NO20020129L - Nye estere utledet fra nukleosider, fremgangsmåte for fremstilling og preparater inneholdende dem - Google Patents

Nye estere utledet fra nukleosider, fremgangsmåte for fremstilling og preparater inneholdende dem

Info

Publication number
NO20020129L
NO20020129L NO20020129A NO20020129A NO20020129L NO 20020129 L NO20020129 L NO 20020129L NO 20020129 A NO20020129 A NO 20020129A NO 20020129 A NO20020129 A NO 20020129A NO 20020129 L NO20020129 L NO 20020129L
Authority
NO
Norway
Prior art keywords
nucleosides
esters derived
hydroxyl
preparation
methods
Prior art date
Application number
NO20020129A
Other languages
English (en)
Other versions
NO20020129D0 (no
Inventor
Patrick Vlieghe
Jean-Louis Braus
Thierry Clerc
Jean-Pierre Salles
Original Assignee
Laphal Sa Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laphal Sa Lab filed Critical Laphal Sa Lab
Publication of NO20020129D0 publication Critical patent/NO20020129D0/no
Publication of NO20020129L publication Critical patent/NO20020129L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

R2 representerer hydrogen eller hydroksyl, R3 representerer hydrogen, hykdroksyl eller azido og den prikkede linjen, når den er til stede, representerer en karbon-karbon dobbeltbinding. De foreliggende forbindelser er anvendelige som antivirale midler. Sammendrag Den foreliggende oppfinnelse angår området organisk kjemi, og mer spesielt området terapeutisk kjemi. Oppfinnelsen angår mer spesielt to nye estere utledet fra nukleosider med den generelle formel (I): Z - A - C - O- O (I) hvori A representerer en divalent gruppe valgt fra -(CH2)n-, - (CH2) - NH-, -(CH2)n - O -; NH - O - (CH2)n n er et tall fra l til 12; Z representerer aminogruppe, hydroksyl- eller alkyl, og "nukleosid"-gruppen er en rest av hydroksylert nukleosid, med den generelle formel: hvori RI representerer et radikal valgt fra: O R, H N/^. O hvor R4 representerer metyl, trifluormetyl eller halovinyl,
NO20020129A 1999-07-12 2002-01-11 Nye estere utledet fra nukleosider, fremgangsmåte for fremstilling og preparater inneholdende dem NO20020129L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9909004A FR2796384A1 (fr) 1999-07-12 1999-07-12 Nouveaux esters derives de nucleosides, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
PCT/FR2000/002002 WO2001004134A2 (fr) 1999-07-12 2000-07-11 Nouveaux esters derives de nucleosides, leurs procedes de preparation et les compositions pharmaceutiques en renfermant

Publications (2)

Publication Number Publication Date
NO20020129D0 NO20020129D0 (no) 2002-01-11
NO20020129L true NO20020129L (no) 2002-03-11

Family

ID=9547990

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020129A NO20020129L (no) 1999-07-12 2002-01-11 Nye estere utledet fra nukleosider, fremgangsmåte for fremstilling og preparater inneholdende dem

Country Status (10)

Country Link
JP (1) JP2003504377A (no)
AP (1) AP2002002395A0 (no)
AU (1) AU6452300A (no)
BR (1) BR0012381A (no)
CA (1) CA2374411A1 (no)
FR (1) FR2796384A1 (no)
IL (1) IL147449A0 (no)
NO (1) NO20020129L (no)
PL (1) PL352486A1 (no)
WO (1) WO2001004134A2 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099442A1 (ja) 2010-02-15 2011-08-18 日産化学工業株式会社 β－グリコシド化合物の製造方法
WO2011099443A1 (ja) * 2010-02-15 2011-08-18 日産化学工業株式会社 β－ジヒドロフラン誘導化合物、β－ジヒドロフラン誘導化合物またはβ－テトラヒドロフラン誘導化合物の製造方法、β－グリコシド化合物、β－グリコシド化合物の製造方法、並びに、４'－エチニルｄ４Ｔ及びその類縁化合物の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200000398T2 (tr) * 1997-08-15 2000-07-21 Medivir Ab Hepatit B virüsü (HBV) retroviral ters transkriptaz ve DNA polimeraz inhibe edicilerini içeren antiviraller gibi nükleozidlerin analogları.

Also Published As

Publication number Publication date
NO20020129D0 (no) 2002-01-11
PL352486A1 (en) 2003-08-25
WO2001004134A2 (fr) 2001-01-18
FR2796384A1 (fr) 2001-01-19
AP2002002395A0 (en) 2002-03-31
JP2003504377A (ja) 2003-02-04
IL147449A0 (en) 2002-08-14
WO2001004134A3 (fr) 2001-09-27
BR0012381A (pt) 2002-03-26
CA2374411A1 (fr) 2001-01-18
AU6452300A (en) 2001-01-30

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