AP2002002395A0 - Novel esters derived from nucleosides, preparation methods and pharmaceutical compositions containing them. - Google Patents

Novel esters derived from nucleosides, preparation methods and pharmaceutical compositions containing them.

Info

Publication number
AP2002002395A0
AP2002002395A0 APAP/P/2002/002395A AP2000002395A AP2002002395A0 AP 2002002395 A0 AP2002002395 A0 AP 2002002395A0 AP 2000002395 A AP2000002395 A AP 2000002395A AP 2002002395 A0 AP2002002395 A0 AP 2002002395A0
Authority
AP
ARIPO
Prior art keywords
nucleosides
esters derived
pharmaceutical compositions
compositions containing
novel esters
Prior art date
Application number
APAP/P/2002/002395A
Inventor
Patrick Vlieghe
Jean-Louis Kraus
Thierry Clerc
Jean-Pierre Salles
Original Assignee
Laboratoires Laphal S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Laphal S A filed Critical Laboratoires Laphal S A
Publication of AP2002002395A0 publication Critical patent/AP2002002395A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

The invention concerns the field of organic chemistry, and more precisely, that of therapeutic chemistry. More particularly, the invention concerns novel esters derived from nucleosides of general formula (i)wherein: a represents a divalent group selected among -(ch2)n-, -(ch2)n -nh-, -(ch2)n -o-; (a); (b); (c); (d); (e); n is an integer ranging between 1 and 12; z represents an amino, hydrosyl or an alkyl group; and the nucleoside group is the radical of a hydroxylated nucleoside of general formula (i)wherein: r1 represents a radical selected among (2)and (3)wherein: r4 represents a methyl, trifluoromethyl or halovinyl; r2 represents a hydrogen or a hydroxyl; r3 represents a hydrogen, a hydroxyl or an azido; and the dotted line represents an optional carbon-carbon double bond. The invention is useful as an antiviral agent.
APAP/P/2002/002395A 1999-07-12 2000-07-11 Novel esters derived from nucleosides, preparation methods and pharmaceutical compositions containing them. AP2002002395A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9909004A FR2796384A1 (en) 1999-07-12 1999-07-12 NOVEL ESTERS DERIVED FROM NUCLEOSIDES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
PCT/FR2000/002002 WO2001004134A2 (en) 1999-07-12 2000-07-11 Novel esters derived from nucleosides, preparation methods and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AP2002002395A0 true AP2002002395A0 (en) 2002-03-31

Family

ID=9547990

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2002/002395A AP2002002395A0 (en) 1999-07-12 2000-07-11 Novel esters derived from nucleosides, preparation methods and pharmaceutical compositions containing them.

Country Status (10)

Country Link
JP (1) JP2003504377A (en)
AP (1) AP2002002395A0 (en)
AU (1) AU6452300A (en)
BR (1) BR0012381A (en)
CA (1) CA2374411A1 (en)
FR (1) FR2796384A1 (en)
IL (1) IL147449A0 (en)
NO (1) NO20020129L (en)
PL (1) PL352486A1 (en)
WO (1) WO2001004134A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5765536B2 (en) 2010-02-15 2015-08-19 日産化学工業株式会社 Process for producing β-glycoside compound
US9212174B2 (en) 2010-02-15 2015-12-15 Nissan Chemical Industries, Ltd. Certain β-dihydrofuran derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ300757B6 (en) * 1997-08-15 2009-08-05 Medivir Ab Nucleoside analogs, such as antiviral agents containing inhibitors of retroviral reverse transcriptase and DNA polymerase of hepatitis B virus (HBV)

Also Published As

Publication number Publication date
WO2001004134A3 (en) 2001-09-27
BR0012381A (en) 2002-03-26
WO2001004134A2 (en) 2001-01-18
NO20020129D0 (en) 2002-01-11
CA2374411A1 (en) 2001-01-18
PL352486A1 (en) 2003-08-25
AU6452300A (en) 2001-01-30
NO20020129L (en) 2002-03-11
IL147449A0 (en) 2002-08-14
FR2796384A1 (en) 2001-01-19
JP2003504377A (en) 2003-02-04

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