NO20012833L - <Alfa>-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppe - Google Patents

<Alfa>-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppe

Info

Publication number
NO20012833L
NO20012833L NO20012833A NO20012833A NO20012833L NO 20012833 L NO20012833 L NO 20012833L NO 20012833 A NO20012833 A NO 20012833A NO 20012833 A NO20012833 A NO 20012833A NO 20012833 L NO20012833 L NO 20012833L
Authority
NO
Norway
Prior art keywords
methylbenzyl
alpha
herpes virus
phenylenediamine group
thiourea inhibitors
Prior art date
Application number
NO20012833A
Other languages
English (en)
Norwegian (no)
Other versions
NO20012833D0 (no
Inventor
Jonathan David Bloom
Kevin Joseph Curran
Martin Joseph Digrandi
Russel George Dushin
Stanley Albert Lang
Emily Boucher Norton
Adma Antonia Ross
Bryan Mark O'hara
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO20012833D0 publication Critical patent/NO20012833D0/no
Publication of NO20012833L publication Critical patent/NO20012833L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
NO20012833A 1998-12-09 2001-06-08 <Alfa>-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppe NO20012833L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20890298A 1998-12-09 1998-12-09
PCT/US1999/028839 WO2000034260A2 (en) 1998-12-09 1999-12-06 Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group

Publications (2)

Publication Number Publication Date
NO20012833D0 NO20012833D0 (no) 2001-06-08
NO20012833L true NO20012833L (no) 2001-08-02

Family

ID=22776519

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012833A NO20012833L (no) 1998-12-09 2001-06-08 <Alfa>-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppe

Country Status (21)

Country Link
EP (1) EP1137645B1 (cs)
JP (1) JP2002531555A (cs)
KR (1) KR20010089551A (cs)
CN (1) CN1165531C (cs)
AR (1) AR035308A1 (cs)
AT (1) ATE267824T1 (cs)
AU (1) AU1934600A (cs)
BR (1) BR9916084A (cs)
CA (1) CA2350833A1 (cs)
CZ (1) CZ20012067A3 (cs)
DE (1) DE69917673T2 (cs)
DK (1) DK1137645T3 (cs)
EA (1) EA004205B1 (cs)
ES (1) ES2221470T3 (cs)
HU (1) HUP0104492A3 (cs)
IL (1) IL143183A0 (cs)
NO (1) NO20012833L (cs)
NZ (1) NZ512135A (cs)
PT (1) PT1137645E (cs)
WO (1) WO2000034260A2 (cs)
ZA (1) ZA200104376B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
ES2254385T3 (es) 2000-02-29 2006-06-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
DE60133743T2 (de) * 2000-08-21 2009-07-02 Pacific Corp. Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten
JP4360885B2 (ja) 2003-11-28 2009-11-11 富士フイルム株式会社 アルキルチオ基を有する芳香族アミン化合物の製造方法
CA2619366A1 (en) * 2005-08-22 2007-03-01 Amgen Inc. Bis-aryl urea compounds for the treatment of protein kinase-mediated diseases
WO2008057972A1 (en) 2006-11-02 2008-05-15 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
CN112807294B (zh) * 2019-11-18 2023-09-05 武汉大学 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用
CN115433093A (zh) * 2022-09-26 2022-12-06 无锡双启科技有限公司 一种3-氯-4-三氟甲基苯胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210683B (en) * 1990-06-18 1995-06-28 Sandoz Ag Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same
EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
GB9519270D0 (en) * 1995-09-21 1995-11-22 Sandoz Pharma Uk Organic compounds
CZ298463B6 (cs) * 1996-04-23 2007-10-10 Vertex Pharmaceuticals Incorporated Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují

Also Published As

Publication number Publication date
HUP0104492A3 (en) 2002-12-28
CA2350833A1 (en) 2000-06-15
PT1137645E (pt) 2004-09-30
ATE267824T1 (de) 2004-06-15
DE69917673T2 (de) 2005-06-09
BR9916084A (pt) 2001-09-04
KR20010089551A (ko) 2001-10-06
DE69917673D1 (de) 2004-07-01
HUP0104492A2 (hu) 2002-04-29
NO20012833D0 (no) 2001-06-08
WO2000034260A3 (en) 2000-09-08
JP2002531555A (ja) 2002-09-24
WO2000034260A2 (en) 2000-06-15
NZ512135A (en) 2003-12-19
AR035308A1 (es) 2004-05-12
CN1329608A (zh) 2002-01-02
ZA200104376B (en) 2002-08-28
DK1137645T3 (da) 2004-08-09
EP1137645A2 (en) 2001-10-04
CZ20012067A3 (cs) 2001-10-17
CN1165531C (zh) 2004-09-08
ES2221470T3 (es) 2004-12-16
EA200100638A1 (ru) 2001-12-24
EP1137645B1 (en) 2004-05-26
EA004205B1 (ru) 2004-02-26
AU1934600A (en) 2000-06-26
IL143183A0 (en) 2002-04-21

Similar Documents

Publication Publication Date Title
NO20013674L (no) Acetyleniske &lt;alfa&gt;-aminosyre-baserte sulfonamid- hydroksamsyre TACE-inhibitorer
BR9306463A (pt) Alfa alumina
DK1049695T3 (da) 2-Phenyl-substituerede imidazotriazinoner som phosphodiesterase-inhibitorer
DE69838515D1 (de) Aminothiazole zur hemmung cyclinabhängiger kinasen
BR9801538A (pt) Designação de transceptores flutuantes para radiocelular
NO982907D0 (no) Tyrosinderivater som &lt;alfa&gt;-v-integrininhibitorer
NO20012834D0 (no) Acetamid- og substituerte acetamid-holdige tioureainhibitorer for herpesvirus
ATE289509T1 (de) Acyl guanidin natrium/protonen-austauschhemmer
NO20012833D0 (no) &lt;Alfa&gt;-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppe
NO20012835D0 (no) Heterocykliske karboksamid-holdige tiourea-inhibitorer for herpesvirus inneholdende en substituert fenylendiamingruppe
NO20012838D0 (no) Tiourea-inhibitorer for herpesvirus
IL143182A0 (en) Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
NO20012837D0 (no) Tiourea-inhibitorer for herpesvirus
NO20012836D0 (no) Tiourea-inhibitorer for herpes virus
IT242819Y1 (it) Confezione per la trasformazione di rifiuti di tipo vegetale-organico
NO991675L (no) Fremgangsmaate for alkylering av hindrede sulfonamider
SI1137645T1 (en) Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
NO982531D0 (no) Fremstilling av &lt;alfa&gt;-tokoferol
ID20135A (id) Alat untuk pelaksanaan penekan jari
DK1012180T3 (da) Hepatitis C-inhibitorpeptidanaloger
NO20006214L (no) &lt;alfa&gt;-(1-piperaziny1)acetamidoarenkarboksylsyrederivater som antidiabetiske midler
ITMI982758A1 (it) Procedimento per la purificazione di 7-glutaril aca
IT1279584B1 (it) Fionda di tipo perfezionato
ITMN970037A1 (it) Pinza per la movimentazione di lastre
IT1296764B1 (it) Movimentazione di piastrelle.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application