NO20013141L - Arylalkanoylderivater, fremgangsmåter for fremstilling derav, deres anvendelse og farmasöytiske preparater inneholdende disse - Google Patents
Arylalkanoylderivater, fremgangsmåter for fremstilling derav, deres anvendelse og farmasöytiske preparater inneholdende disseInfo
- Publication number
- NO20013141L NO20013141L NO20013141A NO20013141A NO20013141L NO 20013141 L NO20013141 L NO 20013141L NO 20013141 A NO20013141 A NO 20013141A NO 20013141 A NO20013141 A NO 20013141A NO 20013141 L NO20013141 L NO 20013141L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compounds
- compound
- blood coagulation
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100001A EP1022268A1 (de) | 1999-01-02 | 1999-01-02 | Arylalkanoylderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und diese enthaltende pharmazeutische Zubereitungen |
EP99119538 | 1999-10-01 | ||
PCT/EP1999/010341 WO2000040548A1 (en) | 1999-01-02 | 1999-12-23 | Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20013141D0 NO20013141D0 (no) | 2001-06-22 |
NO20013141L true NO20013141L (no) | 2001-08-03 |
Family
ID=26152842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20013141A NO20013141L (no) | 1999-01-02 | 2001-06-22 | Arylalkanoylderivater, fremgangsmåter for fremstilling derav, deres anvendelse og farmasöytiske preparater inneholdende disse |
Country Status (20)
Country | Link |
---|---|
US (1) | US6759420B1 (de) |
EP (1) | EP1150946B1 (de) |
JP (1) | JP2002534408A (de) |
KR (1) | KR20010089753A (de) |
CN (1) | CN1332723A (de) |
AR (1) | AR022130A1 (de) |
AT (1) | ATE292114T1 (de) |
AU (1) | AU2285700A (de) |
BR (1) | BR9916733A (de) |
CA (1) | CA2358581C (de) |
CZ (1) | CZ20012378A3 (de) |
DE (1) | DE69924527T2 (de) |
ES (1) | ES2239478T3 (de) |
HK (1) | HK1041687A1 (de) |
HU (1) | HUP0202647A3 (de) |
IL (1) | IL144095A0 (de) |
NO (1) | NO20013141L (de) |
NZ (1) | NZ512669A (de) |
TR (1) | TR200101980T2 (de) |
WO (1) | WO2000040548A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1127884A1 (de) | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Neue Malonsäure Derivaie, Verfahren zu ihrer Herstellung, ihre Verwendung als Inhibitor der Faktor XA Aktivtät und pharmazeutische Zusammensetzungen diese enthaltend |
US7335673B2 (en) | 2000-08-11 | 2008-02-26 | Kaken Pharmaceutical Co., Ltd. | 2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage |
DE10204072A1 (de) * | 2002-01-31 | 2003-08-14 | Morphochem Ag Komb Chemie | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
US7479502B2 (en) | 2002-12-03 | 2009-01-20 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
US7682782B2 (en) * | 2004-10-29 | 2010-03-23 | Affymetrix, Inc. | System, method, and product for multiple wavelength detection using single source excitation |
CA2587444C (en) | 2004-11-12 | 2013-09-10 | Ucl Business Plc | Guanidine derivatives as inhibitors of ddah |
AR067329A1 (es) * | 2007-06-13 | 2009-10-07 | Bristol Myers Squibb Co | Analogos dipeptidos como inhibidores del factor de coagulacion |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2593812B1 (fr) * | 1986-01-24 | 1988-08-26 | Sanofi Sa | Derives na-substitues des na-arylsulfonylaminoacyl p-amidinophenylalaninamides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
PT84170B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
DE69333639D1 (en) * | 1992-01-30 | 2004-11-04 | Dendreon Corp | Trypsininhibitoren |
US5576342A (en) * | 1992-03-13 | 1996-11-19 | Bayer Aktiengesellschaft | Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives |
CN1181091C (zh) * | 1994-04-26 | 2004-12-22 | 西莱克泰德公司 | 因子Xa抑制剂 |
US6025472A (en) * | 1994-12-21 | 2000-02-15 | Corvas International, Inc. | N-substituted glycine derivatives as enzyme inhibitors |
RO117913B1 (ro) * | 1996-01-02 | 2002-09-30 | Aventis Pharmaceuticals Inc. | Derivaţi de n-[(amino-(imino)metil)fenil]propil amide substituite, compoziţie farmaceutică care îi conţine şi metodă de tratament |
RU2225397C2 (ru) | 1997-12-24 | 2004-03-10 | Авентис Фарма Дойчланд Гмбх | Производные индола как ингибиторы фактора Ха |
KR20010101355A (ko) | 1999-01-02 | 2001-11-14 | 로버트 흐라이탁, 미쉘 베스트 | 신규한 말론산 유도체, 이의 제조 방법, 이의 용도 및이를 함유하는 약제학적 조성물(인자 xa 활성 억제) |
-
1999
- 1999-12-23 DE DE69924527T patent/DE69924527T2/de not_active Expired - Lifetime
- 1999-12-23 CN CN99815252A patent/CN1332723A/zh active Pending
- 1999-12-23 NZ NZ512669A patent/NZ512669A/en unknown
- 1999-12-23 KR KR1020017008423A patent/KR20010089753A/ko not_active Application Discontinuation
- 1999-12-23 WO PCT/EP1999/010341 patent/WO2000040548A1/en active IP Right Grant
- 1999-12-23 ES ES99967001T patent/ES2239478T3/es not_active Expired - Lifetime
- 1999-12-23 AU AU22857/00A patent/AU2285700A/en not_active Abandoned
- 1999-12-23 JP JP2000592257A patent/JP2002534408A/ja active Pending
- 1999-12-23 IL IL14409599A patent/IL144095A0/xx unknown
- 1999-12-23 HU HU0202647A patent/HUP0202647A3/hu unknown
- 1999-12-23 BR BR9916733-6A patent/BR9916733A/pt not_active Application Discontinuation
- 1999-12-23 AT AT99967001T patent/ATE292114T1/de not_active IP Right Cessation
- 1999-12-23 CZ CZ20012378A patent/CZ20012378A3/cs unknown
- 1999-12-23 TR TR2001/01980T patent/TR200101980T2/xx unknown
- 1999-12-23 EP EP99967001A patent/EP1150946B1/de not_active Expired - Lifetime
- 1999-12-23 CA CA002358581A patent/CA2358581C/en not_active Expired - Fee Related
- 1999-12-28 US US09/472,936 patent/US6759420B1/en not_active Expired - Lifetime
- 1999-12-28 AR ARP990106794A patent/AR022130A1/es not_active Application Discontinuation
-
2001
- 2001-06-22 NO NO20013141A patent/NO20013141L/no not_active Application Discontinuation
-
2002
- 2002-05-04 HK HK02103394.4A patent/HK1041687A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
DE69924527D1 (de) | 2005-05-04 |
HK1041687A1 (zh) | 2002-07-19 |
CA2358581A1 (en) | 2000-07-13 |
CA2358581C (en) | 2010-02-02 |
ATE292114T1 (de) | 2005-04-15 |
NO20013141D0 (no) | 2001-06-22 |
US6759420B1 (en) | 2004-07-06 |
KR20010089753A (ko) | 2001-10-08 |
AU2285700A (en) | 2000-07-24 |
AR022130A1 (es) | 2002-09-04 |
WO2000040548A1 (en) | 2000-07-13 |
TR200101980T2 (tr) | 2002-04-22 |
JP2002534408A (ja) | 2002-10-15 |
EP1150946B1 (de) | 2005-03-30 |
EP1150946A1 (de) | 2001-11-07 |
CN1332723A (zh) | 2002-01-23 |
HUP0202647A3 (en) | 2003-12-29 |
NZ512669A (en) | 2003-11-28 |
BR9916733A (pt) | 2001-09-25 |
IL144095A0 (en) | 2002-05-23 |
DE69924527T2 (de) | 2006-02-09 |
CZ20012378A3 (cs) | 2001-09-12 |
HUP0202647A2 (hu) | 2002-11-28 |
ES2239478T3 (es) | 2005-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9916732A (pt) | Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa) | |
NZ530782A (en) | Aminoisoxazole derivatives active as kinase inhibitors | |
NO20060113L (no) | Pyrrolo(3,4-c)pyrazolderivater aktive som kinase inhibitorer | |
WO2005005414A3 (en) | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | |
WO2002012242A3 (en) | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | |
MXPA04012965A (es) | Inhibidores virales. | |
MY120064A (en) | Indole derivatives as inhibitors or factor xa | |
MEP60908A (en) | 2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds | |
ATE388951T1 (de) | Dpp-iv-inhibierende purin-derivative zur behandlung von diabetes | |
BR0108694A (pt) | Derivados de ácido malÈnico, processo para preparação dos mesmos, uso dos mesmos como inibidor de atividade do fator xa e composições farmacêuticas que contêm os mesmos | |
CA2148928A1 (en) | Pharmacologically active pyridine derivatives and processes for the preparation thereof | |
CA2030433A1 (en) | New isoquinoline- carboxamide amino acid derivatives useful for treatment of viral diseases | |
NO20051265L (no) | Anvendelse av og noen nye imidazopyridiner | |
GB0102687D0 (en) | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them | |
RU94040859A (ru) | Аминопроизводные оксо- и гидрокси-замещенных углеводородов, способы получения, фармацевтические композиции, способ ингибирования ретровирусной протеазы, способ лечения спида у млекопитающих | |
CN106928198B (zh) | 磺酰胺衍生物及其制备方法与应用 | |
NO20025810D0 (no) | Faktor VIIA-inhibitoriske (tio)ureaderivater, deres fremstilling og anvendelse | |
WO2005014572A8 (en) | Pyrimidylpyrrole derivatives active as kinase inhibitors | |
RU94046093A (ru) | Производные 7-(2-аминоэтил)бензотиазолона, способ их получения, промежуточные соединения, фармкомпозиция | |
NO983992L (no) | Serinprotease inhibitorer | |
NO983991L (no) | Serin-protease-inhibitorer | |
WO2004018463A3 (en) | Pyridyl substituted heterocycles useful for treating or preventing hcv infection | |
NO20013141L (no) | Arylalkanoylderivater, fremgangsmåter for fremstilling derav, deres anvendelse og farmasöytiske preparater inneholdende disse | |
MXPA02006249A (es) | Nuevos derivados de azabiciclooctano, utiles en el tratamiento de arritmias cardiacas. | |
EP4043467A1 (de) | Klasse von funktionellen molekülen, die auf proteolysewege abzielen, herstellung und verwendung davon |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |