ATE531690T1 - Inhibitoren von peptiddeformylase - Google Patents

Inhibitoren von peptiddeformylase

Info

Publication number
ATE531690T1
ATE531690T1 AT02756123T AT02756123T ATE531690T1 AT E531690 T1 ATE531690 T1 AT E531690T1 AT 02756123 T AT02756123 T AT 02756123T AT 02756123 T AT02756123 T AT 02756123T AT E531690 T1 ATE531690 T1 AT E531690T1
Authority
AT
Austria
Prior art keywords
inhibitors
peptide deformylase
deformylase
peptide
novel
Prior art date
Application number
AT02756123T
Other languages
English (en)
Inventor
Christensen, Iv
Maxwell CUMMINGS
Joseph Karpinski
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Application granted granted Critical
Publication of ATE531690T1 publication Critical patent/ATE531690T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
AT02756123T 2001-06-05 2002-06-04 Inhibitoren von peptiddeformylase ATE531690T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29596301P 2001-06-05 2001-06-05
PCT/US2002/017697 WO2002098901A2 (en) 2001-06-05 2002-06-04 Peptide deformylase inhibitors

Publications (1)

Publication Number Publication Date
ATE531690T1 true ATE531690T1 (de) 2011-11-15

Family

ID=23139980

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02756123T ATE531690T1 (de) 2001-06-05 2002-06-04 Inhibitoren von peptiddeformylase

Country Status (7)

Country Link
US (1) US6852882B2 (de)
EP (1) EP1399416B1 (de)
JP (1) JP4266815B2 (de)
AT (1) ATE531690T1 (de)
AU (1) AU2002322035A1 (de)
ES (1) ES2374664T3 (de)
WO (1) WO2002098901A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1515956A4 (de) * 2002-06-06 2005-08-10 Smithkline Beecham Peptiddeformylaseinhibitoren
KR100723539B1 (ko) 2005-10-05 2007-06-04 주식회사 프로메디텍 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물
EP2170814B1 (de) * 2007-06-12 2016-08-17 Achaogen, Inc. Antibakterielle mittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002502815A (ja) * 1998-02-07 2002-01-29 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 抗菌剤
GB9929979D0 (en) * 1999-12-17 2000-02-09 Darwin Discovery Ltd Hydroxamic acid derivatives
AR028075A1 (es) * 2000-05-05 2003-04-23 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
AR029916A1 (es) * 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas

Also Published As

Publication number Publication date
US6852882B2 (en) 2005-02-08
EP1399416B1 (de) 2011-11-02
WO2002098901A3 (en) 2003-03-06
JP2005502599A (ja) 2005-01-27
US20040157916A1 (en) 2004-08-12
WO2002098901A2 (en) 2002-12-12
AU2002322035A1 (en) 2002-12-16
ES2374664T3 (es) 2012-02-20
EP1399416A2 (de) 2004-03-24
JP4266815B2 (ja) 2009-05-20
EP1399416A4 (de) 2005-12-28

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