NO20020129L - New esters derived from nucleosides, methods of preparation and preparations containing them - Google Patents

New esters derived from nucleosides, methods of preparation and preparations containing them

Info

Publication number
NO20020129L
NO20020129L NO20020129A NO20020129A NO20020129L NO 20020129 L NO20020129 L NO 20020129L NO 20020129 A NO20020129 A NO 20020129A NO 20020129 A NO20020129 A NO 20020129A NO 20020129 L NO20020129 L NO 20020129L
Authority
NO
Norway
Prior art keywords
nucleosides
esters derived
hydroxyl
preparation
methods
Prior art date
Application number
NO20020129A
Other languages
Norwegian (no)
Other versions
NO20020129D0 (en
Inventor
Patrick Vlieghe
Jean-Louis Braus
Thierry Clerc
Jean-Pierre Salles
Original Assignee
Laphal Sa Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laphal Sa Lab filed Critical Laphal Sa Lab
Publication of NO20020129D0 publication Critical patent/NO20020129D0/en
Publication of NO20020129L publication Critical patent/NO20020129L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

R2 representerer hydrogen eller hydroksyl, R3 representerer hydrogen, hykdroksyl eller azido og den prikkede linjen, når den er til stede, representerer en karbon-karbon dobbeltbinding. De foreliggende forbindelser er anvendelige som antivirale midler. Sammendrag Den foreliggende oppfinnelse angår området organisk kjemi, og mer spesielt området terapeutisk kjemi. Oppfinnelsen angår mer spesielt to nye estere utledet fra nukleosider med den generelle formel (I): Z - A - C - O- O (I) hvori A representerer en divalent gruppe valgt fra -(CH2)n-, - (CH2) - NH-, -(CH2)n - O -; NH - O - (CH2)n n er et tall fra l til 12; Z representerer aminogruppe, hydroksyl- eller alkyl, og "nukleosid"-gruppen er en rest av hydroksylert nukleosid, med den generelle formel: hvori RI representerer et radikal valgt fra: O R, H N/^. O hvor R4 representerer metyl, trifluormetyl eller halovinyl,R 2 represents hydrogen or hydroxyl, R 3 represents hydrogen, hydroxyl or azido and the dotted line, when present, represents a carbon-carbon double bond. The present compounds are useful as antiviral agents. Summary The present invention relates to the field of organic chemistry, and more particularly to the field of therapeutic chemistry. More particularly, this invention relates to two novel esters derived from nucleosides of general formula (I): Z - A - C - O - O (I) wherein A represents a divalent group selected from - (CH 2) n -, - (CH 2) - NH-, - (CH2) n - O -; NH - O - (CH 2) n n is a number from 1 to 12; Z represents amino group, hydroxyl or alkyl, and the "nucleoside" group is a residue of hydroxylated nucleoside, of the general formula: wherein R 1 represents a radical selected from: O R, H N / R. O wherein R 4 represents methyl, trifluoromethyl or halovinyl,

NO20020129A 1999-07-12 2002-01-11 New esters derived from nucleosides, methods of preparation and preparations containing them NO20020129L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9909004A FR2796384A1 (en) 1999-07-12 1999-07-12 NOVEL ESTERS DERIVED FROM NUCLEOSIDES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
PCT/FR2000/002002 WO2001004134A2 (en) 1999-07-12 2000-07-11 Novel esters derived from nucleosides, preparation methods and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
NO20020129D0 NO20020129D0 (en) 2002-01-11
NO20020129L true NO20020129L (en) 2002-03-11

Family

ID=9547990

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020129A NO20020129L (en) 1999-07-12 2002-01-11 New esters derived from nucleosides, methods of preparation and preparations containing them

Country Status (10)

Country Link
JP (1) JP2003504377A (en)
AP (1) AP2002002395A0 (en)
AU (1) AU6452300A (en)
BR (1) BR0012381A (en)
CA (1) CA2374411A1 (en)
FR (1) FR2796384A1 (en)
IL (1) IL147449A0 (en)
NO (1) NO20020129L (en)
PL (1) PL352486A1 (en)
WO (1) WO2001004134A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5924479B2 (en) * 2010-02-15 2016-05-25 日産化学工業株式会社 Method for producing β-dihydrofuran-derived compound, β-dihydrofuran-derived compound or β-tetrahydrofuran-derived compound, and method for producing β-glycoside compound
EP2537851B1 (en) 2010-02-15 2015-06-10 Nissan Chemical Industries, Ltd. Process for preparation of b-glycoside compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69829784T2 (en) * 1997-08-15 2006-02-16 Medivir Ab 3'-fluorinated guanosine derivatives for the treatment or prophylaxis of HBV or retroviral infections

Also Published As

Publication number Publication date
WO2001004134A3 (en) 2001-09-27
BR0012381A (en) 2002-03-26
NO20020129D0 (en) 2002-01-11
CA2374411A1 (en) 2001-01-18
WO2001004134A2 (en) 2001-01-18
AU6452300A (en) 2001-01-30
IL147449A0 (en) 2002-08-14
FR2796384A1 (en) 2001-01-19
AP2002002395A0 (en) 2002-03-31
JP2003504377A (en) 2003-02-04
PL352486A1 (en) 2003-08-25

Similar Documents

Publication Publication Date Title
Martin et al. Synthesis and antiviral activity of monofluoro and difluoro analogs of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)
ES2279559T3 (en) SYNTHESIS PROCEDURE AND COMPOSITIONS OF BCH-189 AND RELATED COMPOUNDS.
EP0342203B1 (en) 2',3' dideoxyribofuranoxide derivatives
ATE346851T1 (en) MULTIFUNCTIONAL THIOXANTHONE PHOTOINITIATORS
MY115183A (en) Process for purifying and isolating 2''-deoxy-2'',2''- difluoronucleosides
MXPA05010824A (en) Bicyclic compounds as nr2b receptor antagonists.
NO20045235L (en) Tetrahydropyranyl cyclopentyltetrahydropyridopyridine modulators with chemokine receptor activity
NO20065830L (en) Substituted 2-quinolyloxazoles useful as PDE4 inhibitors.
SK6722000A3 (en) Adenosine derivatives, method for their preparation, pharmaceutical composition containing the same and their use
ATE372316T1 (en) MULTIFUNCTIONAL PHOTOINITIATORS
IL159203A0 (en) Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases
JP2022517113A (en) New Substituted Sulfonylurea Derivatives
CA2243121A1 (en) Aspartyl protease inhibitors
KR20060091050A (en) Novel lincomycin derivatives possessing antimicrobial activity
WO2006061585A1 (en) Pyrrolidine compounds
NO20020129L (en) New esters derived from nucleosides, methods of preparation and preparations containing them
NO20032291L (en) pyrimidine
FR2878528A1 (en) 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDES, THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF
NO951433L (en) Chemical connections
NO169007B (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE URIDIN DERIVATIVES
NO20041573L (en) Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical preparations containing the same
NO169652B (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE GUANINE DERIVATIVES
CA2079815A1 (en) Carbo-nucleoside derivatives
US4140850A (en) 2,2'-Anhydrotriazine nucleosides and process for preparing the same
Schoffers et al. Chemical synthesis of scyllo-inosamine and catabolism studies in Sinorhizobium meliloti

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application