kelly M Peptide deformylase inhibitors

Also Published As

Publication number Publication date
NZ521560A (en) 2004-05-28
BR0110206A (pt) 2003-01-28
ES2300330T3 (es) 2008-06-16
US6806369B2 (en) 2004-10-19
US20040192719A1 (en) 2004-09-30
NO20025281D0 (no) 2002-11-04
KR20020093127A (ko) 2002-12-12
HUP0302505A2 (hu) 2003-12-29
DE60133273T2 (de) 2009-03-05
EP1283711A1 (en) 2003-02-19
US7115605B2 (en) 2006-10-03
PL359865A1 (en) 2004-09-06
JP2003532677A (ja) 2003-11-05
EP1283711B1 (en) 2008-03-19
CZ20023618A3 (cs) 2003-09-17
WO2001085170A9 (en) 2006-01-26
EP1283711A4 (en) 2003-05-21
AR029916A1 (es) 2003-07-23
US20040053932A1 (en) 2004-03-18
DE60133273D1 (de) 2008-04-30
AU2001261218A1 (en) 2001-11-20
IL152638A0 (en) 2003-06-24
CN1427721A (zh) 2003-07-02
WO2001085170A1 (en) 2001-11-15
CA2408236A1 (en) 2001-11-15
ATE389403T1 (de) 2008-04-15
MXPA02010843A (es) 2003-03-27

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