BR9912816A - Therapeutic composition based on flavonoids, intended for use in the treatment of tumors by cytotoxic agents - Google Patents

Therapeutic composition based on flavonoids, intended for use in the treatment of tumors by cytotoxic agents

Info

Publication number
BR9912816A
BR9912816A BR9912816-0A BR9912816A BR9912816A BR 9912816 A BR9912816 A BR 9912816A BR 9912816 A BR9912816 A BR 9912816A BR 9912816 A BR9912816 A BR 9912816A
Authority
BR
Brazil
Prior art keywords
tumors
treatment
intended
flavonoids
cytotoxic agents
Prior art date
Application number
BR9912816-0A
Other languages
Portuguese (pt)
Inventor
Francis Darro
Robert Kiss
Armand Frydman
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of BR9912816A publication Critical patent/BR9912816A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçãO TERAPêUTICA à BASE DE FLAVONóIDES, TENCIONADA PARA USO NO TRATAMENTO DE TUMORES POR AGENTES CITOTóXICOS"<D>. A presente invenção refere-se a composição tendo uma atividade sobre a proliferação de células clonogênicas em tumores e compreendendo uma quantidade terapeuticamente eficaz de um flavonóide, em particular um composto selecionado entre os compostos de fórmula (I) em que; R~ 1~, R~ 2~, R~ 3~ e R~ 4~, R~ 5~ e R~ 6~ são conforme definidos na reivindicação 2. A composição referida é planejada para uso no tratamento de tumores com agentes citotóxicos.Invention Patent: <B> "THERAPEUTIC COMPOSITION BASED ON FLAVONOIDS, INTENDED FOR USE IN THE TREATMENT OF TUMORS BY CYTOXOTIC AGENTS" <D>. The present invention relates to the composition having an activity on the proliferation of clonogenic cells in tumors and comprising a therapeutically effective amount of a flavonoid, in particular a compound selected from the compounds of formula (I) in which; R ~ 1 ~, R ~ 2 ~, R ~ 3 ~ and R ~ 4 ~, R ~ 5 ~ and R ~ 6 ~ are as defined in claim 2. The said composition is intended for use in the treatment of tumors with cytotoxic agents .

BR9912816-0A 1998-07-15 1999-07-13 Therapeutic composition based on flavonoids, intended for use in the treatment of tumors by cytotoxic agents BR9912816A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9809058A FR2781153B1 (en) 1998-07-15 1998-07-15 FLAVONOID-BASED THERAPEUTIC COMPOSITION FOR USE IN THE TREATMENT OF TUMORS WITH CYTOTOXIC AGENTS
PCT/FR1999/001714 WO2000003706A1 (en) 1998-07-15 1999-07-13 Therapeutic composition based on flavonoids for use in the treatment of tumours with cytotoxic agents

Publications (1)

Publication Number Publication Date
BR9912816A true BR9912816A (en) 2001-05-08

Family

ID=9528648

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912816-0A BR9912816A (en) 1998-07-15 1999-07-13 Therapeutic composition based on flavonoids, intended for use in the treatment of tumors by cytotoxic agents

Country Status (12)

Country Link
EP (1) EP1096930A1 (en)
JP (1) JP2002520356A (en)
KR (1) KR20020003349A (en)
CN (1) CN1139384C (en)
AU (1) AU4789099A (en)
BR (1) BR9912816A (en)
CA (1) CA2337179A1 (en)
EA (1) EA200100140A1 (en)
FR (1) FR2781153B1 (en)
IL (1) IL140588A0 (en)
WO (1) WO2000003706A1 (en)
ZA (1) ZA200100239B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069949A2 (en) * 2001-03-06 2002-09-12 Prendergast Patrick T Combination therapy for reduction of toxycity of chemotherapeutic agents
EP1808172A3 (en) * 2002-03-06 2010-05-26 Activephyto Technologies Limited Botanical extract compositions and methods of use
AU2003217982A1 (en) * 2002-03-06 2003-09-22 The Medical Research And Education Trust Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol
US20030229136A1 (en) 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
CN1679539A (en) * 2005-01-20 2005-10-12 吴一心 Synergic medicinal composition for preventing from tumor
CA2600797A1 (en) * 2005-03-11 2006-09-21 The Regents Of The University Of Michigan Chromen-4-one inhibitors of anti-apoptotic bcl-2 family members and the uses thereof
GB0808974D0 (en) * 2008-05-16 2008-06-25 Veritron Ltd Plant extract and its therapeutic use
US9808477B2 (en) * 2015-07-29 2017-11-07 Macau University Of Science And Technology Use of nobiletin in cancer treatment
US9808439B2 (en) * 2015-07-29 2017-11-07 Macau University Of Science And Technology Use of tangeretin in cancer treatment
JP6775226B2 (en) * 2016-06-30 2020-10-28 国立大学法人広島大学 Anti-cancer drug action enhancer and anti-cancer drug kit equipped with it
CN106562954A (en) * 2016-11-11 2017-04-19 黄冈师范学院 Application of (demethylated) polymethoxylated flavones and paclitaxel drugs in preparation of drugs for treating non-small cell lung cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0617304B2 (en) * 1982-09-09 1994-03-09 理化学研究所 Anti-cancer drug
JPS5959627A (en) * 1982-09-27 1984-04-05 Tatsuo Miyoshi Carcinostatic agent
JPS60199817A (en) * 1984-03-23 1985-10-09 Rikagaku Kenkyusho Carcinostatic agent
JPS632925A (en) * 1986-06-23 1988-01-07 Nippon Kayaku Co Ltd C-kinase inhibitor and anti-tumor agent
FR2633182B1 (en) * 1988-06-23 1993-07-23 Beljanski Mirko ANTI-CANCER PHARMACEUTICAL COMPOSITION AND METHOD OF USING THE INVENTION
JPH04103532A (en) * 1990-08-24 1992-04-06 Tatsuo Miyoshi Carcinostatic agent
JPH04103529A (en) * 1990-08-24 1992-04-06 Tatsuo Miyoshi Carcinostatic agent
JP2514500B2 (en) * 1991-09-14 1996-07-10 呉羽化学工業株式会社 Multidrug resistance inhibitor and expression inhibitor
EP0642793A4 (en) * 1992-05-11 1995-03-29 Tsumura & Co. Apoptosis inducer.
WO1996031206A2 (en) * 1995-04-07 1996-10-10 Warner-Lambert Company Flavones and coumarins as agents for the treatment of atherosclerosis
DE29719198U1 (en) * 1997-10-29 1998-04-23 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, 14558 Bergholz-Rehbrücke Flavono / flavonoid preparation

Also Published As

Publication number Publication date
AU4789099A (en) 2000-02-07
JP2002520356A (en) 2002-07-09
CN1139384C (en) 2004-02-25
EA200100140A1 (en) 2001-06-25
FR2781153B1 (en) 2001-08-03
ZA200100239B (en) 2002-01-09
IL140588A0 (en) 2002-02-10
KR20020003349A (en) 2002-01-12
CN1313765A (en) 2001-09-19
CA2337179A1 (en) 2000-01-27
WO2000003706A1 (en) 2000-01-27
EP1096930A1 (en) 2001-05-09
FR2781153A1 (en) 2000-01-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.