BR0012381A - esters derived from nucleosides, their preparation processes and pharmaceutical compositions containing them - Google Patents
esters derived from nucleosides, their preparation processes and pharmaceutical compositions containing themInfo
- Publication number
- BR0012381A BR0012381A BR0012381-1A BR0012381A BR0012381A BR 0012381 A BR0012381 A BR 0012381A BR 0012381 A BR0012381 A BR 0012381A BR 0012381 A BR0012381 A BR 0012381A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxyl
- pharmaceutical compositions
- nucleoside
- preparation processes
- esters derived
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"éSTERES DERIVADOS DE NUCLEOSìDEOS, SEUS PROCESSOS DE PREPARAçãO E COMPOSIçõES FARMACêUTICAS QUE, OS CONTêM". A presente invenção se refere ao campo da química orgânica e, mais especificamente, ao da química terapêutica. A invenção tem, mais particularmente, por objeto novos ésteres derivados de nucleosídeos de fórmula genérica (I) em que A representa um grupo divalente escolhido em -(CH~ 2~)~ n~-, (CH~ 2~)~ n~-NH-, -(CH~ 2~)~ n~-O-; (CH~ 2~)~ n~- n é um número inteiro variando de 1 a 12; Z representa um grupo amino, hidroxila ou alquila, e o grupo "nucleosídeo" é o resíduo de um nucleosídeo hidroxilado de fórmula genérica: em que R~ 1~ representa um radical escolhido em: em que R~ 4~ representa uma metila, triflúormetila ou halovinila, R~ 2~ representa um hidrogênio ou uma hidroxila, R~ 3~ representa um hidrogênio, uma hidroxila ou um azido, e a linha pontilhada simboliza uma eventual dupla ligação carbono-carbono. Utilização como agente antiviral."ESTERS DERIVED FROM NUCLEOSIDS, THEIR PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM". The present invention concerns the field of organic chemistry and, more specifically, that of therapeutic chemistry. The invention relates more particularly to new nucleoside-derived esters of generic formula (I) in which A represents a divalent group chosen in - (CH ~ 2 ~) ~ n ~ -, (CH ~ 2 ~) ~ n ~ -NH-, - (CH ~ 2 ~) ~ n ~ -O-; (CH ~ 2 ~) ~ n ~ - n is an integer ranging from 1 to 12; Z represents an amino, hydroxyl or alkyl group, and the "nucleoside" group is the residue of a hydroxylated nucleoside of generic formula: where R ~ 1 ~ represents a radical chosen from: where R ~ 4 ~ represents a methyl, trifluoromethyl or halovinyl, R ~ 2 ~ represents hydrogen or hydroxyl, R ~ 3 ~ represents hydrogen, hydroxyl or azido, and the dotted line symbolizes an eventual carbon-carbon double bond. Use as an antiviral agent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9909004A FR2796384A1 (en) | 1999-07-12 | 1999-07-12 | NOVEL ESTERS DERIVED FROM NUCLEOSIDES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
| PCT/FR2000/002002 WO2001004134A2 (en) | 1999-07-12 | 2000-07-11 | Novel esters derived from nucleosides, preparation methods and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012381A true BR0012381A (en) | 2002-03-26 |
Family
ID=9547990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012381-1A BR0012381A (en) | 1999-07-12 | 2000-07-11 | esters derived from nucleosides, their preparation processes and pharmaceutical compositions containing them |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JP2003504377A (en) |
| AP (1) | AP2002002395A0 (en) |
| AU (1) | AU6452300A (en) |
| BR (1) | BR0012381A (en) |
| CA (1) | CA2374411A1 (en) |
| FR (1) | FR2796384A1 (en) |
| IL (1) | IL147449A0 (en) |
| NO (1) | NO20020129L (en) |
| PL (1) | PL352486A1 (en) |
| WO (1) | WO2001004134A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130008546A (en) | 2010-02-15 | 2013-01-22 | 닛산 가가쿠 고교 가부시키 가이샤 | PROCESS FOR PREPARATION OF β-GLYCOSIDE COMPOUNDS |
| KR20130008547A (en) * | 2010-02-15 | 2013-01-22 | 닛산 가가쿠 고교 가부시키 가이샤 | β-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING β-DIHYDROFURAN DERIVING COMPOUND OR β-TETRAHYDROFURAN DERIVING COMPOUND, β-GLYCOSIDE COMPOUND, METHOD FOR PRODUCING β-GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3844654B2 (en) * | 1997-08-15 | 2006-11-15 | メディヴィル・アクチボラグ | Nucleoside analogs such as retroviral reverse transcriptase and antiviral agents including inhibitors of hepatitis B virus (HBV) DNA polymerase |
-
1999
- 1999-07-12 FR FR9909004A patent/FR2796384A1/en active Pending
-
2000
- 2000-07-11 IL IL14744900A patent/IL147449A0/en unknown
- 2000-07-11 PL PL00352486A patent/PL352486A1/en unknown
- 2000-07-11 JP JP2001509743A patent/JP2003504377A/en not_active Withdrawn
- 2000-07-11 AP APAP/P/2002/002395A patent/AP2002002395A0/en unknown
- 2000-07-11 AU AU64523/00A patent/AU6452300A/en not_active Abandoned
- 2000-07-11 WO PCT/FR2000/002002 patent/WO2001004134A2/en not_active Application Discontinuation
- 2000-07-11 CA CA002374411A patent/CA2374411A1/en not_active Abandoned
- 2000-07-11 BR BR0012381-1A patent/BR0012381A/en not_active Application Discontinuation
-
2002
- 2002-01-11 NO NO20020129A patent/NO20020129L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001004134A3 (en) | 2001-09-27 |
| AP2002002395A0 (en) | 2002-03-31 |
| AU6452300A (en) | 2001-01-30 |
| NO20020129D0 (en) | 2002-01-11 |
| JP2003504377A (en) | 2003-02-04 |
| IL147449A0 (en) | 2002-08-14 |
| FR2796384A1 (en) | 2001-01-19 |
| CA2374411A1 (en) | 2001-01-18 |
| PL352486A1 (en) | 2003-08-25 |
| NO20020129L (en) | 2002-03-11 |
| WO2001004134A2 (en) | 2001-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |